Title: Book the Best BOUTIQUE Hotels in South Carolina Midlands in 2025 | Expedia.ca [South Carolina Midlands Travel Guide](https://expedia.ca/South-Carolina-Midlands.dx6057938)[Hotels in South Carolina Midlands](https://expedia.ca/South-Carolina-Midlands-Hotels.d6057938.Travel-Guide-Hotels)[Vacation Rentals in South Carolina Midlands](https://expedia.ca/South-Carolina-Midlands-Vacation-Rentals.d6057938.Travel-Guide-VacationRentals)[Flights to South Carolina Midlands](https://expedia.ca/Cheap-Flights-To-South-Carolina-Midlands.d6057938.Travel-Guide-Flights)[Things to do in South Carolina Midlands](https://expedia.ca/Things-To-Do-In-South-Carolina-Midlands.d6057938.Travel-Guide-Activities)[South Carolina Midlands Car Rentals](https://expedia.ca/Car-Rentals-In-South-Carolina-Midlands.d6057938.Car-Rental-Guide)[South Carolina Midlands Vacation Packages](https://expedia.ca/South-Carolina-Midlands.d6057938.Destination-Travel-Guides) ![South Carolina State House](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/184000/184006-State-House.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find Boutique Hotels in South Carolina Midlands, SC ![calendar shield illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation ![deals illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) ![bed illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on South Carolina Midlands Boutique Hotels Tonight [Oct 7 - Oct 8](https://www.expedia.ca/Hotel-Search?regionId=6057938&startDate=2025-10-07&endDate=2025-10-08&adults=2&propertyStyle=BOUTIQUE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Oct 8 - Oct 9](https://www.expedia.ca/Hotel-Search?regionId=6057938&startDate=2025-10-08&endDate=2025-10-09&adults=2&propertyStyle=BOUTIQUE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Oct 10 - Oct 12](https://www.expedia.ca/Hotel-Search?regionId=6057938&startDate=2025-10-10&endDate=2025-10-12&adults=2&propertyStyle=BOUTIQUE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Oct 17 - Oct 19](https://www.expedia.ca/Hotel-Search?regionId=6057938&startDate=2025-10-17&endDate=2025-10-19&adults=2&propertyStyle=BOUTIQUE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top South Carolina Midlands Boutique Hotels We don't have any properties that match your exact search [See all properties in South Carolina Midlands](https://expedia.ca/Hotel-Search?startDate=2025-10-21&endDate=2025-10-22®ionId=6057938&adults=2) ## Recommended hotels in South Carolina Midlands ![Lobby](https://images.trvl-media.com/lodging/93000000/92610000/92601000/92600969/5c693db6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/93000000/92610000/92601000/92600969/cce2b53c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Business centre](https://images.trvl-media.com/lodging/93000000/92610000/92601000/92600969/11da224f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, 2 Queen Beds, Accessible, Bathtub (Mobility & Hearing)](https://images.trvl-media.com/lodging/93000000/92610000/92601000/92600969/828f10f5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Tru By Hilton Santee Santee 9.2/10 Wonderful (556) "Great stay" CA $156 CA $173 total includes taxes & fees Nov 2 - Nov 3 [](https://www.expedia.ca/Santee-Hotels-Tru-By-Hilton-Santee.h92600969.Hotel-Information) ![Free daily full breakfast](https://images.trvl-media.com/lodging/90000000/89930000/89925000/89924960/3922a50b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/90000000/89930000/89925000/89924960/b5d1b31f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, Select Comfort beds, individually decorated](https://images.trvl-media.com/lodging/90000000/89930000/89925000/89924960/ec16b3cc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, Select Comfort beds, individually decorated](https://images.trvl-media.com/lodging/90000000/89930000/89925000/89924960/92abd6b6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Springhill Suites by Marriott Cheraw Cheraw 9.4/10 Exceptional (259) "Great room and hotel. Would definitely recommend and stay again." CA $149 CA $167 total includes taxes & fees Oct 19 - Oct 20 [](https://www.expedia.ca/Cheraw-Hotels-Springhill-Suites-By-Marriott-Cheraw.h89924960.