Upstate South Carolina Vacation Rentals
Change your mind
Book hotels with free cancellation
Be picky
Search almost a million properties worldwide
Check prices for these dates
Next weekend
In two weeks
In one month
In two months
Browse Select Upstate South Carolina Vacation Homes
Our top choices for Upstate South Carolina vacation homes

Cottage by the lakeshore with a private hot tub!
Cottage by the lakeshore with a private hot tub!
8.8 out of 10, Excellent, (8)
The price is CA $154
CA $271 total
includes taxes & fees
Aug 24 - Aug 25

Cozy 2 bedroom home near downtown Gaffney.
Cozy 2 bedroom home near downtown Gaffney.
9.8 out of 10, Exceptional, (27)
The price is CA $138
CA $315 total
includes taxes & fees
Aug 23 - Aug 24

Lake Hartwell Frank Howard Home Clemson
Lake Hartwell Frank Howard Home Clemson
The price is CA $103
CA $555 total
includes taxes & fees
Aug 24 - Aug 25

⭐️Hot Tub⭐️ Luxury Getaway Near GSP Airport Downtown Greer Greenville Spartanburg
⭐️Hot Tub⭐️ Luxury Getaway Near GSP Airport Downtown Greer Greenville Spartanburg
10.0 out of 10, Exceptional, (38)
The price is CA $125
CA $285 total
includes taxes & fees
Aug 25 - Aug 26

Charming 2-bedroom house in Clemson 4mi. from Death Valley and 1mi. from Mac's
Charming 2-bedroom house in Clemson 4mi. from Death Valley and 1mi. from Mac's
The price is CA $1,043
CA $1,587 total
includes taxes & fees
Aug 31 - Sep 1

Charming luxury cottage in the heart of Boiling Springs
Charming luxury cottage in the heart of Boiling Springs
9.0 out of 10, Wonderful, (4)
The price is CA $125
CA $270 total
includes taxes & fees
Aug 24 - Aug 25

The Blue Bungalow by Unity Park - Newly Renovated
The Blue Bungalow by Unity Park - Newly Renovated
9.8 out of 10, Exceptional, (69)
The price is CA $104
CA $275 total
includes taxes & fees
Sep 2 - Sep 3

Field Trip Unit 9 Small Bell Tent
Field Trip Unit 9 Small Bell Tent
10.0 out of 10, Exceptional, (2)
The price is CA $169
CA $281 total
includes taxes & fees
Aug 24 - Aug 25
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Save an average of 15% on thousands of hotels when you're signed in
Top Upstate South Carolina Hotel Reviews

Hyatt Place Greenville Downtown
10/10 Excellent
Find out more about Upstate South Carolina
Find out more about Upstate South Carolina
Upstate South Carolina Vacation Homes information
Number of reviews | 826 |
---|---|
Accommodation | 979 Vacation Homes |
Lowest Price | CA $105 |
Highest Price | CA $250 |
Explore a world of travel with Expedia
Explore a world of travel with Expedia
Popular Destinations
- Vacation Homes in Gaffney
- Vacation Homes in Greenville
- Vacation Homes in Spartanburg
- Vacation Homes in Anderson
- Vacation Homes in Simpsonville
- Vacation Homes in Duncan
- Vacation Homes in Clemson
- Vacation Homes in Seneca
- Vacation Homes in Central
- Vacation Homes in Greer
- Vacation Homes in Easley
- Vacation Homes in Walhalla
- Vacation Homes in Salem
- Vacation Homes in Cleveland
- Vacation Homes in Sunset
- Vacation Homes in Travelers Rest
Top Vacation Homes in Other Destinations
More Accommodation Types in Upstate South Carolina
- Apartments in Upstate South Carolina
- Cottages in Upstate South Carolina
- Cabin Rentals in Upstate South Carolina
- Condo Rentals in Upstate South Carolina
- Motels in Upstate South Carolina
- Farmstay in Upstate South Carolina
- Villas in Upstate South Carolina
- B&B in Upstate South Carolina
- RV Parks in Upstate South Carolina
- Aparthotels in Upstate South Carolina
- Guest Houses in Upstate South Carolina
- Chalets in Upstate South Carolina
- Lodges in Upstate South Carolina
- Condo Resorts in Upstate South Carolina
- Resorts in Upstate South Carolina
- Houseboats in Upstate South Carolina
- Hotels
All Accommodation Types
Be inspired: Top Vacation Homes destinations in 2025
- Orlando Vacation Homes
- Florida Vacation Homes
- Kissimmee Vacation Homes
- Hawaii Vacation Homes
- Costa Rica Vacation Homes
- Walt Disney World® Vacation Homes
- Palm Springs Vacation Homes
- Naples Vacation Homes
- Victoria Vacation Homes
- Kelowna Vacation Homes
- Toronto Vacation Homes
- Las Vegas Vacation Homes
- Vancouver Vacation Homes
- Mexico Vacation Homes
- Phoenix Vacation Homes
- Fort Lauderdale Vacation Homes
- Davenport Vacation Homes
- Myrtle Beach Vacation Homes
- Los Angeles Vacation Homes
- Cape Coral Vacation Homes
More ways to book
Expedia's Latest Trends
Hotels
Packages
Vacation Rentals