Title: Book the Best BUSINESS Hotels in Central Missouri in 2026 | Expedia.ca [Central Missouri Travel Guide](https://expedia.ca/Central-Missouri.dx6058776)[Hotels in Central Missouri](https://expedia.ca/Central-Missouri-Hotels.d6058776.Travel-Guide-Hotels)[Vacation Rentals in Central Missouri](https://expedia.ca/Central-Missouri-Vacation-Rentals.d6058776.Travel-Guide-VacationRentals)[Flights to Central Missouri](https://expedia.ca/Cheap-Flights-To-Central-Missouri.d6058776.Travel-Guide-Flights)[Things to do in Central Missouri](https://expedia.ca/Things-To-Do-In-Central-Missouri.d6058776.Travel-Guide-Activities)[Central Missouri Car Rentals](https://expedia.ca/Car-Rentals-In-Central-Missouri.d6058776.Car-Rental-Guide)[Central Missouri Vacation Packages](https://expedia.ca/Central-Missouri.d6058776.Destination-Travel-Guides) ![Missouri State Capitol which includes an administrative building, heritage architecture and a fountain](https://images.trvl-media.com/place/6092643/f7036169-7e6d-403b-b3a3-fac711433497.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://images.trvl-media.com/place/6092643/f7036169-7e6d-403b-b3a3-fac711433497.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Central Missouri Business Hotels Tonight [Jan 25 - Jan 26](https://www.expedia.ca/Hotel-Search?regionId=6058776&startDate=2026-01-25&endDate=2026-01-26&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) Tomorrow [Jan 26 - Jan 27](https://www.expedia.ca/Hotel-Search?regionId=6058776&startDate=2026-01-26&endDate=2026-01-27&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) Next weekend [Jan 30 - Feb 1](https://www.expedia.ca/Hotel-Search?regionId=6058776&startDate=2026-01-30&endDate=2026-02-01&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) In two weeks [Feb 6 - Feb 8](https://www.expedia.ca/Hotel-Search?regionId=6058776&startDate=2026-02-06&endDate=2026-02-08&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) ## Our top choices for Central Missouri business-friendly hotels ![Free daily full breakfast](https://images.trvl-media.com/lodging/13000000/12550000/12546300/12546284/89f564da.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fitness facility](https://images.trvl-media.com/lodging/13000000/12550000/12546300/12546284/e7c009b8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/13000000/12550000/12546300/12546284/a18974cd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/13000000/12550000/12546300/12546284/2c317c73.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Best Western Plus Columbia Inn [](https://www.expedia.ca/Columbia-Hotels-Best-Western-Plus-Columbia-Inn.h12546284.Hotel-Information) Columbia 9.0/10 Wonderful (1,226 reviews) "Very clean, smelled fresh, staff friendly!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Darci CA $95 CA $108 total includes taxes & fees Jan 27 - Jan 28 [](https://www.expedia.ca/Columbia-Hotels-Best-Western-Plus-Columbia-Inn.h12546284.Hotel-Information) ![Lobby lounge](https://images.trvl-media.com/lodging/22000000/21390000/21389900/21389857/61567d36.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, laptop workspace, blackout drapes, iron/ironing board](https://images.trvl-media.com/lodging/22000000/21390000/21389900/21389857/d9d4349f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, laptop workspace, blackout drapes, iron/ironing board](https://images.trvl-media.com/lodging/22000000/21390000/21389900/21389857/f11d51d5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool, outdoor pool](https://images.trvl-media.com/lodging/22000000/21390000/21389900/21389857/3abac008.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Drury Plaza Hotel Columbia East [](https://www.expedia.ca/Columbia-Hotels-Drury-Plaza-Hotel-Columbia-East.h21389857.Hotel-Information) Columbia 9.6/10 Exceptional (1,361 reviews) "Great stay, very clean and very nice!