Book The Best Hotels in Mill Creek, IL for 2026 from CA $95 - Fully Refundable Options

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Our top choices for Mill Creek hotels

A spacious lobby with a curved staircase, large windows, and a seating area with a rug.

A modern living room with a large sectional sofa, a flat-screen TV, and a view of the sea through large windows.

A hotel room with two beds, a desk, a chair, and a view of the city.

A modern outdoor seating area with a fire feature, a stone wall, and a view of the sunset.

1. The Riverview

Cape Girardeau

Alyssa

CA $145

CA $163 total

includes taxes & fees

Oct 7 - Oct 8

A hotel room with a blue sofa, an orange ottoman, a desk with a lamp, a television, and a window with curtains.

A hotel room with two beds, a window with curtains, an air conditioning unit, and a lamp on a nightstand.

A reception area with a wooden reception desk, two blue armchairs with orange cushions, a patterned side table, and a wall-mounted lamp.

A Dear Tree Inn building with a covered entrance and a clear sky at dusk.

2. Pear Tree Inn Cape Girardeau West

Cape Girardeau

Elizabeth

CA $102

CA $116 total

includes taxes & fees

Oct 11 - Oct 12

A spacious lobby with a curved seating area, a reception desk, and a large window providing natural light.

A spacious lobby with a circular seating area, a stone fireplace, and modern lighting fixtures.

A Drury Plaza Hotel with a modern design, featuring a prominent entrance, multiple floors, and a clear sky.

3. Drury Plaza Hotel Cape Girardeau Conference Center

Cape Girardeau

Sandra

CA $142

CA $160 total

includes taxes & fees

Oct 7 - Oct 8

A modern living room with a sofa, armchairs, a coffee table, and a TV mounted on the wall.

An indoor swimming pool with lounge chairs and tables, large windows, and a view of the outside.

A reception area with a wooden reception desk, a glass door leading to a storage room, and a decorative wall piece.

A modern living room with a sofa, a coffee table, and a dining area with chairs and a table.

4. Fairfield Inn & Suites by Marriott Cape Girardeau

Cape Girardeau

Carlos

CA $144

CA $162 total

includes taxes & fees

Oct 8 - Oct 9

A hotel room with a large bed, two bedside lamps, a chair, and a wooden headboard.

A plate of mixed greens salad with cherry tomatoes and croutons, a bowl of baked pasta, and a glass of red wine on a wooden table.

A breakfast setting with waffles, scrambled eggs, toast, a glass of orange juice, and a white mug on a table with a green placemat.

A bowl of cereal with raisins and milk, a half orange, and a sandwich on a table with a yellow napkin.

5. Drury Inn & Suites Cape Girardeau

Cape Girardeau

Teresa

CA $131

CA $148 total

includes taxes & fees

Oct 11 - Oct 12

A spacious lobby with marble flooring, elegant seating, and a grand staircase.

A Courtyard by Marriott hotel with a modern brick facade, large windows, and a covered entrance area.

A spacious living room with a sofa set, a coffee table, and a dining area.

A modern hotel lobby with a framed advertisement for breakfast at the new Bistro, a seating area with sofas and a coffee table, and a decorative mirror reflecting the space.

6. Courtyard by Marriott Cape Girardeau Downtown

Cape Girardeau

Kristin

CA $178

CA $202 total

includes taxes & fees

Oct 12 - Oct 13

A spacious lobby with a fireplace, comfortable seating, a staircase, and a large chandelier.

An indoor swimming pool with a clear view of the pool area, including the pool's edge, a set of stairs leading into the pool, and a few lounge chairs and tables around the pool.

A spacious hotel lobby with a high ceiling, a central seating area with sofas and chairs, a fireplace, and a television mounted on the wall.

A hotel room with a bed, desk, chair, TV, and a small kitchenette area.

7. Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Cape Girardeau

ELAINE

CA $144

CA $163 total

includes taxes & fees

Oct 11 - Oct 12

A spacious dining area with high ceilings, large windows, and modern lighting fixtures.

A large indoor swimming pool with clear blue water, surrounded by tiled flooring and blue walls.

A hotel room with a bed, a desk with a television, a chair, a suitcase, and a map on the wall.

