Title: Hotels by Highgate Independent in Historic Route 66 from CA $263 | Expedia.ca [Historic Route 66 Travel Guide](https://expedia.ca/Historic-Route-66.dx702654640613646336)[Hotels in Historic Route 66](https://expedia.ca/Historic-Route-66-Hotels.d702654640613646336.Travel-Guide-Hotels)[Vacation Rentals in Historic Route 66](https://expedia.ca/Historic-Route-66-Vacation-Rentals.d702654640613646336.Travel-Guide-VacationRentals)[Flights to Historic Route 66](https://expedia.ca/Cheap-Flights-To-Historic-Route-66.d702654640613646336.Travel-Guide-Flights)[Historic Route 66 Car Rentals](https://expedia.ca/Car-Rentals-In-Historic-Route-66.d702654640613646336.Car-Rental-Guide)[Historic Route 66 Vacation Packages](https://expedia.ca/Historic-Route-66.d702654640613646336.Destination-Travel-Guides) ![](https://mediaim.expedia.com/destination/9/17f13edc580f92fbd02b78ad30e73751.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find Hotels by Highgate Independent in Historic Route 66 from CA $263 ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check prices for these dates Tonight [Oct 11 - Oct 12](https://www.expedia.ca/Hotel-Search?regionId=702654640613646336&startDate=2025-10-11&endDate=2025-10-12&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Oct 12 - Oct 13](https://www.expedia.ca/Hotel-Search?regionId=702654640613646336&startDate=2025-10-12&endDate=2025-10-13&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Oct 17 - Oct 19](https://www.expedia.ca/Hotel-Search?regionId=702654640613646336&startDate=2025-10-17&endDate=2025-10-19&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two weeks [Oct 24 - Oct 26](https://www.expedia.ca/Hotel-Search?regionId=702654640613646336&startDate=2025-10-24&endDate=2025-10-26&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top Historic Route 66 Highgate Independent Hotels ![Indoor pool](https://images.trvl-media.com/lodging/77000000/76270000/76267500/76267438/a9b3121a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lounge](https://images.trvl-media.com/lodging/77000000/76270000/76267500/76267438/eacd6d88.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Studio, 1 Queen Bed (Studio Apartment) | Private kitchen](https://images.trvl-media.com/lodging/77000000/76270000/76267500/76267438/1bf06d5d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium Apartment, 2 Bedrooms | Living area](https://images.trvl-media.com/lodging/77000000/76270000/76267500/76267438/ecc0a878.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Sentral Michigan Avenue Downtown Chicago 9.2/10 Wonderful (955) "Great location and cleanliness of rooms. Staff was extremely helpful " CA $189 CA $263 total includes taxes & fees Nov 11 - Nov 12 [](https://www.expedia.ca/Chicago-Hotels-Sentral-Michigan-Avenue.h76267438.