Title: Book the Best BUSINESS Hotels in Downtown San Diego in 2025 | Expedia.ca [Downtown San Diego Travel Guide](https://expedia.ca/San-Diego-Downtown-San-Diego.dx800123)[Vacation Rentals in San Diego](https://expedia.ca/San-Diego-Vacation-Rentals.d3073.Travel-Guide-VacationRentals)[Flights to San Diego](https://expedia.ca/Cheap-Flights-To-San-Diego.d3073.Travel-Guide-Flights)[Things to do in San Diego](https://expedia.ca/Things-To-Do-In-San-Diego.d3073.Travel-Guide-Activities)[Downtown San Diego Car Rentals](https://expedia.ca/Car-Rentals-In-Downtown-San-Diego.d800123.Car-Rental-Guide)[Downtown San Diego Vacations](https://expedia.ca/Downtown-San-Diego.d800123.Destination-Travel-Guides) ![](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/480000/480742-Maritime-Museum-Of-San-Diego.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find Business Hotels in Downtown San Diego, CA from CA $213 ![calendar shield illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation ![deals illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) ![bed illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Downtown San Diego Business Hotels Tonight [Sep 24 - Sep 25](https://www.expedia.ca/Hotel-Search?regionId=800123&startDate=2025-09-24&endDate=2025-09-25&adults=2&travelerType=BUSINESS&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Sep 25 - Sep 26](https://www.expedia.ca/Hotel-Search?regionId=800123&startDate=2025-09-25&endDate=2025-09-26&adults=2&travelerType=BUSINESS&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Sep 26 - Sep 28](https://www.expedia.ca/Hotel-Search?regionId=800123&startDate=2025-09-26&endDate=2025-09-28&adults=2&travelerType=BUSINESS&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Oct 3 - Oct 5](https://www.expedia.ca/Hotel-Search?regionId=800123&startDate=2025-10-03&endDate=2025-10-05&adults=2&travelerType=BUSINESS&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top Downtown San Diego Business Hotels ## Our top choices for Downtown San Diego business-friendly hotels ![Lobby lounge](https://images.trvl-media.com/lodging/33000000/32400000/32393800/32393708/3ced364d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast](https://images.trvl-media.com/lodging/33000000/32400000/32393800/32393708/00abc97b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/33000000/32400000/32393800/32393708/69474629.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/33000000/32400000/32393800/32393708/3c739431.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Ayres Hotel San Diego South - Chula Vista Otay Ranch 9.8/10 Exceptional (1097) "Very nice clean hotel " CA $172 CA $190 total includes taxes & fees Oct 14 - Oct 15 [](https://www.expedia.ca/Chula-Vista-Hotels-Ayres-Hotel-San-Diego-South-Chula-Vista.h32393708.Hotel-Information) ![Garden](https://images.trvl-media.com/lodging/42000000/41510000/41504800/41504735/0bbd67f4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/42000000/41510000/41504800/41504735/43ef19cb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, in-room safe, desk, laptop workspace](https://images.trvl-media.com/lodging/42000000/41510000/41504800/41504735/7442075b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/42000000/41510000/41504800/41504735/8077fd39.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Legacy Resort Hotel & Spa Mission Valley 9.2/10 Wonderful (2891) "Great stay overall" CA $218 CA $250 total includes taxes & fees Sep 28 - Sep 29 [](https://www.expedia.ca/San-Diego-Hotels-Legacy-Resort-Hotel-Spa.h41504735.Hotel-Information) ![Reception](https://images.trvl-media.com/lodging/13000000/12970000/12963400/12963301/cc52443d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/13000000/12970000/12963400/12963301/w3837h2557x3y3-af97ac41.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/13000000/12970000/12963400/12963301/w3837h2560x3y0-23cd0701.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby lounge](https://images.trvl-media.com/lodging/13000000/12970000/12963400/12963301/1375264c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hampton Inn & Suites San Diego Seaworld Point Loma 8.8/10 Excellent (85) "Enjoyed our stay." CA $208 CA $239 total includes taxes & fees Sep 28 - Sep 29 [](https://www.expedia.ca/San-Diego-Hotels-Hampton-Inn-Suites-San-Diego-Point-Loma.h12963301.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/3000000/2920000/2918200/2918129/a0a6825c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Bar (on property)](https://images.trvl-media.com/lodging/3000000/2920000/2918200/2918129/a9bcd444.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool](https://images.trvl-media.com/lodging/3000000/2920000/2918200/2918129/e3befa7e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Bar (on property)](https://images.trvl-media.com/lodging/3000000/2920000/2918200/2918129/49bcb235.