Title: Book the Best BUSINESS Hotels in South Carolina Midlands in 2026 | Expedia.ca [South Carolina Midlands Travel Guide](https://expedia.ca/South-Carolina-Midlands.dx6057938)[Hotels in South Carolina Midlands](https://expedia.ca/South-Carolina-Midlands-Hotels.d6057938.Travel-Guide-Hotels)[Vacation Rentals in South Carolina Midlands](https://expedia.ca/South-Carolina-Midlands-Vacation-Rentals.d6057938.Travel-Guide-VacationRentals)[Flights to South Carolina Midlands](https://expedia.ca/Cheap-Flights-To-South-Carolina-Midlands.d6057938.Travel-Guide-Flights)[Things to do in South Carolina Midlands](https://expedia.ca/Things-To-Do-In-South-Carolina-Midlands.d6057938.Travel-Guide-Activities)[South Carolina Midlands Car Rentals](https://expedia.ca/Car-Rentals-In-South-Carolina-Midlands.d6057938.Car-Rental-Guide)[South Carolina Midlands Vacation Packages](https://expedia.ca/South-Carolina-Midlands.d6057938.Destination-Travel-Guides) ![South Carolina State House](https://images.trvl-media.com/place/6082681/1934af6a-1aa9-4e01-8cd3-8eb8fe4af18f.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find Business Hotels in South Carolina Midlands, SC from CA $103 - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on South Carolina Midlands Business Hotels Tonight [Jan 3 - Jan 4](https://www.expedia.ca/Hotel-Search?regionId=6057938&startDate=2026-01-03&endDate=2026-01-04&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) Tomorrow [Jan 4 - Jan 5](https://www.expedia.ca/Hotel-Search?regionId=6057938&startDate=2026-01-04&endDate=2026-01-05&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) Next weekend [Jan 9 - Jan 11](https://www.expedia.ca/Hotel-Search?regionId=6057938&startDate=2026-01-09&endDate=2026-01-11&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) In two weeks [Jan 16 - Jan 18](https://www.expedia.ca/Hotel-Search?regionId=6057938&startDate=2026-01-16&endDate=2026-01-18&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) ## Our top choices for South Carolina Midlands business-friendly hotels ![Exterior](https://images.trvl-media.com/lodging/48000000/47090000/47086800/47086732/96d5feb4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/48000000/47090000/47086800/47086732/0b9239a1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/48000000/47090000/47086800/47086732/e4f3361f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/48000000/47090000/47086800/47086732/00586c85.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Park Inn by Radisson Florence, SC [](https://www.expedia.ca/Florence-Hotels-Park-Inn-By-Radisson-Florence.h47086732.Hotel-Information) Florence 9.0/10 Wonderful (2233) "Nice hotel" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) PATRICK CA $116 CA $130 total includes taxes & fees Jan 11 - Jan 12 [](https://www.expedia.ca/Florence-Hotels-Park-Inn-By-Radisson-Florence.h47086732.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/39000000/38340000/38336400/38336321/a0861bce.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Coffee service](https://images.trvl-media.com/lodging/39000000/38340000/38336400/38336321/22e67acb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/39000000/38340000/38336400/38336321/0ea8f0b4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 1 King Bed with Sofa bed, Accessible, Non Smoking](https://images.trvl-media.com/lodging/39000000/38340000/38336400/38336321/83187168.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Comfort Inn & Suites Florence Center Area [](https://www.expedia.ca/Florence-Hotels-Comfort-Inn-Suites.h38336321.Hotel-Information) Florence 9.2/10 Wonderful (1195) "Great location, friendly staff. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Defelicio CA $135 CA $151 total includes taxes & fees Jan 18 - Jan 19 [](https://www.expedia.ca/Florence-Hotels-Comfort-Inn-Suites.h38336321.Hotel-Information) ![Breakfast and dinner served](https://images.trvl-media.com/lodging/18000000/17370000/17370000/17369973/9eb183a0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fitness facility](https://images.trvl-media.com/lodging/18000000/17370000/17370000/17369973/191bc09f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, pillowtop beds, desk, iron/ironing board](https://images.trvl-media.com/lodging/18000000/17370000/17370000/17369973/485b8fc6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/18000000/17370000/17370000/17369973/7f5dfdba.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Courtyard by Marriott Columbia Cayce [](https://www.expedia.ca/Columbia-Hotels-Courtyard-By-Marriott-Columbia-Cayce.h17369973.Hotel-Information) Cayce 9.0/10 Wonderful (663) "Clean room" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Francois CA $139 CA $154 total includes taxes & fees Jan 11 - Jan 12 [](https://www.expedia.ca/Columbia-Hotels-Courtyard-By-Marriott-Columbia-Cayce.h17369973.Hotel-Information) ![Room, 2 Queen Beds, Non Smoking](https://images.trvl-media.com/lodging/1000000/20000/15400/15379/1987eeb3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/20000/15400/15379/25ebdfeb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/20000/15400/15379/756b4cd6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/20000/15400/15379/c7187353.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Baymont by Wyndham Santee [](https://www.expedia.ca/Orangeburg-Hotels-Baymont-By-Wyndham-Santee.h15379.Hotel-Information) Santee 8.0/10 Very good (1424) "Room was very nice and staff was very nice" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Rupert CA $103 CA $114 total includes taxes & fees Jan 5 - Jan 6 [](https://www.expedia.ca/Orangeburg-Hotels-Baymont-By-Wyndham-Santee.h15379.Hotel-Information) ![BBQ/picnic area](https://images.trvl-media.com/lodging/1000000/30000/22000/21992/5f4afc1a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![In-room safe, individually furnished, desk, laptop workspace](https://images.trvl-media.com/lodging/1000000/30000/22000/21992/5ca250d9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![LCD TV](https://images.trvl-media.com/lodging/1000000/30000/22000/21992/bea66887.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/1000000/30000/22000/21992/2c42ebe7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hampton Inn Rock Hill [](https://www.expedia.ca/Rock-Hill-Hotels-Hampton-Inn-Rock-Hill.h21992.Hotel-Information) Rock Hill 9.2/10 Wonderful (1005) "We have stayed here several times and it never disappoints! Room is clean, staff very friendly, and they provide a great breakfast!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Erma CA $107 CA $119 total includes taxes & fees Jan 19 - Jan 20 [](https://www.expedia.ca/Rock-Hill-Hotels-Hampton-Inn-Rock-Hill.h21992.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/970000/970000/969975/9fdaeb31.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/970000/970000/969975/bdf580c5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Hypo-allergenic bedding, in-room safe, desk, laptop workspace](https://images.trvl-media.com/lodging/1000000/970000/970000/969975/94573105.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free buffet breakfast](https://images.trvl-media.com/lodging/1000000/970000/970000/969975/83cb7582.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Express Hotel & Suites Florence I-95 at Hwy 327 by IHG [](https://www.expedia.ca/Florence-Hotels-Holiday-Inn-Express-Hotel-Suites-Florence-I-95-At-Hwy-327.h969975.Hotel-Information) Florence 8.6/10 Excellent (1010) "Friendly staff, quick check in, nice lobby" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jennifer CA $157 CA $175 total includes taxes & fees Jan 18 - Jan 19 [](https://www.expedia.ca/Florence-Hotels-Holiday-Inn-Express-Hotel-Suites-Florence-I-95-At-Hwy-327.h969975.Hotel-Information) ![Front of property - evening/night](https://images.trvl-media.com/lodging/33000000/32780000/32772900/32772870/c29c3321.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/33000000/32780000/32772900/32772870/c8bc9166.