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2025-10-25&endDate=2025-10-26®ionId=702654640613646336&adults=2&sort=RECOMMENDED&openPlayBack=true) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in](https://expedia.ca/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FHistoric-Route-66-Hotels-Highgate-Independent.0-0-d702654640613646336--bHighgateIndependent.Travel-Guide-Filter-Hotels)[Sign up, it's free](https://expedia.ca/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FHistoric-Route-66-Hotels-Highgate-Independent.0-0-d702654640613646336--bHighgateIndependent.Travel-Guide-Filter-Hotels) ## Top Historic Route 66 Hotel Reviews ![Holiday Inn Chicago Dwtn - The Mart by IHG](//images.trvl-media.com/lodging/1000000/10000/5500/5467/2806d344_y.jpg) ### Holiday Inn Chicago Dwtn - The Mart by IHG 10/10 Excellent "Great hotel - great location. It's a bummer that the view from the restaurant/bar isn't as cool as it used to be, because of the new buildings in front of it, but it's still pretty - and the drinks and food are very good. Room was very nice and clean. " [](https://expedia.ca/Chicago-Hotels-Holiday-Inn-Chicago-Dwtn-Wolf-Point.h5467.Hotel-Information) ![The Aquarius Casino Resort, BW Premier Collection](//images.trvl-media.com/lodging/1000000/10000/5100/5073/095f8970_y.jpg) ### The Aquarius Casino Resort, BW Premier Collection 10/10 Excellent "Great " [](https://expedia.ca/Laughlin-Hotels-The-Aquarius-Casino-Resort.h5073.Hotel-Information) ![Embassy Suites by Hilton Chicago Downtown River North](//images.trvl-media.com/lodging/1000000/20000/11600/11580/w3840h2859x0y0-5fc518eb_y.jpg) ### Embassy Suites by Hilton Chicago Downtown River North 10/10 Excellent "The onsite parking is worth the money compared to other lots. Walk where you can. The Embassy is in the perfect location for a lot of attractions." [](https://expedia.ca/Chicago-Hotels-Embassy-Suites-Chicago-Downtown.h11580.Hotel-Information) ![The Allegro Royal Sonesta Hotel Chicago Loop](//images.trvl-media.com/lodging/1000000/40000/34500/34496/69c2e798_y.jpg) ### The Allegro Royal Sonesta Hotel Chicago Loop 10/10 Excellent "We stayed here for two nights, and I would definitely stay again. It is located next to the Cadillac Palace theater, and about a block from the Wells and Washington L stop. It was easy to take the train around the city, or walk to beautiful city views and great restaurants. The staff was friendly, the room was clean and quiet. Great for a weekend in Chicago!" [](https://expedia.ca/Chicago-Hotels-The-Allegro-Royal-Sonesta-Hotel.h34496.Hotel-Information) ![The Whitehall Hotel, BW Premier Collection](//images.trvl-media.com/lodging/1000000/20000/18000/17903/daaf5f2e_y.jpg) ### The Whitehall Hotel, BW Premier Collection 10/10 Excellent "This was definitely the perfect choice to stay " [](https://expedia.ca/Chicago-Hotels-The-Whitehall-Hotel.h17903.Hotel-Information) ![Sable at Navy Pier Chicago, Curio Collection by Hilton](//images.trvl-media.com/lodging/58000000/57660000/57651200/57651125/6c1738b5_y.jpg) ### Sable at Navy Pier Chicago, Curio Collection by Hilton 10/10 Excellent "Absolutely loved this place.... views were great, staff was great, atmosphere was great! One of my most favorite places to