Title: Book the Best BUSINESS Hotels in Downtown San Diego in 2026 | Expedia.ca [Downtown San Diego Travel Guide](https://expedia.ca/San-Diego-Downtown-San-Diego.dx800123)[Vacation Rentals in San Diego](https://expedia.ca/San-Diego-Vacation-Rentals.d3073.Travel-Guide-VacationRentals)[Flights to San Diego](https://expedia.ca/Cheap-Flights-To-San-Diego.d3073.Travel-Guide-Flights)[Things to do in San Diego](https://expedia.ca/Things-To-Do-In-San-Diego.d3073.Travel-Guide-Activities)[Downtown San Diego Car Rentals](https://expedia.ca/Car-Rentals-In-Downtown-San-Diego.d800123.Car-Rental-Guide)[Downtown San Diego Vacations](https://expedia.ca/Downtown-San-Diego.d800123.Destination-Travel-Guides) ![Seaport Village featuring a church or cathedral](https://images.trvl-media.com/place/502533/365f2852-ae5f-4c96-a03a-d10b3391e979.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find Business Hotels in Downtown San Diego, CA from CA $159 - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Downtown San Diego Business Hotels Tonight [Dec 28 - Dec 29](https://www.expedia.ca/Hotel-Search?regionId=800123&startDate=2025-12-28&endDate=2025-12-29&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) Tomorrow [Dec 29 - Dec 30](https://www.expedia.ca/Hotel-Search?regionId=800123&startDate=2025-12-29&endDate=2025-12-30&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) Next weekend [Jan 2 - Jan 4](https://www.expedia.ca/Hotel-Search?regionId=800123&startDate=2026-01-02&endDate=2026-01-04&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) In two weeks [Jan 9 - Jan 11](https://www.expedia.ca/Hotel-Search?regionId=800123&startDate=2026-01-09&endDate=2026-01-11&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) ## Our top choices for Downtown San Diego business-friendly hotels ![Exterior](https://images.trvl-media.com/lodging/3000000/2920000/2918200/2918129/a0a6825c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/3000000/2920000/2918200/2918129/f3168007.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Bar (on property)](https://images.trvl-media.com/lodging/3000000/2920000/2918200/2918129/a9bcd444.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool](https://images.trvl-media.com/lodging/3000000/2920000/2918200/2918129/e3befa7e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Residence Inn by Marriott San Diego Downtown/Gaslamp Quarter [](https://www.expedia.ca/San-Diego-Hotels-Residence-Inn-By-Marriott-San-Diego-DowntownGaslamp-Quarter.h2918129.Hotel-Information) Downtown San Diego 9.0/10 Wonderful (1240) "Clean, courteous staff, good location. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Carla CA $150 CA $174 total includes taxes & fees Dec 30 - Dec 31 [](https://www.expedia.ca/San-Diego-Hotels-Residence-Inn-By-Marriott-San-Diego-DowntownGaslamp-Quarter.h2918129.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/10000/900/858/c5325c92.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Down comforters, pillowtop beds, in-room safe, desk](https://images.trvl-media.com/lodging/1000000/10000/900/858/93b051f7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![3 outdoor pools, cabanas (surcharge), pool umbrellas](https://images.trvl-media.com/lodging/1000000/10000/900/858/543624c5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Penthouse](https://images.trvl-media.com/lodging/1000000/10000/900/858/36c2b78d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hyatt Regency Mission Bay Spa and Marina [](https://www.expedia.ca/San-Diego-Hotels-Hyatt-Regency-Mission-Bay-Spa-And-Marina.h858.Hotel-Information) Mission Bay 8.4/10 Very good (1583) "Totally Recommend! Rooms are really clean and comfortable, the staff are great as well. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Fernando CA $165 CA $262 total includes taxes & fees Jan 10 - Jan 11, 2026 [](https://www.expedia.ca/San-Diego-Hotels-Hyatt-Regency-Mission-Bay-Spa-And-Marina.h858.Hotel-Information) ![Deluxe Room, 2 Queen Beds](https://images.trvl-media.com/lodging/1000000/20000/12100/12073/8cee884b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/20000/12100/12073/152ea7ee.