Title: Book the Best BUSINESS Hotels in Central Missouri in 2026 | Expedia.ca [Central Missouri Travel Guide](https://expedia.ca/Central-Missouri.dx6058776)[Hotels in Central Missouri](https://expedia.ca/Central-Missouri-Hotels.d6058776.Travel-Guide-Hotels)[Vacation Rentals in Central Missouri](https://expedia.ca/Central-Missouri-Vacation-Rentals.d6058776.Travel-Guide-VacationRentals)[Flights to Central Missouri](https://expedia.ca/Cheap-Flights-To-Central-Missouri.d6058776.Travel-Guide-Flights)[Things to do in Central Missouri](https://expedia.ca/Things-To-Do-In-Central-Missouri.d6058776.Travel-Guide-Activities)[Central Missouri Car Rentals](https://expedia.ca/Car-Rentals-In-Central-Missouri.d6058776.Car-Rental-Guide)[Central Missouri Vacation Packages](https://expedia.ca/Central-Missouri.d6058776.Destination-Travel-Guides) ![Missouri State Capitol which includes an administrative building, heritage architecture and a fountain](https://images.trvl-media.com/place/6092643/f7036169-7e6d-403b-b3a3-fac711433497.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find Business Hotels in Central Missouri, MO from CA $91 - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Central Missouri Business Hotels Tonight [Dec 27 - Dec 28](https://www.expedia.ca/Hotel-Search?regionId=6058776&startDate=2025-12-27&endDate=2025-12-28&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) Tomorrow [Dec 28 - Dec 29](https://www.expedia.ca/Hotel-Search?regionId=6058776&startDate=2025-12-28&endDate=2025-12-29&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) Next weekend [Jan 2 - Jan 4](https://www.expedia.ca/Hotel-Search?regionId=6058776&startDate=2026-01-02&endDate=2026-01-04&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) In two weeks [Jan 9 - Jan 11](https://www.expedia.ca/Hotel-Search?regionId=6058776&startDate=2026-01-09&endDate=2026-01-11&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) ## Our top choices for Central Missouri business-friendly hotels ![Lobby](https://images.trvl-media.com/lodging/1000000/50000/40800/40728/7e36eb59.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/1000000/50000/40800/40728/d106f50c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/50000/40800/40728/7a41768f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![5 bars/lounges, poolside bar](https://images.trvl-media.com/lodging/1000000/50000/40800/40728/40992baf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Lodge Of Four Seasons Golf Resort, Marina & Spa [](https://www.expedia.ca/Osage-Beach-Hotels-Lodge-Of-Four-Seasons-Golf-Resort.h40728.Hotel-Information) Lake Ozark 7.4/10 Good (1086) "Great Stay" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Karen CA $105 CA $146 total includes taxes & fees Jan 12 - Jan 13, 2026 [](https://www.expedia.ca/Osage-Beach-Hotels-Lodge-Of-Four-Seasons-Golf-Resort.h40728.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/30000/22400/22359/86998653.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/1000000/30000/22400/22359/16b33223.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, Multiple Beds, Non Smoking](https://images.trvl-media.com/lodging/1000000/30000/22400/22359/9c49804e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Gym](https://images.trvl-media.com/lodging/1000000/30000/22400/22359/ea852bf5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Wyndham Executive Center Columbia [](https://www.expedia.ca/Columbia-Hotels-Holiday-Inn-Executive-Center-Columbia-Mall.h22359.Hotel-Information) Columbia 8.4/10 Very good (1005) "Spotless room, friendly staff" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Kent CA $116 CA $131 total includes taxes & fees Jan 25 - Jan 26, 2026 [](https://www.expedia.ca/Columbia-Hotels-Holiday-Inn-Executive-Center-Columbia-Mall.h22359.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/13000000/12550000/12546300/12546284/2c317c73.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/13000000/12550000/12546300/12546284/805c2520.