stay." [](https://expedia.ca/Chicago-Hotels-Sable-At-Navy-Pier-Chicago.h57651125.Hotel-Information) ![citizenM Chicago Downtown](//images.trvl-media.com/lodging/83000000/82660000/82652400/82652306/55b627dd_y.jpg) ### citizenM Chicago Downtown 10/10 Excellent "The property of the hotel was very much nice , art work was uniquely designed ! Very tea as the new generation would say ! The distant of everything being close to the river, Michigan Ave and very good restaurants . I believe this will be our new Chicago hotel every time we stay ! " [](https://expedia.ca/Chicago-Hotels-CitizenM-Chicago-Downtown.h82652306.Hotel-Information) ![Congress Plaza Hotel](//images.trvl-media.com/lodging/1000000/10000/6500/6452/a9ee91b7_y.jpg) ### Congress Plaza Hotel 10/10 Excellent "This was our 3rd time staying here in 6 months. As always…excellent experience! " [](https://expedia.ca/Chicago-Hotels-Congress-Plaza-Hotel.h6452.Hotel-Information) ![Club Quarters Hotel, Central Loop, Chicago](//images.trvl-media.com/lodging/1000000/570000/565800/565746/19b0236f_y.jpg) ### Club Quarters Hotel, Central Loop, Chicago 10/10 Excellent "Perfecto .Se encuentra en el centro." [](https://expedia.ca/Chicago-Hotels-Club-Quarters-Hotel.h565746.Hotel-Information) ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - Other - More ways to book - [5 Star Hotels in Quad Cities](https://www.expedia.ca/5Star-Quad-Cities-Hotels.s50-0-d603001.Travel-Guide-Filter-Hotels) - [Hotels near Lake Michigan](https://www.expedia.ca/Lake-Michigan-Hotels.0-l6338716-0.Travel-Guide-Filter-Hotels) - [Aparthotels in Ohio River Valley](https://www.expedia.ca/Ohio-River-Valley-Apart-Hotels.d6233674-aaApartHotels.Travel-Guide-Accommodation) - [B&B in Ohio River Valley](https://www.expedia.ca/Ohio-River-Valley-Bed-And-Breakfast.d6233674-aaBedAndBreakfast.Travel-Guide-Accommodation) - [Cabin Rentals in Ohio River Valley](https://www.expedia.ca/Ohio-River-Valley-Cabins.d6233674-aaCabins.Travel-Guide-Accommodation) - [Chalets in Ohio River Valley](https://www.expedia.ca/Ohio-River-Valley-Chalets.d6233674-aaChalets.Travel-Guide-Accommodation) - [Condo Rentals in Ohio River Valley](https://www.expedia.ca/Ohio-River-Valley-Condos.d6233674-aaCondos.Travel-Guide-Accommodation) - [Adults Only Resorts & in Ohio River Valley](https://www.expedia.ca/Ohio-River-Valley-Hotels-Adults-Only-Resorts.0-0-d6233674-tAdultsOnlyResorts.Travel-Guide-Filter-Hotels) - [Beach Hotel Hotels in Ohio River Valley](https://www.expedia.ca/Ohio-River-Valley-Hotels-Beach-Hotel.0-0-d6233674-tBeachHotel.Travel-Guide-Filter-Hotels) - [Best Western Hotels in Ohio River Valley](https://www.expedia.ca/Ohio-River-Valley-Hotels-Best-Western.0-0-d6233674--bBestWestern.Travel-Guide-Filter-Hotels) - [Boutique Hotels in Ohio River Valley](https://www.expedia.ca/Ohio-River-Valley-Hotels-Boutique-Hotel.0-0-d6233674-tBoutiqueHotel.Travel-Guide-Filter-Hotels) - [Cheap Hotels in Ohio River Valley](https://www.expedia.ca/Ohio-River-Valley-Hotels-Cheap-Hotels.0-0-d6233674-tCheapHotels.Travel-Guide-Filter-Hotels) - [Golf Hotels in Ohio River