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Hypo-allergenic bedding, in-room safe, desk, iron/ironing board](https://images.trvl-media.com/lodging/1000000/20000/12100/12073/91c34fa4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/20000/12100/12073/9f5b2440.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Manchester Grand Hyatt San Diego [](https://www.expedia.ca/San-Diego-Hotels-Manchester-Grand-Hyatt-San-Diego.h12073.Hotel-Information) Downtown San Diego 9.0/10 Wonderful (2880) "Everything was great and so convenient to everywhere we wanted to go to" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Julio J CA $241 CA $354 total includes taxes & fees Dec 29 - Dec 30 [](https://www.expedia.ca/San-Diego-Hotels-Manchester-Grand-Hyatt-San-Diego.h12073.Hotel-Information) ![2 outdoor pools, open 6 AM to 10:00 PM, cabanas (surcharge)](https://images.trvl-media.com/lodging/1000000/30000/24400/24394/9078a9ee.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![View from property](https://images.trvl-media.com/lodging/1000000/30000/24400/24394/3be512ed.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![View from property](https://images.trvl-media.com/lodging/1000000/30000/24400/24394/5488e3f5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 bars/lounges, poolside bar](https://images.trvl-media.com/lodging/1000000/30000/24400/24394/eb8b9673.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Marriott Marquis San Diego Marina [](https://www.expedia.ca/San-Diego-Hotels-Marriott-Marquis-San-Diego-Marina.h24394.Hotel-Information) Downtown San Diego 9.2/10 Wonderful (1959) "Best place to stay with family in San diego" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) vishakha CA $239 CA $349 total includes taxes & fees Jan 3 - Jan 4, 2026 [](https://www.expedia.ca/San-Diego-Hotels-Marriott-Marquis-San-Diego-Marina.h24394.Hotel-Information) ![Terrace/patio](https://images.trvl-media.com/lodging/1000000/20000/11200/11177/c44ff51d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/20000/11200/11177/5142b853.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![City view](https://images.trvl-media.com/lodging/1000000/20000/11200/11177/88f9cd22.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/20000/11200/11177/7f3bc7ed.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Wyndham San Diego Bayside [](https://www.expedia.ca/San-Diego-Hotels-Wyndham-San-Diego-Bayside.h11177.Hotel-Information) Downtown San Diego 8.4/10 Very good (6039) "Always an amazing stay" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jana CA $185 CA $254 total includes taxes & fees Dec 30 - Dec 31 [](https://www.expedia.ca/San-Diego-Hotels-Wyndham-San-Diego-Bayside.h11177.Hotel-Information) ![Standard Room, 1 King Bed, Non Smoking, Bay View](https://images.trvl-media.com/lodging/1000000/180000/170400/170338/6fe441dd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, pillowtop beds, in-room safe, desk](https://images.trvl-media.com/lodging/1000000/180000/170400/170338/3eeea039.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, pillowtop beds, in-room safe, desk](https://images.trvl-media.com/lodging/1000000/180000/170400/170338/66a8936b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/1000000/180000/170400/170338/1e0934c7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The DEXTRO Little Italy, BW Premier Collection [](https://www.expedia.ca/San-Diego-Hotels-Four-Points-By-Sheraton-San-Diego-Downtown-Little-Italy.h170338.Hotel-Information) Downtown San Diego 8.8/10 Excellent (804) "would stay again and recommend " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Brendi CA $142 CA $165 total includes taxes & fees Jan 4 - Jan 5, 2026 [](https://www.expedia.ca/San-Diego-Hotels-Four-Points-By-Sheraton-San-Diego-Downtown-Little-Italy.h170338.Hotel-Information) ![Outdoor pool, sun loungers](https://images.trvl-media.com/lodging/2000000/1880000/1871700/1871645/9fc82331.