Title: Lignumvitae Key Botanical State Park Vacation Home Rentals from CA $404: Search Top Private Vacation Homes for Rent | Expedia.ca [Lignumvitae Key Botanical State Park Travel Guide](https://expedia.ca/Lignumvitae-Key-Botanical-State-Park.dx553248621532652349)[Hotels in Lignumvitae Key Botanical State Park](https://expedia.ca/Lignumvitae-Key-Botanical-State-Park-Hotels.d553248621532652349.Travel-Guide-Hotels)[Vacation Rentals in Lignumvitae Key Botanical State Park](https://expedia.ca/Lignumvitae-Key-Botanical-State-Park-Vacation-Rentals.d553248621532652349.Travel-Guide-VacationRentals)[Flights to Lignumvitae Key Botanical State Park](https://expedia.ca/Cheap-Flights-To-Lignumvitae-Key-Botanical-State-Park.d553248621532652349.Travel-Guide-Flights)[Lignumvitae Key Botanical State Park Car Rentals](https://expedia.ca/Car-Rentals-In-Lignumvitae-Key-Botanical-State-Park.d553248621532652349.Car-Rental-Guide)[Lignumvitae Key Botanical State Park Vacation Packages](https://expedia.ca/Lignumvitae-Key-Botanical-State-Park.d553248621532652349.Destination-Travel-Guides) ![Florida Keys Brewing Co. showing signage](https://images.trvl-media.com/place/553248635997958830/30b22f53-286f-436b-ae7a-d035c9062e6c.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Lignumvitae Key Botanical State Park Vacation Rentals - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check prices for these dates Next weekend [Dec 5 - Dec 7](https://www.expedia.ca/Hotel-Search?regionId=553248621532652349&startDate=2025-12-05&endDate=2025-12-07&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two weeks [Dec 12 - Dec 14](https://www.expedia.ca/Hotel-Search?regionId=553248621532652349&startDate=2025-12-12&endDate=2025-12-14&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In one month [Dec 26 - Dec 28](https://www.expedia.ca/Hotel-Search?regionId=553248621532652349&startDate=2025-12-26&endDate=2025-12-28&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two months [Jan 23 - Jan 25](https://www.expedia.ca/Hotel-Search?regionId=553248621532652349&startDate=2026-01-23&endDate=2026-01-25&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Browse Select Lignumvitae Key Botanical State Park Vacation Homes ![Beach nearby, sun loungers, beach towels](https://images.trvl-media.com/lodging/56000000/55190000/55183800/55183749/9d06b7de.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/56000000/55190000/55183800/55183749/a2de89b6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/56000000/55190000/55183800/55183749/03594f35.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/56000000/55190000/55183800/55183749/7fbea524.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Vacation Home in Key Largo 9.6/10 Exceptional (45) "We had fun.we will be back next year." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Thomas A. CA $118 CA $404 total includes taxes & fees Dec 1 - Dec 2 [](https://www.expedia.ca/Key-Largo-Hotels-Cozy-Home-Beach.h55183749.Hotel-Information) ![Marina](https://images.trvl-media.com/lodging/91000000/90180000/90174100/90174063/2e6dec1b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/91000000/90180000/90174100/90174063/46854630.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV](https://images.trvl-media.com/lodging/91000000/90180000/90174100/90174063/97916ab6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool, a heated pool](https://images.trvl-media.com/lodging/91000000/90180000/90174100/90174063/w1536h1023x0y1-0e4e0b92.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Vacation Home in Key Largo 9.6/10 Exceptional (81) "The place was clean and nice, no problems at all. Plenty of room for my family. Wish we could have stayed longer!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Brad W. CA $162 CA $510 total includes taxes & fees Dec 1 - Dec 2 [](https://www.expedia.ca/Key-Largo-Hotels-New-Tiny-Home-Paddle-Boards.h90174063.Hotel-Information) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/100000000/99970000/99961500/99961430/94241dd6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 bedrooms, iron/ironing board, WiFi, bed sheets](https://images.trvl-media.com/lodging/100000000/99970000/99961500/99961430/b3fdbd21.