Title: Book the Best South Carolina Midlands SPA Resorts from CA $123 - Spa Hotels in South Carolina Midlands, SC | Expedia.ca [South Carolina Midlands Travel Guide](https://expedia.ca/South-Carolina-Midlands.dx6057938)[Hotels in South Carolina Midlands](https://expedia.ca/South-Carolina-Midlands-Hotels.d6057938.Travel-Guide-Hotels)[Vacation Rentals in South Carolina Midlands](https://expedia.ca/South-Carolina-Midlands-Vacation-Rentals.d6057938.Travel-Guide-VacationRentals)[Flights to South Carolina Midlands](https://expedia.ca/Cheap-Flights-To-South-Carolina-Midlands.d6057938.Travel-Guide-Flights)[South Carolina Midlands Car Rentals](https://expedia.ca/Car-Rentals-In-South-Carolina-Midlands.d6057938.Car-Rental-Guide)[South Carolina Midlands Vacation Packages](https://expedia.ca/South-Carolina-Midlands.d6057938.Destination-Travel-Guides) ![South Carolina State House](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/184000/184006-State-House.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find Spa Hotels in South Carolina Midlands, SC from CA $123 ![calendar shield illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation ![deals illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) ![bed illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on South Carolina Midlands Spa Hotels Tonight [Sep 25 - Sep 26](https://www.expedia.ca/Hotel-Search?regionId=6057938&startDate=2025-09-25&endDate=2025-09-26&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Sep 26 - Sep 27](https://www.expedia.ca/Hotel-Search?regionId=6057938&startDate=2025-09-26&endDate=2025-09-27&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Sep 26 - Sep 28](https://www.expedia.ca/Hotel-Search?regionId=6057938&startDate=2025-09-26&endDate=2025-09-28&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Oct 3 - Oct 5](https://www.expedia.ca/Hotel-Search?regionId=6057938&startDate=2025-10-03&endDate=2025-10-05&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top South Carolina Midlands Spa Hotels ![Reception](https://images.trvl-media.com/lodging/1000000/50000/42900/42876/e1b59003.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![In-room safe, desk, iron/ironing board, free cribs/infant beds](https://images.trvl-media.com/lodging/1000000/50000/42900/42876/94a4d77a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Restaurant](https://images.trvl-media.com/lodging/1000000/50000/42900/42876/88f4ba4b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/1000000/50000/42900/42876/f287bfc0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hampton Inn & Suites Florence Center Florence 9.0/10 Wonderful (779) "My children stayed here and said it was super nice, very comfortable beds!!" CA $164 CA $184 total includes taxes & fees Oct 19 - Oct 20 [](https://www.expedia.ca/Florence-Hotels-Hampton-Inn-Suites-Florence-Center.h42876.Hotel-Information) ![View from property](https://images.trvl-media.com/lodging/1000000/800000/798500/798446/317b0952.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 indoor pools, seasonal outdoor pool, cabanas (surcharge)](https://images.trvl-media.com/lodging/1000000/800000/798500/798446/96f40d74.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![3 bars/lounges, lobby lounge](https://images.trvl-media.com/lodging/1000000/800000/798500/798446/24906fad.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Cottage, 4 Bedrooms, Balcony](https://images.trvl-media.com/lodging/1000000/800000/798500/798446/9a165410.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Ballantyne, A Luxury Collection Hotel, Charlotte Ballantyne 9.2/10 Wonderful (994) "Great overall stay. Beutiful hotel. " CA $434 CA $500 total includes taxes & fees Sep 28 - Sep 29 [](https://www.expedia.ca/Charlotte-Hotels-The-Ballantyne.h798446.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/40000000/39640000/39637100/39637010/38e4995a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Snack bar](https://images.trvl-media.com/lodging/40000000/39640000/39637100/39637010/aeeef90b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, hypo-allergenic bedding, pillowtop beds](https://images.trvl-media.com/lodging/40000000/39640000/39637100/39637010/a74038c0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Business centre](https://images.trvl-media.com/lodging/40000000/39640000/39637100/39637010/30a1e4b0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Tru By Hilton Columbia Greystone Columbia 9.2/10 Wonderful (1012) "Nice place to stay " CA $164 CA $187 total includes taxes & fees Oct 5 - Oct 6 [](https://www.expedia.ca/Columbia-Hotels-Tru-By-Hilton-Columbia-Greystone.h39637010.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/39000000/38340000/38336400/38336321/a0861bce.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Seasonal outdoor pool](https://images.trvl-media.com/lodging/39000000/38340000/38336400/38336321/c7afe694.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 1 King Bed with Sofa bed, Accessible, Non Smoking](https://images.trvl-media.com/lodging/39000000/38340000/38336400/38336321/83187168.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Coffee service](https://images.trvl-media.com/lodging/39000000/38340000/38336400/38336321/22e67acb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Comfort Inn & Suites Florence 9.2/10 Wonderful (1089) "The staff at check in was very friendly and cheerful. Property is convenient to restaurants and is clean and quiet. Love the gnome decorations!" CA $133 CA $149 total includes taxes & fees Sep 28 - Sep 29 [](https://www.expedia.ca/Florence-Hotels-Comfort-Inn-Suites.h38336321.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/24000000/23710000/23704200/23704165/2c0ae9c5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Seasonal outdoor pool, open 9:00 AM to 9:00 PM, pool umbrellas](https://images.trvl-media.com/lodging/24000000/23710000/23704200/23704165/75b299aa.