Title: Book the Best PET FRIENDLY Hotels in South Carolina Midlands, SC from CA $106 - South Carolina Midlands Dog-Friendly Hotels | Expedia.ca [South Carolina Midlands Travel Guide](https://expedia.ca/South-Carolina-Midlands.dx6057938)[Hotels in South Carolina Midlands](https://expedia.ca/South-Carolina-Midlands-Hotels.d6057938.Travel-Guide-Hotels)[Vacation Rentals in South Carolina Midlands](https://expedia.ca/South-Carolina-Midlands-Vacation-Rentals.d6057938.Travel-Guide-VacationRentals)[Flights to South Carolina Midlands](https://expedia.ca/Cheap-Flights-To-South-Carolina-Midlands.d6057938.Travel-Guide-Flights)[Things to do in South Carolina Midlands](https://expedia.ca/Things-To-Do-In-South-Carolina-Midlands.d6057938.Travel-Guide-Activities)[South Carolina Midlands Car Rentals](https://expedia.ca/Car-Rentals-In-South-Carolina-Midlands.d6057938.Car-Rental-Guide)[South Carolina Midlands Vacation Packages](https://expedia.ca/South-Carolina-Midlands.d6057938.Destination-Travel-Guides) ![South Carolina State House](https://images.trvl-media.com/place/6082681/1934af6a-1aa9-4e01-8cd3-8eb8fe4af18f.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find Pet-friendly Hotels in South Carolina Midlands, SC from CA $106 - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on South Carolina Midlands Pet-friendly Hotels Tonight [Dec 16 - Dec 17](https://www.expedia.ca/Hotel-Search?regionId=6057938&startDate=2025-12-16&endDate=2025-12-17&adults=2&amenities=PETS&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Dec 17 - Dec 18](https://www.expedia.ca/Hotel-Search?regionId=6057938&startDate=2025-12-17&endDate=2025-12-18&adults=2&amenities=PETS&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Dec 19 - Dec 21](https://www.expedia.ca/Hotel-Search?regionId=6057938&startDate=2025-12-19&endDate=2025-12-21&adults=2&amenities=PETS&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Dec 26 - Dec 28](https://www.expedia.ca/Hotel-Search?regionId=6057938&startDate=2025-12-26&endDate=2025-12-28&adults=2&amenities=PETS&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Our top choices for South Carolina Midlands pet-friendly hotels ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/93000000/92610000/92601000/92600969/4b412627.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Business centre](https://images.trvl-media.com/lodging/93000000/92610000/92601000/92600969/11da224f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/93000000/92610000/92601000/92600969/40f69ad1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/93000000/92610000/92601000/92600969/cce2b53c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Tru By Hilton Santee [](https://www.expedia.ca/Santee-Hotels-Tru-By-Hilton-Santee.h92600969.Hotel-Information) Santee 9.2/10 Wonderful (638) "Nice place to stay" ![Canada](https://a.travel-assets.com/egds/marks/flags/ca.svg) Tanya CA $131 CA $146 total includes taxes & fees Jan 11 - Jan 12, 2026 [](https://www.expedia.ca/Santee-Hotels-Tru-By-Hilton-Santee.h92600969.Hotel-Information) ![Breakfast and dinner served](https://images.trvl-media.com/lodging/18000000/17370000/17370000/17369973/9eb183a0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/18000000/17370000/17370000/17369973/92ac7237.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/18000000/17370000/17370000/17369973/7f5dfdba.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/18000000/17370000/17370000/17369973/e288e3a2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Courtyard by Marriott Columbia Cayce [](https://www.expedia.ca/Columbia-Hotels-Courtyard-By-Marriott-Columbia-Cayce.h17369973.Hotel-Information) Cayce 9.0/10 Wonderful (654) "Room was clean. staff was very pleasant. Cafe / Bistro was good and convenient. Easy parking on site." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) joan CA $139 CA $154 total includes taxes & fees Jan 11 - Jan 12, 2026 [](https://www.expedia.ca/Columbia-Hotels-Courtyard-By-Marriott-Columbia-Cayce.h17369973.Hotel-Information) ![Free daily full breakfast](https://images.trvl-media.com/lodging/1000000/10000/5100/5038/e9b1ea9e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/10000/5100/5038/b50995e4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/10000/5100/5038/2db4f7f5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/10000/5100/5038/470d616b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### La Quinta Inn by Wyndham Columbia SE / Fort Jackson [](https://www.expedia.ca/Columbia-Hotels-La-Quinta-Inn-By-Wyndham-Columbia-SE-Fort-Jackson.h5038.Hotel-Information) Columbia 7.6/10 Good (1006) "Great breakfast and great staff" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jean CA $95 CA $106 total includes taxes & fees Dec 21 - Dec 22 [](https://www.expedia.ca/Columbia-Hotels-La-Quinta-Inn-By-Wyndham-Columbia-SE-Fort-Jackson.h5038.