Title: Browse the Best South Carolina Midlands Resorts | Expedia.ca [South Carolina Midlands Travel Guide](https://expedia.ca/South-Carolina-Midlands.dx6057938)[Hotels in South Carolina Midlands](https://expedia.ca/South-Carolina-Midlands-Hotels.d6057938.Travel-Guide-Hotels)[Vacation Rentals in South Carolina Midlands](https://expedia.ca/South-Carolina-Midlands-Vacation-Rentals.d6057938.Travel-Guide-VacationRentals)[Flights to South Carolina Midlands](https://expedia.ca/Cheap-Flights-To-South-Carolina-Midlands.d6057938.Travel-Guide-Flights)[Things to do in South Carolina Midlands](https://expedia.ca/Things-To-Do-In-South-Carolina-Midlands.d6057938.Travel-Guide-Activities)[South Carolina Midlands Car Rentals](https://expedia.ca/Car-Rentals-In-South-Carolina-Midlands.d6057938.Car-Rental-Guide)[South Carolina Midlands Vacation Packages](https://expedia.ca/South-Carolina-Midlands.d6057938.Destination-Travel-Guides) ![South Carolina State House](https://images.trvl-media.com/place/6082681/1934af6a-1aa9-4e01-8cd3-8eb8fe4af18f.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Search Resort Hotels in South Carolina Midlands - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check prices for these dates Next weekend [Nov 28 - Nov 30](https://www.expedia.ca/Hotel-Search?regionId=6057938&startDate=2025-11-28&endDate=2025-11-30&adults=2&lodging=HOTEL_RESORT&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two weeks [Dec 5 - Dec 7](https://www.expedia.ca/Hotel-Search?regionId=6057938&startDate=2025-12-05&endDate=2025-12-07&adults=2&lodging=HOTEL_RESORT&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In one month [Dec 19 - Dec 21](https://www.expedia.ca/Hotel-Search?regionId=6057938&startDate=2025-12-19&endDate=2025-12-21&adults=2&lodging=HOTEL_RESORT&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two months [Jan 16 - Jan 18](https://www.expedia.ca/Hotel-Search?regionId=6057938&startDate=2026-01-16&endDate=2026-01-18&adults=2&lodging=HOTEL_RESORT&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Browse Select South Carolina Midlands Resorts No exact matches found, but these alternatives could be just right ## Recommended hotels in South Carolina Midlands ![Lobby](https://images.trvl-media.com/lodging/93000000/92610000/92601000/92600969/5c693db6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/93000000/92610000/92601000/92600969/cce2b53c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, 2 Queen Beds, Accessible, Bathtub (Mobility & Hearing)](https://images.trvl-media.com/lodging/93000000/92610000/92601000/92600969/828f10f5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Business centre](https://images.trvl-media.com/lodging/93000000/92610000/92601000/92600969/11da224f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Tru By Hilton Santee Santee 9.2/10 Wonderful (604) "Nice place to stay" ![Canada](https://a.travel-assets.com/egds/marks/flags/ca.svg) Tanya CA $144 CA $160 total includes taxes & fees Dec 7 - Dec 8 [](https://www.expedia.ca/Santee-Hotels-Tru-By-Hilton-Santee.h92600969.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/39000000/38340000/38336400/38336321/a0861bce.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/39000000/38340000/38336400/38336321/0ea8f0b4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Seasonal outdoor pool](https://images.trvl-media.com/lodging/39000000/38340000/38336400/38336321/c7afe694.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Coffee service](https://images.trvl-media.com/lodging/39000000/38340000/38336400/38336321/22e67acb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Comfort Inn & Suites Florence Center Area Florence 9.2/10 Wonderful (1150) "Enjoyed our stay there. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Cathy CA $138 CA $154 total includes taxes & fees Nov 23 - Nov 24 [](https://www.expedia.ca/Florence-Hotels-Comfort-Inn-Suites.h38336321.Hotel-Information) ![Property amenity](https://images.trvl-media.com/lodging/1000000/30000/26200/26116/dfe24eeb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/30000/26200/26116/170f28f7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/1000000/30000/26200/26116/67341601.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/1000000/30000/26200/26116/3029fb89.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Fairfield Inn & Suites by Marriott Santee Santee 9.8/10 Exceptional (1006) "Very welcoming, hotel has a clean and friendly presentation." ![Canada](https://a.travel-assets.com/egds/marks/flags/ca.svg) VALERIE AND JOHN CA $162 CA $180 total includes taxes & fees Dec 7 - Dec 8 [](https://www.expedia.ca/Orangeburg-Hotels-Fairfield-Inn-Suites-By-Marriott-Santee.h26116.Hotel-Information) ![Front of property - evening/night](https://images.trvl-media.com/lodging/33000000/32780000/32772900/32772870/c29c3321.