Antofagasta Region Vacation Packages

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Top vacation destinations in Antofagasta Region

FlightsFlightsHotelsHotels

San Pedro de Atacama

San Pedro de Atacama

Antofagasta Region Hotel Deals

Diego de Almagro San Pedro de Atacama

Diego de Almagro San Pedro de Atacama

3 out of 5
Toconao 460 San Pedro de Atacama Antofagasta
Fully refundableReserve now, pay when you stay
The price is CA $133 per night from Jun 26 to Jun 27
CA $133
CA $133 total
Jun 26 - Jun 27
8.2/10 Very Good! (391 reviews)
"A gentleman at the front desk was quite rude. We booked two rooms, and neither of them had heating, even though the outside temperature dropped to 2°C at night. In addition, the doors and windows were not properly sealed, making the rooms even colder. The next morning, for our second night’s stay, ..."

Reviewed on May 20, 2026

Diego de Almagro San Pedro de Atacama
Hotel La Casa de Don Tomas

Hotel La Casa de Don Tomas

3 out of 5
Calle Tocopilla Sitio 18 San Pedro de Atacama
Fully refundableReserve now, pay when you stay
The price is CA $297 per night from Jun 24 to Jun 25
CA $297
CA $297 total
Jun 24 - Jun 25
9.2/10 Wonderful! (419 reviews)
"We didn't realize there were 2 properties under la casa de Don Tomas (check when booking!). We were dropped off at the original location based on the address we gave from Expedia but after speaking with reception at check-in were directed to their El Refugio location, which is the newer expansion ..."

Reviewed on Jun 4, 2026

Hotel La Casa de Don Tomas
Sami Atacama Lodge

Sami Atacama Lodge

3 out of 5
Pasaje Alana No.2 Ayllu De Solcor San Pedro de Atacama
The price is CA $86 per night from Jun 28 to Jun 29
CA $86
CA $86 total
Jun 28 - Jun 29
8.2/10 Very Good! (362 reviews)
"The hotel is a very nice eco friendly hotel indeed with quite nice amenities. The hotel at times is hard to find given the roads that lead into it aren’t easy to navigate. The staff at times aren’t there at reception but overall quite a good stay indeed for the price and note that the area around ..."

Reviewed on Apr 6, 2026

Sami Atacama Lodge
See all 325 properties in Antofagasta Region
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
All Inclusive Vacations
All Inclusive Vacations
Beach Vacations
Beach Vacations
Family Vacations
Family Vacations

Frequently asked questions

How much does an Antofagasta Region vacation package cost?
From as low as . Yes, you read that right. Our Antofagasta Region packages are the best way to stretch your budget. Combine your hotels, flights and car rentals and discover this lively destination.
How do I get a cheap travel package to Antofagasta Region?
Our Antofagasta Region vacation packages promise plenty of savings for the savvy traveler. For the best deals, simply bundle your hotel, flights and activities into an affordable package. But impressive bargains are only the start of your next unforgettable adventure. Book with Expedia and you'll have more than 550 airlines and 1,000,000 properties throughout the world to pick from. Whatever your budget, there's a package that's perfect for you.
What are the top hotels in Antofagasta Region?
Have a look at ibis Antofagasta and NH Antofagasta. They're the first choice for lots of travelers to Antofagasta. If San Pedro de Atacama is on your travel itinerary, Park Hotel Calama and Noi Casa Atacama are cozy options.
How far in advance should I book my Antofagasta Region vacation?
It can be tricky to know when is the ideal time to book your trip to Antofagasta Region. But typically the earlier you book, the better the prices. Sometimes, you can reserve your flights and hotels up to a year before your departure date. If you're considering a last-minute getaway, no need to stress! There are fabulous deals featured on Expedia every single day.
What does an Expedia Antofagasta Region travel package include?
From hotels and airfares to rental cars, Expedia can help you shape an Antofagasta Region package that's perfect for you. Vacationing for a week or two? Consider a rental car, hotel and flight bundle. If you're taking a short break, a flight and hotel deal could be more your style. Activities can also be added once you've made your booking. Our vacation packages make it simple to save and plan.
What should I know before booking an Antofagasta Region travel package?
Tailor deals to suit your budget with an Expedia package. Airfares, hotels, rental cars — we're a one-stop shop for all of them. You'll save precious dollars just for bundling your bookings. Whether you're embarking on a skiing adventure or drinking cocktails on a beach, your perfect getaway is just clicks away.
Can I choose my airline with an Antofagasta Region Expedia vacation package?
Expedia has access to more than 550 airline partners worldwide, so you sure can! Simply select your preferred carrier and put together the perfect Antofagasta Region trip.
If I'm not able to travel, can I cancel my Antofagasta Region vacation package?
Whether it's your flight or hotel, you can cancel and rebook it. Locked in your Antofagasta Region vacation package in the last 24 hours? You may be able to make changes at no cost. For bookings older than that, you may be charged a fee by your hotel, airline or car rental company. For further information, visit our Customer Service Portal. We'll help you every step of the way.

Discover the most popular places to visit in Antofagasta Region

Valley of the Moon

Valley of the Moon

Treat your eyes to the variety of colors in a deserted valley that looks like a scene from a science fiction movie.

Valley of the Moon
Chaxa Lagoon

Chaxa Lagoon

Marvel at the scores of pink flamingos and other birds that manage to live next to this remarkable lagoon in the salt desert.

Chaxa Lagoon

Plaza de San Pedro de Atacama

You can find out about the history of San Pedro de Atacama when you stop by Plaza de San Pedro de Atacama. You can seek out the local tours in this quaint area.

Plaza de San Pedro de Atacama

What to do in Antofagasta Region

Tour to the Valley of the Moon San Pedro de Atacama

Tour to the Valley of the Moon San Pedro de Atacama

CA $51
per adult
94% of travellers recommend
Tour to the Valley of the Moon San Pedro de Atacama
Astronomical Experience with Astrophotography in Atacama

Astronomical Experience with Astrophotography in Atacama

CA $58
per adult
Astronomical Experience with Astrophotography in Atacama
Tatio Geyser - Atacama

Small-Group Tour to Tatio Geysers Machuca Village & Rio Putana wetlands

CA $109
per adult
Small-Group Tour to Tatio Geysers Machuca Village & Rio Putana wetlands
See all activities in Antofagasta Region
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.