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Shower, hair dryer, towels, soap](https://images.trvl-media.com/lodging/100000000/99970000/99961500/99961430/95c54ed2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV](https://images.trvl-media.com/lodging/100000000/99970000/99961500/99961430/006a1068.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Vacation Home in Key Largo 9.8/10 Exceptional (27) "It was clean and a very nice place to stay. Plenty of room and awesome amenities." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Eric M. CA $220 CA $636 total includes taxes & fees Nov 30 - Dec 1 [](https://www.expedia.ca/Key-Largo-Hotels-Charming-Home-In-Key-Largo.h99961430.Hotel-Information) ![Property grounds](https://images.trvl-media.com/lodging/28000000/27450000/27442300/27442290/643f4a4b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/28000000/27450000/27442300/27442290/784806b4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Marina](https://images.trvl-media.com/lodging/28000000/27450000/27442300/27442290/69ad98a2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool, a heated pool](https://images.trvl-media.com/lodging/28000000/27450000/27442300/27442290/c07c8b32.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Vacation Home in Key Largo 9.4/10 Exceptional (61) "Easy clean condo " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Stephen G. CA $384 CA $876 total includes taxes & fees Dec 4 - Dec 5 [](https://www.expedia.ca/Key-Largo-Hotels-LICENSED-MANAGER-MODERN-22-COCONUT-PALM-VILLA-OCEANFRONT-BEACH-RESORT.h27442290.Hotel-Information) ![On the beach, sun loungers, beach towels](https://images.trvl-media.com/lodging/121000000/120630000/120624700/120624610/33d50685.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 bedrooms, desk, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/121000000/120630000/120624700/120624610/91fc885e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/121000000/120630000/120624700/120624610/0915fdf4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/121000000/120630000/120624700/120624610/3bdab314.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Vacation Home in Key Largo 10/10 Exceptional (43) "Good location. Lagoon and pool right outside door. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Debra C. CA $253 CA $676 total includes taxes & fees Nov 30 - Dec 1 [](https://www.expedia.ca/Key-Largo-Hotels-Marvelous-2-Bedroom-House-With-AC-In-Key-Largo.h120624610.Hotel-Information) ![Interior](https://images.trvl-media.com/lodging/89000000/88950000/88950000/88949924/7207b32f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/89000000/88950000/88950000/88949924/b420f068.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Marina](https://images.trvl-media.com/lodging/89000000/88950000/88950000/88949924/2085c0a2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, iron/ironing board, internet, bed sheets](https://images.trvl-media.com/lodging/89000000/88950000/88950000/88949924/ffec4934.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Vacation Home in Key Largo 9.8/10 Exceptional (11) "We loved our stay at the waterfront cabanas! The location is 10/10 with an awesome waterfront bar/restaurant and coffee truck within walking distance. We truly felt like keys locals staying here - highly recommend! " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Brittany M. CA $318 CA $572 total includes taxes & fees Dec 4 - Dec 5 [](https://www.expedia.ca/Key-Largo-Hotels-4-Cozy-Waterfront-Apartment-In-Key-Largo.h88949924.Hotel-Information) ![Beach](https://images.trvl-media.com/lodging/25000000/24210000/24204500/24204423/32bcd8a0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV](https://images.trvl-media.com/lodging/25000000/24210000/24204500/24204423/49f2540a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 bedrooms, iron/ironing board, WiFi, bed sheets](https://images.trvl-media.com/lodging/25000000/24210000/24204500/24204423/92474552.