Title: Car Rental Midway Point of Route 66, TX - Expedia.ca [Adrian Travel Guide](https://expedia.ca/Adrian.dx3000422512)[Midway Point of Route 66 Hotels](https://expedia.ca/Midway-Point-Of-Route-66-Hotels.0-l938001438370816000-0.Travel-Guide-Filter-Hotels)[Flights to Adrian](https://expedia.ca/Cheap-Flights-To-Adrian.d3000422512.Travel-Guide-Flights)[Midway Point of Route 66 Vacations](https://expedia.ca/Midway-Point-Of-Route-66-Adrian.d938001438370816000.Vacation-Attraction) ![](https://a.travel-assets.com/travel-assets-manager/fallback-images-brand/bex_car.jpeg?impolicy=fcrop&w=1200&h=300&q=medium) # Midway Point of Route 66 Car Rental ## Search and Compare from Car Companies in Midway Point of Route 66 ## Featured car rental suppliers Compare from agencies ![car supplier logos](https://forever.travel-assets.com/flex/flexmanager/images/2022/05/16/BEXCA-car-suppliers-logo-desktop.jpg) Compare car suppliers to unlock big savings, and package your flight, hotel, and car to save even more. Members save 10% more on select hotels, cars, activities and vacation rentals. [Sign up.](https://www.expedia.ca/signup?enable_registration=true&rfrr=TG.CM) Enjoy maximum flexibility with penalty-free cancellation on most car rentals. ## Top Car Deals in Midway Point of Route 66 \* Price found within the past 6 days. Click for updated prices. ### Economy Chevrolet Spark or similar - 4 people Adrian, Texas, USA ![Chevrolet Spark](//images.trvl-media.com/media/content/shared/images/car/Common_90X50/US_EC.png) [](https://expedia.ca/carsearch?paandi=true&fdrp=1&styp=2&dagv=1&subm=1&locn=Midway%20Point%20of%20Route%2066,%20Adrian,%20Texas,%20United%20States%20of%20America&dpln=938001438370816000&date1=18/09/2025&date2=20/09/2025&crfrr=defaultFlex&SearchType=Place&selCC=[%22economy%22]) ### Compact Ford Focus or similar - 4 people Adrian, Texas, USA ![Ford Focus](//images.trvl-media.com/media/content/shared/images/car/Common_90X50/US_CC.png) [](https://expedia.ca/carsearch?paandi=true&fdrp=1&styp=2&dagv=1&subm=1&locn=Midway%20Point%20of%20Route%2066,%20Adrian,%20Texas,%20United%20States%20of%20America&dpln=938001438370816000&date1=18/09/2025&date2=20/09/2025&crfrr=defaultFlex&SearchType=Place&selCC=[%22compact%22]) ### Midsize Toyota Corolla or similar - 5 people Adrian, Texas, USA ![Toyota Corolla](//images.trvl-media.com/media/content/shared/images/car/Common_90X50/US_IC.png) [](https://expedia.ca/carsearch?paandi=true&fdrp=1&styp=2&dagv=1&subm=1&locn=Midway%20Point%20of%20Route%2066,%20Adrian,%20Texas,%20United%20States%20of%20America&dpln=938001438370816000&date1=18/09/2025&date2=20/09/2025&crfrr=defaultFlex&SearchType=Place&selCC=[%22midsize%22]) ### SUV Jeep Compass or similar - 5 people Adrian, Texas, USA ![Jeep Compass](//images.trvl-media.com/media/content/shared/images/car/Common_90X50/US_SF.png) [](https://expedia.ca/carsearch?paandi=true&fdrp=1&styp=2&dagv=1&subm=1&locn=Midway%20Point%20of%20Route%2066,%20Adrian,%20Texas,%20United%20States%20of%20America&dpln=938001438370816000&date1=18/09/2025&date2=20/09/2025&crfrr=defaultFlex&SearchType=Place&selCC=[%22suv%22]) ### Don't see what you're looking for? See all car rentals in Midway Point of Route 66 [View all cars](https://expedia.ca/carsearch?paandi=true&fdrp=1&styp=2&dagv=1&subm=1&locn=Midway%20Point%20of%20Route%2066,%20Adrian,%20Texas,%20United%20States%20of%20America&dpln=938001438370816000&date1=18/09/2025&date2=20/09/2025&crfrr=defaultFlex&SearchType=Place) ## Car Rental Information | Popular car types: | [SUV](https://www.expedia.ca/lp/b/car-rental/suv?rfrr=car.table.SUV), [Full