Valley](https://www.expedia.ca/Ohio-River-Valley-Hotels-Golf-Hotel.0-0-d6233674-tGolfHotel.Travel-Guide-Filter-Hotels) - [Historic Hotels in Ohio River Valley](https://www.expedia.ca/Ohio-River-Valley-Hotels-Historic-Hotel.0-0-d6233674-tHistoricHotel.Travel-Guide-Filter-Hotels) - [Hotels with a Pool in Ohio River Valley](https://www.expedia.ca/Ohio-River-Valley-Hotels-Hotel-With-Pool.0-0-d6233674-tHotelwithPool.Travel-Guide-Filter-Hotels) - [Hotels with Balconies in Ohio River Valley](https://www.expedia.ca/Ohio-River-Valley-Hotels-Hotels-With-Balconies.0-0-d6233674-tHotelswithBalconies.Travel-Guide-Filter-Hotels) - [Hotels with Waterslides in Ohio River Valley](https://www.expedia.ca/Ohio-River-Valley-Hotels-Hotels-With-Waterslides.0-0-d6233674-tHotelswithWaterslides.Travel-Guide-Filter-Hotels) - [Lake Hotels in Ohio River Valley](https://www.expedia.ca/Ohio-River-Valley-Hotels-Lake-Hotels.0-0-d6233674-tLakeHotels.Travel-Guide-Filter-Hotels) - [Luxury Hotels in Ohio River Valley](https://www.expedia.ca/Ohio-River-Valley-Hotels-Luxury-Hotel.0-0-d6233674-tLuxuryHotel.Travel-Guide-Filter-Hotels) - [Marriott Hotels & Resorts in Ohio River Valley](https://www.expedia.ca/Ohio-River-Valley-Hotels-Marriott-Hotels-Resorts.0-0-d6233674--bMarriottHotelsResorts.Travel-Guide-Filter-Hotels) - [Motel 6 Hotels in Ohio River Valley](https://www.expedia.ca/Ohio-River-Valley-Hotels-Motel-6.0-0-d6233674--bMotel6.Travel-Guide-Filter-Hotels) - [Pet-Friendly Hotels in Ohio River Valley](https://www.expedia.ca/Ohio-River-Valley-Hotels-Pet-Friendly-Hotel.0-0-d6233674-tPetfriendlyHotel.Travel-Guide-Filter-Hotels) - [Romantic Hotels in Ohio River Valley](https://www.expedia.ca/Ohio-River-Valley-Hotels-Romantic-Hotel.0-0-d6233674-tRomanticHotel.Travel-Guide-Filter-Hotels) - [Spa Hotels in Ohio River Valley](https://www.expedia.ca/Ohio-River-Valley-Hotels-Spa-Hotel.0-0-d6233674-tSpaHotel.Travel-Guide-Filter-Hotels) - [Waterpark Hotels in Ohio River Valley](https://www.expedia.ca/Ohio-River-Valley-Hotels-Waterpark-Hotels.0-0-d6233674-tWaterparkHotels.Travel-Guide-Filter-Hotels) - [Ohio River Valley Hotels](https://www.expedia.ca/Ohio-River-Valley-Hotels.d6233674.Travel-Guide-Hotels) - [Treehouses in Ohio River Valley](https://www.expedia.ca/Ohio-River-Valley-Treehouses.d6233674-aaTreehouses.Travel-Guide-Accommodation) - [B&B in Quad Cities](https://www.expedia.ca/Quad-Cities-Bed-And-Breakfast.d603001-aaBedAndBreakfast.Travel-Guide-Accommodation) - [Cabin Rentals in Quad Cities](https://www.expedia.ca/Quad-Cities-Cabins.d603001-aaCabins.Travel-Guide-Accommodation) - [Best Western Hotels in Quad Cities](https://www.expedia.ca/Quad-Cities-Hotels-Best-Western.0-0-d603001--bBestWestern.Travel-Guide-Filter-Hotels) - [Boutique Hotels in Quad Cities](https://www.expedia.ca/Quad-Cities-Hotels-Boutique-Hotel.0-0-d603001-tBoutiqueHotel.Travel-Guide-Filter-Hotels) - [Casino Hotels in Quad Cities](https://www.expedia.ca/Quad-Cities-Hotels-Casino-Hotel.0-0-d603001-tCasinoHotel.Travel-Guide-Filter-Hotels) - [Hotels & Resorts for Couples in Quad