Title: Book the Best BUSINESS Hotels in Eastern Panama in 2025 | Expedia.ca [Eastern Panama Travel Guide](https://expedia.ca/Eastern-Panama.dx6246114)[Hotels in Eastern Panama](https://expedia.ca/Eastern-Panama-Hotels.d6246114.Travel-Guide-Hotels)[Vacation Rentals in Eastern Panama](https://expedia.ca/Eastern-Panama-Vacation-Rentals.d6246114.Travel-Guide-VacationRentals)[Flights to Eastern Panama](https://expedia.ca/Cheap-Flights-To-Eastern-Panama.d6246114.Travel-Guide-Flights)[Things to do in Eastern Panama](https://expedia.ca/Things-To-Do-In-Eastern-Panama.d6246114.Travel-Guide-Activities)[Eastern Panama Car Rentals](https://expedia.ca/Car-Rentals-In-Eastern-Panama.d6246114.Car-Rental-Guide)[Eastern Panama Vacation Packages](https://expedia.ca/Eastern-Panama.d6246114.Destination-Travel-Guides) ![](https://mediaim.expedia.com/destination/1/5d18772a3c60968c8280d6082bb3d1e6.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find Business Hotels in Eastern Panama ![calendar shield illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation ![deals illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) ![bed illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Eastern Panama Business Hotels Tonight [Oct 2 - Oct 3](https://www.expedia.ca/Hotel-Search?regionId=6246114&startDate=2025-10-02&endDate=2025-10-03&adults=2&travelerType=BUSINESS&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Oct 3 - Oct 4](https://www.expedia.ca/Hotel-Search?regionId=6246114&startDate=2025-10-03&endDate=2025-10-04&adults=2&travelerType=BUSINESS&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Oct 3 - Oct 5](https://www.expedia.ca/Hotel-Search?regionId=6246114&startDate=2025-10-03&endDate=2025-10-05&adults=2&travelerType=BUSINESS&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Oct 10 - Oct 12](https://www.expedia.ca/Hotel-Search?regionId=6246114&startDate=2025-10-10&endDate=2025-10-12&adults=2&travelerType=BUSINESS&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top Eastern Panama Business Hotels ![On the beach](https://images.trvl-media.com/lodging/13000000/12290000/12285300/12285229/82f24727.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Traditional Cabin, 1 Bedroom, Ocean View](https://images.trvl-media.com/lodging/13000000/12290000/12285300/12285229/bbd15b84.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Breakfast, lunch, dinner served; Regional cuisine ](https://images.trvl-media.com/lodging/13000000/12290000/12285300/12285229/e7fb3a59.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/13000000/12290000/12285300/12285229/68fb5c4d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Akwadup Lodge Casco Viejo 5.0/10 (2) "First of all, we chose this place because of lack of transport options to the Northwestern part of San Blas. We got a direct flight to Achutupu runway, an experience in itself. We were picked up by Jeronimo, the 80year old owner of the lodge. The lodge is old but kept spic and span. We were a bit disapointed to be the only tourists, however, it had some charme to be the only visitors to the island. Unfortunately, the rest of the island that belonged to other people but uninhabited had lots of... [](https://www.expedia.ca/San-Blas-Islands-Hotels-Akwadup-Lodge.h12285229.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2025-10-16&endDate=2025-10-17®ionId=6246114&adults=2&travelerType=business_friendly&sort=RECOMMENDED&openPlayBack=true) ## Top Eastern Panama Hotel Reviews