Size](https://www.expedia.ca/lp/b/car-rental/fullsize?rfrr=car.table.FullSize), [Economy](https://www.expedia.ca/lp/b/car-rental/economy?rfrr=car.table.Economy) | | --- | --- | | Car suppliers available: | | | Our best deal of the day: | | | Our second best deal of the day: | | | Our third best deal of the day: | | | From the airport to your hotel: | [Airport Transportation](https://www.expedia.ca/ground-transfers?rfrr=car.table.AirportTransportation) | - Experience new places with Expedia ### Cities near Midway Point of Route 66 - [Car rentals in Hereford](https://expedia.ca/Car-Rentals-In-Hereford.d8336.Car-Rental-Guide) - [Car rentals in Vega](https://expedia.ca/Car-Rentals-In-Vega.d10261.Car-Rental-Guide) - [Car rentals in West Texas](https://expedia.ca/Car-Rentals-In-West-Texas.d6229323.Car-Rental-Guide) - [Car rentals in The South](https://expedia.ca/Car-Rentals-In-The-South.d6209865.Car-Rental-Guide) - [Car rentals in Central United States](https://expedia.ca/Car-Rentals-In-Central-United-States.d6209877.Car-Rental-Guide) - [Car rentals in Panhandle Plains](https://expedia.ca/Car-Rentals-In-Panhandle-Plains.d6058805.Car-Rental-Guide) - [Car rentals in Great Plains](https://expedia.ca/Car-Rentals-In-Great-Plains.d6209958.Car-Rental-Guide) ### Car Rental Deals in Top Destinations - [Car rentals in Las Vegas](https://expedia.ca/Car-Rentals-In-Las-Vegas.d178276.Car-Rental-Guide) - [Car rentals in New York](https://expedia.ca/Car-Rentals-In-New-York.d178293.Car-Rental-Guide) - [Car rentals in Orlando](https://expedia.ca/Car-Rentals-In-Orlando.d178294.Car-Rental-Guide) - [Car rentals in London](https://expedia.ca/Car-Rentals-In-London.d178279.Car-Rental-Guide) - [Car rentals in Paris](https://expedia.ca/Car-Rentals-In-Paris.d179898.Car-Rental-Guide) - [Car rentals in Cancun](https://expedia.ca/Car-Rentals-In-Cancun.d179995.Car-Rental-Guide) - [Car rentals in Miami](https://expedia.ca/Car-Rentals-In-Miami.d178286.Car-Rental-Guide) - [Car rentals in Los Angeles](https://expedia.ca/Car-Rentals-In-Los-Angeles.d178280.Car-Rental-Guide) - [Car rentals in Rome](https://expedia.ca/Car-Rentals-In-Rome.d179899.Car-Rental-Guide) - [Car rentals in Punta Cana](https://expedia.ca/Car-Rentals-In-Punta-Cana.d601906.Car-Rental-Guide) - [Car rentals in Riviera Maya](https://expedia.ca/Car-Rentals-In-Riviera-Maya.d602901.Car-Rental-Guide) - [Car rentals in Barcelona](https://expedia.ca/Car-Rentals-In-Barcelona.d179992.Car-Rental-Guide) - [Car rentals in San Francisco](https://expedia.ca/Car-Rentals-In-San-Francisco.d178305.Car-Rental-Guide) - [Car rentals in San Diego County](https://expedia.ca/Destinations-In-San-Diego-County.d178304.Car-Rental-Destinations) - [Car rentals in Oahu](https://expedia.ca/Car-Rentals-In-Oahu.d180077.Car-Rental-Guide) - [Car rentals in Chicago](https://expedia.ca/Car-Rentals-In-Chicago.d178248.Car-Rental-Guide) ### Top Hotels in Midway Point of Route 66 - [Capital O Route 66 Country Inn Vega Tx](https://expedia.ca/Vega-Hotels-Americas-Best-Value-Inn-Suites-Vega.h15301.Hotel-Information) - [Days Inn by Wyndham Vega TX](https://expedia.ca/Vega-Hotels-Days-Inn-By-Wyndham-Vega-TX.h120685.Hotel-Information) - [Bonanza Motel Vega](https://expedia.ca/Vega-Hotels-Bonanza-Motel-Vega.h16781444.Hotel-Information) ![](https://a.travel-assets.com/mad-service/footer/bnaBanners/BEX_Footer.jpg) ## Go further with the Expedia app Save on select hotels and earn double points when you book on the app. Our app deals help you to save on trips so you can travel more and manage it all on the go. Scan the QR code with your device camera and download our app ![QR code to download the app](data:image/png;base64,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)