Title: Lewis and Clark Trail Trailhead in St. Louis - Tours and Activities | Expedia.ca [Lewis and Clark Trail Trailhead Hotels](https://expedia.ca/Lewis-And-Clark-Trail-Trailhead-Hotels.0-l641530008594042880-0.Travel-Guide-Filter-Hotels)[Flights to St. Louis](https://expedia.ca/Cheap-Flights-To-St-Louis.d178309.Travel-Guide-Flights)[Things to do in St. Louis](https://expedia.ca/Things-To-Do-In-St-Louis.d178309.Travel-Guide-Activities)[Lewis and Clark Trail Trailhead Car Rentals](https://expedia.ca/Car-Rentals-In-Lewis-And-Clark-Trail-Trailhead.d641530008594042880.Car-Rental-Guide)[St. Louis Vacation Packages](https://expedia.ca/St-Louis.d178309.Destination-Travel-Guides) # Lewis and Clark Trail Trailhead Tours and Activities ## Visit Lewis and Clark Trail Trailhead Activities [St. Louis travel guide](https://expedia.ca/St-Louis.dx178309) --- --- ## Plan a trip to see Lewis and Clark Trail Trailhead Price found within the past 48 hours. Click for updated prices. ![Hotel Indigo St Louis - Central West End by IHG](https://images.trvl-media.com/lodging/1000000/30000/22100/22068/bd89b9ce_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Hotel Indigo St Louis - Central West End by IHG Central West End CA $1,076 per person Mar 26 - Mar 31 found 23 hours ago Roundtrip non-stop flight included Regina (YQR) to St. Louis (STL) 8.2/10 Very Good! (1,000 reviews) Just a really cool place. One of the cleanest hotels I've stayed in i St Louis. Everyone was really friendly. Reviewed on Feb 6, 2026 ![The Wildwood Hotel](https://images.trvl-media.com/lodging/2000000/1770000/1768200/1768149/800a6847_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### The Wildwood Hotel CA $1,196 per person Mar 26 - Mar 31 found 23 hours ago Roundtrip non-stop flight included Regina (YQR) to St. Louis (STL) 9.2/10 Wonderful! (1,600 reviews) Great room and friendly staff in a nice area. Will come again. Reviewed on Feb 11, 2026 ![The Westin St. Louis](https://images.trvl-media.com/lodging/1000000/470000/460400/460354/a27d8a03_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### The Westin St. Louis Downtown St. Louis CA $1,875 per person Mar 26 - Mar 31 found 23 hours ago Roundtrip non-stop flight included Regina (YQR) to St. Louis (STL) 8.6/10 Excellent! (1,001 reviews) Dirty towels and rude front desk staff member One of the lights in the room was broken. Shower head was also dirty. Overall could’ve been better Reviewed on Feb 12, 2026 ### Popular places to visit ![Wetlands landscape with a bird blind and cloudy sky reflected in a lake at the August A. Busch Memorial Conservation Area in St. Charles County Missouri](https://images.trvl-media.com/place/6160337/5138d652-49fb-41de-8fd4-a7bb27471f3e.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### August A. Busch Memorial Conservation Area Explore the great outdoors at August A. Busch Memorial Conservation Area, a lovely green space in Defiance. While in this family-friendly area, you can savor the top-notch restaurants. [](https://expedia.ca/August-A-Busch-Memorial-Conservation-Area-St-Louis.d6160337.Vacation-Attraction) ![9-11 memorial in New York ](https://images.trvl-media.com/place/6268196/1e2df18b-5a0c-4e2a-9bc0-6956a83c47d9.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### 9-11 Memorial Learn about the local history of O'Fallon when you spend time at 9-11 Memorial. While in this family-friendly area, you can savor the top-notch restaurants. [](https://expedia.ca/9-11-Memorial-St-Louis.d6268196.Vacation-Attraction) ![Missouri wineries have some of the most superb wine we've ever tasted! We recommend sipping on some chambourcin while basking in the sunshine. ](https://images.trvl-media.com/place/553248621532648567/f82f9409-75a2-47f3-a8fc-2d7c278cc07c.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Chandler Hill Vineyards You can enjoy a tasting or tour at Chandler Hill Vineyards during your travels to Defiance. While in this romantic area, you can savor the top-notch restaurants. [](https://expedia.ca/Chandler-Hill-Vineyards-Defiance.d553248621532648567.Vacation-Attraction) #### Weldon Spring Site Interpretive Center You can spend time browsing the exhibits at Weldon Spring Site Interpretive Center during your trip to Weldon Spring Heights. Attend a sporting event while in this family-friendly area or simply enjoy the top-notch restaurants. [](https://expedia.ca/Weldon-Spring-Site-Interpretive-Center-St-Louis.d553248621532648611.Vacation-Attraction) #### Hamburg Trail Trailhead You can take time to visit Hamburg Trail Trailhead during your travels to Hamburg. [](https://expedia.ca/Hamburg-Trail-Trailhead-St-Louis.d641529175733194752.Vacation-Attraction) #### Missouri Bluffs Golf Course Enjoy a round of golf in Weldon Spring Heights at Missouri Bluffs Golf Course. Experience the great live music or attend a sporting event in this family-friendly area. [](https://expedia.ca/Missouri-Bluffs-Golf-Course-St-Louis.d553248621532648614.Vacation-Attraction) --- ## Best