Title: Book the Best Santa Cruz Island LUXURY Hotels - Upscale Hotels in Santa Cruz Island | Expedia.ca [Santa Cruz Island Travel Guide](https://expedia.ca/Santa-Cruz-Island.dx6053670)[Hotels in Santa Cruz Island](https://expedia.ca/Santa-Cruz-Island-Hotels.d6053670.Travel-Guide-Hotels)[Vacation Rentals in Santa Cruz Island](https://expedia.ca/Santa-Cruz-Island-Vacation-Rentals.d6053670.Travel-Guide-VacationRentals)[Flights to Santa Cruz Island](https://expedia.ca/Cheap-Flights-To-Santa-Cruz-Island.d6053670.Travel-Guide-Flights)[Things to do in Santa Cruz Island](https://expedia.ca/Things-To-Do-In-Santa-Cruz-Island.d6053670.Travel-Guide-Activities)[Santa Cruz Island Car Rentals](https://expedia.ca/Car-Rentals-In-Santa-Cruz-Island.d6053670.Car-Rental-Guide)[Santa Cruz Island Vacation Packages](https://expedia.ca/Santa-Cruz-Island.d6053670.Destination-Travel-Guides) ![](https://mediaim.expedia.com/destination/1/04d5e478ee175ffd174b1e23d51916f4.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find luxury hotels in Santa Cruz Island ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Santa Cruz Island Luxury Hotels Tonight [Oct 12 - Oct 13](https://www.expedia.ca/Hotel-Search?regionId=6053670&startDate=2025-10-12&endDate=2025-10-13&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Oct 13 - Oct 14](https://www.expedia.ca/Hotel-Search?regionId=6053670&startDate=2025-10-13&endDate=2025-10-14&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Oct 17 - Oct 19](https://www.expedia.ca/Hotel-Search?regionId=6053670&startDate=2025-10-17&endDate=2025-10-19&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two weeks [Oct 24 - Oct 26](https://www.expedia.ca/Hotel-Search?regionId=6053670&startDate=2025-10-24&endDate=2025-10-26&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top Santa Cruz Island Luxury Hotels ![Exterior](https://images.trvl-media.com/lodging/11000000/10090000/10087200/10087137/08eca00e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/11000000/10090000/10087200/10087137/7d701bfa.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe Room, 2 Double Beds](https://images.trvl-media.com/lodging/11000000/10090000/10087200/10087137/d196b036.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Dining](https://images.trvl-media.com/lodging/11000000/10090000/10087200/10087137/507bf9e5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hotel Ninfa Puerto Ayora 8.4/10 Very good (213) "Great hotel to use as your base while exploring Galapagos, and a lovely pool, hot tub and bar to come home to at the end of the day" [](https://www.expedia.ca/Puerto-Ayora-Hotels-Hotel-Ninfa.h10087137.Hotel-Information) ![Breakfast, lunch, dinner served; international cuisine, ocean views ](https://images.trvl-media.com/lodging/3000000/2060000/2057800/2057779/4a332d25.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/3000000/2060000/2057800/2057779/92acdc7e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite Signature | Terrace/patio](https://images.trvl-media.com/lodging/3000000/2060000/2057800/2057779/f9620d53.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite Signature](https://images.trvl-media.com/lodging/3000000/2060000/2057800/2057779/a7defe75.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Blu Galapagos Sustainable Waterfront Lodge Puerto Ayora 8.8/10 Excellent (120) "We had a great stay at Blu Galapagos. Loved the location and our room was perfect - Great view, well maintained and had a king bed. Even if the description says queen bed and the picture looks like a king, you can trust the picture. Morning breakfast with iguanas and seals, and all day Galapagos coffee availability made this stay special. " CA $221 CA $243 total Nov 3 - Nov 4 [](https://www.expedia.ca/Puerto-Ayora-Hotels-Galapagos-Habitat-By-Eco-Luxury-Group.h2057779.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/2000000/1870000/1862600/1862515/62b50762.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Boating](https://images.trvl-media.com/lodging/2000000/1870000/1862600/1862515/1802a44b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium Double Room](https://images.trvl-media.com/lodging/2000000/1870000/1862600/1862515/w2236h1687x0y0-81876455.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/2000000/1870000/1862600/1862515/75f9c54d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Finch Bay Galapagos Hotel Puerto Ayora 9.2/10 Wonderful (87) "Beautiful resort, impeccably clean, very kind and enthusiastic staff. Delicious restaurant. 5 stars all around, we will definitely return!" CA $657 CA $736 total Nov 5 - Nov 6 [](https://www.expedia.ca/Puerto-Ayora-Hotels-Finch-Bay-Galapagos-Hotel.h1862515.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2025-10-26&endDate=2025-10-27®ionId=6053670&adults=2&star=50&sort=RECOMMENDED&openPlayBack=true) ## Find out more about Santa Cruz Island ### Santa Cruz Islandand its attractions for luxury travelers Santa Cruz Island in the Galápagos is a paradise for luxury travellers seeking a unique blend of adventure and comfort. Begin your exploration at the Charles Darwin Research Station, where you can learn about the conservation efforts for the iconic Galápagos tortoises while enjoying the lush surroundings. For exquisite diving experiences, head to the underwater marvels of Devil's Crown, where you can swim alongside vibrant marine life in crystal-clear waters. The stunning white sands of Tortuga Bay offer a serene escape, perfect for sunbathing or kayaking in a picturesque setting. Indulge in gourmet dining at local high-end restaurants that serve fresh seafood and local delicacies, with many breathtaking ocean views. A stay in the upscale area of Puerto Ayora provides luxurious hotel options with personalised services, allowing you to unwind after a day of exploration. Hotels here often feature spacious suites, infinity pools, and spa treatments, ensuring that your needs are met with the utmost care and attention. ## Top Santa Cruz Island Hotel Reviews ![Blu Galapagos Sustainable Waterfront Lodge](//images.trvl-media.com/lodging/3000000/2060000/2057800/2057779/4a332d25_y.jpg) ### Blu Galapagos Sustainable Waterfront Lodge 10/10 Excellent "I was very pleased with Blu Galapagos. The rooms were very clean, great view, very helpful staff. My only recommendation would be to not use the tour company in the hotel. I booked a tour after being very specific in what I wanted to see. I was assured it was possible but once I arrived the tour guide explained there was not enough time within my limited time to see what I came for. Very disappointed. Was not offered any refund or other compensation. The tour was not inexpensive and feel I was completely lied to and intentionally misled. " [](https://expedia.ca/Puerto-Ayora-Hotels-Galapagos-Habitat-By-Eco-Luxury-Group.h2057779.Hotel-Information) ![Hotel Ninfa](//images.trvl-media.com/lodging/11000000/10090000/10087200/10087137/08eca00e_y.jpg) ### Hotel Ninfa 10/10 Excellent "Great" [](https://expedia.ca/Puerto-Ayora-Hotels-Hotel-Ninfa.h10087137.Hotel-Information) ![Finch Bay Galapagos Hotel](//images.trvl-media.com/lodging/2000000/1870000/1862600/1862515/62b50762_y.jpg) ### Finch Bay Galapagos Hotel 10/10 Excellent "Beautiful resort, impeccably clean, very kind and enthusiastic staff. Delicious restaurant. 5 stars all around, we will definitely return!" 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