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/25000000/24210000/24204500/24204423/530b0205.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Vacation Home in Key Largo 9.0/10 Wonderful (129) "We stayed in 2 vrbo properties while in Florida. This one met and exceeded our expectations. We would stay again without hesitation." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Kelly M. CA $349 CA $770 total includes taxes & fees Nov 30 - Dec 1 [](https://www.expedia.ca/Key-Largo-Hotels-Relax-And-Enjoy-Beautiful-Key-Largo-Townhome.h24204423.Hotel-Information) ![Outdoor dining](https://images.trvl-media.com/lodging/102000000/101390000/101384800/101384797/46d848f4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/102000000/101390000/101384800/101384797/a862a694.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Marina](https://images.trvl-media.com/lodging/102000000/101390000/101384800/101384797/60e64b8a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![TV](https://images.trvl-media.com/lodging/102000000/101390000/101384800/101384797/73c3cc7b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Vacation Home in Key Largo 10/10 Exceptional (8) "Awesome place. Very well kept. Definitely coming back!!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) ERIKA R. CA $316 CA $692 total includes taxes & fees Nov 30 - Dec 1 [](https://www.expedia.ca/Key-Largo-Hotels-Kawama-G12-Upscale-OceansideVilla-With-Marina-22.h101384797.Hotel-Information) ![Beach](https://images.trvl-media.com/lodging/35000000/34420000/34412600/34412502/9e094b5f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Game room](https://images.trvl-media.com/lodging/35000000/34420000/34412600/34412502/0eff2ccc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor dining](https://images.trvl-media.com/lodging/35000000/34420000/34412600/34412502/162f943b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![A heated pool](https://images.trvl-media.com/lodging/35000000/34420000/34412600/34412502/56e02b4d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Vacation Home in Key Largo 9.8/10 Exceptional (66) "This place was perfect for 9 people. Both the condo and the area had plenty to do " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Ethan CA $349 CA $1,051 total includes taxes & fees Nov 30 - Dec 1 [](https://www.expedia.ca/Key-Largo-Hotels-Sunrise-Escape-Ocean-Front-Villa-Sleeps-10.h34412502.Hotel-Information) ![Marina](https://images.trvl-media.com/lodging/56000000/55190000/55186000/55185936/88377e50.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Beach nearby, sun loungers, beach towels](https://images.trvl-media.com/lodging/56000000/55190000/55186000/55185936/a381fdfe.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/56000000/55190000/55186000/55185936/f3ee7112.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Pool](https://images.trvl-media.com/lodging/56000000/55190000/55186000/55185936/9f308d75.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Vacation Home in Key Largo 9.6/10 Exceptional (62) "Great little place with awesome outdoor area. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) James D. CA $165 CA $513 total includes taxes & fees Dec 2 - Dec 3 [](https://www.expedia.ca/Key-Largo-Hotels-Tiny-House-On-The-Water-Pool.h55185936.Hotel-Information) ![A heated pool](https://images.trvl-media.com/lodging/102000000/102000000/101993800/101993768/e38839ad.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/102000000/102000000/101993800/101993768/12e5eb22.