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Breakfast, lunch, dinner served; Californian cuisine, ocean views ](https://images.trvl-media.com/lodging/2000000/1880000/1871700/1871645/06f19e3f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 bars/lounges, lobby lounge](https://images.trvl-media.com/lodging/2000000/1880000/1871700/1871645/ed2e1ba0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/2000000/1880000/1871700/1871645/2df2def5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hilton San Diego Bayfront [](https://www.expedia.ca/San-Diego-Hotels-Hilton-San-Diego-Bayfront.h1871645.Hotel-Information) Downtown San Diego 8.6/10 Excellent (1895) "Enjoyed my stay" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Brandon CA $164 CA $257 total includes taxes & fees Jan 4 - Jan 5, 2026 [](https://www.expedia.ca/San-Diego-Hotels-Hilton-San-Diego-Bayfront.h1871645.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/10000/1500/1466/04fbf5a2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 bars/lounges](https://images.trvl-media.com/lodging/1000000/10000/1500/1466/a35bbd39.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![View from room](https://images.trvl-media.com/lodging/1000000/10000/1500/1466/3db72c22.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/10000/1500/1466/0e02d545.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### San Diego Marriott Gaslamp Quarter [](https://www.expedia.ca/San-Diego-Hotels-San-Diego-Marriott-Gaslamp-Quarter.h1466.Hotel-Information) Downtown San Diego 8.8/10 Excellent (1608) "Very friendly staff!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) kelli CA $185 CA $214 total includes taxes & fees Jan 4 - Jan 5, 2026 [](https://www.expedia.ca/San-Diego-Hotels-San-Diego-Marriott-Gaslamp-Quarter.h1466.Hotel-Information) ![Outdoor pool, pool umbrellas, sun loungers](https://images.trvl-media.com/lodging/1000000/560000/551900/551889/fc9f5c5b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/560000/551900/551889/62b86c17.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 1 Bedroom, Non Smoking | Living area](https://images.trvl-media.com/lodging/1000000/560000/551900/551889/14ea58da.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/1000000/560000/551900/551889/896515f9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hampton Inn San Diego-Downtown [](https://www.expedia.ca/San-Diego-Hotels-Hampton-Inn-San-Diego-Downtown.h551889.Hotel-Information) Downtown San Diego 8.2/10 Very good (2309) "Nice and convenient place to stay!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Esperanza CA $137 CA $159 total includes taxes & fees Jan 18 - Jan 19, 2026 [](https://www.expedia.ca/San-Diego-Hotels-Hampton-Inn-San-Diego-Downtown.h551889.Hotel-Information) ![Outdoor pool, open 7:00 AM to 10:00 PM, cabanas (surcharge)](https://images.trvl-media.com/lodging/1000000/30000/25600/25598/bbcdbd6d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![On the beach, white sand, windsurfing, beach volleyball](https://images.trvl-media.com/lodging/1000000/30000/25600/25598/c20f7d47.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 restaurants, breakfast, lunch, dinner served; American cuisine](https://images.trvl-media.com/lodging/1000000/30000/25600/25598/de48676b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, down comforters, pillowtop beds, in-room safe](https://images.trvl-media.com/lodging/1000000/30000/25600/25598/c2cecb91.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### San Diego Mission Bay Resort [](https://www.expedia.ca/San-Diego-Hotels-San-Diego-Mission-Bay-Resort.h25598.Hotel-Information) Mission Bay 8.4/10 Very good (1314) "Room was super clean and updated, location up against the bay was perfect. We really enjoyed our stay and want to come back soon!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Haley CA $193 CA $284 total includes taxes & fees Jan 1 - Jan 2, 2026 [](https://www.expedia.ca/San-Diego-Hotels-San-Diego-Mission-Bay-Resort.h25598.