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Joshua CA $134 CA $152 total includes taxes & fees Feb 1 - Feb 2 [](https://www.expedia.ca/Columbia-Hotels-Drury-Plaza-Hotel-Columbia-East.h21389857.Hotel-Information) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/1000000/890000/882800/882709/4afed9f8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/890000/882800/882709/faed32e3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/890000/882800/882709/13784ba7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Seasonal outdoor pool, pool umbrellas](https://images.trvl-media.com/lodging/1000000/890000/882800/882709/31f23fbf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Sleep Inn & Suites Lake of the Ozarks [](https://www.expedia.ca/Osage-Beach-Hotels-Sleep-Inn-Suites-Lake-Of-The-Ozarks.h882709.Hotel-Information) Camdenton 8.8/10 Excellent (989 reviews) "Great location yet quite. Exceptionally clean and comfortable" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Phillip K. CA $150 CA $163 total includes taxes & fees Feb 1 - Feb 2 [](https://www.expedia.ca/Osage-Beach-Hotels-Sleep-Inn-Suites-Lake-Of-The-Ozarks.h882709.Hotel-Information) ![Poolside bar](https://images.trvl-media.com/lodging/1000000/50000/40800/40728/a2724c85.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/1000000/50000/40800/40728/d106f50c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool, seasonal outdoor pool](https://images.trvl-media.com/lodging/1000000/50000/40800/40728/6c7ed08b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/50000/40800/40728/7a41768f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Lodge Of Four Seasons Golf Resort, Marina & Spa [](https://www.expedia.ca/Osage-Beach-Hotels-Lodge-Of-Four-Seasons-Golf-Resort.h40728.Hotel-Information) Lake Ozark 7.4/10 Good (1,102 reviews) "This is a wonderful hotel to stay. They have wonderful views and great space to relax. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Renee CA $179 CA $227 total includes taxes & fees Jan 30 - Jan 31 [](https://www.expedia.ca/Osage-Beach-Hotels-Lodge-Of-Four-Seasons-Golf-Resort.h40728.Hotel-Information) ![Casino](https://images.trvl-media.com/lodging/10000000/9750000/9747200/9747129/d7688c2c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 restaurants, breakfast, lunch, dinner served; American cuisine](https://images.trvl-media.com/lodging/10000000/9750000/9747200/9747129/8976c793.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/10000000/9750000/9747200/9747129/0c19f127.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Casino](https://images.trvl-media.com/lodging/10000000/9750000/9747200/9747129/ea366975.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Isle of Capri Casino Hotel Boonville - A Caesars Rewards Destination [](https://www.expedia.ca/Columbia-Hotels-Isle-Of-Capri-Casino-Hotel-Boonville.h9747129.Hotel-Information) Boonville 8.2/10 Very good (960 reviews) "Great stay" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Denver [](https://www.expedia.ca/Columbia-Hotels-Isle-Of-Capri-Casino-Hotel-Boonville.h9747129.Hotel-Information) ![Indoor pool](https://images.trvl-media.com/lodging/2000000/1330000/1328700/1328698/7967f13d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Restaurant](https://images.trvl-media.com/lodging/2000000/1330000/1328700/1328698/56b61525.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/2000000/1330000/1328700/1328698/57a2f2e6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/2000000/1330000/1328700/1328698/d6dce786.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Parkfield Inn [](https://www.expedia.ca/Clinton-Hotels-Parkfield-Inn.h1328698.Hotel-Information) Clinton 9.2/10 Wonderful (982 reviews) "Very clean rooms and excellent service" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Sherry CA $132 CA $149 total includes taxes & fees Jan 27 - Jan 28 [](https://www.expedia.ca/Clinton-Hotels-Parkfield-Inn.h1328698.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/300000/295800/295773/02d32208.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Room, 2 Queen Beds](https://images.trvl-media.com/lodging/1000000/300000/295800/295773/4a08555c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Point of interest](https://images.trvl-media.com/lodging/1000000/300000/295800/295773/3207573e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/300000/295800/295773/570b3164.