Title: Book the Best HISTORIC Hotels in Upstate South Carolina in 2025 | Expedia.ca [Upstate South Carolina Travel Guide](https://expedia.ca/Upstate-South-Carolina.dx6057939)[Hotels in Upstate South Carolina](https://expedia.ca/Upstate-South-Carolina-Hotels.d6057939.Travel-Guide-Hotels)[Vacation Rentals in Upstate South Carolina](https://expedia.ca/Upstate-South-Carolina-Vacation-Rentals.d6057939.Travel-Guide-VacationRentals)[Flights to Upstate South Carolina](https://expedia.ca/Cheap-Flights-To-Upstate-South-Carolina.d6057939.Travel-Guide-Flights)[Things to do in Upstate South Carolina](https://expedia.ca/Things-To-Do-In-Upstate-South-Carolina.d6057939.Travel-Guide-Activities)[Upstate South Carolina Car Rentals](https://expedia.ca/Car-Rentals-In-Upstate-South-Carolina.d6057939.Car-Rental-Guide)[Upstate South Carolina Vacation Packages](https://expedia.ca/Upstate-South-Carolina.d6057939.Destination-Travel-Guides) ![Greenville - Spartanburg featuring mountains, views and a sunset](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/63000/63748-Greenville-Spartanburg.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find Historic Hotels in Upstate South Carolina, SC ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Upstate South Carolina Historic Hotels Tonight [Oct 15 - Oct 16](https://www.expedia.ca/Hotel-Search?regionId=6057939&startDate=2025-10-15&endDate=2025-10-16&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Oct 16 - Oct 17](https://www.expedia.ca/Hotel-Search?regionId=6057939&startDate=2025-10-16&endDate=2025-10-17&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Oct 17 - Oct 19](https://www.expedia.ca/Hotel-Search?regionId=6057939&startDate=2025-10-17&endDate=2025-10-19&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Oct 24 - Oct 26](https://www.expedia.ca/Hotel-Search?regionId=6057939&startDate=2025-10-24&endDate=2025-10-26&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top Upstate South Carolina Historic Hotels ![Exterior](https://images.trvl-media.com/lodging/3000000/2560000/2558700/2558616/ff716430.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Room, 2 Queen Beds, Microwave (Minifridge)](https://images.trvl-media.com/lodging/3000000/2560000/2558700/2558616/168f9ed8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily self-serve breakfast](https://images.trvl-media.com/lodging/3000000/2560000/2558700/2558616/78b30d8b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fitness facility](https://images.trvl-media.com/lodging/3000000/2560000/2558700/2558616/e68ec3f8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Express & Suites Clemson by IHG Clemson 8.8/10 Excellent (944) "Had a great stay at this hotel. Conveniently located near restaurants. " CA $167 CA $185 total includes taxes & fees Oct 19 - Oct 20 [](https://www.expedia.ca/Anderson-Hotels-Holiday-Inn-Express-Suites-Clemson.h2558616.Hotel-Information) ![Cookware/dishes/utensils, dining tables](https://images.trvl-media.com/lodging/103000000/102560000/102557000/102556973/c6422e48.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/103000000/102560000/102557000/102556973/0bc117de.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/103000000/102560000/102557000/102556973/59b14248.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/103000000/102560000/102557000/102556973/ee9cd8a3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Chic Downtown 2BR Condo walk to The Well Arena Greenville Downtown 9.6/10 Exceptional (5) "Condo is very comfortable & location was good. Stayed two nights." CA $178 CA $407 total includes taxes & fees Nov 2 - Nov 3 [](https://www.expedia.ca/Greenville-Hotels-Chic-Downtown-2BR-Condo-Walk-To-The-Well-Arena.h102556973.Hotel-Information) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/113000000/112030000/112024200/112024164/19e28a5f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV](https://images.trvl-media.com/lodging/113000000/112030000/112024200/112024164/63beb273.