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, blackout drapes, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/33000000/32780000/32772900/32772870/bee831df.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool](https://images.trvl-media.com/lodging/33000000/32780000/32772900/32772870/ad4579b6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hyatt Place Florence Downtown [](https://www.expedia.ca/Florence-Hotels-Hyatt-Place-Florence-Downtown.h32772870.Hotel-Information) Florence 9.0/10 Wonderful (1007) "Great experience in a nice hotel in downtown." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) HATIM CA $137 CA $154 total includes taxes & fees Jan 12 - Jan 13 [](https://www.expedia.ca/Florence-Hotels-Hyatt-Place-Florence-Downtown.h32772870.Hotel-Information) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/50000000/49040000/49035900/49035821/7a0bd1a2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Studio, 1 King Bed, Non Smoking, Refrigerator & Microwave (Wet bar)](https://images.trvl-media.com/lodging/50000000/49040000/49035900/49035821/bf4e355a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Studio, 1 King Bed, Non Smoking, Refrigerator & Microwave (Wet bar)](https://images.trvl-media.com/lodging/50000000/49040000/49035900/49035821/8d5a8da8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool, open 9:00 AM to 10:00 PM, pool umbrellas, sun loungers](https://images.trvl-media.com/lodging/50000000/49040000/49035900/49035821/2b82d8b9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hampton Inn & Suites Lexington Columbia [](https://www.expedia.ca/Columbia-Hotels-Hampton-Inn-Suites-Lexington.h49035821.Hotel-Information) Lexington 9.8/10 Exceptional (601) "Clean and comfortable room, friendly staff, great location." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Allison CA $145 CA $161 total includes taxes & fees Jan 16 - Jan 17 [](https://www.expedia.ca/Columbia-Hotels-Hampton-Inn-Suites-Lexington.h49035821.Hotel-Information) ![Free daily full breakfast](https://images.trvl-media.com/lodging/1000000/10000/5100/5038/e9b1ea9e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/10000/5100/5038/470d616b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 King Bed, Refreshed Deluxe Room, Non-Smoking](https://images.trvl-media.com/lodging/1000000/10000/5100/5038/71345cfe.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/10000/5100/5038/2db4f7f5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### La Quinta Inn by Wyndham Columbia SE / Fort Jackson [](https://www.expedia.ca/Columbia-Hotels-La-Quinta-Inn-By-Wyndham-Columbia-SE-Fort-Jackson.h5038.Hotel-Information) Columbia 7.8/10 Good (1016) "Very Clean and newly renovated. Decent breakfast and helpful staff." ![Canada](https://a.travel-assets.com/egds/marks/flags/ca.svg) Elizabeth CA $92 CA $103 total includes taxes & fees Jan 11 - Jan 12 [](https://www.expedia.ca/Columbia-Hotels-La-Quinta-Inn-By-Wyndham-Columbia-SE-Fort-Jackson.h5038.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/2000000/1520000/1513800/1513707/f8933df9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/2000000/1520000/1513800/1513707/7b635fb9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/2000000/1520000/1513800/1513707/45d8f751.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/2000000/1520000/1513800/1513707/0f2c01c0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hilton Garden Inn Columbia/Harbison [](https://www.expedia.ca/Columbia-Hotels-Hilton-Garden-Inn-ColumbiaHarbison.h1513707.Hotel-Information) Columbia 9.0/10 Wonderful (1910) "Great stay, would do it again." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Fred CA $111 CA $125 total includes taxes & fees Jan 11 - Jan 12 [](https://www.expedia.ca/Columbia-Hotels-Hilton-Garden-Inn-ColumbiaHarbison.h1513707.