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/102000000/102000000/101993800/101993768/ea984adc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Beach nearby](https://images.trvl-media.com/lodging/102000000/102000000/101993800/101993768/2c22a63b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Vacation Home in Key Largo CA $320 CA $500 total includes taxes & fees Dec 3 - Dec 4 [](https://www.expedia.ca/Key-Largo-Hotels-The-Largo-Airstream-In-Paradise-At-Largo-Resort-By-Rentyl-Resorts.h101993768.Hotel-Information) ![Pool](https://images.trvl-media.com/lodging/113000000/112190000/112183700/112183617/748b49ac.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![TV, video games](https://images.trvl-media.com/lodging/113000000/112190000/112183700/112183617/37117a10.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/113000000/112190000/112183700/112183617/762f90b8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Beach nearby](https://images.trvl-media.com/lodging/113000000/112190000/112183700/112183617/80c6989b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Vacation Home in Key Largo 10/10 Exceptional (4) "Loved the location and views, house is amazing" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Dan L. CA $487 CA $1,113 total includes taxes & fees Dec 4 - Dec 5 [](https://www.expedia.ca/Key-Largo-Hotels-Key-Largo-Oceanfront-Oasis-W-Pool-Hot-Tub.h112183617.Hotel-Information) ![1 bedroom, desk, iron/ironing board, travel crib](https://images.trvl-media.com/lodging/35000000/34550000/34548900/34548876/6781facc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV](https://images.trvl-media.com/lodging/35000000/34550000/34548900/34548876/2a6f7c04.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, desk, iron/ironing board, travel crib](https://images.trvl-media.com/lodging/35000000/34550000/34548900/34548876/472b31db.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Hair dryer, towels](https://images.trvl-media.com/lodging/35000000/34550000/34548900/34548876/eeb33358.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Vacation Home in Key Largo 10/10 Exceptional (2) " We regret that we only booked for one night. We will definitely return for a longer stay. Everything about Key Largo Resort was perfect! The setting, the location, the accommodations, everything! Thank you for an amazing experience! We will be back! " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Kimberly V. CA $502 CA $729 total includes taxes & fees Dec 1 - Dec 2 [](https://www.expedia.ca/Key-Largo-Hotels-Serene-Bungalow-In-Paradise-At-Largo-Resort-By-Rentyl-Resorts.h34548876.Hotel-Information) ![Outdoor dining](https://images.trvl-media.com/lodging/28000000/27140000/27131200/27131178/62418801.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/28000000/27140000/27131200/27131178/w1337h900x13y0-6639d081.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV](https://images.trvl-media.com/lodging/28000000/27140000/27131200/27131178/a0f1cacc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/28000000/27140000/27131200/27131178/4a1dc468.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Vacation Home in Key Largo 9.4/10 Exceptional (221) "Great location. Nice layout. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Warren M. CA $368 CA $792 total includes taxes & fees Nov 30 - Dec 1 [](https://www.expedia.ca/Key-Largo-Hotels-Key-Largo-Kawama-Villa-L1.h27131178.Hotel-Information) ![A heated pool](https://images.trvl-media.com/lodging/73000000/72660000/72653600/72653526/dd319adc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/73000000/72660000/72653600/72653526/481549f2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor dining](https://images.trvl-media.com/lodging/73000000/72660000/72653600/72653526/3c06d12a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/73000000/72660000/72653600/72653526/7c8d5a10.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Vacation Home in Rock Harbor 10/10 Exceptional (85) "Great place, great hosts. We'll probably be backThank you" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Curt B. CA $335 CA $786 total includes taxes & fees Nov 30 - Dec 1 [](https://www.expedia.ca/Key-Largo-Hotels-Beautiful-Oceanside-Mariners-3-Bedroom-Townhome.h72653526.Hotel-Information) ![Beach nearby](https://images.trvl-media.com/lodging/34000000/33940000/33939100/33939052/6aaab228.