Title: Book the Best Mesopotamia SPA Resorts - Spa Hotels in Mesopotamia | Expedia.ca [Mesopotamia Travel Guide](https://expedia.ca/Mesopotamia.dx6208836)[Hotels in Mesopotamia](https://expedia.ca/Mesopotamia-Hotels.d6208836.Travel-Guide-Hotels)[Vacation Rentals in Mesopotamia](https://expedia.ca/Mesopotamia-Vacation-Rentals.d6208836.Travel-Guide-VacationRentals)[Flights to Mesopotamia](https://expedia.ca/Cheap-Flights-To-Mesopotamia.d6208836.Travel-Guide-Flights)[Mesopotamia Car Rentals](https://expedia.ca/Car-Rentals-In-Mesopotamia.d6208836.Car-Rental-Guide)[Mesopotamia Vacation Packages](https://expedia.ca/Mesopotamia.d6208836.Destination-Travel-Guides) ![Mesopotamia which includes forests](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/196000/196542-Mesopotamia.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find Spa Hotels in Mesopotamia - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Mesopotamia Spa Hotels Tonight [Nov 4 - Nov 5](https://www.expedia.ca/Hotel-Search?regionId=6208836&startDate=2025-11-04&endDate=2025-11-05&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Nov 5 - Nov 6](https://www.expedia.ca/Hotel-Search?regionId=6208836&startDate=2025-11-05&endDate=2025-11-06&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Nov 7 - Nov 9](https://www.expedia.ca/Hotel-Search?regionId=6208836&startDate=2025-11-07&endDate=2025-11-09&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Nov 14 - Nov 16](https://www.expedia.ca/Hotel-Search?regionId=6208836&startDate=2025-11-14&endDate=2025-11-16&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top Mesopotamia Spa Hotels ![Indoor pool, 2 outdoor pools, pool umbrellas, sun loungers](https://images.trvl-media.com/lodging/112000000/111550000/111541700/111541690/182c3232.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Superior Double Room](https://images.trvl-media.com/lodging/112000000/111550000/111541700/111541690/e22e8bc7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/112000000/111550000/111541700/111541690/384ea822.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast](https://images.trvl-media.com/lodging/112000000/111550000/111541700/111541690/a0871cfa.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Mayim Hotel Termal & SPA Concordia 8.8/10 Excellent (5) "Muy lindo hotel , lástima q se rompió el aire acondicionado y no hay secador de pelo an la habitación " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Catalina CA $133 CA $133 total Nov 10 - Nov 11 [](https://www.expedia.ca/Concordia-Hotels-Mayim-Hotel-Termal-SPA.h111541690.Hotel-Information) ![Couples treatment rooms, body treatments, aromatherapy, body scrubs](https://images.trvl-media.com/lodging/37000000/36810000/36801000/36800965/96c06c0b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium Double Room](https://images.trvl-media.com/lodging/37000000/36810000/36801000/36800965/4e070a0a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Couples treatment rooms, body treatments, aromatherapy, body scrubs](https://images.trvl-media.com/lodging/37000000/36810000/36801000/36800965/2f9d647c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/37000000/36810000/36801000/36800965/6a6d02f8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Maran Suites & Towers - Hotel & Spa Parana 9.0/10 Wonderful (30) "Property is fine. The woman who checked me in was extremely rude. Rooms don’t have accessible access to outlets." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Brian CA $140 CA $140 total Nov 9 - Nov 10 [](https://www.expedia.ca/Parana-Hotels-Maran-Suites-Towers-Hotel-Spa.h36800965.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/12000000/11880000/11876000/11875903/afd7d710.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![TV](https://images.trvl-media.com/lodging/12000000/11880000/11876000/11875903/7876fff6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property entrance](https://images.trvl-media.com/lodging/12000000/11880000/11876000/11875903/f32e7494.