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/50000000/49040000/49035900/49035821/bed9bec2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, laptop workspace, bed sheets](https://images.trvl-media.com/lodging/50000000/49040000/49035900/49035821/421910eb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fitness facility](https://images.trvl-media.com/lodging/50000000/49040000/49035900/49035821/4e5c59d9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/50000000/49040000/49035900/49035821/bb785af0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hampton Inn & Suites Lexington Columbia [](https://www.expedia.ca/Columbia-Hotels-Hampton-Inn-Suites-Lexington.h49035821.Hotel-Information) Lexington 9.8/10 Exceptional (593) "Clean and comfortable room, friendly staff, great location." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Allison CA $142 CA $158 total includes taxes & fees Jan 11 - Jan 12, 2026 [](https://www.expedia.ca/Columbia-Hotels-Hampton-Inn-Suites-Lexington.h49035821.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/40000000/39480000/39474900/39474840/9cbe600c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/40000000/39480000/39474900/39474840/56d0510c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/40000000/39480000/39474900/39474840/47c4a854.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily full breakfast](https://images.trvl-media.com/lodging/40000000/39480000/39474900/39474840/c563e2d5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Express Richburg by IHG [](https://www.expedia.ca/Rock-Hill-Hotels-Holiday-Inn-Express-Richburg.h39474840.Hotel-Information) Richburg 9.2/10 Wonderful (645) "Everything was enjoyable " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) George CA $142 CA $159 total includes taxes & fees Jan 4 - Jan 5, 2026 [](https://www.expedia.ca/Rock-Hill-Hotels-Holiday-Inn-Express-Richburg.h39474840.Hotel-Information) ![Room, 2 Queen Beds, Non Smoking](https://images.trvl-media.com/lodging/1000000/20000/15400/15379/1987eeb3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast](https://images.trvl-media.com/lodging/1000000/20000/15400/15379/1c5cc7ad.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/20000/15400/15379/25ebdfeb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/20000/15400/15379/756b4cd6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Baymont by Wyndham Santee [](https://www.expedia.ca/Orangeburg-Hotels-Baymont-By-Wyndham-Santee.h15379.Hotel-Information) Santee 8.0/10 Very good (1416) "Very friendly staff. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Ramil CA $110 CA $122 total includes taxes & fees Dec 17 - Dec 18 [](https://www.expedia.ca/Orangeburg-Hotels-Baymont-By-Wyndham-Santee.h15379.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/39000000/38340000/38336400/38336321/fad493a2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Pillowtop beds, desk, blackout drapes, iron/ironing board](https://images.trvl-media.com/lodging/39000000/38340000/38336400/38336321/6df606aa.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast](https://images.trvl-media.com/lodging/39000000/38340000/38336400/38336321/fefdad76.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 2 Queen Beds, Non Smoking](https://images.trvl-media.com/lodging/39000000/38340000/38336400/38336321/a63ff680.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Comfort Inn & Suites Florence Center Area [](https://www.expedia.ca/Florence-Hotels-Comfort-Inn-Suites.h38336321.Hotel-Information) Florence 9.2/10 Wonderful (1169) "Enjoyed our stay there. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Cathy CA $133 CA $149 total includes taxes & fees Dec 29 - Dec 30 [](https://www.expedia.ca/Florence-Hotels-Comfort-Inn-Suites.h38336321.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/48000000/47090000/47086800/47086732/e4f3361f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/48000000/47090000/47086800/47086732/00586c85.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, down comforters, pillowtop beds, in-room safe](https://images.trvl-media.com/lodging/48000000/47090000/47086800/47086732/0c64863b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/48000000/47090000/47086800/47086732/96d5feb4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Park Inn by Radisson Florence, SC [](https://www.expedia.ca/Florence-Hotels-Park-Inn-By-Radisson-Florence.h47086732.Hotel-Information) Florence 9.0/10 Wonderful (2196) "Breakfast was great, room very clean ." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Leann CA $116 CA $130 total includes taxes & fees Dec 24 - Dec 25 [](https://www.expedia.ca/Florence-Hotels-Park-Inn-By-Radisson-Florence.h47086732.Hotel-Information) ![Seasonal outdoor pool](https://images.trvl-media.com/lodging/2000000/1880000/1878000/1877930/w3840h2556x0y4-5cb4ef80.