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Executive Room, 1 King Bed, Non Smoking, Refrigerator & Microwave](https://images.trvl-media.com/lodging/13000000/12550000/12546300/12546284/fd258818.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/13000000/12550000/12546300/12546284/c428cb4b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Best Western Plus Columbia Inn [](https://www.expedia.ca/Columbia-Hotels-Best-Western-Plus-Columbia-Inn.h12546284.Hotel-Information) Columbia 8.8/10 Excellent (1205) "Stayed here several times and was very happy with our stay. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Reynaldo CA $95 CA $108 total includes taxes & fees Dec 29 - Dec 30 [](https://www.expedia.ca/Columbia-Hotels-Best-Western-Plus-Columbia-Inn.h12546284.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/70000/61500/61461/68d45684.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, laptop workspace, iron/ironing board, free cribs/infant beds](https://images.trvl-media.com/lodging/1000000/70000/61500/61461/03574155.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/70000/61500/61461/234ceb40.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/70000/61500/61461/154d2b9e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Quality Inn Warrensburg [](https://www.expedia.ca/Warrensburg-Hotels-Quality-Inn.h61461.Hotel-Information) Warrensburg 8.6/10 Excellent (644) "Staff was great and hotel had the best amenities in the area." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Michael CA $115 CA $132 total includes taxes & fees Jan 3 - Jan 4, 2026 [](https://www.expedia.ca/Warrensburg-Hotels-Quality-Inn.h61461.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/8000000/7680000/7678000/7677926/8a05cd33.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/8000000/7680000/7678000/7677926/4d96f21b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/8000000/7680000/7678000/7677926/w6000h3998x0y0-b5960fdf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/8000000/7680000/7678000/7677926/83e9f93b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Express Hotel & Suites Columbia Univ Area-Hwy 63 by IHG [](https://www.expedia.ca/Columbia-Hotels-Holiday-Inn-Express-Hotel-Suites-Columbia-Univ-Area-Hwy-63.h7677926.Hotel-Information) Columbia 8.8/10 Excellent (1000) "Very clean hotel with friendly staff" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Sara CA $135 CA $154 total includes taxes & fees Jan 18 - Jan 19, 2026 [](https://www.expedia.ca/Columbia-Hotels-Holiday-Inn-Express-Hotel-Suites-Columbia-Univ-Area-Hwy-63.h7677926.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/220000/218400/218324/63ed2b69.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Egyptian cotton sheets, premium bedding, down comforters, pillowtop beds](https://images.trvl-media.com/lodging/1000000/220000/218400/218324/2fda3d5c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/1000000/220000/218400/218324/1ca6fbf8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Restaurant](https://images.trvl-media.com/lodging/1000000/220000/218400/218324/1372b8c9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Quality Inn St. Robert - Ft. Leonard Wood [](https://www.expedia.ca/Rolla-Hotels-Quality-Inn-St-Robert-Ft-Leonard-Wood.h218324.Hotel-Information) St. Robert 7.8/10 Good (62) "The staff was great and the room was clean." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Emily CA $76 CA $91 total includes taxes & fees Dec 28 - Dec 29 [](https://www.expedia.ca/Rolla-Hotels-Quality-Inn-St-Robert-Ft-Leonard-Wood.h218324.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/860000/856000/855996/8cf3b5be.