Title: Book the Best Eastern Panama LUXURY Hotels - Upscale Hotels in Eastern Panama | Expedia.ca

[Eastern Panama Travel Guide](https://expedia.ca/Eastern-Panama.dx6246114)[Hotels in Eastern Panama](https://expedia.ca/Eastern-Panama-Hotels.d6246114.Travel-Guide-Hotels)[Vacation Rentals in Eastern Panama](https://expedia.ca/Eastern-Panama-Vacation-Rentals.d6246114.Travel-Guide-VacationRentals)[Flights to Eastern Panama](https://expedia.ca/Cheap-Flights-To-Eastern-Panama.d6246114.Travel-Guide-Flights)[Things to do in Eastern Panama](https://expedia.ca/Things-To-Do-In-Eastern-Panama.d6246114.Travel-Guide-Activities)[Eastern Panama Car Rentals](https://expedia.ca/Car-Rentals-In-Eastern-Panama.d6246114.Car-Rental-Guide)[Eastern Panama Vacation Packages](https://expedia.ca/Eastern-Panama.d6246114.Destination-Travel-Guides)

![50 Shades of blue. Sailing through the San Blas Islands in Panama lets you experience  a pure paradise and crystal clear water. You can buy fresh fish and other seefood drirectly from local fishermen. If you want you can also play Robinson Crusoe on islands with literally only one palm tree. 
#BVSBlue](https://images.trvl-media.com/place/6246376/42fe0cae-c805-47d5-a705-ee119c68d58c.jpg?impolicy=fcrop&w=1200&h=500&q=medium)

Photo by Nico Barner

# Find luxury hotels in Eastern Panama

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## Check availability on Eastern Panama Luxury Hotels

Tonight

[Dec 28 - Dec 29](https://www.expedia.ca/Hotel-Search?regionId=6246114&startDate=2025-12-28&endDate=2025-12-29&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property)

Tomorrow

[Dec 29 - Dec 30](https://www.expedia.ca/Hotel-Search?regionId=6246114&startDate=2025-12-29&endDate=2025-12-30&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property)

Next weekend

[Jan 2 - Jan 4](https://www.expedia.ca/Hotel-Search?regionId=6246114&startDate=2026-01-02&endDate=2026-01-04&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property)

In two weeks

[Jan 9 - Jan 11](https://www.expedia.ca/Hotel-Search?regionId=6246114&startDate=2026-01-09&endDate=2026-01-11&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property)

No exact matches found, but these alternatives could be just right

## Recommended hotels in Eastern Panama

![Exterior](https://images.trvl-media.com/lodging/96000000/95810000/95807400/95807391/1b4156f6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Free WiFi](https://images.trvl-media.com/lodging/96000000/95810000/95807400/95807391/7fd698a0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/96000000/95810000/95807400/95807391/309e8ef7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Living area](https://images.trvl-media.com/lodging/96000000/95810000/95807400/95807391/5ebfc967.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Cocoloco - Catamaran Lagoon 52F SAN BLAS

[](https://www.expedia.ca/Nargana-Hotels-Cocoloco-Catamaran-Lagoon-52F-SAN-BLAS.h95807391.Hotel-Information)

Narganá

CA $2,618

CA $2,887 total

includes taxes & fees

Jan 11 - Jan 12, 2026

[](https://www.expedia.ca/Nargana-Hotels-Cocoloco-Catamaran-Lagoon-52F-SAN-BLAS.h95807391.Hotel-Information)

![Beach](https://images.trvl-media.com/lodging/121000000/120040000/120034500/120034445/0b910251.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Miscellaneous](https://images.trvl-media.com/lodging/121000000/120040000/120034500/120034445/3d134b58.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fridge, stovetop, coffee/tea maker, toaster](https://images.trvl-media.com/lodging/121000000/120040000/120034500/120034445/bb4bcbb3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![View from property](https://images.trvl-media.com/lodging/121000000/120040000/120034500/120034445/83e04d0e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### All inclusive 4-bedroom Catamaran up to 8 people in San Blas Panama

[](https://www.expedia.ca/Fabulous-4-Bedroom-Catamaran-In-San-Blas-Panama.h120034445.Hotel-Information)