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/24000000/23710000/23704200/23704165/3d870b01.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/24000000/23710000/23704200/23704165/7a53262d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Express & Suites Charlotte - Ballantyne by IHG Ballantyne 8.6/10 Excellent (1016) "Very pleasant stay. Friendly staff, comfortable bed, great location. Would stay there again. " CA $119 CA $138 total includes taxes & fees Sep 28 - Sep 29 [](https://www.expedia.ca/Charlotte-Hotels-Holiday-Inn-Express-Suites-Charlotte-Ballantyne.h23704165.Hotel-Information) ![Property amenity](https://images.trvl-media.com/lodging/1000000/30000/26200/26116/dfe24eeb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/30000/26200/26116/e78e5670.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/1000000/30000/26200/26116/67341601.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/30000/26200/26116/170f28f7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Fairfield Inn & Suites by Marriott Santee Santee 9.8/10 Exceptional (1002) "Great stay for a quick weekend getaway!" CA $174 CA $193 total includes taxes & fees Oct 1 - Oct 2 [](https://www.expedia.ca/Orangeburg-Hotels-Fairfield-Inn-Suites-By-Marriott-Santee.h26116.Hotel-Information) ![Desk, laptop workspace, blackout drapes, iron/ironing board](https://images.trvl-media.com/lodging/1000000/160000/156200/156154/fc8387a7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/160000/156200/156154/ea250700.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Business centre](https://images.trvl-media.com/lodging/1000000/160000/156200/156154/c1effa28.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/160000/156200/156154/d7244627.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Best Western Rock Hill Rock Hill 8.6/10 Excellent (1003) "Very nice stay" CA $111 CA $123 total includes taxes & fees Oct 1 - Oct 2 [](https://www.expedia.ca/Rock-Hill-Hotels-Best-Western-Rock-Hill.h156154.Hotel-Information) ![Free daily on-the-go breakfast](https://images.trvl-media.com/lodging/22000000/21600000/21599900/21599838/134f5e4e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, stovetop, dishwasher](https://images.trvl-media.com/lodging/22000000/21600000/21599900/21599838/6aa9d343.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/22000000/21600000/21599900/21599838/ec33708d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/22000000/21600000/21599900/21599838/351de30c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Homewood Suites by Hilton Florence Florence 8.4/10 Very good (642) "Front desk hosts were very nice and helpful." CA $170 CA $196 total includes taxes & fees Oct 7 - Oct 8 [](https://www.expedia.ca/Florence-Hotels-Homewood-Suites-By-Hilton-Florence.h21599838.Hotel-Information) ![In-room safe, desk, iron/ironing board, free cribs/infant beds](https://images.trvl-media.com/lodging/2000000/1740000/1730200/1730120/6933816e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/2000000/1740000/1730200/1730120/f9cef7b9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![View from room](https://images.trvl-media.com/lodging/2000000/1740000/1730200/1730120/d28f0fa4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/2000000/1740000/1730200/1730120/3523a753.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hilton Columbia Center Downtown Columbia 8.8/10 Excellent (1003) "The hotel is beautiful and the location was perfect!" CA $208 CA $237 total includes taxes & fees Oct 5 - Oct 6 [](https://www.expedia.ca/Columbia-Hotels-Hilton-Columbia-Center.h1730120.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/65000000/64120000/64113300/64113256/b802124b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, in-room safe, desk, laptop workspace](https://images.trvl-media.com/lodging/65000000/64120000/64113300/64113256/40c7e3fe.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily on-the-go breakfast](https://images.trvl-media.com/lodging/65000000/64120000/64113300/64113256/70fd4ea0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/65000000/64120000/64113300/64113256/w6000h3996x0y0-583c8121.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### avid Hotel Fort Mill - Carowinds Blvd by IHG Fort Mill 9.0/10 Wonderful (722) "Great location and very nice facilities." CA $128 CA $145 total includes taxes & fees Sep 29 - Sep 30 [](https://www.expedia.ca/Rock-Hill-Hotels-Avid-Hotel-Fort-Mill-Amusement-Park.h64113256.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2025-10-09&endDate=2025-10-10®ionId=6057938&adults=2&amenities=SPA_ON_SITE&sort=RECOMMENDED&openPlayBack=true) ## Top South Carolina Midlands Hotel Reviews ![Graduate by Hilton Columbia SC](//images.trvl-media.com/lodging/3000000/2520000/2515100/2515057/22f12a1f_y.jpg) ### Graduate by Hilton Columbia SC 10/10 Excellent "Great place! Really neat decor and feel! Highly recommend for those wanting to be close to campus! " [](https://expedia.ca/Columbia-Hotels-Graduate-Columbia.h2515057.Hotel-Information) ![Country Inn & Suites by Radisson, Columbia, SC](//images.trvl-media.com/lodging/1000000/210000/202900/202867/04e820c9_y.jpg) ### Country Inn & Suites by Radisson, Columbia, SC 10/10 Excellent "Very mice" [](https://expedia.ca/Columbia-Hotels-Country-Inn-Suites-By-Radisson.h202867.Hotel-Information) ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - Vacation Rental - More ways to book - [Hotels near Allen University](https://www.expedia.ca/Allen-University-Hotels.0-l6245638-0.Travel-Guide-Filter-Hotels) - [B&B in Arcadia Lakes](https://www.expedia.ca/Arcadia-Lakes-Bed-And-Breakfast.d553248634998974994-aaBedAndBreakfast.Travel-Guide-Accommodation) - [Guest Houses in Arcadia Lakes](https://www.expedia.ca/Arcadia-Lakes-Guest-Houses.d553248634998974994-aaGuestHouses.Travel-Guide-Accommodation) - [Arcadia Lakes Hotels](https://www.expedia.ca/Arcadia-Lakes-Hotels.d553248634998974994.Travel-Guide-Hotels) - 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