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/34000000/33940000/33939100/33939052/c840eecb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![A heated pool](https://images.trvl-media.com/lodging/34000000/33940000/33939100/33939052/d5c60edf_edited_19d5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Marina](https://images.trvl-media.com/lodging/34000000/33940000/33939100/33939052/69d6dfcf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Vacation Home in Key Largo 9.8/10 Exceptional (138) "The property is absolutely stunning, not a detail un touched !! The property owner was very kind and accommodating, very knowledgeable and helpful with suggestions. My girls trip turned out perfectly! So thankful… I highly recommend.." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Shane D. CA $377 CA $831 total includes taxes & fees Nov 30 - Dec 1 [](https://www.expedia.ca/Key-Largo-Hotels-Waterfront-Town-Home-On-A-Lagoon.h33939052.Hotel-Information) ![Fridge, microwave, stovetop, cookware/dishes/utensils](https://images.trvl-media.com/lodging/34000000/33570000/33564300/33564261/ab304c7a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/34000000/33570000/33564300/33564261/365afb00.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 bedrooms, internet](https://images.trvl-media.com/lodging/34000000/33570000/33564300/33564261/195d0389.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, stovetop, cookware/dishes/utensils](https://images.trvl-media.com/lodging/34000000/33570000/33564300/33564261/b11e12fe.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Vacation Home in Key Largo 9.4/10 Exceptional (46) "This was a very cute resort, with perfect views! We were able to stay with our family and even bring our puppies. We had an absolutely amazing time!!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Shane F. CA $384 CA $776 total includes taxes & fees Dec 1 - Dec 2 [](https://www.expedia.ca/Key-Largo-Hotels-Waterfront-Cottage-Beach-And-Dockage-Open-Water-Views.h33564261.Hotel-Information) ![Property grounds](https://images.trvl-media.com/lodging/69000000/68910000/68907000/68906944/w1123h750x106y0-d60943bf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/69000000/68910000/68907000/68906944/w1123h750x106y0-91132719.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Beach nearby, beach towels](https://images.trvl-media.com/lodging/69000000/68910000/68907000/68906944/7c43b63d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/69000000/68910000/68907000/68906944/w1123h750x106y0-b71fa06d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Vacation Home in Duck Key 9.6/10 Exceptional (46) "Clean property! Great views! Great communication with owner! Perfect location- close to marathon and key west! " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) candi b. CA $300 CA $770 total includes taxes & fees Dec 9 - Dec 10 [](https://www.expedia.ca/Marathon-Hotels-Townhouse-On-Duck-Key.h68906944.Hotel-Information) ![Beach](https://images.trvl-media.com/lodging/54000000/53710000/53703000/53703000/7c7df51a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/54000000/53710000/53703000/53703000/010f7709.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV](https://images.trvl-media.com/lodging/54000000/53710000/53703000/53703000/0163e6a7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor dining](https://images.trvl-media.com/lodging/54000000/53710000/53703000/53703000/65bffc0a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Vacation Home in Key Largo 9.6/10 Exceptional (135) "We live our stay, everything was super clean and house is amazing, everything was so close." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Ana L. CA $370 CA $807 total includes taxes & fees Nov 30 - Dec 1 [](https://www.expedia.ca/Key-Largo-Hotels-Key-Largo-Villa.h53703000.Hotel-Information) ![On the beach](https://images.trvl-media.com/lodging/33000000/32720000/32710600/32710557/849463db.