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Residence Inn by Marriott San Diego Downtown/Gaslamp Quarter Downtown San Diego 9.0/10 Wonderful (1137) "Great stay! " CA $242 CA $280 total includes taxes & fees Sep 28 - Sep 29 [](https://www.expedia.ca/San-Diego-Hotels-Residence-Inn-By-Marriott-San-Diego-DowntownGaslamp-Quarter.h2918129.Hotel-Information) ![Bar (on property)](https://images.trvl-media.com/lodging/1000000/180000/170400/170338/84efd019.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, pillowtop beds, in-room safe, desk](https://images.trvl-media.com/lodging/1000000/180000/170400/170338/w3837h2560x3y0-07d390b2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool, pool umbrellas, sun loungers](https://images.trvl-media.com/lodging/1000000/180000/170400/170338/36f8ccfd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/180000/170400/170338/w3840h2557x0y3-2d2de3f2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The DEXTRO Little Italy, BW Premier Collection Downtown San Diego 8.8/10 Excellent (465) "Great place to stay! " CA $166 CA $192 total includes taxes & fees Oct 1 - Oct 2 [](https://www.expedia.ca/San-Diego-Hotels-Four-Points-By-Sheraton-San-Diego-Downtown-Little-Italy.h170338.Hotel-Information) ![Terrace/patio](https://images.trvl-media.com/lodging/1000000/20000/11200/11177/c44ff51d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/20000/11200/11177/7f3bc7ed.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/20000/11200/11177/5142b853.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![32-inch LCD TV with digital channels, TV](https://images.trvl-media.com/lodging/1000000/20000/11200/11177/d5ea2f3b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Wyndham San Diego Bayside Downtown San Diego 8.4/10 Very good (5940) "Great stay near the airport." CA $211 CA $284 total includes taxes & fees Oct 26 - Oct 27 [](https://www.expedia.ca/San-Diego-Hotels-Wyndham-San-Diego-Bayside.h11177.Hotel-Information) ![Outdoor pool, open 7:00 AM to 10:00 PM, free cabanas, sun loungers](https://images.trvl-media.com/lodging/14000000/13340000/13339900/13339817/308d14a8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Breakfast, lunch, dinner served; American cuisine ](https://images.trvl-media.com/lodging/14000000/13340000/13339900/13339817/a15a7e64.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/14000000/13340000/13339900/13339817/dc05fea3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, 2 Queen Beds, Harbour View | View from room](https://images.trvl-media.com/lodging/14000000/13340000/13339900/13339817/15c37db5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hilton Garden Inn San Diego Downtown/Bayside Downtown San Diego 8.6/10 Excellent (1164) "Great place to stay. Clean and quiet. " CA $228 CA $264 total includes taxes & fees Sep 29 - Sep 30 [](https://www.expedia.ca/San-Diego-Hotels-Hilton-Garden-Inn-San-Diego-DowntownBayside.h13339817.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/920000/914400/914373/236157bf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, blackout drapes, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/1000000/920000/914400/914373/8114cbc5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/1000000/920000/914400/914373/w395h595x4y3-183171c0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/1000000/920000/914400/914373/dc860349.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### La Pensione Hotel Downtown San Diego 8.6/10 Excellent (1881) "Great place to stay they are right in the middle of everything " CA $199 CA $226 total includes taxes & fees Sep 29 - Sep 30 [](https://www.expedia.ca/San-Diego-Hotels-La-Pensione-Hotel.h914373.Hotel-Information) ![2 restaurants, breakfast, dinner served; American cuisine](https://images.trvl-media.com/lodging/12000000/11020000/11016900/11016895/3b8ccbdc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 restaurants, breakfast, dinner served; American cuisine](https://images.trvl-media.com/lodging/12000000/11020000/11016900/11016895/f25e22be.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/12000000/11020000/11016900/11016895/8b73ff14.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Executive Room, 1 King Bed](https://images.trvl-media.com/lodging/12000000/11020000/11016900/11016895/213d1c23.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Courtyard by Marriott San Diego Gaslamp/Convention Center Downtown San Diego 8.6/10 Excellent (1001) "Very clean and great location " CA $261 CA $303 total includes taxes & fees Oct 20 - Oct 21 [](https://www.expedia.ca/San-Diego-Hotels-Courtyard-By-Marriott-San-Diego-GaslampConvention-Center.h11016895.Hotel-Information) ![Lobby lounge](https://images.trvl-media.com/lodging/21000000/20650000/20643300/20643207/51750adb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Bar (on property)](https://images.trvl-media.com/lodging/21000000/20650000/20643300/20643207/501ed0f1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, stovetop, dishwasher](https://images.trvl-media.com/lodging/21000000/20650000/20643300/20643207/fbe77ad7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Bar (on property)](https://images.trvl-media.com/lodging/21000000/20650000/20643300/20643207/ce6ad25d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### TownePlace Suites by Marriott San Diego Downtown Downtown San Diego 8.8/10 Excellent (1005) "The staff was super helpful and the breakfast was excellent " CA $195 CA $226 total includes taxes & fees Oct 6 - Oct 7 [](https://www.expedia.ca/San-Diego-Hotels-TownePlace-Suites-By-Marriott-San-Diego-Downtown.h20643207.