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/2000000/1880000/1878000/1877930/w3840h2557x0y3-a96a0495.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/2000000/1880000/1878000/1877930/w3837h2558x3y4-5a11a251.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast](https://images.trvl-media.com/lodging/2000000/1880000/1878000/1877930/w3837h2482x3y0-b2c385e0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Spark by Hilton Orangeburg [](https://www.expedia.ca/Orangeburg-Hotels-Spark-By-Hilton-Orangeburg.h1877930.Hotel-Information) Orangeburg 7.8/10 Good (1006) "My first time staying at this Spark, and it was a good experience overall; no check in issues, clean room, good price point, and respectful staff. Would stay here again if in the area. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Karesha CA $120 CA $133 total includes taxes & fees Dec 31 - Jan 1, 2026 [](https://www.expedia.ca/Orangeburg-Hotels-Spark-By-Hilton-Orangeburg.h1877930.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/40000000/39640000/39637100/39637010/38e4995a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Hypo-allergenic bedding, pillowtop beds, individually decorated](https://images.trvl-media.com/lodging/40000000/39640000/39637100/39637010/fdff122d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/40000000/39640000/39637100/39637010/5c21e195.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/40000000/39640000/39637100/39637010/2c8bbdb5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Tru By Hilton Columbia Greystone [](https://www.expedia.ca/Columbia-Hotels-Tru-By-Hilton-Columbia-Greystone.h39637010.Hotel-Information) Columbia 9.2/10 Wonderful (1007) "Nice place to stay" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Beth CA $131 CA $149 total includes taxes & fees Dec 27 - Dec 28 [](https://www.expedia.ca/Columbia-Hotels-Tru-By-Hilton-Columbia-Greystone.h39637010.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2025-12-30&endDate=2025-12-31®ionId=6057938&adults=2&amenities=PETS&sort=RECOMMENDED&openPlayBack=true) ## Find out more about South Carolina Midlands ### Discover top South Carolina Midlands attractions with your pet In the heart of South Carolina Midlands, pet owners can delight in a range of activities that cater to both their furry companions and the family. Start your adventure at Congaree National Park, where you can wander along scenic trails, allowing your dog to explore the lush landscapes and unique ecosystems; remember to keep them leashed as you traverse the park’s ancient trees. For a leisurely day out, head to the Riverwalk Park in West Columbia, an ideal spot for a riverside stroll or a picnic with your pet. The vibrant outdoor space features walking paths and open areas for your canine to frolic, while you soak in the picturesque views of the Saluda River. If you fancy some local culture, stop by the South Carolina State Museum, where many events and exhibits welcome pets, allowing you to enjoy art and history together. After a day of exploring, unwind in the charming town of Lexington, known for its boutique pet-friendly accommodations that offer a warm welcome to your four-legged friends. Here, you can relax in hotels that provide thoughtful amenities, such as pet beds and treats, ensuring a comfortable stay for all. With easy access to parks and lakes, you’ll create unforgettable memories while enjoying the relaxed Southern hospitality. ## Top South Carolina Midlands Hotel Reviews ![Hyatt Place Columbia/Downtown/The Vista](https://images.trvl-media.com/lodging/9000000/8700000/8690600/8690567/c2bace01_y.jpg) ### Hyatt Place Columbia/Downtown/The Vista 10/10 Excellent "Clean room great staff " [](https://expedia.ca/Columbia-Hotels-Hyatt-Place-ColumbiaDowntownThe-Vista.h8690567.Hotel-Information) ![La Quinta Inn by Wyndham Columbia SE / Fort Jackson](https://images.trvl-media.com/lodging/1000000/10000/5100/5038/e9b1ea9e_y.jpg) ### La Quinta Inn by Wyndham Columbia SE / Fort Jackson 10/10 Excellent "Great room, recently renovated." [](https://expedia.ca/Columbia-Hotels-La-Quinta-Inn-By-Wyndham-Columbia-SE-Fort-Jackson.h5038.Hotel-Information) ![ La Quinta Inn by Wyndham Columbia NE/Fort Jackson](https://images.trvl-media.com/lodging/1000000/50000/43600/43541/ebebcc50_y.jpg) ### La Quinta Inn by Wyndham Columbia NE/Fort Jackson 10/10 Excellent "Cleaned and nice place to stay and friendly people." [](https://expedia.ca/Columbia-Hotels-La-Quinta-Inn-Suites-By-Wyndham-Columbia-NE-Fort-Jackson.h43541.Hotel-Information) ![Clarion Pointe Rock Hill Near University](https://images.trvl-media.com/lodging/1000000/30000/22100/22006/69d65d2e_y.jpg) ### Clarion Pointe Rock Hill Near University 10/10 Excellent "Very clean, great staff!" 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