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2026-01-18&endDate=2026-01-19®ionId=6057938&adults=2&travelerType=business_friendly&sort=RECOMMENDED&openPlayBack=true) ## Top South Carolina Midlands Hotel Reviews ![La Quinta Inn by Wyndham Columbia SE / Fort Jackson](https://images.trvl-media.com/lodging/1000000/10000/5100/5038/e9b1ea9e_y.jpg) ### La Quinta Inn by Wyndham Columbia SE / Fort Jackson 10/10 Excellent "Room was clean, staff was friendly " [](https://expedia.ca/Columbia-Hotels-La-Quinta-Inn-By-Wyndham-Columbia-SE-Fort-Jackson.h5038.Hotel-Information) ![Holiday Inn Express & Suites Columbia-I-26 @ Harbison Blvd by IHG](https://images.trvl-media.com/lodging/1000000/690000/688700/688607/805d082b_y.jpg) ### Holiday Inn Express & Suites Columbia-I-26 @ Harbison Blvd by IHG 10/10 Excellent "As always great place " [](https://expedia.ca/Columbia-Hotels-Holiday-Inn-Express-Suites-Columbia-I-26-Harbison-Blvd.h688607.Hotel-Information) ![Hyatt Place Columbia/Downtown/The Vista](https://images.trvl-media.com/lodging/9000000/8700000/8690600/8690567/c2bace01_y.jpg) ### Hyatt Place Columbia/Downtown/The Vista 10/10 Excellent " Room was great. Breakfast was okay" [](https://expedia.ca/Columbia-Hotels-Hyatt-Place-ColumbiaDowntownThe-Vista.h8690567.Hotel-Information) ![Howard Johnson by Wyndham Florence](https://images.trvl-media.com/lodging/1000000/20000/11100/11037/32fd6fc1_y.jpg) ### Howard Johnson by Wyndham Florence 10/10 Excellent "Clean rooms, good breakfast " [](https://expedia.ca/Florence-Hotels-Howard-Johnson-By-Wyndham-Florence.h11037.Hotel-Information) ![Hampton Inn & Suites Florence Center](https://images.trvl-media.com/lodging/1000000/50000/42900/42876/e1b59003_y.jpg) ### Hampton Inn & Suites Florence Center 10/10 Excellent "Staff was great room was what was expected " [](https://expedia.ca/Florence-Hotels-Hampton-Inn-Suites-Florence-Center.h42876.Hotel-Information) ![Hilton Garden Inn Columbia/Harbison](https://images.trvl-media.com/lodging/2000000/1520000/1513800/1513707/f8933df9_y.jpg) ### Hilton Garden Inn Columbia/Harbison 10/10 Excellent "Everything was excellent " [](https://expedia.ca/Columbia-Hotels-Hilton-Garden-Inn-ColumbiaHarbison.h1513707.Hotel-Information) ![Courtyard by Marriott Columbia Downtown at USC](https://images.trvl-media.com/lodging/1000000/10000/2300/2289/w3996h2667x0y0-8dd1e3e0_y.jpg) ### Courtyard by Marriott Columbia Downtown at USC 10/10 Excellent "Multiple things stood out to me: top-notch customer service. The facility, when you walk in, had a great aroma, in the lobby area. The rooms were clean. Everything was perfect. I had a great time." [](https://expedia.ca/Columbia-Hotels-Courtyard-By-Marriott-Columbia-Downtown-At-USC.h2289.Hotel-Information) ![Baymont by Wyndham Columbia Fort Jackson](https://images.trvl-media.com/lodging/1000000/580000/574500/574461/c68af965_y.jpg) ### Baymont by Wyndham Columbia Fort Jackson 10/10 Excellent "Excellent, very attentive staff, delicious breakfast " [](https://expedia.ca/Columbia-Hotels-Baymont-By-Wyndham-Columbia-Fort-Jackson.h574461.Hotel-Information) ![Sleep Inn Columbia](https://images.trvl-media.com/lodging/1000000/130000/127000/126908/de238acf_y.jpg) ### Sleep Inn Columbia 10/10 Excellent "Great value " [](https://expedia.ca/Columbia-Hotels-Sleep-Inn-At-Bush-River-Road.h126908.Hotel-Information) ## Frequently asked questions ### How much do business-friendly hotels in South Carolina Midlands cost? ### What are the best business-friendly hotels in South Carolina Midlands? ### How many business-friendly hotels are there in South Carolina Midlands? ### What are the best cheap business-friendly hotels in South Carolina Midlands? ### What are the top business-friendly motels in South Carolina Midlands? ### Are there any family-friendly hotels in South Carolina Midlands that are also business friendly? ### Why book your business-friendly hotel in South Carolina Midlands with Expedia? ### How can I find cheap business-friendly hotels in South Carolina Midlands? ### What is there to do in South Carolina Midlands near my business-friendly hotel? ## Explore a world of travel with Expedia - 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