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, desk, iron/ironing board, WiFi](https://images.trvl-media.com/lodging/113000000/112030000/112024200/112024164/503ffee7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/113000000/112030000/112024200/112024164/68676aa9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### 1br Apt in Historic Triplex - 5min walk Swamp Rabbit Trail, 15min walk to dntwn Greenville Downtown 8.8/10 Excellent (3) "Cute place. Interesting neighborhood. Close enough to the event I was attending to walk and avoid parking fees. " CA $119 CA $337 total includes taxes & fees Oct 27 - Oct 28 [](https://www.expedia.ca/Greenville-Hotels-1br-Apt-In-Historic-Triplex-5min-Walk-Swamp-Rabbit-Trail.h112024164.Hotel-Information) ![Terrace/patio](https://images.trvl-media.com/lodging/30000000/29940000/29935300/29935238/d8b4f3c5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/30000000/29940000/29935300/29935238/6d8a33de.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/30000000/29940000/29935300/29935238/21a53dc2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![3 bedrooms, in-room safe, desk, iron/ironing board](https://images.trvl-media.com/lodging/30000000/29940000/29935300/29935238/c3ec8e86.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Make Memories on Mulberry Greenville 10/10 Exceptional (93) "Spacious, well-equipped house provided the perfect place for our group of friends to attend our bridge tournament downtown. The large dining table and outdoor seating encouraged sitting and visiting. A responsive host who provided a welcome breakfast helped make it a great visit; we hope to enjoy it again in the future." CA $192 CA $337 total includes taxes & fees Oct 23 - Oct 24 [](https://www.expedia.ca/Greenville-Hotels-Make-Memories-On-Mulberry.h29935238.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/670000/663800/663745/5698a443.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/1000000/670000/663800/663745/f9b74c9e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/1000000/670000/663800/663745/b23cade1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/1000000/670000/663800/663745/eb2a711e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Pettigru Place Bed & Breakfast Greenville Downtown 10/10 Exceptional (123) "One of my favorite places to stay in Greenville. It is such a quaint bed and breakfast despite how close it is to downtown. Excellent service and amazing accommodations. " CA $326 CA $358 total includes taxes & fees Oct 26 - Oct 27 [](https://www.expedia.ca/Greenville-Hotels-Pettigru-Place-Bed-Breakfast.h663745.Hotel-Information) ![Cookware/dishes/utensils, spices](https://images.trvl-media.com/lodging/104000000/103660000/103651700/103651672/03778862.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, WiFi, bed sheets](https://images.trvl-media.com/lodging/104000000/103660000/103651700/103651672/cf6a2389.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/104000000/103660000/103651700/103651672/cf9dd524.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Living area](https://images.trvl-media.com/lodging/104000000/103660000/103651700/103651672/bdafab76.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Cozy Downtown Loft for Two + Pets, Walk to Main St Greenville Downtown 8.8/10 Excellent (5) "Just a great time in Greenville and with a great place to stay; very comfortable in a great location. We loved having such a well supplied kitchen to cook in. The host is top notch, always with quick answers to what seemed like a lot of questions. Very welcoming; we'll surely be back and highly recommend the Loft, especially for couples looking for something special." CA $134 CA $310 total includes taxes & fees Nov 11 - Nov 12 [](https://www.expedia.ca/Greenville-Hotels-Cozy-Downtown-Loft-For-Two-Pets.h103651672.