Title: Looe Key National Marine Sanctuary in United States of America - Tours and Activities | Expedia.ca [Looe Key National Marine Sanctuary Hotels](https://expedia.ca/Looe-Key-National-Marine-Sanctuary-Hotels.0-l553248621533115813-0.Travel-Guide-Filter-Hotels)[Flights to United States of America](https://expedia.ca/Destinations-In-United-States-Of-America.d201.Flight-Destinations)[Looe Key National Marine Sanctuary Car Rentals](https://expedia.ca/Car-Rentals-In-Looe-Key-National-Marine-Sanctuary.d553248621533115813.Car-Rental-Guide)[United States of America Vacations](https://expedia.ca/United-States-Of-America.d201.Destination-Travel-Guides) # Looe Key National Marine Sanctuary Tours and Activities ## Visit Looe Key National Marine Sanctuary Activities --- --- ## Plan a trip to see Looe Key National Marine Sanctuary Price found within the past 48 hours. Click for updated prices. ![Harrah’s Las Vegas – A Caesars Rewards Destination](https://images.trvl-media.com/lodging/1000000/50000/41400/41307/85070847_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Harrah’s Las Vegas – A Caesars Rewards Destination Las Vegas Strip CA $202 per person Feb 2 - Feb 6 found 1 day ago Roundtrip flight included Vancouver (YVR) to Las Vegas (LAS) 7.8/10 Good! (13,790 reviews) Clean room, friendly staff, Reviewed on Dec 16, 2025 ![Westgate Lakes Resort & Spa Universal Studios Area](https://images.trvl-media.com/lodging/1000000/810000/805000/804984/86e77c07_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Westgate Lakes Resort & Spa Universal Studios Area CA $559 per person Mar 5 - Mar 10 found 18 hours ago Roundtrip flight included Toronto (YYZ) to Orlando (MCO) 8.2/10 Very Good! (5,482 reviews) Room was nice and clean staff was friendly. Had one incident but not a big deal by any means. Only issue was whoever was smoking on their balcony made it hard for us to sleep as our room smelled like that every night they were there. Didnt tell on them (i was into that too for awhile) but thought it was inconsiderate of them Reviewed on Dec 16, 2025 ![Hawks Cay Resort](https://images.trvl-media.com/lodging/1000000/10000/6100/6068/b1845555_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Hawks Cay Resort CA $1,555 per person Mar 7 - Mar 14 found 1 day ago Roundtrip flight included Toronto (YYZ) to Miami (MIA) 8/10 Very Good! (1,003 reviews) The resort was beautiful, the room was nice and clean although the day after we arrived housekeeping did not come to our room to empty garbages and give us fresh towels and had to ask at front desk. But after that it was not a problem. Also 1 morning we woke up to no water in our room and had to call front desk and eventually was turned back on. Other than those things we had a nice time. Reviewed on Dec 14, 2025 ### Popular places to visit ![South Beach featuring a sandy beach and a coastal town as well as a large group of people](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/63000/63988-South-Beach-Fm.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Florida Keys Beaches 4.5/5(29 reviews) Why not spend a lazy afternoon at Florida Keys Beaches during your trip to Long Beach Estates? [](https://expedia.ca/Florida-Keys-Beaches-Florida.d553248635976496782.Vacation-Attraction) #### Munson Island Commune with nature and explore the great outdoors at Munson Island during your travels in Big Pine Key. While you're in the area, stroll along the beaches. [](https://expedia.ca/Munson-Island-Big-Pine-Key.d874556621345521664.Vacation-Attraction) #### Big Munson Island Commune with nature and explore the great outdoors at Big Munson Island during your travels in Big Pine Key. While you're in the area, stroll along the beaches. [](https://expedia.ca/Big-Munson-Island-Big-Pine-Key.d874555262665744384.Vacation-Attraction) #### Newfound Harbor Keys Commune with nature and explore the great outdoors at Newfound Harbor Keys during your travels in Big Pine Key. While you're in the area, wander around the natural setting. [](https://expedia.ca/Newfound-Harbor-Keys-Big-Pine-Key.d874556615670603776.Vacation-Attraction) #### Hopkins Island Commune with nature and explore the great outdoors at Hopkins Island during your travels in Big Pine Key. While you're in the area, wander around the natural setting. [](https://expedia.ca/Hopkins-Island-Big-Pine-Key.d874555017892454400.Vacation-Attraction) #### Cook Island Commune with nature and explore the great outdoors at Cook Island during your travels in Big Pine Key. While you're in the area, wander around the natural setting. [](https://expedia.ca/Cook-Island-Florida.d553248635976197877.Vacation-Attraction) --- ## Best Lodging Options Near Looe Key National Marine Sanctuary ## Check availability on hotels close to Looe Key National Marine Sanctuary [Tonight ](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.CheckPrices.Package&adults=2&openPlayBack=true®ionId=553248621533115813&startDate=2025-12-16&endDate=2025-12-17)[Dec 16 - Dec 17](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.CheckPrices.Package&adults=2&openPlayBack=true®ionId=553248621533115813&startDate=2025-12-16&endDate=2025-12-17) [Tomorrow night ](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.CheckPrices.Package&adults=2&openPlayBack=true®ionId=553248621533115813&startDate=2025-12-17&endDate=2025-12-18)[Dec 17 - Dec 18](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.CheckPrices.Package&adults=2&openPlayBack=true®ionId=553248621533115813&startDate=2025-12-17&endDate=2025-12-18) [This weekend ](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.CheckPrices.Package&adults=2&openPlayBack=true®ionId=553248621533115813&startDate=19%2F12%2F2025&endDate=21%2F12%2F2025)[Dec 19 - Dec 21](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.CheckPrices.Package&adults=2&openPlayBack=true®ionId=553248621533115813&startDate=19%2F12%2F2025&endDate=21%2F12%2F2025) [Next weekend ](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.CheckPrices.Package&adults=2&openPlayBack=true®ionId=553248621533115813&startDate=26%2F12%2F2025&endDate=28%2F12%2F2025)[Dec 26 - Dec 28](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.CheckPrices.Package&adults=2&openPlayBack=true®ionId=553248621533115813&startDate=26%2F12%2F2025&endDate=28%2F12%2F2025) ![Looe Key Reef Resort](https://images.trvl-media.com/lodging/5000000/4760000/4759500/4759500/63d12f01_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Looe Key Reef Resort 27340 Overseas Highway Summerland Key FL [](https://expedia.ca/Ramrod-Key-Hotels-Looe-Key-Reef-Resort.h4759500.Hotel-Information) ![300’ Private Beach, Pool & Rooftop w Panoramic Ocean Views](https://images.trvl-media.com/lodging/90000000/89060000/89054800/89054710/8a158c84_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### 300’ Private Beach, Pool & Rooftop w Panoramic Ocean Views Big Pine Key FL [](https://expedia.ca/Big-Pine-Key-Hotels-300-Private-Beach.h89054710.Hotel-Information) ![Barnacle Resort](https://images.trvl-media.com/lodging/91000000/90990000/90989500/90989471/048a25f3_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Barnacle Resort 1557 Long Beach Dr Big Pine Key FL [](https://expedia.ca/Big-Pine-Key-Hotels-Barnacle-Bed-And-Breakfast.h90989471.Hotel-Information) ![Star Room Barnacle Resort](https://images.trvl-media.com/lodging/112000000/111160000/111152500/111152457/9bf80e17_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Star Room Barnacle Resort Big Pine Key FL [](https://expedia.ca/Big-Pine-Key-Hotels-Star-Room-Barnacle-Bnb.h111152457.Hotel-Information) ![Treehouse Private Village Barnacle Resort](https://images.trvl-media.com/lodging/112000000/111160000/111152500/111152459/d1e84791_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Treehouse Private Village Barnacle Resort Big Pine Key FL [](https://expedia.ca/Big-Pine-Key-Hotels-Treehouse-Private-Village.h111152459.Hotel-Information) ![Ocean Depth Room Barnacle Resort](https://images.trvl-media.com/lodging/112000000/111160000/111152500/111152453/4bef164b_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Ocean Depth Room Barnacle Resort Big Pine Key FL [](https://expedia.ca/Big-Pine-Key-Hotels-Ocean-Depth-Room-Barnacle-Bed-And-Breakfast.h111152453.Hotel-Information) ![Beach View Room Dormitory Room Barnacle Resort](https://images.trvl-media.com/lodging/112000000/111280000/111271600/111271548/22b78c46_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Beach View Room Dormitory Room Barnacle Resort Big Pine Key FL [](https://expedia.ca/Big-Pine-Key-Hotels-Beach-View-Room-Barnacle-Bed-And-Breakfast.h111271548.Hotel-Information) ![Ocean View Suite Barnacle Resort](https://images.trvl-media.com/lodging/112000000/111160000/111152500/111152455/ce8ae237_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Ocean View Suite Barnacle Resort Big Pine Key FL [](https://expedia.ca/Big-Pine-Key-Hotels-Ocean-View-Room-Barnacle-Bed-And-Breakfast.h111152455.Hotel-Information) ![Anchors Aweigh: Stunning Oceanfront Views, Dockage, Private Pool, Tiki Hut, Spacious & Dog-Friendly!](https://images.trvl-media.com/lodging/71000000/70040000/70039800/70039765/f6b32105_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Anchors Aweigh: Stunning Oceanfront Views, Dockage, Private Pool, Tiki Hut, Spacious & Dog-Friendly! Summerland Key FL [](https://expedia.ca/Summerland-Key-Hotels-Anchors-Aweigh-10-Off-Fall-2025.h70039765.Hotel-Information) [See all 786 properties in Looe Key National Marine Sanctuary](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Package®ionId=553248621533115813) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.