Title: Upstate South Carolina Vacation Home Rentals from CA $301: Search Top Private Vacation Homes for Rent | Expedia.ca [Upstate South Carolina Travel Guide](https://expedia.ca/Upstate-South-Carolina.dx553248635975748552)[Hotels in Upstate South Carolina](https://expedia.ca/Upstate-South-Carolina-Hotels.d553248635975748552.Travel-Guide-Hotels)[Vacation Rentals in Upstate South Carolina](https://expedia.ca/Upstate-South-Carolina-Vacation-Rentals.d553248635975748552.Travel-Guide-VacationRentals)[Flights to Upstate South Carolina](https://expedia.ca/Cheap-Flights-To-Upstate-South-Carolina.d553248635975748552.Travel-Guide-Flights)[Things to do in Upstate South Carolina](https://expedia.ca/Things-To-Do-In-Upstate-South-Carolina.d553248635975748552.Travel-Guide-Activities)[Upstate South Carolina Car Rentals](https://expedia.ca/Car-Rentals-In-Upstate-South-Carolina.d553248635975748552.Car-Rental-Guide)[Upstate South Carolina Vacation Packages](https://expedia.ca/Upstate-South-Carolina.d553248635975748552.Destination-Travel-Guides) ![Greenville - Spartanburg featuring mountains, views and a sunset](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/63000/63748-Greenville-Spartanburg.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Upstate South Carolina Vacation Rentals ![calendar shield illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation ![deals illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) ![bed illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check prices for these dates Next weekend [Oct 3 - Oct 5](https://www.expedia.ca/Hotel-Search?regionId=553248635975748552&startDate=2025-10-03&endDate=2025-10-05&adults=2&lodging=VACATION_HOME&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two weeks [Oct 10 - Oct 12](https://www.expedia.ca/Hotel-Search?regionId=553248635975748552&startDate=2025-10-10&endDate=2025-10-12&adults=2&lodging=VACATION_HOME&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In one month [Oct 24 - Oct 26](https://www.expedia.ca/Hotel-Search?regionId=553248635975748552&startDate=2025-10-24&endDate=2025-10-26&adults=2&lodging=VACATION_HOME&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two months [Nov 21 - Nov 23](https://www.expedia.ca/Hotel-Search?regionId=553248635975748552&startDate=2025-11-21&endDate=2025-11-23&adults=2&lodging=VACATION_HOME&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Browse Select Upstate South Carolina Vacation Homes ![Interior](https://images.trvl-media.com/lodging/58000000/57380000/57370700/57370635/c32a6cf3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/58000000/57380000/57370700/57370635/7f1b16fe.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV, fireplace, offices](https://images.trvl-media.com/lodging/58000000/57380000/57370700/57370635/2858581d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV, fireplace, offices](https://images.trvl-media.com/lodging/58000000/57380000/57370700/57370635/104dfb43.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Luxurious Ladson House-B in Greenville, South Carolina Greenville 9.8/10 Exceptional (16) "Great location, spacious and clean. Good communication with host. Would recommend!" [](https://www.expedia.ca/Greenville-Spartanburg-Hotels-Luxurious-Ladson-House-B-In-Greenville.h57370635.Hotel-Information) ![Outdoor dining](https://images.trvl-media.com/lodging/84000000/83470000/83463500/83463426/755a52ed.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/84000000/83470000/83463500/83463426/4069311a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Game room](https://images.trvl-media.com/lodging/84000000/83470000/83463500/83463426/cfc18a6b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![6 bedrooms, desk, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/84000000/83470000/83463500/83463426/1600672f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Brand New 6BR/6BA Luxury, 20min to Clemson. Wooded flat lot/firepit/pool table! West Union 10/10 Exceptional (27) "Truly a magnificent property on Lake Keowee. We had plenty of room for eight of us and activities abound! It's a magical place, we look forward to returning. " [](https://www.expedia.ca/West-Union-Hotels-Brand-New-Construction-Very-Close-To-Clemson.h83463426.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/111000000/110940000/110933200/110933184/bd95c835.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/111000000/110940000/110933200/110933184/936c2e83.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/111000000/110940000/110933200/110933184/8adaaa00.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/111000000/110940000/110933200/110933184/cf688f9c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Travelers Rest Treasure - Pets Welcome Sleeps 8 - 3 Bedroom 2 Bath Travelers Rest 10/10 Exceptional (21) "We were in awe as we opened the door!Very clean… very well stocked…very warm and inviting. Highly recommend!!" [](https://www.expedia.ca/Travelers-Rest-Hotels-Travelers-Rest-Treasure-Pet-Friendly.h110933184.Hotel-Information) ![Terrace/patio](https://images.trvl-media.com/lodging/115000000/114610000/114607200/114607128/1571c192.