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/113000000/112030000/112023800/112023725/5aaa51c0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/113000000/112030000/112023800/112023725/a9d9deed.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, iron/ironing board, WiFi, bed sheets](https://images.trvl-media.com/lodging/113000000/112030000/112023800/112023725/edf36fb8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV](https://images.trvl-media.com/lodging/113000000/112030000/112023800/112023725/9149f7ad.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### 1 bedroom apt, Steps from Swamp Rabbit Trail, 15 minute walk to Main st. Greenville Downtown 10/10 Exceptional (2) "Good location, accurate listing. Walked to Main St for dinner, felt safe no issues. Enjoyed coffee at Down Under. Had a little street noise but quiet after 10. " CA $169 CA $406 total includes taxes & fees Oct 17 - Oct 18 [](https://www.expedia.ca/Greenville-Hotels-1-Bedroom-Apt.h112023725.Hotel-Information) ![Dining](https://images.trvl-media.com/lodging/113000000/112030000/112024400/112024327/47bd746a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/113000000/112030000/112024400/112024327/30159069.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, dishwasher](https://images.trvl-media.com/lodging/113000000/112030000/112024400/112024327/e3736c39.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/113000000/112030000/112024400/112024327/7059d3dc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### 2bed Apt - 5 min walk to Swamp Rabbit - 15min walk to downtown - 3min walk BSWA Greenville Downtown 10/10 Exceptional (7) "Our family of 4 enjoyed our stay in this historic home! The home has character, was clean and had plenty of room with comfortable beds. It's close to downtown with all of the shops and a variety of restaurants. Greenville is a great town to visit!" CA $177 CA $484 total includes taxes & fees Oct 27 - Oct 28 [](https://www.expedia.ca/Greenville-Hotels-2bed-Apt-5-Min-Walk-To-Swamp-Rabbit-15min-Walk-To-Downtown-3min-Walk-BSWA.h112024327.Hotel-Information) ![Outdoor dining](https://images.trvl-media.com/lodging/81000000/80360000/80354000/80353961/7a06d578.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV, fireplace, books](https://images.trvl-media.com/lodging/81000000/80360000/80354000/80353961/e737cd70.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/81000000/80360000/80354000/80353961/644bb751.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/81000000/80360000/80354000/80353961/c5e809ea.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Designer Retreat in Quaint Historic District w Front Porch Dining under the oaks Greenville Downtown 10/10 Exceptional (66) "Gorgeous home, ideal location!Everything we needed plus some!Enjoyed our stay so much!" CA $441 CA $882 total includes taxes & fees Oct 26 - Oct 27 [](https://www.expedia.ca/Greenville-Hotels-Designer-Retreat-In-Quaint-Historic-District-W-Front-Porch-Dining-Under-The-Oaks.h80353961.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/2000000/1220000/1213000/1212931/e60a54aa.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property entrance](https://images.trvl-media.com/lodging/2000000/1220000/1213000/1212931/42f27498.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Room, 1 King Bed, Non Smoking](https://images.trvl-media.com/lodging/2000000/1220000/1213000/1212931/d45644f2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/2000000/1220000/1213000/1212931/8f8be646.