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/860000/856000/855996/15c2b3f6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool, open 8:00 AM to 11:00 PM, pool umbrellas, sun loungers](https://images.trvl-media.com/lodging/1000000/860000/856000/855996/ae716caf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, blackout drapes, iron/ironing board, free cribs/infant beds](https://images.trvl-media.com/lodging/1000000/860000/856000/855996/b33bbeb6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Red Roof Inn Osage Beach - Lake of the Ozarks [](https://www.expedia.ca/Osage-Beach-Hotels-Red-Roof-Inn-Osage-Beach-Lake-Of-The-Ozarks.h855996.Hotel-Information) Osage Beach 7.4/10 Good (830) "Great hotel " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Taz [](https://www.expedia.ca/Osage-Beach-Hotels-Red-Roof-Inn-Osage-Beach-Lake-Of-The-Ozarks.h855996.Hotel-Information) ![Free daily self-serve breakfast](https://images.trvl-media.com/lodging/1000000/20000/18300/18239/ad4ef74b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe Room, 1 King Bed](https://images.trvl-media.com/lodging/1000000/20000/18300/18239/94ab4e4d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/1000000/20000/18300/18239/0b98f732.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Hallway](https://images.trvl-media.com/lodging/1000000/20000/18300/18239/46c298e8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Greenlight Inn & Suites [](https://www.expedia.ca/Rolla-Hotels-Greenstay-Hotel-Suites.h18239.Hotel-Information) St. James 8.6/10 Excellent (441) "Great sleep " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Kim CA $80 CA $91 total includes taxes & fees Jan 1 - Jan 2, 2026 [](https://www.expedia.ca/Rolla-Hotels-Greenstay-Hotel-Suites.h18239.Hotel-Information) ![Seasonal outdoor pool, sun loungers](https://images.trvl-media.com/lodging/3000000/2020000/2015400/2015357/21eb378b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Ballroom](https://images.trvl-media.com/lodging/3000000/2020000/2015400/2015357/b09c0391.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/3000000/2020000/2015400/2015357/e77a4ef2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 restaurants, breakfast, lunch, dinner served; Caribbean cuisine](https://images.trvl-media.com/lodging/3000000/2020000/2015400/2015357/926b808f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Camden on the Lake Resort & Spa [](https://www.expedia.ca/Osage-Beach-Hotels-Camden-On-The-Lake-Resort-Spa.h2015357.Hotel-Information) Lake Ozark 9.0/10 Wonderful (1001) "Awesome staff, great food and service!!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Lori [](https://www.expedia.ca/Osage-Beach-Hotels-Camden-On-The-Lake-Resort-Spa.h2015357.Hotel-Information) ![In-room safe, desk, blackout drapes, free cribs/infant beds](https://images.trvl-media.com/lodging/1000000/870000/861500/861493/e99f99fb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Vending machine](https://images.trvl-media.com/lodging/1000000/870000/861500/861493/b608d22f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![ATM/banking on site](https://images.trvl-media.com/lodging/1000000/870000/861500/861493/fd5803b4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe Studio Suite, 1 King Bed, Non Smoking](https://images.trvl-media.com/lodging/1000000/870000/861500/861493/23d9f385.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Super 8 by Wyndham Cuba [](https://www.expedia.ca/Rolla-Hotels-Super-8-By-Wyndham-Cuba.h861493.Hotel-Information) Cuba 8.8/10 Excellent (990) "Clean room, nice staff and relaxing atmosphere " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Sharon CA $113 CA $128 total includes taxes & fees Jan 4 - Jan 5, 2026 [](https://www.expedia.ca/Rolla-Hotels-Super-8-By-Wyndham-Cuba.h861493.