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast](https://images.trvl-media.com/lodging/33000000/32780000/32772900/32772870/cbc9a37d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, blackout drapes, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/33000000/32780000/32772900/32772870/bee831df.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool](https://images.trvl-media.com/lodging/33000000/32780000/32772900/32772870/ad4579b6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hyatt Place Florence Downtown Florence 8.8/10 Excellent (1004) "Great stay" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Michaelle CA $140 CA $157 total includes taxes & fees Dec 8 - Dec 9 [](https://www.expedia.ca/Florence-Hotels-Hyatt-Place-Florence-Downtown.h32772870.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/59000000/58990000/58985600/58985556/2544034c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/59000000/58990000/58985600/58985556/5cc0357e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Room, 2 Queen Beds, Accessible (Comm, Mobility, Access Tub)](https://images.trvl-media.com/lodging/59000000/58990000/58985600/58985556/0392e6eb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Seasonal outdoor pool](https://images.trvl-media.com/lodging/59000000/58990000/58985600/58985556/0cae09f9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Express & Suites Latta by IHG Latta 9.4/10 Exceptional (524) "Clean and beautiful, very friendly staff " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) claudia CA $139 CA $152 total includes taxes & fees Nov 30 - Dec 1 [](https://www.expedia.ca/Florence-Hotels-Holiday-Inn-Express-Suites-Latta.h58985556.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/860000/854800/854789/9aa14a94.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/860000/854800/854789/d1a2214d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/1000000/860000/854800/854789/a579564a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![In-room safe, blackout drapes, free cribs/infant beds, rollaway beds](https://images.trvl-media.com/lodging/1000000/860000/854800/854789/d94f2c84.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hampton Inn Newberry-Opera House Newberry 8.8/10 Excellent (781) "Was a nice hotel in a cute little town. Would stay there again!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Reuben CA $115 CA $127 total includes taxes & fees Dec 7 - Dec 8 [](https://www.expedia.ca/Newberry-Hotels-Hampton-Inn-Newberry-Opera-House.h854789.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/40000000/39640000/39637100/39637010/38e4995a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Snack bar](https://images.trvl-media.com/lodging/40000000/39640000/39637100/39637010/aeeef90b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Business centre](https://images.trvl-media.com/lodging/40000000/39640000/39637100/39637010/30a1e4b0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, hypo-allergenic bedding, pillowtop beds](https://images.trvl-media.com/lodging/40000000/39640000/39637100/39637010/a74038c0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Tru By Hilton Columbia Greystone Columbia 9.2/10 Wonderful (1006) "Great Stay" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Sucorya CA $133 CA $152 total includes taxes & fees Dec 21 - Dec 22 [](https://www.expedia.ca/Columbia-Hotels-Tru-By-Hilton-Columbia-Greystone.h39637010.Hotel-Information) ![Property amenity](https://images.trvl-media.com/lodging/2000000/1830000/1823700/1823665/540a6df8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Seasonal outdoor pool](https://images.trvl-media.com/lodging/2000000/1830000/1823700/1823665/ef70d278.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, in-room safe, desk, blackout drapes](https://images.trvl-media.com/lodging/2000000/1830000/1823700/1823665/a84845d9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily self-serve breakfast](https://images.trvl-media.com/lodging/2000000/1830000/1823700/1823665/5b535249.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Lexington Expo Hotel by IHG Lexington 9.2/10 Wonderful (1000) "Room was great staff was great" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Stephen CA $146 CA $163 total includes taxes & fees Dec 5 - Dec 6 [](https://www.expedia.ca/Lexington-Hotels-Lexington-Expo-Hotel-By-IHG.h1823665.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/48000000/47090000/47086800/47086732/96d5feb4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/48000000/47090000/47086800/47086732/e4f3361f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/48000000/47090000/47086800/47086732/00586c85.