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV, fireplace, books](https://images.trvl-media.com/lodging/115000000/114610000/114607200/114607128/8475e7ff.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/115000000/114610000/114607200/114607128/eeb2e288.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 bedrooms, iron/ironing board, travel crib, free WiFi](https://images.trvl-media.com/lodging/115000000/114610000/114607200/114607128/b20bcdca.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Charming pet-friendly Greenville house with mountain setting and fenced yard Greenville 10/10 Exceptional (7) "Excellent place to stay. Quiet, wooded and out of the way house. But still close to Travelers Rest and Greenville. " CA $139 CA $301 total includes taxes & fees Oct 1 - Oct 2 [](https://www.expedia.ca/Greenville-Hotels-Charming-Pet-Friendly-Greenville-House-With-Mountain-Setting-And-Fenced-Yard.h114607128.Hotel-Information) ![Terrace/patio](https://images.trvl-media.com/lodging/92000000/91350000/91348000/91348000/w1024h680x0y3-85fae223.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior detail](https://images.trvl-media.com/lodging/92000000/91350000/91348000/91348000/w1024h681x0y0-3640f550.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, dishwasher](https://images.trvl-media.com/lodging/92000000/91350000/91348000/91348000/1599e38a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, dishwasher](https://images.trvl-media.com/lodging/92000000/91350000/91348000/91348000/w1024h680x0y3-d9f23bfd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Whimsical 4 bedroom house with a cozy backyard Simpsonville 10/10 Exceptional (34) "Exactly what we needed for our family for a wedding in the area." [](https://www.expedia.ca/Simpsonville-Hotels-Whimsical-4-Bedroom-House-With-A-Cozy-Backyard.h91348000.Hotel-Information) ![Property grounds](https://images.trvl-media.com/lodging/104000000/103920000/103914400/103914366/14d2d432.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/104000000/103920000/103914400/103914366/a48caf77.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/104000000/103920000/103914400/103914366/ea6993f9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/104000000/103920000/103914400/103914366/3be2f5fc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Fairview Luxury Oasis Spartanburg 10/10 Exceptional (23) "Very clean and nice property and neighborhood. My employees enjoyed the stay." CA $257 CA $521 total includes taxes & fees Sep 30 - Oct 1 [](https://www.expedia.ca/Spartanburg-Hotels-Fairview-Luxury-Oasis.h103914366.Hotel-Information) ![Outdoor dining](https://images.trvl-media.com/lodging/117000000/116630000/116622200/116622146/41e036b0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/117000000/116630000/116622200/116622146/71331ca3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/117000000/116630000/116622200/116622146/cd2aeece.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/117000000/116630000/116622200/116622146/96b9a76a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Lake Keowee Lakefront Cove, Private Dock, Deep Water Access, Kayaks & more Six Mile 10/10 Exceptional (5) "We found this place last minute and was blown away at how great it was. Within 10 minutes of arriving I caught a fish off the dock and my kids were enjoying a little paddle boarding! The house has everything you need in the kitchen, bathrooms, and bedrooms. It was easy to relax and enjoy the lake without worry about anything. The beds were comfortable, the porch was relaxing, and the cove was quiet. Two king beds made it perfect for two families as the adults had great sleeping arrangements. We... [](https://www.expedia.ca/Six-Mile-Hotels-Lake-Keowees-Diamond-In-The-Cove.h116622146.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/118000000/117770000/117764800/117764713/w1239h698x3y3-27d6457f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Dishwasher](https://images.trvl-media.com/lodging/118000000/117770000/117764800/117764713/332a5793_edited_45c3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/118000000/117770000/117764800/117764713/66a386e2_edited_ecaa.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Dishwasher](https://images.trvl-media.com/lodging/118000000/117770000/117764800/117764713/edaa5dbe_edited_0c01.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Luxury 4BR/4BA Lake Keowee Retreat- Mountain Cabin Vibes + Private Dock Seneca 10/10 Exceptional (6) [](https://www.expedia.ca/Seneca-Hotels-Luxury-4BR4BA-Lake-Keowee-Retreat-Mountain-Cabin-Vibes-Private-Dock.h117764713.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/35000000/34280000/34275000/34274917/5f2faa1d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/35000000/34280000/34275000/34274917/41105754.