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/98000000/97060000/97060000/97059954/155bc881.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, 2 Queen Beds](https://images.trvl-media.com/lodging/98000000/97060000/97060000/97059954/b2143a34.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Snack bar](https://images.trvl-media.com/lodging/98000000/97060000/97060000/97059954/86eed8e4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/98000000/97060000/97060000/97059954/838029e7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### TRU BY Hilton North Augusta North Augusta 9.6/10 Exceptional (189) "Room clean, staff is always so nice! " CA $153 CA $171 total includes taxes & fees Nov 2 - Nov 3 [](https://www.expedia.ca/North-Augusta-Hotels-TRU-BY-Hilton-North-Augusta.h97059954.Hotel-Information) ![Property amenity](https://images.trvl-media.com/lodging/77000000/76030000/76026200/76026194/0724af0f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Hypo-allergenic bedding, desk, laptop workspace, blackout drapes](https://images.trvl-media.com/lodging/77000000/76030000/76026200/76026194/92c4b04d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/77000000/76030000/76026200/76026194/a0ec666e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/77000000/76030000/76026200/76026194/e765049f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Aloft Florence Florence 8.4/10 Very good (203) "The aloft was modern and clean very accessible to high way;shopping and good" CA $141 CA $158 total includes taxes & fees Oct 12 - Oct 13 [](https://www.expedia.ca/Florence-Hotels-Aloft-Florence.h76026194.Hotel-Information) ![Property amenity](https://images.trvl-media.com/lodging/114000000/113200000/113199800/113199721/bc3c7b02.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Rollaway beds, free WiFi, bed sheets](https://images.trvl-media.com/lodging/114000000/113200000/113199800/113199721/959d5eb7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast](https://images.trvl-media.com/lodging/114000000/113200000/113199800/113199721/304e106b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/114000000/113200000/113199800/113199721/1fb98cce.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Springhill Suites By Marriott Camden Camden 9.4/10 Exceptional (11) "Nice rooms, comfortable bed and very clean." CA $245 CA $275 total includes taxes & fees Oct 31 - Nov 1 [](https://www.expedia.ca/Camden-Hotels-Springhill-Suites-By-Marriott-Camden.h113199721.Hotel-Information) ![Front of property - evening/night](https://images.trvl-media.com/lodging/33000000/32780000/32772900/32772870/c29c3321.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/33000000/32780000/32772900/32772870/c8bc9166.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast](https://images.trvl-media.com/lodging/33000000/32780000/32772900/32772870/cbc9a37d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool](https://images.trvl-media.com/lodging/33000000/32780000/32772900/32772870/ad4579b6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hyatt Place Florence Downtown Florence 8.8/10 Excellent (1005) "Great location & staff" CA $156 CA $175 total includes taxes & fees Nov 3 - Nov 4 [](https://www.expedia.ca/Florence-Hotels-Hyatt-Place-Florence-Downtown.h32772870.Hotel-Information) ![Room, 2 Queen Beds, Non Smoking](https://images.trvl-media.com/lodging/1000000/20000/15400/15379/1987eeb3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/20000/15400/15379/25ebdfeb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/20000/15400/15379/c7187353.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast](https://images.trvl-media.com/lodging/1000000/20000/15400/15379/c5237c95.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Baymont by Wyndham Santee Santee 8.0/10 Very good (1351) "A nice location, plenty of parking, nice that breakfast was included. " CA $105 CA $116 total includes taxes & fees Oct 8 - Oct 9 [](https://www.expedia.ca/Orangeburg-Hotels-Baymont-By-Wyndham-Santee.h15379.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/92000000/91920000/91916600/91916506/b5706b38.