Guna Yala Comarca

CA $1,157

CA $1,369 total

includes taxes & fees

Jan 5 - Jan 6, 2026

[](https://www.expedia.ca/Fabulous-4-Bedroom-Catamaran-In-San-Blas-Panama.h120034445.Hotel-Information)

![Deluxe Room](https://images.trvl-media.com/lodging/97000000/96740000/96735000/96734959/7979d8c3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Deluxe Room](https://images.trvl-media.com/lodging/97000000/96740000/96735000/96734959/2321221d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Deluxe Room | View from room](https://images.trvl-media.com/lodging/97000000/96740000/96735000/96734959/90212b31.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Sauna, steam room](https://images.trvl-media.com/lodging/97000000/96740000/96735000/96734959/0f5b4937.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Ciel y Miel 

[](https://www.expedia.ca/Cacique-Hotels-Ciel-Y-Miel.h96734959.Hotel-Information)

Cacique

10/10

Exceptional

(9)

"Love this place and would return back numerous times"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Sean

CA $637

CA $701 total

includes taxes & fees

Dec 31 - Jan 1, 2026

[](https://www.expedia.ca/Cacique-Hotels-Ciel-Y-Miel.h96734959.Hotel-Information)

![Beach](https://images.trvl-media.com/lodging/72000000/71150000/71141100/71141036/803cd264.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Aerial view](https://images.trvl-media.com/lodging/72000000/71150000/71141100/71141036/9304c3cb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Aerial view](https://images.trvl-media.com/lodging/72000000/71150000/71141100/71141036/b3c05fe0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Aerial view](https://images.trvl-media.com/lodging/72000000/71150000/71141100/71141036/c41bafb2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Catamaran experience in paradise

[](https://www.expedia.ca/San-Blas-Islands-Hotels-Catamaran-Experience-In-Paradise.h71141036.Hotel-Information)

Guna Yala Comarca

CA $805

CA $1,654 total

includes taxes & fees

Dec 29 - Dec 30

[](https://www.expedia.ca/San-Blas-Islands-Hotels-Catamaran-Experience-In-Paradise.h71141036.Hotel-Information)

![Beach nearby, beach towels](https://images.trvl-media.com/lodging/114000000/113060000/113058600/113058539/3296d6de.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fridge, oven, stovetop, coffee/tea maker](https://images.trvl-media.com/lodging/114000000/113060000/113058600/113058539/07d1058d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Property grounds](https://images.trvl-media.com/lodging/114000000/113060000/113058600/113058539/6f230b81.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/114000000/113060000/113058600/113058539/bed98230.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Exclusive sailboat for 2 people all inclusive in San Blas islands

[](https://www.expedia.ca/Ailigandi-Hotels-Vrbo-Property.h113058539.Hotel-Information)

Guna Yala

CA $615

CA $695 total

includes taxes & fees

Jan 8 - Jan 9, 2026

[](https://www.expedia.ca/Ailigandi-Hotels-Vrbo-Property.h113058539.Hotel-Information)

![Aerial view](https://images.trvl-media.com/lodging/38000000/37810000/37804600/37804534/7a4cf19e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Restaurant](https://images.trvl-media.com/lodging/38000000/37810000/37804600/37804534/587acb7a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Basic Room, 2 Double Beds | Garden view](https://images.trvl-media.com/lodging/38000000/37810000/37804600/37804534/1cc9d52d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Property grounds](https://images.trvl-media.com/lodging/38000000/37810000/37804600/37804534/1370ba19.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

###  San Blas Paradise Private Cabins on Shipwreck Island - meals included

[](https://www.expedia.ca/San-Blas-Islands-Hotels-Cabins-In-Perro-Island.h37804534.Hotel-Information)

Narganá

[](https://www.expedia.ca/San-Blas-Islands-Hotels-Cabins-In-Perro-Island.h37804534.Hotel-Information)

![Panoramic Cabin, Ocean View | Beach/ocean view](https://images.trvl-media.com/lodging/38000000/37770000/37767000/37766985/ede84b95.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Restaurant](https://images.trvl-media.com/lodging/38000000/37770000/37767000/37766985/caaaab49.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Panoramic Cabin, Ocean View](https://images.trvl-media.com/lodging/38000000/37770000/37767000/37766985/w2878h1920x0y0-df17b8ba.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Panoramic Cabin, Ocean View](https://images.trvl-media.com/lodging/38000000/37770000/37767000/37766985/7708eca7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Private Ocean-Front Cabin with private bathroom on San Blas Island