Cities](https://www.expedia.ca/Quad-Cities-Hotels-Couples-Resorts-Hotels.0-0-d603001-tCouplesResortsHotels.Travel-Guide-Filter-Hotels) - [Family Hotels in Quad Cities](https://www.expedia.ca/Quad-Cities-Hotels-Family-Hotel.0-0-d603001-tFamilyHotel.Travel-Guide-Filter-Hotels) - [Historic Hotels in Quad Cities](https://www.expedia.ca/Quad-Cities-Hotels-Historic-Hotel.0-0-d603001-tHistoricHotel.Travel-Guide-Filter-Hotels) - [Honeymoon Resorts and in Quad Cities](https://www.expedia.ca/Quad-Cities-Hotels-Honeymoon-Hotels.0-0-d603001-tHoneymoonHotels.Travel-Guide-Filter-Hotels) - [Hotels with Early Check-in in Quad Cities](https://www.expedia.ca/Quad-Cities-Hotels-Hotel-With-Early-Check-In.0-0-d603001-thotelwithearlycheckin.Travel-Guide-Filter-Hotels) - [Hotels with a Pool in Quad Cities](https://www.expedia.ca/Quad-Cities-Hotels-Hotel-With-Pool.0-0-d603001-tHotelwithPool.Travel-Guide-Filter-Hotels) - [Hotels with Wifi in Quad Cities](https://www.expedia.ca/Quad-Cities-Hotels-Hotel-With-Wifi.0-0-d603001-tHotelwithwifi.Travel-Guide-Filter-Hotels) - [Hotels with Bar in Quad Cities](https://www.expedia.ca/Quad-Cities-Hotels-Hotels-With-Bar.0-0-d603001-tHotelswithBar.Travel-Guide-Filter-Hotels) - [Hotels with Free Airport Shuttle in Quad Cities](https://www.expedia.ca/Quad-Cities-Hotels-Hotels-With-Free-Airport-Shuttle.0-0-d603001-tHotelswithFreeAirportShuttle.Travel-Guide-Filter-Hotels) - [Hotels with Free Breakfast in Quad Cities](https://www.expedia.ca/Quad-Cities-Hotels-Hotels-With-Free-Breakfast.0-0-d603001-tHotelswithFreeBreakfast.Travel-Guide-Filter-Hotels) - [Hotels with Hot Tubs in Quad Cities](https://www.expedia.ca/Quad-Cities-Hotels-Hotels-With-Hot-Tubs.0-0-d603001-tHotelsWithHotTubs.Travel-Guide-Filter-Hotels) - [Hotels with an Indoor Pool in Quad Cities](https://www.expedia.ca/Quad-Cities-Hotels-Hotels-With-Indoor-Pool.0-0-d603001-tHotelswithIndoorPool.Travel-Guide-Filter-Hotels) - [Hotels with Kitchenettes in Quad Cities](https://www.expedia.ca/Quad-Cities-Hotels-Hotels-With-Kitchenettes.0-0-d603001-tHotelswithKitchenettes.Travel-Guide-Filter-Hotels) - [Luxury Hotels in Quad Cities](https://www.expedia.ca/Quad-Cities-Hotels-Luxury-Hotel.0-0-d603001-tLuxuryHotel.Travel-Guide-Filter-Hotels) - [Motel 6 Hotels in Quad Cities](https://www.expedia.ca/Quad-Cities-Hotels-Motel-6.0-0-d603001--bMotel6.Travel-Guide-Filter-Hotels) - [Pet-Friendly Hotels in Quad Cities](https://www.expedia.ca/Quad-Cities-Hotels-Pet-Friendly-Hotel.0-0-d603001-tPetfriendlyHotel.Travel-Guide-Filter-Hotels) - [Romantic Hotels in Quad Cities](https://www.expedia.ca/Quad-Cities-Hotels-Romantic-Hotel.0-0-d603001-tRomanticHotel.Travel-Guide-Filter-Hotels) - [Spa Hotels in Quad Cities](https://www.expedia.ca/Quad-Cities-Hotels-Spa-Hotel.0-0-d603001-tSpaHotel.Travel-Guide-Filter-Hotels) - [Waterpark Hotels in Quad Cities](https://www.expedia.ca/Quad-Cities-Hotels-Waterpark-Hotels.0-0-d603001-tWaterparkHotels.Travel-Guide-Filter-Hotels) - [Quad Cities Hotels](https://www.expedia.ca/Quad-Cities-Hotels.d603001.Travel-Guide-Hotels) - [B&B