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/12000000/11880000/11876000/11875903/750a674d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Club Valle Termal Resort Federacion 9.2/10 Wonderful (93) "Lamentablemente el lugar no refleja lo contratado por la plataforma. Cuando llegamos no tenían nuestras reservas, nos enviaron a una habitación con puerta de vidrio que no cerraba, arañas en la habitación, las sábanas viejas y manchadas, colchones vencidos y sin forro. Una experiencia espeluznante. " ![Costa Rica](https://a.travel-assets.com/egds/marks/flags/cr.svg) Pablo CA $67 CA $67 total Dec 1 - Dec 2 [](https://www.expedia.ca/Federacion-Hotels-Club-Valle-Termal-Resort.h11875903.Hotel-Information) ![2 bedrooms, premium bedding, pillowtop beds, individually decorated](https://images.trvl-media.com/lodging/100000000/99270000/99269400/99269311/9cad496d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Business Apartment | Living area](https://images.trvl-media.com/lodging/100000000/99270000/99269400/99269311/1f4c0785.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/100000000/99270000/99269400/99269311/5f45ac2e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Business Apartment | Private kitchen](https://images.trvl-media.com/lodging/100000000/99270000/99269400/99269311/3ee5dbf3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Agustín 1 Apart Parana 9.0/10 Wonderful (4) "Meu problema foi só a garagem, o apartamento é ótimo, limpeza estava impecável." ![Brazil](https://a.travel-assets.com/egds/marks/flags/br.svg) Jose rodrigo kallas CA $126 CA $126 total Nov 6 - Nov 7 [](https://www.expedia.ca/Parana-Hotels-Agustin-1-Apart.h99269311.Hotel-Information) ![Seasonal outdoor pool, open noon to 11:00 PM, sun loungers](https://images.trvl-media.com/lodging/5000000/4420000/4411700/4411601/456e237c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property entrance](https://images.trvl-media.com/lodging/5000000/4420000/4411700/4411601/59acb415.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/5000000/4420000/4411700/4411601/98196436.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Garden](https://images.trvl-media.com/lodging/5000000/4420000/4411700/4411601/d89014ef.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### La Casona de Susana Colon 7.4/10 Good (25) "La propietaria respeta el precio acordado. En verano si usás más de 8 horas por día el aire acondicionado te cobran un plus." ![Argentina](https://a.travel-assets.com/egds/marks/flags/ar.svg) Marlene Ruth CA $67 CA $67 total Dec 3 - Dec 4 [](https://www.expedia.ca/Colon-Hotels-La-Casona-De-Susana.h4411601.Hotel-Information) ![Terrace/patio](https://images.trvl-media.com/lodging/34000000/33350000/33347000/33346911/ee9ad702.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property - evening/night](https://images.trvl-media.com/lodging/34000000/33350000/33347000/33346911/dd41bc20.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/34000000/33350000/33347000/33346911/e70d9e85.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/34000000/33350000/33347000/33346911/459986e2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hotel y Spa Termas del Este Federacion 8.4/10 Very good (12) "good for a 1 night stay" ![Canada](https://a.travel-assets.com/egds/marks/flags/ca.svg) Chase [](https://www.expedia.ca/Federacion-Hotels-Hotel-Y-Spa-Termas-Del-Este.h33346911.Hotel-Information) ![Outdoor pool](https://images.trvl-media.com/lodging/115000000/114110000/114109800/114109755/cb01ff56.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Hallway](https://images.trvl-media.com/lodging/115000000/114110000/114109800/114109755/0f7006fe.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/115000000/114110000/114109800/114109755/cdd97d7b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/115000000/114110000/114109800/114109755/c1286a77.