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Comfort Inn St. Robert / Fort Leonard Wood [](https://www.expedia.ca/Rolla-Hotels-Comfort-Inn-St-Robert-Fort-Leonard-Wood.h295773.Hotel-Information) St. Robert 9.2/10 Wonderful (1,006 reviews) "The staff was great, the room was clean and perfect for my dog. The dog area was a plus! It's an awesome place to stay." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Anthony CA $129 CA $145 total includes taxes & fees Feb 9 - Feb 10 [](https://www.expedia.ca/Rolla-Hotels-Comfort-Inn-St-Robert-Fort-Leonard-Wood.h295773.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/220000/218400/218324/63ed2b69.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![BBQ/picnic area](https://images.trvl-media.com/lodging/1000000/220000/218400/218324/1f5aac04.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/1000000/220000/218400/218324/1ca6fbf8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/220000/218400/218324/e9902c5a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Quality Inn St. Robert - Ft. Leonard Wood [](https://www.expedia.ca/Rolla-Hotels-Quality-Inn-St-Robert-Ft-Leonard-Wood.h218324.Hotel-Information) St. Robert 7.4/10 Good (78 reviews) "The staff was great and the room was clean." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Emily CA $88 CA $103 total includes taxes & fees Jan 31 - Feb 1 [](https://www.expedia.ca/Rolla-Hotels-Quality-Inn-St-Robert-Ft-Leonard-Wood.h218324.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/2000000/1660000/1658500/1658463/c8809092.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, desk, iron/ironing board, free cribs/infant beds](https://images.trvl-media.com/lodging/2000000/1660000/1658500/1658463/186b1405.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/2000000/1660000/1658500/1658463/32f9c183.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/2000000/1660000/1658500/1658463/985231b2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Country Inn & Suites by Radisson, Columbia, MO [](https://www.expedia.ca/Columbia-Hotels-Country-Inn-Suites-By-Radisson.h1658463.Hotel-Information) Columbia 9.0/10 Wonderful (1,742 reviews) "Room, staff and breakfast were wonderful." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Marvin CA $107 CA $121 total includes taxes & fees Feb 15 - Feb 16 [](https://www.expedia.ca/Columbia-Hotels-Country-Inn-Suites-By-Radisson.h1658463.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/800000/794300/794290/22e30a85.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lounge](https://images.trvl-media.com/lodging/1000000/800000/794300/794290/5302832b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Pillowtop beds, in-room safe, desk, laptop workspace](https://images.trvl-media.com/lodging/1000000/800000/794300/794290/16c08a6c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/1000000/800000/794300/794290/f26bf08a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hotel Bothwell Sedalia Central District, an Ascend Collection Hotel [](https://www.expedia.ca/Clinton-Hotels-Hotel-Bothwell-Sedalia-Central-District.h794290.Hotel-Information) Sedalia Downtown Historic District 9.2/10 Wonderful (587 reviews) "Great place. Beautifully decorated for the season. Great staff. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Leah CA $144 CA $164 total includes taxes & fees Feb 26 - Feb 27 [](https://www.expedia.ca/Clinton-Hotels-Hotel-Bothwell-Sedalia-Central-District.h794290.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2026-02-09&endDate=2026-02-10®ionId=6058776&adults=2&travelerType=business_friendly&sort=RECOMMENDED&openPlayBack=true) ## Top Central Missouri Hotel Reviews ![Wingate by Wyndham - Columbia](https://images.trvl-media.com/lodging/1000000/990000/986100/986086/a16387a6_y.jpg) ### Wingate by Wyndham - Columbia 10/10 Excellent "Jason greeted us kindly and honored our request for their most quiet room to ensure a good night’s sleep. We had noisy neighbors the night before at another hotel while traveling across the country. Our room was the best!! We didn’t hear anyone and we had the best sleep!! Thank you Jason. In the morning, we enjoyed a warm delicious breakfast of eggs, sausage, pancakes, fruit and more. Everything and everyone was so accommodating. Thank you Wingate! " [](https://expedia.ca/Columbia-Hotels-Wingate-By-Wyndham-Columbia.h986086.Hotel-Information) ![Days