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Inn on the Square, an Ascend Collection Hotel Uptown Greenwood 9.2/10 Wonderful (698) "It was a very clean and beautiful lace to stay. We were there for our honeymoon " CA $166 CA $184 total includes taxes & fees Oct 26 - Oct 27 [](https://www.expedia.ca/Greenwood-Hotels-Inn-On-The-Square.h1212931.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2025-10-29&endDate=2025-10-30®ionId=6057939&adults=2&specialized_stays_group_explore=historic_property&sort=RECOMMENDED&openPlayBack=true) ## Top Upstate South Carolina Hotel Reviews ![Best Western Plus Greenville I-385 Inn & Suites](//images.trvl-media.com/lodging/1000000/30000/23100/23003/20a0c66a_y.jpg) ### Best Western Plus Greenville I-385 Inn & Suites 10/10 Excellent "Excellent" [](https://expedia.ca/Greenville-Hotels-Best-Western-Plus-Greenville-I-385-Inn-Suites.h23003.Hotel-Information) ![Hilton Greenville](//images.trvl-media.com/lodging/1000000/30000/23200/23172/401b294d_y.jpg) ### Hilton Greenville 10/10 Excellent "The staff were very friendly. I checked out and left my phone in the room and they allowed me to go back in the room, no hassle at all to retrieve my phone!!" [](https://expedia.ca/Greenville-Hotels-Hilton-Greenville.h23172.Hotel-Information) ![Hyatt Regency Greenville](//images.trvl-media.com/lodging/1000000/30000/22300/22252/fa37e256_y.jpg) ### Hyatt Regency Greenville 10/10 Excellent "Clean room, beautiful view!" [](https://expedia.ca/Greenville-Hotels-Hyatt-Regency-Greenville.h22252.Hotel-Information) ![Crowne Plaza Hotel Greenville-I-385-Roper Mtn Rd by IHG](//images.trvl-media.com/lodging/1000000/10000/1400/1379/91409d5a_y.jpg) ### Crowne Plaza Hotel Greenville-I-385-Roper Mtn Rd by IHG 10/10 Excellent "Clean room" [](https://expedia.ca/Greenville-Hotels-Crowne-Plaza-Hotel-Greenville-I-385-Roper-Mtn-Rd.h1379.Hotel-Information) ![La Quinta Inn & Suites by Wyndham Greenville Haywood](//images.trvl-media.com/lodging/1000000/170000/165800/165759/89ed0b3d_y.jpg) ### La Quinta Inn & Suites by Wyndham Greenville Haywood 10/10 Excellent "Clean rooms" [](https://expedia.ca/Greenville-Hotels-La-Quinta-Inn-Suites-By-Wyndham-Greenville-Haywood.h165759.Hotel-Information) ![Drury Inn & Suites Greenville](//images.trvl-media.com/lodging/2000000/1540000/1533500/1533439/6d7853ae_y.jpg) ### Drury Inn & Suites Greenville 10/10 Excellent "Stayed for a quick stop but everything was good " [](https://expedia.ca/Greenville-Hotels-Drury-Inn-Suites-Greenville.h1533439.Hotel-Information) ![Hampton Inn & Suites Greenville Airport, SC](//images.trvl-media.com/lodging/12000000/11920000/11919200/11919192/de1bb5e2_y.jpg) ### Hampton Inn & Suites Greenville Airport, SC 10/10 Excellent "Clean room " [](https://expedia.ca/Greenville-Hotels-Hampton-Inn-Suites-Greenville-Airport.h11919192.Hotel-Information) ![Embassy Suites Greenville Golf Resort & Conference Center](//images.trvl-media.com/lodging/1000000/10000/3300/3223/31b0d05e_y.jpg) ### Embassy Suites Greenville Golf Resort & Conference Center 10/10 Excellent "Everything is super nice and clean" [](https://expedia.ca/Greenville-Hotels-Embassy-Suites-Greenville-Golf-Resort-Conference-Center.h3223.Hotel-Information) ![Courtyard by Marriott Greenville Haywood Mall](//images.trvl-media.com/lodging/1000000/10000/7800/7800/22a42572_y.jpg) ### Courtyard by Marriott Greenville Haywood Mall 10/10 Excellent "Good stay!" 