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2026-01-10&endDate=2026-01-11®ionId=6058776&adults=2&travelerType=business_friendly&sort=RECOMMENDED&openPlayBack=true) ## Top Central Missouri Hotel Reviews ![Country Inn & Suites by Radisson, Columbia, MO](https://images.trvl-media.com/lodging/2000000/1660000/1658500/1658463/c8809092_y.jpg) ### Country Inn & Suites by Radisson, Columbia, MO 10/10 Excellent "Great and friendly check in" [](https://expedia.ca/Columbia-Hotels-Country-Inn-Suites-By-Radisson.h1658463.Hotel-Information) ![Wyndham Executive Center Columbia](https://images.trvl-media.com/lodging/1000000/30000/22400/22359/86998653_y.jpg) ### Wyndham Executive Center Columbia 10/10 Excellent "Everything was clean and the staff was very on top of it! " [](https://expedia.ca/Columbia-Hotels-Holiday-Inn-Executive-Center-Columbia-Mall.h22359.Hotel-Information) ![Baymont by Wyndham Columbia, MO](https://images.trvl-media.com/lodging/1000000/50000/40200/40115/08435bc3_y.jpg) ### Baymont by Wyndham Columbia, MO 10/10 Excellent "We had a great stay at this place. We tend to drive between Denver and St. Louis area often, and it’s nice to have this place on our list of approved places. You can tell they really care about providing a nice place to stay." [](https://expedia.ca/Columbia-Hotels-La-Quinta-Inn-Suites-By-Wyndham-Columbia.h40115.Hotel-Information) ![Stoney Creek Hotel Columbia](https://images.trvl-media.com/lodging/2000000/1060000/1052400/1052330/5398551a_y.jpg) ### Stoney Creek Hotel Columbia 10/10 Excellent "Everything was as expected. " [](https://expedia.ca/Columbia-Hotels-Stoney-Creek-Hotel-Columbia.h1052330.Hotel-Information) ![Holiday Inn Express Hotel & Suites Columbia Univ Area-Hwy 63 by IHG](https://images.trvl-media.com/lodging/8000000/7680000/7678000/7677926/8a05cd33_y.jpg) ### Holiday Inn Express Hotel & Suites Columbia Univ Area-Hwy 63 by IHG 10/10 Excellent "Very clean hotel with friendly staff" [](https://expedia.ca/Columbia-Hotels-Holiday-Inn-Express-Hotel-Suites-Columbia-Univ-Area-Hwy-63.h7677926.Hotel-Information) ![Lodge Of Four Seasons Golf Resort, Marina & Spa](https://images.trvl-media.com/lodging/1000000/50000/40800/40728/7e36eb59_y.jpg) ### Lodge Of Four Seasons Golf Resort, Marina & Spa 10/10 Excellent "Loved the warm pool! The Santa workshop treat was amazing! " [](https://expedia.ca/Osage-Beach-Hotels-Lodge-Of-Four-Seasons-Golf-Resort.h40728.Hotel-Information) ![Camden on the Lake Resort & Spa](https://images.trvl-media.com/lodging/3000000/2020000/2015400/2015357/21eb378b_y.jpg) ### Camden on the Lake Resort & Spa 10/10 Excellent "It was fancy. " [](https://expedia.ca/Osage-Beach-Hotels-Camden-On-The-Lake-Resort-Spa.h2015357.Hotel-Information) ![Capitol Plaza Hotel Jefferson City](https://images.trvl-media.com/lodging/1000000/10000/400/369/ad47cfa0_y.jpg) ### Capitol Plaza Hotel Jefferson City 10/10 Excellent "Yes but not perfect just couple hairs on bed but perfect hotel. Fall in love with best hotel in jefferson city. My new home when i visit Jefferson city " [](https://expedia.ca/Columbia-Hotels-Capitol-Plaza-Hotel-Jefferson-City.h369.Hotel-Information) ![Wingate by Wyndham - Columbia](https://images.trvl-media.com/lodging/1000000/990000/986100/986086/a16387a6_y.jpg) ### Wingate by Wyndham - Columbia 10/10 Excellent "Friendly staff. Large room and clean " [](https://expedia.ca/Columbia-Hotels-Wingate-By-Wyndham-Columbia.h986086.Hotel-Information) ## Frequently asked questions ### How much do business-friendly hotels in Central Missouri cost? ### What are the best business-friendly hotels in Central Missouri? ### How many business-friendly hotels are there in Central Missouri? ### What are the best cheap business-friendly hotels in Central Missouri? ### Are there any family-friendly hotels in Central Missouri that are also business friendly? ### Are there any 5-star business-friendly hotels in Central Missouri? ### Why book your business-friendly hotel in Central Missouri with Expedia? ### How can I find cheap business-friendly hotels in Central Missouri? ### What is there to do in Central Missouri near my business-friendly hotel? ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - Vacation Rental - Other - More ways to book - [Apache Flats Hotels ](https://www.expedia.ca/Apache-Flats-Hotels.d553248635975850469.Travel-Guide-Hotels) - 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