in Southeast Iowa](https://www.expedia.ca/Southeast-Iowa-Bed-And-Breakfast.d6234151-aaBedAndBreakfast.Travel-Guide-Accommodation) - [Americinn Hotels in Southeast Iowa](https://www.expedia.ca/Southeast-Iowa-Hotels-Americinn.0-0-d6234151--bAmericinn.Travel-Guide-Filter-Hotels) - [Luxury Hotels in Southeast Iowa](https://www.expedia.ca/Southeast-Iowa-Hotels-Luxury-Hotel.0-0-d6234151-tLuxuryHotel.Travel-Guide-Filter-Hotels) - [Pet-Friendly Hotels in Southeast Iowa](https://www.expedia.ca/Southeast-Iowa-Hotels-Pet-Friendly-Hotel.0-0-d6234151-tPetfriendlyHotel.Travel-Guide-Filter-Hotels) - [Romantic Hotels in Southeast Iowa](https://www.expedia.ca/Southeast-Iowa-Hotels-Romantic-Hotel.0-0-d6234151-tRomanticHotel.Travel-Guide-Filter-Hotels) - [Southeast Iowa Hotels](https://www.expedia.ca/Southeast-Iowa-Hotels.d6234151.Travel-Guide-Hotels) - [Flights to Ohio River Valley](https://www.expedia.ca/Cheap-Flights-To-Ohio-River-Valley.d6233674.Travel-Guide-Flights) - [Flights to Quad Cities](https://www.expedia.ca/Cheap-Flights-To-Quad-Cities.d603001.Travel-Guide-Flights) - [Flights to Southeast Iowa](https://www.expedia.ca/Cheap-Flights-To-Southeast-Iowa.d6234151.Travel-Guide-Flights) - [Flights from Calgary to Quad Cities](https://www.expedia.ca/lp/flights/178245/603001/calgary-to-quad-cities) - [Flights from Calgary to Ohio River Valley](https://www.expedia.ca/lp/flights/178245/6233674/calgary-to-ohio-river-valley) - [Flights from Chicago to Quad Cities](https://www.expedia.ca/lp/flights/178248/603001/chicago-to-quad-cities) - [Flights from Columbus to Quad Cities](https://www.expedia.ca/lp/flights/178251/603001/columbus-to-quad-cities) - [Flights from Dallas to Ohio River Valley](https://www.expedia.ca/lp/flights/178253/6233674/dallas-to-ohio-river-valley) - [Flights from Indianapolis to Quad Cities](https://www.expedia.ca/lp/flights/178266/603001/indianapolis-to-quad-cities) - [Flights from Miami to Ohio River Valley](https://www.expedia.ca/lp/flights/178286/6233674/miami-to-ohio-river-valley) - [Flights from Minneapolis - St. Paul to Quad Cities](https://www.expedia.ca/lp/flights/178287/603001/minneapolis-st-paul-to-quad-cities) - [Flights from Minneapolis - St. Paul to Ohio River Valley](https://www.expedia.ca/lp/flights/178287/6233674/minneapolis-st-paul-to-ohio-river-valley) - [Flights from Orlando to Ohio River Valley](https://www.expedia.ca/lp/flights/178294/6233674/orlando-to-ohio-river-valley) - [Flights from Seattle to Quad Cities](https://www.expedia.ca/lp/flights/178307/603001/seattle-to-quad-cities) - [Flights from Toronto to Quad Cities](https://www.expedia.ca/lp/flights/178314/603001/toronto-to-quad-cities) - [Flights from Toronto to Ohio River Valley](https://www.expedia.ca/lp/flights/178314/6233674/toronto-to-ohio-river-valley) - [Flights from Vancouver to Ohio River Valley](https://www.expedia.ca/lp/flights/178315/6233674/vancouver-to-ohio-river-valley) - [Flights from Edmonton to Quad Cities](https://www.expedia.ca/lp/flights/180002/603001/edmonton-to-quad-cities) - [Flights