Title: Book the Best HISTORIC Hotels in Mesopotamia in 2026 | Expedia.ca

[Mesopotamia Travel Guide](https://expedia.ca/Mesopotamia.dx6208836)[Hotels in Mesopotamia](https://expedia.ca/Mesopotamia-Hotels.d6208836.Travel-Guide-Hotels)[Vacation Rentals in Mesopotamia](https://expedia.ca/Mesopotamia-Vacation-Rentals.d6208836.Travel-Guide-VacationRentals)[Flights to Mesopotamia](https://expedia.ca/Cheap-Flights-To-Mesopotamia.d6208836.Travel-Guide-Flights)[Mesopotamia Car Rentals](https://expedia.ca/Car-Rentals-In-Mesopotamia.d6208836.Car-Rental-Guide)[Mesopotamia Vacation Packages](https://expedia.ca/Mesopotamia.d6208836.Destination-Travel-Guides)

![Mesopotamia showing a river or creek and forests](https://images.trvl-media.com/place/6208836/ca0c6990-9932-4f38-bee6-e89ce7080803.jpg?impolicy=fcrop&w=1200&h=500&q=medium)

# Find Historic Hotels in Mesopotamia 

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## Check availability on Mesopotamia Historic Hotels

Tonight

[Dec 18 - Dec 19](https://www.expedia.ca/Hotel-Search?regionId=6208836&startDate=2025-12-18&endDate=2025-12-19&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Tomorrow

[Dec 19 - Dec 20](https://www.expedia.ca/Hotel-Search?regionId=6208836&startDate=2025-12-19&endDate=2025-12-20&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

This weekend

[Dec 19 - Dec 21](https://www.expedia.ca/Hotel-Search?regionId=6208836&startDate=2025-12-19&endDate=2025-12-21&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Next weekend

[Dec 26 - Dec 28](https://www.expedia.ca/Hotel-Search?regionId=6208836&startDate=2025-12-26&endDate=2025-12-28&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

## Our top choices for Mesopotamia historic hotels

![Casino](https://images.trvl-media.com/lodging/2000000/1200000/1197100/1197026/a75881f1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Reception hall](https://images.trvl-media.com/lodging/2000000/1200000/1197100/1197026/028ca893.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![View from room](https://images.trvl-media.com/lodging/2000000/1200000/1197100/1197026/d7ac2335.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Property entrance](https://images.trvl-media.com/lodging/2000000/1200000/1197100/1197026/21b37ac2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Amérian Hotel Casino Gala

[](https://www.expedia.ca/Resistencia-Hotels-Amerian-Hotel-Casino-Gala.h1197026.Hotel-Information)

Resistencia

9.0/10

Wonderful

(167)

"Good check in"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Paul

[](https://www.expedia.ca/Resistencia-Hotels-Amerian-Hotel-Casino-Gala.h1197026.Hotel-Information)

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

[View all properties](https://expedia.ca/Hotel-Search?startDate=2026-01-01&endDate=2026-01-02&regionId=6208836&adults=2&specialized_stays_group_explore=historic_property&sort=RECOMMENDED&openPlayBack=true)

## Top Mesopotamia Hotel Reviews

![Holiday Inn Express Rosario by IHG](https://images.trvl-media.com/lodging/4000000/3250000/3243000/3242923/502819d5_y.jpg)

### Holiday Inn Express Rosario by IHG

10/10 Excellent

"It's a perfect please to stay! "

[](https://expedia.ca/Rosario-Hotels-Holiday-Inn-Express-Rosario.h3242923.Hotel-Information)

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