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/48000000/47090000/47086800/47086732/0b9239a1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Park Inn by Radisson Florence, SC Florence 9.0/10 Wonderful (2191) "Friendly and efficient staff and a nice room for my overnight stay." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Carole CA $131 CA $147 total includes taxes & fees Dec 7 - Dec 8 [](https://www.expedia.ca/Florence-Hotels-Park-Inn-By-Radisson-Florence.h47086732.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/80000/74500/74404/484ca695.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, desk, soundproofing, iron/ironing board](https://images.trvl-media.com/lodging/1000000/80000/74500/74404/c105915a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast](https://images.trvl-media.com/lodging/1000000/80000/74500/74404/f63ba12c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Seasonal outdoor pool, sun loungers](https://images.trvl-media.com/lodging/1000000/80000/74500/74404/824b9567.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### La Quinta Inn & Suites by Wyndham Florence Florence 8.0/10 Very good (1678) "Friendly staff, clean just what I was looking for!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Bradford CA $124 CA $138 total includes taxes & fees Dec 12 - Dec 13 [](https://www.expedia.ca/Florence-Hotels-La-Quinta-Inn-Suites-By-Wyndham-Florence.h74404.Hotel-Information) ![Terrace/patio](https://images.trvl-media.com/lodging/4000000/3200000/3191900/3191843/35e61449.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/4000000/3200000/3191900/3191843/d933487d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Meeting facility](https://images.trvl-media.com/lodging/4000000/3200000/3191900/3191843/b4cc4b6f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/4000000/3200000/3191900/3191843/e3b96f81.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hilton Garden Inn Columbia Airport West Columbia 9.0/10 Wonderful (1007) "Great place to stay. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Melonie CA $144 CA $157 total includes taxes & fees Dec 21 - Dec 22 [](https://www.expedia.ca/Columbia-Hotels-Hilton-Garden-Inn-Columbia-Airport.h3191843.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/2000000/1520000/1513800/1513707/f8933df9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/2000000/1520000/1513800/1513707/7b635fb9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior entrance](https://images.trvl-media.com/lodging/2000000/1520000/1513800/1513707/0a695ca8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/2000000/1520000/1513800/1513707/0f2c01c0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hilton Garden Inn Columbia/Harbison Columbia 9.0/10 Wonderful (1825) "great hotel " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Ben CA $111 CA $125 total includes taxes & fees Nov 30 - Dec 1 [](https://www.expedia.ca/Columbia-Hotels-Hilton-Garden-Inn-ColumbiaHarbison.h1513707.Hotel-Information) ![Room, 2 Queen Beds, Non Smoking](https://images.trvl-media.com/lodging/1000000/20000/15400/15379/1987eeb3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast](https://images.trvl-media.com/lodging/1000000/20000/15400/15379/c5237c95.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/20000/15400/15379/25ebdfeb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/20000/15400/15379/c7187353.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Baymont by Wyndham Santee Santee 8.0/10 Very good (1394) "The best stay" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Terez CA $112 CA $124 total includes taxes & fees Nov 23 - Nov 24 [](https://www.expedia.ca/Orangeburg-Hotels-Baymont-By-Wyndham-Santee.h15379.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/2000000/1170000/1160800/1160796/c0bcb33a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool, sun loungers](https://images.trvl-media.com/lodging/2000000/1170000/1160800/1160796/7cb8c23e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast](https://images.trvl-media.com/lodging/2000000/1170000/1160800/1160796/87830651.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, Multiple Beds, Accessible, Non Smoking](https://images.trvl-media.com/lodging/2000000/1170000/1160800/1160796/5507646b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Country Inn & Suites by Radisson, Columbia Airport, SC Cayce 8.2/10 Very good (1000) "We enjoyed our stay. The room was clean and the staff were wonderful!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Marilyn CA $141 CA $157 total includes taxes & fees Dec 11 - Dec 12 [](https://www.expedia.ca/Columbia-Hotels-Country-Inn-Suites-By-Radisson.h1160796.