from Edmonton to Ohio River Valley](https://www.expedia.ca/lp/flights/180002/6233674/edmonton-to-ohio-river-valley) - [Flights from Québec City to Ohio River Valley](https://www.expedia.ca/lp/flights/180017/6233674/quebec-city-to-ohio-river-valley) - [Flights from Amarillo to Quad Cities](https://www.expedia.ca/lp/flights/371/603001/amarillo-to-quad-cities) - [Flights from Hamilton to Quad Cities](https://www.expedia.ca/lp/flights/3963/603001/hamilton-to-quad-cities) - [Flights from Fort Lauderdale to Ohio River Valley](https://www.expedia.ca/lp/flights/601750/6233674/fort-lauderdale-to-ohio-river-valley) - [Flights from Newark to Ohio River Valley](https://www.expedia.ca/lp/flights/601760/6233674/newark-to-ohio-river-valley) - [Flights from Buffalo to Quad Cities](https://www.expedia.ca/lp/flights/602674/603001/buffalo-to-quad-cities) - [Flights from Buffalo to Ohio River Valley](https://www.expedia.ca/lp/flights/602674/6233674/buffalo-to-ohio-river-valley) - [Flights from Birmingham to Ohio River Valley](https://www.expedia.ca/lp/flights/602981/6233674/birmingham-to-ohio-river-valley) - [Flights from Quad Cities](https://www.expedia.ca/lp/flights/603001/flights-from-quad-cities) - [Flights from Winnipeg to Quad Cities](https://www.expedia.ca/lp/flights/6141041/603001/winnipeg-to-quad-cities) - [Flights from Ohio River Valley](https://www.expedia.ca/lp/flights/6233674/flights-from-ohio-river-valley) - [Lake Michigan](https://www.expedia.ca/Lake-Michigan-United-States-of-America.d6338716.Vacation-Attraction) - [Visit Ohio River Valley](https://www.expedia.ca/Ohio-River-Valley.dx6233674) - [Quad Cities Vacations](https://www.expedia.ca/Quad-Cities.d603001.Destination-Travel-Guides) - [Visit Quad Cities](https://www.expedia.ca/Quad-Cities.dx603001) - [Visit Southeast Iowa](https://www.expedia.ca/Southeast-Iowa.dx6234151) - [Ace Rental Cars in Quad Cities](https://www.expedia.ca/Ace-Car-Rentals-In-Quad-Cities.d603001-c2.Car-Rental-Guide-Suppliers) - [Advantage Rent-A-Car Rental Cars in Ohio River Valley](https://www.expedia.ca/Advantage-Rent-A-Car-Car-Rentals-In-Ohio-River-Valley.d6233674-c3.Car-Rental-Guide-Suppliers) - [Avis Rental Cars in Quad Cities](https://www.expedia.ca/Avis-Car-Rentals-In-Quad-Cities.d603001-c41.Car-Rental-Guide-Suppliers) - [Car rentals near Quad Cities](https://www.expedia.ca/Car-Rentals-In-Quad-Cities.d603001.Car-Rental-Guide) - [Pickup Car Rentals in Ohio River Valley](https://www.expedia.ca/Pickup-Car-Rentals-In-Ohio-River-Valley.d6233674-tPickup.Car-Rental-Guide-Class) - [Thrifty Car Rental Rental Cars in Ohio River Valley](https://www.expedia.ca/Thrifty-Car-Rental-Car-Rentals-In-Ohio-River-Valley.d6233674-c45.Car-Rental-Guide-Suppliers) - [Things to do in Quad Cities](https://www.expedia.ca/Things-To-Do-In-Quad-Cities.d603001.Travel-Guide-Activities) - [Book Highgate Independent in Historic Route 66 on Expedia.com](https://www.expedia.com/Historic-Route-66-Hotels-Highgate-Independent.0-0-d702654640613646336--bHighgateIndependent.Travel-Guide-Filter-Hotels)