Inn by Wyndham Boonville](https://images.trvl-media.com/lodging/1000000/50000/42300/42233/026391fa_y.jpg) ### Days Inn by Wyndham Boonville 10/10 Excellent "Didn’t care for the bed frame when I sat on the edge of the bed, felt like I was gonna fall off mattress was not supported along the edge" [](https://expedia.ca/Columbia-Hotels-Days-Inn-By-Wyndham-Boonville.h42233.Hotel-Information) ![Quality Inn St. Robert - Ft. Leonard Wood](https://images.trvl-media.com/lodging/1000000/220000/218400/218324/63ed2b69_y.jpg) ### Quality Inn St. Robert - Ft. Leonard Wood 10/10 Excellent "Room a litte dated. Chair fabric worn...bath tub tap dripping. Large rooms comfortable bed" [](https://expedia.ca/Rolla-Hotels-Quality-Inn-St-Robert-Ft-Leonard-Wood.h218324.Hotel-Information) ![Lodge Of Four Seasons Golf Resort, Marina & Spa](https://images.trvl-media.com/lodging/1000000/50000/40800/40728/7e36eb59_y.jpg) ### Lodge Of Four Seasons Golf Resort, Marina & Spa 10/10 Excellent "very nice" [](https://expedia.ca/Osage-Beach-Hotels-Lodge-Of-Four-Seasons-Golf-Resort.h40728.Hotel-Information) ![Stoney Creek Hotel Columbia](https://images.trvl-media.com/lodging/2000000/1060000/1052400/1052330/5398551a_y.jpg) ### Stoney Creek Hotel Columbia 10/10 Excellent "Cute hotel but could use some serious updates. The young guy at the front counter was not overly friendly and welcoming. Theres hardly any staff around. However, the rooms are nice and cozy. The beds are soft and comfy. The lounge chairs are nice also. Some of the staff were friendly and helpful. The breakfast bar is awesome. Overall, great stay and would go back again. " [](https://expedia.ca/Columbia-Hotels-Stoney-Creek-Hotel-Columbia.h1052330.Hotel-Information) ![Country Inn & Suites by Radisson, Columbia, MO](https://images.trvl-media.com/lodging/2000000/1660000/1658500/1658463/c8809092_y.jpg) ### Country Inn & Suites by Radisson, Columbia, MO 10/10 Excellent "Everyone and everything was amazing! Property was clean, safe and reflected the photos. I/we will stay here again when in Columbia...MIZ ZOU!!" [](https://expedia.ca/Columbia-Hotels-Country-Inn-Suites-By-Radisson.h1658463.Hotel-Information) ![Drury Inn & Suites Columbia Stadium Boulevard](https://images.trvl-media.com/lodging/1000000/50000/42200/42129/3e728377_y.jpg) ### Drury Inn & Suites Columbia Stadium Boulevard 10/10 Excellent "Exceptionally friendly and helpful staff! Clean, spacious room. Free upgrade. All amenities were great. Recommend highly!" [](https://expedia.ca/Columbia-Hotels-Drury-Inn-Suites-Columbia-Stadium-Boulevard.h42129.Hotel-Information) ![Comfort Suites Jefferson City](https://images.trvl-media.com/lodging/2000000/1100000/1091800/1091710/004cc990_y.jpg) ### Comfort Suites Jefferson City 10/10 Excellent "Everything was clean, room was comfortable, breakfast was good" [](https://expedia.ca/Columbia-Hotels-Comfort-Suites-Jefferson-City.h1091710.Hotel-Information) ![Comfort Inn St. Robert / Fort Leonard Wood](https://images.trvl-media.com/lodging/1000000/300000/295800/295773/4a08555c_y.jpg) ### Comfort Inn St. Robert / Fort Leonard Wood 10/10 Excellent "Very clean and staff was friendly!" [](https://expedia.ca/Rolla-Hotels-Comfort-Inn-St-Robert-Fort-Leonard-Wood.h295773.Hotel-Information) ## Frequently asked questions ### How much do business-friendly hotels in Central Missouri cost? ### What are the best business-friendly hotels in Central Missouri? ### How many business-friendly hotels are there in Central Missouri? ### What are the best cheap business-friendly hotels in Central Missouri? ### Are there any family-friendly hotels in Central Missouri that are also business friendly? ### Are there any 5-star business-friendly hotels in Central Missouri? ### Why book your business-friendly hotel in Central Missouri with Expedia? ### How can I find cheap business-friendly hotels in Central Missouri? ### What is there to do in Central Missouri near my business-friendly hotel? ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - Vacation Rental - Other - More ways to book - [Apache Flats Hotels ](https://www.expedia.ca/Apache-Flats-Hotels.d553248635975850469.Travel-Guide-Hotels) - 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