A gym with exercise equipment, a treadmill, and a wall-mounted TV.

8. Hampton Inn Cape Girardeau I 55 East

Cape Girardeau

Rebekah

CA $150

CA $170 total

includes taxes & fees

Oct 8 - Oct 9

A spacious living area with a high ceiling, a green accent wall, and a wooden balcony railing.

A reception desk with a green wall, a wooden door, and a sign that reads 'QUALITY INN.'

A hotel room with a large bathtub, a bed with a wooden headboard, a nightstand with a lamp, and a painting of a building on the wall.

A restaurant with multiple tables and chairs, an exit sign, a television, and a counter with food items.

9. Quality Inn Cape Girardeau North

Cape Girardeau

Danny

CA $85

CA $95 total

includes taxes & fees

Nov 1 - Nov 2

A hotel with a modern design, featuring a prominent sign for Candlewood Suites. There are multiple parking spaces visible in front of the building.

A hotel entrance with a large tree, a well-maintained garden with various plants and flowers, and a parking lot.

An indoor swimming pool with tiled flooring, a seating area with chairs, and a staircase leading to a door.

A hotel patio with a gazebo, outdoor seating, and a view of the road.

10. Candlewood Suites Cape Girardeau by IHG

Cape Girardeau

Samuel

CA $121

CA $144 total

includes taxes & fees

Oct 11 - Oct 12

A hotel room with a bed, desk, chair, television, and two wall-mounted lamps.

A hotel room with a kitchenette, a bed, a dining table with chairs, a TV mounted on the wall, and a dresser.

A motel with multiple floors, a parking lot, and a staircase leading to the upper floors.

A bathroom with a marble wall and a white bathtub.

11. Town House Inn Cape Giradreau

Cape Girardeau

Joshua

CA $100

CA $116 total

includes taxes & fees

Oct 4 - Oct 5

A rustic lodge with a steeply pitched roof, a central entrance with a door, and a porch with multiple lights.

A rustic building with a thatched roof, surrounded by dense greenery and a gravel path leading to it.

A cozy log cabin interior with a wooden staircase, a cushioned sofa, a small table, and a lamp.

A cozy living room with a brown leather sofa, a wooden coffee table, and a window with a view of trees.

12. Makanda Inn

Makanda

Michele

CA $309

CA $353 total

includes taxes & fees

Oct 14 - Oct 15

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Top Mill Creek Hotel Reviews

Drury Inn & Suites Cape Girardeau

10/10 Excellent

"EVERYONE was EXTREMELY FRIENDLY even maintenance all FRIENDLY"

Quality Inn Cape Girardeau North

10/10 Excellent

"Great place great breakfast great room staff was great"

* On the Wine Trail * Hot Tub * Wi-Fi *

10/10 Excellent

"I really could not say a bad thing about this place. I felt comfortable and welcomed immediately when I walked in. They have a cabin log journal that everyone writes down the experiences they had and it was such a lovely touch to see how others had a great time, and to learn other spots to check out. Snack basket was a great perk too! If in the area again, I would choose the wine loft a thousand times."

Candlewood Suites Cape Girardeau by IHG

10/10 Excellent

"trodo estubo excelente gracias por sus servicios"

Hampton Inn Cape Girardeau I 55 East

8/10 Good

"Liked the cleanliness of the room, and every time my family left or when returning to our room the staff said hello. What I didn’t like there were a lot of ants in the room where the especially by the TV and desks."

Courtyard by Marriott Cape Girardeau Downtown

10/10 Excellent

"Very nice! Bed was comfortable and room had a very large bathroom and shower. Towels were thick and fluffy. Enjoyed having a bar downstairs with a fun friendly staff. Will stay there again when I’m coming through."

Rest, Relax and Renew. Our log cabin experience awaits your arrival.

10/10 Excellent

"Beautiful quaint cabin! Had everything you could need. Would definitely recommend to anyone looking for a nice place to stay."

New cabin in the woods with private hot tub

10/10 Excellent

"Very nice place!"

Secluded Rental Cabin on Southern Illinois Wine Trail, Private Hot Tub

10/10 Excellent

"Wyatt’s Cabin is in such a beautiful setting. We really enjoyed our stay!"