Lodging Options Near Lewis and Clark Trail Trailhead ## Check availability on hotels close to Lewis and Clark Trail Trailhead [Tonight ](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.CheckPrices.Package&adults=2&openPlayBack=true®ionId=641530008594042880&startDate=2026-02-13&endDate=2026-02-14)[Feb 13 - Feb 14](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.CheckPrices.Package&adults=2&openPlayBack=true®ionId=641530008594042880&startDate=2026-02-13&endDate=2026-02-14) [Tomorrow night ](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.CheckPrices.Package&adults=2&openPlayBack=true®ionId=641530008594042880&startDate=2026-02-14&endDate=2026-02-15)[Feb 14 - Feb 15](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.CheckPrices.Package&adults=2&openPlayBack=true®ionId=641530008594042880&startDate=2026-02-14&endDate=2026-02-15) [This weekend ](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.CheckPrices.Package&adults=2&openPlayBack=true®ionId=641530008594042880&startDate=13%2F02%2F2026&endDate=15%2F02%2F2026)[Feb 13 - Feb 15](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.CheckPrices.Package&adults=2&openPlayBack=true®ionId=641530008594042880&startDate=13%2F02%2F2026&endDate=15%2F02%2F2026) ![The Wildwood Hotel](https://images.trvl-media.com/lodging/2000000/1770000/1768200/1768149/800a6847_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### The Wildwood Hotel 2801 Fountain Pl Wildwood MO [](https://expedia.ca/St-Louis-Hotels-The-Wildwood-Hotel.h1768149.Hotel-Information) ![Comfort Inn & Suites St. Louis - O'Fallon](https://images.trvl-media.com/lodging/1000000/930000/922100/922031/7c698b9f_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Comfort Inn & Suites St. Louis - O'Fallon 100 Comfort Inn Ct O'Fallon MO [](https://expedia.ca/St-Louis-Hotels-Comfort-Inn-Suites-St-Louis-OFallon.h922031.Hotel-Information) ![Drury Plaza Hotel St. Louis Chesterfield](https://images.trvl-media.com/lodging/2000000/1350000/1346800/1346760/c1fcfc39_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Drury Plaza Hotel St. Louis Chesterfield 355 Chesterfield Ctr Chesterfield MO [](https://expedia.ca/St-Louis-Hotels-Drury-Plaza-Hotel-St-Louis-Chesterfield.h1346760.Hotel-Information) ![Fairfield Inn & Suites by Marriott St. Louis Chesterfield](https://images.trvl-media.com/lodging/1000000/130000/126800/126794/b774ae26_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Fairfield Inn & Suites by Marriott St. Louis Chesterfield 1065 Chesterfield Pkwy E Chesterfield MO [](https://expedia.ca/St-Louis-Hotels-SpringHill-Suites-By-Marriott-St-Louis-Chesterfield.h126794.Hotel-Information) ![Extended Stay America Suites St Louis St Peters](https://images.trvl-media.com/lodging/1000000/70000/66100/66038/w2993h2000x0y0-d823c428_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Extended Stay America Suites St Louis St Peters 5555 Veterans Memorial Pkwy St. Peters MO [](https://expedia.ca/St-Louis-Hotels-Extended-Stay-America-Suites-St-Louis-St-Peters.h66038.Hotel-Information) ![Hampton Inn St. Charles St. Peters](https://images.trvl-media.com/lodging/1000000/30000/20200/20181/8c366380_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Hampton Inn St. Charles St. Peters 3720 W Clay St St. Charles MO [](https://expedia.ca/St-Louis-Hotels-Hampton-Inn-St-LouisSt-Charles.h20181.Hotel-Information) ![Hollywood Casino & Hotel St. Louis](https://images.trvl-media.com/lodging/1000000/90000/82600/82568/7188325f_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Hollywood Casino & Hotel St. Louis 777 Casino Center Drive Maryland Heights MO [](https://expedia.ca/St-Louis-Hotels-Hollywood-Casino-Hotel-St-Louis.h82568.Hotel-Information) ![Ameristar Casino Resort and Spa](https://images.trvl-media.com/lodging/2000000/1880000/1873300/1873292/c42cf5fe_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Ameristar Casino Resort and Spa 1 Ameristar Blvd St. Charles MO [](https://expedia.ca/St-Louis-Hotels-Ameristar-Casino-Resort-And-Spa.h1873292.Hotel-Information) ![Best Western Plus The Charles Hotel](https://images.trvl-media.com/lodging/1000000/50000/40300/40297/d9e74cfa_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Best Western Plus The Charles Hotel 1425 South 5th Street St. Charles MO [](https://expedia.ca/St-Louis-Hotels-Best-Western-Plus-The-Charles-Hotel.h40297.Hotel-Information) [See all 2,341 properties in Lewis and Clark Trail Trailhead](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Package®ionId=641530008594042880) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ![](https://forever.travel-assets.com/flex/flexmanager/images/2026/02/06/expedia-sale-2026-desktop-us-ca.jpg?impolicy=fcrop&w=1400&h=600&q=mediumHigh) ## The Annual Vacation Sale Members save up to 40% on hotels and homes. Plan this year’s big trip and save. [Book now](https://expedia.ca/deals?rfrr=DX_POI_Spring_PROMO_641530008594042880)