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/24000000/23710000/23704200/23704165/2c0ae9c5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/24000000/23710000/23704200/23704165/ac69232d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Seasonal outdoor pool, open 9:00 AM to 9:00 PM, pool umbrellas](https://images.trvl-media.com/lodging/24000000/23710000/23704200/23704165/75b299aa.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/24000000/23710000/23704200/23704165/3d870b01.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Express & Suites Charlotte - Ballantyne by IHG Ballantyne 8.8/10 Excellent (1000) "Clean rooms, good breakfast options, and friendly staff." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Denice and Jim CA $84 CA $97 total includes taxes & fees Dec 14 - Dec 15 [](https://www.expedia.ca/Charlotte-Hotels-Holiday-Inn-Express-Suites-Charlotte-Ballantyne.h23704165.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/3000000/2400000/2393000/2392993/36a85f8e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/3000000/2400000/2393000/2392993/a2c60bb5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Snack bar](https://images.trvl-media.com/lodging/3000000/2400000/2393000/2392993/22eb9cd7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/3000000/2400000/2393000/2392993/59604fe9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hampton Inn & Suites Florence-North-I-95 Florence 9.0/10 Wonderful (784) "Clean room, courteous staff and easy access to and from highway." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Joe CA $144 CA $162 total includes taxes & fees Dec 7 - Dec 8 [](https://www.expedia.ca/Florence-Hotels-Hampton-Inn-Suites-Florence-North-I-95.h2392993.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/35000000/34330000/34323400/34323336/1bbd70f5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/35000000/34330000/34323400/34323336/c836e9b5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, 2 Queen Beds, Accessible, Bathtub](https://images.trvl-media.com/lodging/35000000/34330000/34323400/34323336/57735ca3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fitness studio](https://images.trvl-media.com/lodging/35000000/34330000/34323400/34323336/7b01c436.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Tru by Hilton Orangeburg Orangeburg 9.2/10 Wonderful (1008) "Staff was friendly, room was clean and quiet. recommend this property." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Janet CA $144 CA $160 total includes taxes & fees Dec 2 - Dec 3 [](https://www.expedia.ca/Orangeburg-Hotels-Tru-By-Hilton-Orangeburg.h34323336.Hotel-Information) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/32000000/31360000/31356900/31356801/72a817b3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/32000000/31360000/31356900/31356801/86cca9d7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/32000000/31360000/31356900/31356801/6b778e7c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/32000000/31360000/31356900/31356801/97130b24.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hampton Inn & Suites Columbia Killian Road Columbia 9.2/10 Wonderful (1004) "Very neat and quiet. Breakfast was very good. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Esther CA $140 CA $157 total includes taxes & fees Dec 21 - Dec 22 [](https://www.expedia.ca/Columbia-Hotels-Hampton-Inn-Suites-Columbia-Killian-Road.h31356801.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/20000/11100/11037/32fd6fc1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast](https://images.trvl-media.com/lodging/1000000/20000/11100/11037/ebea43b3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, 2 Double Beds, Non Smoking](https://images.trvl-media.com/lodging/1000000/20000/11100/11037/8a1b879d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room amenity](https://images.trvl-media.com/lodging/1000000/20000/11100/11037/b5687a1f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Howard Johnson by Wyndham Florence Florence 8.6/10 Excellent (2443) "Room clean, nice hot water in tub and friendly staff. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Sharon CA $91 CA $102 total includes taxes & fees Nov 24 - Nov 25 [](https://www.expedia.ca/Florence-Hotels-Howard-Johnson-By-Wyndham-Florence.h11037.Hotel-Information) ![Property entrance](https://images.trvl-media.com/lodging/2000000/1220000/1213000/1212931/42f27498.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Room, 2 Queen Beds, Non Smoking](https://images.trvl-media.com/lodging/2000000/1220000/1213000/1212931/02445a7f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior detail](https://images.trvl-media.com/lodging/2000000/1220000/1213000/1212931/a1af3ca9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/2000000/1220000/1213000/1212931/726f3d0d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Inn on the Square, an Ascend Collection Hotel Uptown Greenwood 9.2/10 Wonderful (704) "It was a very clean and beautiful lace to stay. We were there for our honeymoon " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Tracy CA $153 CA $170 total includes taxes & fees Dec 21 - Dec 22 [](https://www.expedia.ca/Greenwood-Hotels-Inn-On-The-Square.h1212931.