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[Waterpark Hotels in Greenville Downtown](https://www.expedia.ca/Greenville-Downtown-Greenville-Hotels-Waterpark-Hotels.0-n6348006-0-tWaterparkHotels.Travel-Guide-Filter-Hotels) - [Hotels near Haywood Mall](https://www.expedia.ca/Haywood-Mall-Hotels.0-l6130785-0.Travel-Guide-Filter-Hotels) - [Cheap Hotels in Mauldin](https://www.expedia.ca/Mauldin-Hotels-Cheap-Hotels.0-0-d183944-tCheapHotels.Travel-Guide-Filter-Hotels) - [Luxury Hotels in Mauldin](https://www.expedia.ca/Mauldin-Hotels-Luxury-Hotel.0-0-d183944-tLuxuryHotel.Travel-Guide-Filter-Hotels) - [Pet-Friendly Hotels in Mauldin](https://www.expedia.ca/Mauldin-Hotels-Pet-Friendly-Hotel.0-0-d183944-tPetfriendlyHotel.Travel-Guide-Filter-Hotels) - [Spa Hotels in Mauldin](https://www.expedia.ca/Mauldin-Hotels-Spa-Hotel.0-0-d183944-tSpaHotel.Travel-Guide-Filter-Hotels) - [Mauldin Hotels](https://www.expedia.ca/Mauldin-Hotels.d183944.Travel-Guide-Hotels) - [Hotels near Prisma Health Greenville Memorial Hospital](https://www.expedia.ca/Prisma-Health-Greenville-Memorial-Hospital-Hotels.0-l553248635941390934-0.Travel-Guide-Filter-Hotels) - [Hotels near Shriners Hospitals for Children Greenville](https://www.expedia.ca/Shriners-Hospitals-For-Children-Greenville-Hotels.0-l704436698448793600-0.Travel-Guide-Filter-Hotels) - [Boutique Hotels in Simpsonville](https://www.expedia.ca/Simpsonville-Hotels-Boutique-Hotel.0-0-d6239-tBoutiqueHotel.Travel-Guide-Filter-Hotels) - [Cheap Hotels in Simpsonville](https://www.expedia.ca/Simpsonville-Hotels-Cheap-Hotels.0-0-d6239-tCheapHotels.Travel-Guide-Filter-Hotels) - [Golf Hotels in Simpsonville](https://www.expedia.ca/Simpsonville-Hotels-Golf-Hotel.0-0-d6239-tGolfHotel.Travel-Guide-Filter-Hotels) - [Luxury Hotels in Simpsonville](https://www.expedia.ca/Simpsonville-Hotels-Luxury-Hotel.0-0-d6239-tLuxuryHotel.Travel-Guide-Filter-Hotels) - [Pet-Friendly Hotels in Simpsonville](https://www.expedia.ca/Simpsonville-Hotels-Pet-Friendly-Hotel.0-0-d6239-tPetfriendlyHotel.Travel-Guide-Filter-Hotels) - [Spa Hotels in Simpsonville](https://www.expedia.ca/Simpsonville-Hotels-Spa-Hotel.0-0-d6239-tSpaHotel.Travel-Guide-Filter-Hotels) - 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Airport (EWR) to Greenville (GDC)](https://www.expedia.ca/lp/flights/ewr/gdc/newark-liberty-intl-airport-to-greenville) - [Flights from Rome (FCO) to Greenville (GDC)](https://www.expedia.ca/lp/flights/fco/gdc/rome-to-greenville) - [Flights from Gatlinburg (GKT) to Greenville (GDC)](https://www.expedia.ca/lp/flights/gkt/gdc/gatlinburg-to-greenville) - [Flights from Gatlinburg (GKT) to Greenville (GMU)](https://www.expedia.ca/lp/flights/gkt/gmu/gatlinburg-to-greenville) - [Flights from Greenwood (GRD) to Greenville (GDC)](https://www.expedia.ca/lp/flights/grd/gdc/greenwood-to-greenville) - [Flights from Greenwood (GRD) to Greenville (GMU)](https://www.expedia.ca/lp/flights/grd/gmu/greenwood-to-greenville) - [Flights from Huntsville (HSV) to Greenville (GMU)](https://www.expedia.ca/lp/flights/hsv/gmu/huntsville-to-greenville) - [Flights from Islip (ISP) to Greenville (GMU)](https://www.expedia.ca/lp/flights/isp/gmu/islip-to-greenville) - [Flights from Jacksonville (JAX) to Greenville (GMU)](https://www.expedia.ca/lp/flights/jax/gmu/jacksonville-to-greenville) - 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[Frankie's Fun Park](https://www.expedia.ca/Frankies-Fun-Park-Greenville.d553248621532656780.Vacation-Attraction) - [Mauldin Vacations](https://www.expedia.ca/Mauldin.d183944.Destination-Travel-Guides) - [Prisma Health Greenville Memorial Hospital](https://www.expedia.ca/Prisma-Health-Greenville-Memorial-Hospital-Greenville.d553248635941390934.Vacation-Attraction) - [Terrace Shopping Center](https://www.expedia.ca/Terrace-Shopping-Center-Greenville.d553248621563220413.Vacation-Attraction) - [Car rentals near Prisma Health Greenville Memorial Hospital](https://www.expedia.ca/Car-Rentals-In-Prisma-Health-Greenville-Memorial-Hospital.d553248635941390934.Car-Rental-Guide) - [Book Historic Hotels in Upstate South Carolina on Expedia.com](https://www.expedia.com/Upstate-South-Carolina-Hotels-Historic-Hotel.0-0-d6057939-tHistoricHotel.Travel-Guide-Filter-Hotels)