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Intersur Colon Colón 10/10 Exceptional (2) "Letti molto comodi, belle piscine, personale gentile, pulizia buona, colazione buona. Ottimo rapporto qualità prezzo. " ![Italy](https://a.travel-assets.com/egds/marks/flags/it.svg) Francesco CA $148 CA $148 total Nov 6 - Nov 7 [](https://www.expedia.ca/Colon-Hotels-Intersur-Colon.h114109755.Hotel-Information) ![Massages](https://images.trvl-media.com/lodging/97000000/96450000/96446000/96445971/bd533bb1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/97000000/96450000/96446000/96445971/1950856d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/97000000/96450000/96446000/96445971/433c57ff.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Restaurant](https://images.trvl-media.com/lodging/97000000/96450000/96446000/96445971/d08855c3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Howard Johnson Plaza La Ribera Resistencia 9.2/10 Wonderful (110) "Excellent hotel! Staff was friendly and professional. Big rooms, super clean. We are a family of 5 (2 adults and 3 kids) and we stayed for 2 nights. We had a great experience! The pool is fantastic, there is a big green outdoor area with playground for kids. We really enjoyed our time there! There is a big shopping centre in front of the hotel. " ![Canada](https://a.travel-assets.com/egds/marks/flags/ca.svg) Ovidio Enrique [](https://www.expedia.ca/Resistencia-Hotels-Howard-Johnson-Plaza-La-Ribera.h96445971.Hotel-Information) ![Sauna, hot stone massages, massages](https://images.trvl-media.com/lodging/72000000/71050000/71042900/71042838/61b1933c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool, seasonal outdoor pool, pool umbrellas, sun loungers](https://images.trvl-media.com/lodging/72000000/71050000/71042900/71042838/153bae1a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Sauna, hot stone massages, massages](https://images.trvl-media.com/lodging/72000000/71050000/71042900/71042838/f09e615e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool, seasonal outdoor pool, pool umbrellas, sun loungers](https://images.trvl-media.com/lodging/72000000/71050000/71042900/71042838/52678907.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Days Inn by Wyndham Zarate Zárate 8.4/10 Very good (94) "Un lugar tranquilo para descansar. " ![Argentina](https://a.travel-assets.com/egds/marks/flags/ar.svg) Daniel [](https://www.expedia.ca/Zarate-Hotels-Days-Inn-Zarate.h71042838.Hotel-Information) ![Sauna, steam room, body treatments, hot stone massages, facials](https://images.trvl-media.com/lodging/4000000/3030000/3023900/3023891/891a8cb3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Casino](https://images.trvl-media.com/lodging/4000000/3030000/3023900/3023891/6fa88a7e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Aerial view](https://images.trvl-media.com/lodging/4000000/3030000/3023900/3023891/3b6899cf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior detail](https://images.trvl-media.com/lodging/4000000/3030000/3023900/3023891/4349e1ae.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Pullman Rosario City Center Hotel Rosario 8.6/10 Excellent (272) "Safe and good hotel. Fitness center needs to be improved" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Olivier [](https://www.expedia.ca/Rosario-Hotels-Pullman-Rosario-City-Center-Hotel.h3023891.