[](https://www.expedia.ca/San-Blas-Islands-Hotels-Cabins-In-Diablo-Island.h37766985.Hotel-Information)

Narganá

CA $257

CA $283 total

includes taxes & fees

Dec 29 - Dec 30

[](https://www.expedia.ca/San-Blas-Islands-Hotels-Cabins-In-Diablo-Island.h37766985.Hotel-Information)

![On the beach, white sand, snorkeling, beach bar](https://images.trvl-media.com/lodging/47000000/46950000/46949700/46949679/eb9f55f8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Panoramic Cabin | Terrace/patio](https://images.trvl-media.com/lodging/47000000/46950000/46949700/46949679/8696040b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![View from property](https://images.trvl-media.com/lodging/47000000/46950000/46949700/46949679/d29880fa.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Panoramic Cabin](https://images.trvl-media.com/lodging/47000000/46950000/46949700/46949679/f7f8513a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### San Blas Private Over-the-Water Cabin

[](https://www.expedia.ca/San-Blas-Islands-Hotels-San-Blas-Private-Over-The-Water-Cabin.h46949679.Hotel-Information)

Narganá

8.0/10

Very good

(2)

"I liked the modern payment system that was used for booking the trip, the food was great, the location was as described. I disliked the communication with the reseller this booking goes through. They dropped the ball on communicating pickup time and itinerary confirmation, even when i tried calling and emailing them. I also disliked the value of what you get with this trip. Id expect better cleanliness and standards for this trip. I also disliked when the staff on the island said i needed to pay...

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Andrew

[](https://www.expedia.ca/San-Blas-Islands-Hotels-San-Blas-Private-Over-The-Water-Cabin.h46949679.Hotel-Information)

![On the beach, white sand](https://images.trvl-media.com/lodging/47000000/46960000/46955400/46955399/287bc182.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Restaurant](https://images.trvl-media.com/lodging/47000000/46960000/46955400/46955399/edcd0ecc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![View from property](https://images.trvl-media.com/lodging/47000000/46960000/46955400/46955399/1c15e003.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Panoramic Cabin](https://images.trvl-media.com/lodging/47000000/46960000/46955400/46955399/4f914323.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### San Blas Private Oceanfront Cabin

[](https://www.expedia.ca/San-Blas-Private-Oceanfront-Cabin.h46955399.Hotel-Information)

Narganá

CA $354

CA $526 total

includes taxes & fees

Dec 29 - Dec 30

[](https://www.expedia.ca/San-Blas-Private-Oceanfront-Cabin.h46955399.Hotel-Information)

![On the beach, sun loungers, beach towels](https://images.trvl-media.com/lodging/72000000/71150000/71150000/71149949/24e34d16.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/72000000/71150000/71150000/71149949/f2a8388a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Terrace/patio](https://images.trvl-media.com/lodging/72000000/71150000/71150000/71149949/0eac3661.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/72000000/71150000/71150000/71149949/b2caffc9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Caribbean getaway: beach cottage just on the sand

[](https://www.expedia.ca/Palenque-Hotels-Caribbean-Getaway-Beach-Cottage-Just-On-The-Sand.h71149949.Hotel-Information)

Palenque

10/10

Exceptional

(1)

"The beach view was perfect! I loved hearing the waves all day and throughout the night. My dog and I enjoyed everything and felt very comfortable. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Beth N.

CA $324

CA $410 total

includes taxes & fees

Dec 29 - Dec 30

[](https://www.expedia.ca/Palenque-Hotels-Caribbean-Getaway-Beach-Cottage-Just-On-The-Sand.h71149949.Hotel-Information)

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

[View all properties](https://expedia.ca/Hotel-Search?startDate=2026-01-11&endDate=2026-01-12&regionId=6246114&adults=2&sort=LUXURY&star=40,50&openPlayBack=true)

## Top Eastern Panama Hotel Reviews