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2025-10-09&endDate=2025-10-10®ionId=800123&adults=2&travelerType=business_friendly&sort=RECOMMENDED&openPlayBack=true) ## Price trends for hotels in Downtown San Diego | Less expensive | More expensive | Next month | | --- | --- | --- | | December | June | CA $271 | | Month | Price | | --- | --- | | January | CA $270 | | February | CA $341 | | March | CA $367 | | April | CA $407 | | May | CA $406 | | June | CA $448 | | July | CA $446 | | August | CA $429 | | September | CA $246 | | October | CA $271 | | November | CA $265 | | December | CA $221 | Price trend information excludes taxes and fees and is based on base rates for a nightly stay for 2 adults found in the last 7 days on our site and averaged for commonly viewed hotels in Downtown San Diego. Select dates and complete search for nightly totals inclusive of taxes and fees. ## Top Downtown San Diego Hotel Reviews ![The Sofia Hotel](//images.trvl-media.com/lodging/2000000/1580000/1573900/1573807/ba6cea84_y.jpg) ### The Sofia Hotel 10/10 Excellent "Beautiful building and great location. " [](https://expedia.ca/San-Diego-Hotels-The-Sofia-Hotel.h1573807.Hotel-Information) ![The Horton Grand, Downtown/Gaslamp Quarter](//images.trvl-media.com/lodging/1000000/20000/11100/11026/ce3fee83_y.jpg) ### The Horton Grand, Downtown/Gaslamp Quarter 10/10 Excellent "I had an amazing stay.It was a beautiful hotel in a great location and the staff was very friendly.They even accommodated early check in!" [](https://expedia.ca/San-Diego-Hotels-The-Horton-Grand.h11026.Hotel-Information) ![The Little Italy Hotel Downtown San Diego](//images.trvl-media.com/lodging/1000000/20000/13300/13205/0339a25b_y.jpg) ### The Little Italy Hotel Downtown San Diego 10/10 Excellent "The property was nice & clean. Parking can get filled but there’s a lot next door, some free parking as well if you get lucky & meter parking " [](https://expedia.ca/San-Diego-Hotels-The-Little-Italy-Hotel-In-Downtown-San-Diego.h13205.Hotel-Information) ![Hilton Garden Inn San Diego Downtown/Bayside](//images.trvl-media.com/lodging/14000000/13340000/13339900/13339817/308d14a8_y.jpg) ### Hilton Garden Inn San Diego Downtown/Bayside 10/10 Excellent "🔥" [](https://expedia.ca/San-Diego-Hotels-Hilton-Garden-Inn-San-Diego-DowntownBayside.h13339817.Hotel-Information) ![Hotel Republic San Diego, Autograph Collection](//images.trvl-media.com/lodging/1000000/900000/898500/898447/e9d3f965_y.jpg) ### Hotel Republic San Diego, Autograph Collection 10/10 Excellent "a good choice" [](https://expedia.ca/San-Diego-Hotels-Hotel-Republic-San-Diego.h898447.Hotel-Information) ![Marriott Marquis San Diego Marina](//images.trvl-media.com/lodging/1000000/30000/24400/24394/9078a9ee_y.jpg) ### Marriott Marquis San Diego Marina 10/10 Excellent "Everything was great" [](https://expedia.ca/San-Diego-Hotels-Marriott-Marquis-San-Diego-Marina.h24394.Hotel-Information) ![Hard Rock Hotel San Diego](//images.trvl-media.com/lodging/2000000/1740000/1731600/1731557/fbbdfc57_y.jpg) ### Hard Rock Hotel San Diego 10/10 Excellent "Loved staying here. Will definitely stay again " [](https://expedia.ca/San-Diego-Hotels-Hard-Rock-Hotel-San-Diego.h1731557.Hotel-Information) ![Wyndham San Diego Bayside](//images.trvl-media.com/lodging/1000000/20000/11200/11177/c44ff51d_y.jpg) ### Wyndham San Diego Bayside 10/10 Excellent "Fun family vacation! Clean, comfy room. So much to do here! Nice staff. The absolute best! Love this place! " [](https://expedia.ca/San-Diego-Hotels-Wyndham-San-Diego-Bayside.h11177.Hotel-Information) ![The DEXTRO Little Italy, BW Premier Collection](//images.trvl-media.com/lodging/1000000/180000/170400/170338/84efd019_y.jpg) ### The DEXTRO Little Italy, BW Premier Collection 10/10 Excellent "Great place near down town San Diego and Little Italy." [](https://expedia.ca/San-Diego-Hotels-Four-Points-By-Sheraton-San-Diego-Downtown-Little-Italy.h170338.Hotel-Information) ## Frequently asked questions ### Why book your business-friendly hotel in Downtown San Diego with Expedia? > Expedia is here to help you find a fantastic business-friendly hotel when work takes you out of town. From free parking and WiFi to on-site restaurants and cafés, our stays come with all you'll need to settle that big contract. ### How can I find cheap business-friendly hotels in Downtown San Diego? > Expedia can help you easily find cheap business-friendly hotels in Downtown San Diego. Head to our "traveller experience" filter and click on "business friendly." This will show you stays with amenities designed to help you work and rest comfortably, like free WiFi and included breakfast. 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