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2025-12-04&endDate=2025-12-05®ionId=6057938&adults=2&lodging=HOTEL_RESORT&sort=RECOMMENDED&openPlayBack=true) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in](https://expedia.ca/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FSouth-Carolina-Midlands-Resort-Hotels.d6057938-aaResortHotels.Travel-Guide-Accommodation)[Sign up, it's free](https://expedia.ca/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FSouth-Carolina-Midlands-Resort-Hotels.d6057938-aaResortHotels.Travel-Guide-Accommodation) ## Top South Carolina Midlands Hotel Reviews ![Baymont by Wyndham Columbia Fort Jackson](https://images.trvl-media.com/lodging/1000000/580000/574500/574461/c68af965_y.jpg) ### Baymont by Wyndham Columbia Fort Jackson 10/10 Excellent "clean room" [](https://expedia.ca/Columbia-Hotels-Baymont-By-Wyndham-Columbia-Fort-Jackson.h574461.Hotel-Information) ![Hilton Garden Inn Columbia/Harbison](https://images.trvl-media.com/lodging/2000000/1520000/1513800/1513707/f8933df9_y.jpg) ### Hilton Garden Inn Columbia/Harbison 10/10 Excellent "Good" [](https://expedia.ca/Columbia-Hotels-Hilton-Garden-Inn-ColumbiaHarbison.h1513707.Hotel-Information) ![Graduate by Hilton Columbia SC](https://images.trvl-media.com/lodging/3000000/2520000/2515100/2515057/22f12a1f_y.jpg) ### Graduate by Hilton Columbia SC 10/10 Excellent "Friendly staff and closeness to campus. " [](https://expedia.ca/Columbia-Hotels-Graduate-Columbia.h2515057.Hotel-Information) ![Country Inn & Suites by Radisson, Columbia, SC](https://images.trvl-media.com/lodging/1000000/210000/202900/202867/04e820c9_y.jpg) ### Country Inn & Suites by Radisson, Columbia, SC 10/10 Excellent "Clean room & nice staff " [](https://expedia.ca/Columbia-Hotels-Country-Inn-Suites-By-Radisson.h202867.Hotel-Information) ![Howard Johnson by Wyndham Florence](https://images.trvl-media.com/lodging/1000000/20000/11100/11037/32fd6fc1_y.jpg) ### Howard Johnson by Wyndham Florence 10/10 Excellent "Check-in was easy. Staff was courteous & effecient" [](https://expedia.ca/Florence-Hotels-Howard-Johnson-By-Wyndham-Florence.h11037.Hotel-Information) ![ La Quinta Inn by Wyndham Columbia NE/Fort Jackson](https://images.trvl-media.com/lodging/1000000/50000/43600/43541/ebebcc50_y.jpg) ### La Quinta Inn by Wyndham Columbia NE/Fort Jackson 10/10 Excellent "." [](https://expedia.ca/Columbia-Hotels-La-Quinta-Inn-Suites-By-Wyndham-Columbia-NE-Fort-Jackson.h43541.Hotel-Information) ![Cambria Hotel Columbia Downtown The Vista](https://images.trvl-media.com/lodging/77000000/76600000/76599300/76599223/e2b9c83a_y.jpg) ### Cambria Hotel Columbia Downtown The Vista 10/10 Excellent "Great customer service and the showers were wonderful nice and clean." [](https://expedia.ca/Columbia-Hotels-Cambria-Hotel-Columbia-Downtown-The-Vista.h76599223.Hotel-Information) ![Super 8 by Wyndham Harbison/Parkridge Hospital](https://images.trvl-media.com/lodging/1000000/530000/523100/523046/42de4f92_y.jpg) ### Super 8 by Wyndham Harbison/Parkridge Hospital 10/10 Excellent "Yes the room was nice and clean " [](https://expedia.ca/Columbia-Hotels-Super-8-By-Wyndham-HarbisonParkridge-Hospital.h523046.Hotel-Information) ![Tru by Hilton Rock Hill](https://images.trvl-media.com/lodging/43000000/42840000/42839800/42839781/b8c73c34_y.jpg) ### Tru by Hilton Rock Hill 10/10 Excellent "Comfortable bed- clean room Good coffee!" [](https://expedia.ca/Rock-Hill-Hotels-Tru-By-Hilton-Rock-Hill.h42839781.Hotel-Information) ## Find out more about South Carolina Midlands ## South Carolina Midlands Resorts information | Number of reviews | | | --- | --- | | Accommodation | Resorts | | Lowest Price | | | Highest Price | | ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - Vacation Rental - More ways to book - [Hotels near Allen University](https://www.expedia.ca/Allen-University-Hotels.0-l6245638-0.Travel-Guide-Filter-Hotels) - [B&B in Arcadia Lakes](https://www.expedia.ca/Arcadia-Lakes-Bed-And-Breakfast.d553248634998974994-aaBedAndBreakfast.Travel-Guide-Accommodation) - [Guest Houses in Arcadia Lakes](https://www.expedia.ca/Arcadia-Lakes-Guest-Houses.d553248634998974994-aaGuestHouses.Travel-Guide-Accommodation) - [Arcadia Lakes Hotels](https://www.expedia.ca/Arcadia-Lakes-Hotels.d553248634998974994.Travel-Guide-Hotels) - [Inns in Arcadia Lakes](https://www.expedia.ca/Arcadia-Lakes-Inns.d553248634998974994-aaInns.Travel-Guide-Accommodation) - 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