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/92000000/91920000/91916600/91916506/045c3b2a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/92000000/91920000/91916600/91916506/1b5eb5f3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/92000000/91920000/91916600/91916506/5952207c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Express & Suites Lexington by IHG Lexington 9.4/10 Exceptional (258) "Friendly staff, clean and spacious rooms. Works well for families visiting USC when downtown Columbia are booked on high volume weekends ( parents weekend and game days)" CA $173 CA $192 total includes taxes & fees Oct 19 - Oct 20 [](https://www.expedia.ca/Lexington-Hotels-Holiday-Inn-Express-Lexington.h91916506.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/2000000/1210000/1202800/1202776/0da1bc1f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, laptop workspace, iron/ironing board, free cribs/infant beds](https://images.trvl-media.com/lodging/2000000/1210000/1202800/1202776/079e4bcc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/2000000/1210000/1202800/1202776/6fee16b1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/2000000/1210000/1202800/1202776/da02b608.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Best Western Executive Inn Latta 8.2/10 Very good (905) "Pet friendly home away from home!" CA $136 CA $149 total includes taxes & fees Oct 13 - Oct 14 [](https://www.expedia.ca/Florence-Hotels-Best-Western-Executive-Inn.h1202776.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/20000/11100/11037/32fd6fc1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast](https://images.trvl-media.com/lodging/1000000/20000/11100/11037/ebea43b3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/1000000/20000/11100/11037/7b1066c5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room amenity](https://images.trvl-media.com/lodging/1000000/20000/11100/11037/b5687a1f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Howard Johnson by Wyndham Florence Florence 8.8/10 Excellent (2387) "Great stay" CA $91 CA $102 total includes taxes & fees Oct 8 - Oct 9 [](https://www.expedia.ca/Florence-Hotels-Howard-Johnson-By-Wyndham-Florence.h11037.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2025-10-21&endDate=2025-10-22®ionId=6057938&adults=2&specialized_stays_group_explore=boutique_property&sort=RECOMMENDED&openPlayBack=true) ## Top South Carolina Midlands Hotel Reviews ![Graduate by Hilton Columbia SC](//images.trvl-media.com/lodging/3000000/2520000/2515100/2515057/22f12a1f_y.jpg) ### Graduate by Hilton Columbia SC 10/10 Excellent "Nice" [](https://expedia.ca/Columbia-Hotels-Graduate-Columbia.h2515057.Hotel-Information) ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - Vacation Rental - More ways to book - [Hotels near Allen University](https://www.expedia.ca/Allen-University-Hotels.0-l6245638-0.Travel-Guide-Filter-Hotels) - [B&B in Arcadia Lakes](https://www.expedia.ca/Arcadia-Lakes-Bed-And-Breakfast.d553248634998974994-aaBedAndBreakfast.Travel-Guide-Accommodation) - [Guest Houses in Arcadia Lakes](https://www.expedia.ca/Arcadia-Lakes-Guest-Houses.d553248634998974994-aaGuestHouses.Travel-Guide-Accommodation) - 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[Flights to Columbia](https://www.expedia.ca/Cheap-Flights-To-Columbia.d764.Travel-Guide-Flights) - [Flights to South Carolina](https://www.expedia.ca/Destinations-In-South-Carolina.d242.Flight-Destinations) - [Flights from Elgin](https://www.expedia.ca/lp/flights/6051125/flights-from-elgin) - [Allen University](https://www.expedia.ca/Allen-University-Downtown-Columbia.d6245638.Vacation-Attraction) - [Visit Blythewood](https://www.expedia.ca/Blythewood.dx180657) - [Visit Lake Carolina](https://www.expedia.ca/Columbia-Lake-Carolina.dx553248635976478007) - [Visit Forest Acres](https://www.expedia.ca/Forest-Acres.dx553248634998960051) - [Visit Killian](https://www.expedia.ca/Killian.dx553248635975872238) - [Avis Rental Cars in Blythewood](https://www.expedia.ca/Avis-Car-Rentals-In-Blythewood.d180657-c41.Car-Rental-Guide-Suppliers) - [Car rental Elgin](https://www.expedia.ca/Car-Rentals-In-Elgin.d6051125.Car-Rental-Guide) - [Blythewood Vacation Rentals](https://www.expedia.ca/Blythewood-Vacation-Rentals.d180657.Travel-Guide-VacationRentals) - 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