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![TV, foosball, stereo](https://images.trvl-media.com/lodging/35000000/34280000/34275000/34274917/85411062.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/35000000/34280000/34275000/34274917/367e18cc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Upper Lake Keowee Waterfront! Covered Dock/Jetports. Mountain Serenity. Sunset 10/10 Exceptional (94) "What an outstanding property ! This was my second stay here and I cannot wait to schedule another week . Thanks to our hosts for creating such a quiet and restful space!" [](https://www.expedia.ca/Sunset-Hotels-Upper-Lake-Keowee-Waterfront-Covered-Dockjetports-Mountain-Serenity.h34274917.Hotel-Information) ![Property grounds](https://images.trvl-media.com/lodging/88000000/87560000/87552100/87552049/436516e9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV](https://images.trvl-media.com/lodging/88000000/87560000/87552100/87552049/345ab4fb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![3 bedrooms, desk, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/88000000/87560000/87552100/87552049/077dae4b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV](https://images.trvl-media.com/lodging/88000000/87560000/87552100/87552049/ff2ee17b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Keowee Adventures ~ Peaceful Lakefront Home on Keowee ~ 7 Miles from Clemson! Seneca 10/10 Exceptional (54) "Great location on the lake. Easy to get to the marina and rent a boat. First time on the lake and we had an awesome time. " [](https://www.expedia.ca/Seneca-Hotels-New-Peaceful-Lakefront-Home-On-Keowee-Only-7-Miles-From-Clemson.h87552049.Hotel-Information) ![Dining](https://images.trvl-media.com/lodging/62000000/61620000/61619300/61619272/614928ce.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV](https://images.trvl-media.com/lodging/62000000/61620000/61619300/61619272/6441a5be.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/62000000/61620000/61619300/61619272/a75d2578.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/62000000/61620000/61619300/61619272/409cd523.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Blues Brothers Hideaway - Lakefront - Fenced yard - Pets Welcome - Clemson 20 mi Fair Play 8.8/10 Excellent (51) "Older folks may find it difficult to get up and down the hill to the lake. Everything else was superb. " [](https://www.expedia.ca/Anderson-Hotels-2-211s-Blues-Brothers-Hideaway-Sleeps-4-8-Wifi-Pets-Welcome.h61619272.Hotel-Information) ![Outdoor dining](https://images.trvl-media.com/lodging/74000000/73980000/73974400/73974359/b04bd3c0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Dining](https://images.trvl-media.com/lodging/74000000/73980000/73974400/73974359/321c8732.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/74000000/73980000/73974400/73974359/a902f25a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/74000000/73980000/73974400/73974359/333b582b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Private, pet-friendly adorable getaway mins to downtown Greenville 9.6/10 Exceptional (107) "House was clean and cozy. Yard was big and perfect for our dogs. Location was great less than 10 min drive to most parks, shopping and restauraunts. Had a great time!" CA $209 CA $436 total includes taxes & fees Sep 28 - Sep 29 [](https://www.expedia.ca/Greenville-Hotels-Private.h73974359.Hotel-Information) ![Terrace/patio](https://images.trvl-media.com/lodging/30000000/29940000/29935300/29935238/d8b4f3c5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![3 bedrooms, in-room safe, desk, iron/ironing board](https://images.trvl-media.com/lodging/30000000/29940000/29935300/29935238/c3ec8e86.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV, DVD player, books, video library](https://images.trvl-media.com/lodging/30000000/29940000/29935300/29935238/e5ec9cb3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/30000000/29940000/29935300/29935238/6d8a33de.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Make Memories on Mulberry Greenville 10/10 Exceptional (93) "Very cozy home. Very clean. Could tell it was important to owners for us to hsve s good time." CA $191 CA $342 total includes taxes & fees Oct 7 - Oct 8 [](https://www.expedia.ca/Greenville-Hotels-Make-Memories-On-Mulberry.h29935238.Hotel-Information) ![Property grounds](https://images.trvl-media.com/lodging/114000000/113090000/113087000/113086989/d430c337.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV, fireplace, table tennis, books](https://images.trvl-media.com/lodging/114000000/113090000/113087000/113086989/dd8a0482.