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2025-11-19&endDate=2025-11-20®ionId=6208836&adults=2&amenities=SPA_ON_SITE&sort=RECOMMENDED&openPlayBack=true) ## Top Mesopotamia Hotel Reviews ![Holiday Inn Express Rosario by IHG](//images.trvl-media.com/lodging/4000000/3250000/3243000/3242923/502819d5_y.jpg) ### Holiday Inn Express Rosario by IHG 10/10 Excellent "Clean room. Everything just like in the pictures. " [](https://expedia.ca/Rosario-Hotels-Holiday-Inn-Express-Rosario.h3242923.Hotel-Information) ![Costarenas Hotel & Spa](//images.trvl-media.com/lodging/16000000/15370000/15362200/15362145/43c3ae01_y.jpg) ### Costarenas Hotel & Spa 2/10 Terrible "Short Version See pictures for detailed information) - Rooms and bathrooms are small, shower already tight spaced with doors that don’t close properly. - By day 3, construction noise and chemicals smells from remodeling work became a big issue. - Receptionist did not offer solutions and lied about remodeling hours. Felt uncomfortable when asked for manager’s name, and refused to give any other information. - Same receptionist reached out later to apologize and acknowledged we should have not been placed in those rooms to begin with. Offered to move us to “upgraded” rooms. - “Upgraded” rooms were even worse. One of the rooms was directly under the ones being remodeled and worked on. Noise began at 8 AM - The other two rooms did not have a functioning air conditioner. Staff gave poor excuse and just said to open windows. There’s tons of noise far into the night from motor bikes and people playing music right across the hotel. - Hotel breakfast was motel level at best. You get eggs swimming in water and some cut up ham. Toasters barely worked, and when staff was asked for replacement they appeared completely clueless. - The spa experience was good when it came to the massage. However “quiet” policy is not enforced and hearing toilets go off right next to the spa area don’t help with the experience. - Check out was the final straw. Desk staff was rude and dismissive of concerns, stating that the room “upgrade” was sufficient compensation for the troubles. " [](https://expedia.ca/Colon-Hotels-Costarenas-Hotel-Spa.h15362145.Hotel-Information) ![Amérian Hotel Casino Gala](//images.trvl-media.com/lodging/2000000/1200000/1197100/1197026/a75881f1_y.jpg) ### Amérian Hotel Casino Gala 10/10 Excellent "Great service and attention!. I highly recommend this hotel . " [](https://expedia.ca/Resistencia-Hotels-Amerian-Hotel-Casino-Gala.h1197026.Hotel-Information) ![Holiday Inn Rosario by IHG](//images.trvl-media.com/lodging/1000000/580000/570400/570357/61653463_y.jpg) ### Holiday Inn Rosario by IHG 10/10 Excellent "Todo perfecto " [](https://expedia.ca/Rosario-Hotels-Holiday-Inn-Rosario.h570357.Hotel-Information) ![Esplendor by Wyndham Savoy Rosario](//images.trvl-media.com/lodging/3000000/2810000/2803500/2803473/36b8ac51_y.jpg) ### Esplendor by Wyndham Savoy Rosario 10/10 Excellent "Excellent hotel Everything very comfortable, and convenient" [](https://expedia.ca/Rosario-Hotels-Esplendor-By-Wyndham-Savoy-Rosario.h2803473.Hotel-Information) ![Howard Johnson by Wyndham Rosario](//images.trvl-media.com/lodging/14000000/13520000/13514300/13514290/3d666cad_y.jpg) ### Howard Johnson by Wyndham Rosario 10/10 Excellent "Super conveniente por precio y calidad." [](https://expedia.ca/Rosario-Hotels-Howard-Johnson-Rosario.h13514290.Hotel-Information) ![Wyndham Garden Campana](//images.trvl-media.com/lodging/1000000/990000/983700/983698/1521535a_y.jpg) ### Wyndham Garden Campana 6/10 Okay "Televisor con problemas de funcionamiento. Ducha que baña todo el baño en lugar de ti. Ventana expuesta al paso de todo el público. " [](https://expedia.ca/Pilar-Hotels-Australis-Campana.h983698.Hotel-Information) ![Hathor Concordia](//images.trvl-media.com/lodging/5000000/4670000/4668300/4668235/cc821f0d_y.jpg) ### Hathor Concordia 10/10 Excellent "Very clean room at affordable price. The dinning is of excellent quality at very reasonable price. The staff are quite friendly and helpful." [](https://expedia.ca/Concordia-Hotels-Hathor-Concordia.h4668235.Hotel-Information) ## Explore a world of travel with Expedia - More ways to book - [Book Spa Hotels in Mesopotamia on Expedia.com.ar](https://www.expedia.com.ar/Mesopotamia-Hoteles-Hotel-Con-Spa.0-0-d6208836-tHotelconspa.Guia-filtrada-de-Hoteles)