Title: Isla Santa Maria Vacation Rentals : Short-Term Rentals for 2025 | Expedia.ca [Isla Santa Maria Travel Guide](https://expedia.ca/Isla-Santa-Maria.dx6101241)[Hotels in Isla Santa Maria](https://expedia.ca/Isla-Santa-Maria-Hotels.d6101241.Travel-Guide-Hotels)[Flights to Isla Santa Maria](https://expedia.ca/Cheap-Flights-To-Isla-Santa-Maria.d6101241.Travel-Guide-Flights)[Isla Santa Maria Car Rentals](https://expedia.ca/Car-Rentals-In-Isla-Santa-Maria.d6101241.Car-Rental-Guide)[Isla Santa Maria Vacation Packages](https://expedia.ca/Isla-Santa-Maria.d6101241.Destination-Travel-Guides) ![Default HTG hotel image](https://a.travel-assets.com/travel-assets-manager/fallback-images-brand/bex_lodging_v2.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Isla Santa Maria Vacation Rentals - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check prices for these dates Tonight [Nov 22 - Nov 23](https://www.expedia.ca/Hotel-Search?regionId=6101241&startDate=2025-11-22&endDate=2025-11-23&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Nov 23 - Nov 24](https://www.expedia.ca/Hotel-Search?regionId=6101241&startDate=2025-11-23&endDate=2025-11-24&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Nov 28 - Nov 30](https://www.expedia.ca/Hotel-Search?regionId=6101241&startDate=2025-11-28&endDate=2025-11-30&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two weeks [Dec 5 - Dec 7](https://www.expedia.ca/Hotel-Search?regionId=6101241&startDate=2025-12-05&endDate=2025-12-07&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Vacation Rentals in Isla Santa Maria ![](https://forever.travel-assets.com/flex/flexmanager/images/2025/11/05/BEX-BF-25_CA_1_Desktop.jpg?impolicy=fcrop&w=1400&h=600&q=mediumHigh) ## Black Friday Sale Limited-time deals: save up to 50% on select hotels [Book now](https://expedia.ca/deals?rfrr=VR_BF_PROMO_6101241) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in](https://expedia.ca/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FIsla-Santa-Maria-Vacation-Rentals.d6101241.Travel-Guide-VacationRentals)[Sign up, it's free](https://expedia.ca/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FIsla-Santa-Maria-Vacation-Rentals.d6101241.Travel-Guide-VacationRentals) ## Top Isla Santa Maria Hotel Reviews ## Find out more about Isla Santa Maria You always said you would go on a dream vacation someday. Now, someday is here. But you don’t just want to dip your toe into the trip of a lifetime, you want to cannon ball into the deep end. Go ahead, unplug and unwind in style. When you book one of our vacation rentals, the ordinary is in the rearview. Instead of sharing your vacation with hundreds of hotel guests, you get to take advantage of all the space at your private apartment or room. You also get to enjoy all the amenities of a private residence for a truly unique and memorable stay. Why don’t you take off your shoes and settle in for a while? Your vacation just got upgraded. As much as you love your short-term rental, it’s always good to get out and explore to soak up . Live like a local: Eat regional food, cheer on the home team, and visit the best cultural attractions in town. No matter the season, there is always something going on in . Seeing all the best attractions is bound to make you fall in love with Isla Santa Maria. Who knows, you may even be tempted to extend your vacation rental stay. There’s a reason home rentals are so popular here—after a long day of exploration, going back to your very own living room to stretch out is a dream come true. It’s your escape so why share it? You deserve your own slice of paradise. Booking your vacation rental on Expedia is simple and safe. Just pick your dates to search for the perfect property and book securely. We let you contact the property owner directly to make any special arrangements. All that’s left to do is show up with bells on and have a memorable vacation. With all the amenities available in short-term rentals, that won’t be hard to do. ## Explore a world of travel with Expedia - Trending destinations on Expedia.ca ### Trending destinations on Expedia.ca - [Canmore Vacation Rentals](https://www.expedia.ca/Canmore-Vacation-Rentals.d10131.Travel-Guide-VacationRentals) - [Maui Vacation Rentals](https://www.expedia.ca/Maui-Vacation-Rentals.d180073.Travel-Guide-VacationRentals) - [Kelowna Vacation Rentals](https://www.expedia.ca/Kelowna-Vacation-Rentals.d3997.Travel-Guide-VacationRentals) - [Whistler Vacation Rentals](https://www.expedia.ca/Whistler-Vacation-Rentals.d4115.Travel-Guide-VacationRentals) - [Florida Vacation Rentals](https://www.expedia.ca/Destinations-In-Florida.d211.Vacation-Rental-Destinations) - [Victoria Vacation Rentals](https://www.expedia.ca/Victoria-Vacation-Rentals.d4138.Travel-Guide-VacationRentals) - [Vancouver Vacation Rentals](https://www.expedia.ca/Vancouver-Vacation-Rentals.d178315.Travel-Guide-VacationRentals) - 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Scan the QR code with your device camera and download our app ![QR code to download the app](data:image/png;base64,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)