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/33000000/32720000/32710600/32710557/8b4bc5aa.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/33000000/32720000/32710600/32710557/862c9346.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Sport court](https://images.trvl-media.com/lodging/33000000/32720000/32710600/32710557/82d11223.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Vacation Home in Key Largo 9.6/10 Exceptional (133) "Nice clean place! It had everything we needed/wanted, and I would stay there again. Enjoy!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Charles P. CA $334 CA $749 total includes taxes & fees Nov 30 - Dec 1 [](https://www.expedia.ca/Key-Largo-Hotels-Key-Largo-Kawama-Villa-N2.h32710557.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2025-12-13&endDate=2025-12-14®ionId=553248621532652349&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&openPlayBack=true) ![](https://forever.travel-assets.com/flex/flexmanager/images/2025/11/05/BEX-BF-25_CA_1_Desktop.jpg?impolicy=fcrop&w=1400&h=600&q=mediumHigh) ## Black Friday Sale Limited-time deals: save up to 50% on select hotels [Book now](https://expedia.ca/deals?rfrr=AA_BF_PROMO_553248621532652349) ## Find vacation rentals that suit your style Aparthotels [](https://www.expedia.ca/Hotel-Search?destination=Lignumvitae+Key+Botanical+State+Park%2C+Florida%2C+United+States+of+America®ionId=553248621532652349&latLong=24.903077%2C-80.695302&adults=2&startDate=2026-02-27&d1=2026-02-27&endDate=2026-03-02&d2=2026-03-02&lodging=APART_HOTEL) Apartments [](https://www.expedia.ca/Hotel-Search?destination=Lignumvitae+Key+Botanical+State+Park%2C+Florida%2C+United+States+of+America®ionId=553248621532652349&latLong=24.903077%2C-80.695302&adults=2&startDate=2026-02-27&d1=2026-02-27&endDate=2026-03-02&d2=2026-03-02&lodging=APARTMENT) Cottages [](https://www.expedia.ca/Hotel-Search?destination=Lignumvitae+Key+Botanical+State+Park%2C+Florida%2C+United+States+of+America®ionId=553248621532652349&latLong=24.903077%2C-80.695302&adults=2&startDate=2026-02-27&d1=2026-02-27&endDate=2026-03-02&d2=2026-03-02&lodging=COTTAGE) Condos [](https://www.expedia.ca/Hotel-Search?destination=Lignumvitae+Key+Botanical+State+Park%2C+Florida%2C+United+States+of+America®ionId=553248621532652349&latLong=24.903077%2C-80.695302&adults=2&startDate=2026-02-27&d1=2026-02-27&endDate=2026-03-02&d2=2026-03-02&lodging=CONDO) Private vacation homes [](https://www.expedia.ca/Hotel-Search?destination=Lignumvitae+Key+Botanical+State+Park%2C+Florida%2C+United+States+of+America®ionId=553248621532652349&latLong=24.903077%2C-80.695302&adults=2&startDate=2026-02-27&d1=2026-02-27&endDate=2026-03-02&d2=2026-03-02&lodging=VACATION_HOME) Villas [](https://www.expedia.ca/Hotel-Search?destination=Lignumvitae+Key+Botanical+State+Park%2C+Florida%2C+United+States+of+America®ionId=553248621532652349&latLong=24.903077%2C-80.695302&adults=2&startDate=2026-02-27&d1=2026-02-27&endDate=2026-03-02&d2=2026-03-02&lodging=VILLA) Houseboats [](https://www.expedia.ca/Hotel-Search?destination=Lignumvitae+Key+Botanical+State+Park%2C+Florida%2C+United+States+of+America®ionId=553248621532652349&latLong=24.903077%2C-80.695302&adults=2&startDate=2026-02-27&d1=2026-02-27&endDate=2026-03-02&d2=2026-03-02&lodging=HOUSE_BOAT) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in](https://expedia.ca/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FLignumvitae-Key-Botanical-State-Park-Private-Vacation-Homes.d553248621532652349-aaPrivateVacationHomes.Travel-Guide-Accommodation)[Sign up, it's free](https://expedia.ca/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FLignumvitae-Key-Botanical-State-Park-Private-Vacation-Homes.d553248621532652349-aaPrivateVacationHomes.Travel-Guide-Accommodation) ## Top Lignumvitae Key Botanical State Park Hotel Reviews ![Drift Hotel](https://images.trvl-media.com/lodging/14000000/13210000/13209600/13209518/f3e504e7_y.jpg) ### Drift Hotel 10/10 Excellent "Room was very