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2026-01-11&endDate=2026-01-12®ionId=800123&adults=2&travelerType=business_friendly&sort=RECOMMENDED&openPlayBack=true) ## Price trends for hotels in Downtown San Diego | Less expensive | More expensive | Next month | | -------------- | -------------- | ---------- | | December | July | CA $227 | | Month | Price | | --------- | ------- | | January | CA $227 | | February | CA $329 | | March | CA $317 | | April | CA $357 | | May | CA $357 | | June | CA $421 | | July | CA $444 | | August | CA $411 | | September | CA $416 | | October | CA $443 | | November | CA $440 | | December | CA $216 | Price trend information excludes taxes and fees and is based on base rates for a nightly stay for 2 adults found in the last 7 days on our site and averaged for commonly viewed hotels in Downtown San Diego. Select dates and complete search for nightly totals inclusive of taxes and fees. ## Top Downtown San Diego Hotel Reviews ![Courtyard by Marriott San Diego Downtown Little Italy](https://images.trvl-media.com/lodging/1000000/20000/13300/13205/db3040ff_y.jpg) ### Courtyard by Marriott San Diego Downtown Little Italy 10/10 Excellent "Excellent " [](https://expedia.ca/San-Diego-Hotels-The-Little-Italy-Hotel-In-Downtown-San-Diego.h13205.Hotel-Information) ![Omni San Diego Hotel at the Ballpark](https://images.trvl-media.com/lodging/1000000/990000/982500/982408/a9075ad6_y.jpg) ### Omni San Diego Hotel at the Ballpark 10/10 Excellent "The hotel was wonderful. The staff were all so friendly and helpful and polite. It was a terrific stay in a great location. Reny the valet was very attentive and helpful as was Mark the bellman. The food was excellent " [](https://expedia.ca/San-Diego-Hotels-Omni-San-Diego-Hotel.h982408.Hotel-Information) ![The Westin San Diego Bayview](https://images.trvl-media.com/lodging/1000000/30000/27600/27516/1b87fc03_y.jpg) ### The Westin San Diego Bayview 10/10 Excellent "Ok" [](https://expedia.ca/San-Diego-Hotels-The-Westin-San-Diego-Downtown.h27516.Hotel-Information) ![Hilton San Diego Bayfront](https://images.trvl-media.com/lodging/2000000/1880000/1871700/1871645/9fc82331_y.jpg) ### Hilton San Diego Bayfront 10/10 Excellent "Sorry, I hate these things. It is a great place. Do your due diligence." [](https://expedia.ca/San-Diego-Hotels-Hilton-San-Diego-Bayfront.h1871645.Hotel-Information) ![Margaritaville Hotel San Diego Gaslamp Quarter](https://images.trvl-media.com/lodging/2000000/1120000/1117700/1117693/0db99a00_y.jpg) ### Margaritaville Hotel San Diego Gaslamp Quarter 10/10 Excellent "Everything was great except there were early morning street noise that tended to wake me up. " [](https://expedia.ca/San-Diego-Hotels-Solamar-San-Diego.h1117693.Hotel-Information) ![Manchester Grand Hyatt San Diego](https://images.trvl-media.com/lodging/1000000/20000/12100/12073/91e2517e_y.jpg) ### Manchester Grand Hyatt San Diego 10/10 Excellent "Rooms were clean as expected. Service was really nice loved the check in agent Anthony. " [](https://expedia.ca/San-Diego-Hotels-Manchester-Grand-Hyatt-San-Diego.h12073.Hotel-Information) ![Marriott Marquis San Diego Marina](https://images.trvl-media.com/lodging/1000000/30000/24400/24394/9078a9ee_y.jpg) ### Marriott Marquis San Diego Marina 10/10 Excellent "It's a great place to visit and share time with friends and family. " [](https://expedia.ca/San-Diego-Hotels-Marriott-Marquis-San-Diego-Marina.h24394.Hotel-Information) ![The Sofia Hotel](https://images.trvl-media.com/lodging/2000000/1580000/1573900/1573807/ba6cea84_y.jpg) ### The Sofia Hotel 10/10 Excellent "Very friendly staff and clean establishment. Conveniently close to all downtown activities " [](https://expedia.ca/San-Diego-Hotels-The-Sofia-Hotel.h1573807.Hotel-Information) ![Embassy Suites by Hilton San Diego Bay Downtown](https://images.trvl-media.com/lodging/1000000/10000/5400/5328/cfe599b5_y.jpg) ### Embassy Suites by Hilton San Diego Bay Downtown 10/10 Excellent "Front desk staff was very efficient " [](https://expedia.ca/San-Diego-Hotels-Embassy-Suites-By-Hilton-San-Diego-Bay-Downtown.h5328.Hotel-Information) ## Frequently asked questions ### Why book your business-friendly hotel in Downtown San Diego with Expedia? ### How can I find cheap business-friendly hotels in Downtown San Diego? ## Explore a world of travel with Expedia - Lodging - More ways to book - [Beach Hotel Hotels in Camp Pendleton Marine Corps Base ](https://www.expedia.ca/Camp-Pendleton-Marine-Corps-Base-Hotels-Beach-Hotel.0-0-d6068523-tBeachHotel.Travel-Guide-Filter-Hotels) - [Hotels with Early Check-in in Camp Pendleton Marine Corps Base ](https://www.expedia.ca/Camp-Pendleton-Marine-Corps-Base-Hotels-Hotel-With-Early-Check-In.0-0-d6068523-thotelwithearlycheckin.Travel-Guide-Filter-Hotels) - 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