clean and the staff were outstanding" [](https://expedia.ca/Key-Largo-Hotels-Drift-Hotel.h13209518.Hotel-Information) ![Cheeca Lodge & Spa](https://images.trvl-media.com/lodging/1000000/10000/5800/5780/617c0723_y.jpg) ### Cheeca Lodge & Spa 10/10 Excellent "We stayed in the newest section of the Cheeca Lodge. It is so incredibly nice! We had other family staying in the lagoon area. We enjoyed all the activities on the property as well. My nephew especially loved the par3 golf course. I really loved the staff at Cheeca Lodge too. Shelia, Amber and David were our poolside attendants, and Jessica at the front desk was very helpful. " [](https://expedia.ca/Islamorada-Hotels-Cheeca-Lodge-Spa.h5780.Hotel-Information) ![Hadley Resort and Marina](https://images.trvl-media.com/lodging/1000000/20000/12200/12200/9afce9bd_y.jpg) ### Hadley Resort and Marina 10/10 Excellent "Everything was excellent " [](https://expedia.ca/Islamorada-Hotels-Hadley-House-Islamorada.h12200.Hotel-Information) ![Creekside Inn](https://images.trvl-media.com/lodging/2000000/1580000/1576800/1576773/5e43c05b_y.jpg) ### Creekside Inn 10/10 Excellent "Clean room, lovely location, accessible to nearby restaurants" [](https://expedia.ca/Tavernier-Hotels-Creekside-Inn-Islamorada.h1576773.Hotel-Information) ![Chesapeake Beach Resort](https://images.trvl-media.com/lodging/1000000/10000/4200/4170/689f4306_y.jpg) ### Chesapeake Beach Resort 10/10 Excellent "Excellent hotel" [](https://expedia.ca/Islamorada-Hotels-Chesapeake-Beach-Resort.h4170.Hotel-Information) ![Waterside Suites & Marina](https://images.trvl-media.com/lodging/1000000/20000/13800/13719/7b7ca43b_y.jpg) ### Waterside Suites & Marina 10/10 Excellent "Place was great, clean, spacious, friendly staff, beautiful view affordable" [](https://expedia.ca/Key-Largo-Hotels-Waterside-Suites-Marina.h13719.Hotel-Information) ![Treasure Harbor](https://images.trvl-media.com/lodging/92000000/91750000/91743100/91743042/12c235b3_y.jpg) ### Treasure Harbor 10/10 Excellent "I am obsessed with tiny houses and this one floats! It was so relaxing to sit on the deck and enjoy the view. The bed was very comfy and the gentle motion of the water put me right to sleep. The staff are friendly and helpful. Islamorada is beautiful and fun to explore." [](https://expedia.ca/Islamorada-Hotels-Treasure-Harbor.h91743042.Hotel-Information) ![Rock Reef Resort](https://images.trvl-media.com/lodging/58000000/57190000/57185500/57185414/6ddda999_y.jpg) ### Rock Reef Resort 10/10 Excellent "The room was spotless" [](https://expedia.ca/Key-Largo-Hotels-Rock-Reef-Resort.h57185414.Hotel-Information) ![Islander Resort](https://images.trvl-media.com/lodging/1000000/480000/475500/475438/5adae4af_y.jpg) ### Islander Resort 10/10 Excellent "Beautiful resort. They have added on a lot of palm trees and a new breakfast restaurant near the pool. Only disappointment was they have removed the hot tub😢we had an ocean view room. They had all been upgraded again. " [](https://expedia.ca/Islamorada-Hotels-Islander-Resort.h475438.Hotel-Information) ## Find out more about Lignumvitae Key Botanical State Park ## Lignumvitae Key Botanical State Park Vacation Homes information | Number of reviews | 1,302 | | --- | --- | | Accommodation | 676 Vacation Homes | | Lowest Price | CA $404 | | Highest Price | CA $1,113 | ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - Vacation Rental - More ways to book - [Hotels near Bud n' Mary's Dive Center](https://www.expedia.ca/Bud-N-Marys-Dive-Center-Hotels.0-l6069243-0.Travel-Guide-Filter-Hotels) - [B&B in Coopertown](https://www.expedia.ca/Coopertown-Bed-And-Breakfast.d6177715-aaBedAndBreakfast.Travel-Guide-Accommodation) - [Guest Houses in Coopertown](https://www.expedia.ca/Coopertown-Guest-Houses.d6177715-aaGuestHouses.Travel-Guide-Accommodation) - [B&B in Elliott Key](https://www.expedia.ca/Elliott-Key-Bed-And-Breakfast.d553248621532652848-aaBedAndBreakfast.Travel-Guide-Accommodation) - 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