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/114000000/113090000/113087000/113086989/d580fd1f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Marina](https://images.trvl-media.com/lodging/114000000/113090000/113087000/113086989/112869d3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Lake Hartwell Waterfront w/Dock, Gameroom, Firepit, Pets, Clemson & Fenced Yard Anderson 10/10 Exceptional (7) "This lakefront rental was absolutely beautiful and relaxing—just what we needed. The whole vibe was perfect, from peaceful mornings by the water to cozy evenings surrounded by nature. And the hosts were amazing—super helpful and great with communication. A truly memorable stay!" [](https://www.expedia.ca/Anderson-Hotels-Lake-Hartwell-Waterfront-Home.h113086989.Hotel-Information) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/97000000/96670000/96668600/96668528/94de9e8a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/97000000/96670000/96668600/96668528/745f8170.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV](https://images.trvl-media.com/lodging/97000000/96670000/96668600/96668528/f8c90e1d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor dining](https://images.trvl-media.com/lodging/97000000/96670000/96668600/96668528/0956b6c8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Grand Greenville Estate ~ walk to Furman & Swamp Rabbit Trail! Greenville 10/10 Exceptional (19) "My family stayed here while attending a wedding. It was a perfect place for us. It was close to downtown and lots of restaurants." CA $238 CA $627 total includes taxes & fees Sep 29 - Sep 30 [](https://www.expedia.ca/Greenville-Hotels-Grand-Greenville-Estate-5-Mins-To-Furman-Swamp-Rabbit-Trail.h96668528.Hotel-Information) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/77000000/76070000/76065900/76065822/ab9ca0b4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/77000000/76070000/76065900/76065822/60baf5ab.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/77000000/76070000/76065900/76065822/1efef3dd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Dining](https://images.trvl-media.com/lodging/77000000/76070000/76065900/76065822/f66328f4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### STRATHAM STATION: 4Bd/2.5Ba in Downtown Greenville, SC Greenville 9.6/10 Exceptional (45) "Enjoys our getaway in Greenville. Spacious house, easy check in. " CA $201 CA $512 total includes taxes & fees Sep 28 - Sep 29 [](https://www.expedia.ca/Greenville-Hotels-Brand-New-Ranch-Vibe-4Bd25Ba-In-Downtown-Greenville.h76065822.Hotel-Information) ![Property grounds](https://images.trvl-media.com/lodging/89000000/88100000/88092400/88092320/bfa818d6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/89000000/88100000/88092400/88092320/31469ffb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Dining](https://images.trvl-media.com/lodging/89000000/88100000/88092400/88092320/1ca40c8f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV, fireplace](https://images.trvl-media.com/lodging/89000000/88100000/88092400/88092320/691f325a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Beautiful home in the Heart of Five Forks, Simpsonville! Simpsonville 10/10 Exceptional (38) "Amazing stay!" [](https://www.expedia.ca/Simpsonville-Hotels-Beautiful-New-Home-In-The-Heart-Of-Five-Forks.h88092320.Hotel-Information) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/100000000/99670000/99667300/99667214/888666a9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/100000000/99670000/99667300/99667214/a9f8df26.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/100000000/99670000/99667300/99667214/125423bf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![4 bedrooms, WiFi](https://images.trvl-media.com/lodging/100000000/99670000/99667300/99667214/6e456968.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Beautiful private farm house in the middle of the city Greenville 9.8/10 Exceptional (12) "There were 2 dads and 2 teenage boys staying for a week-long baseball tournament in Greenville. Perfect location since games were spread out across the Greenville area. Close to downtown and restaurants as well. Plenty of room to spread out and a very nice, clean house." [](https://www.expedia.ca/Greenville-Hotels-Beautiful-Private-Farm-House-In-The-Middle-Of-The-City.h99667214.Hotel-Information) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/90000000/89210000/89205800/89205780/57dfb6d6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Dining](https://images.trvl-media.com/lodging/90000000/89210000/89205800/89205780/316b2e67.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/90000000/89210000/89205800/89205780/f82a81bf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV](https://images.trvl-media.com/lodging/90000000/89210000/89205800/89205780/03a283ca.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### New Construction Townhome Less Than 1 Mile From The Heart Of Downtown Greenville Greenville 9.6/10 Exceptional (62) "Fully equipped kitchen, comfortable beds, close to downtown, easy to communicate with VRBO owner. All 4 adults were very happy with property. " [](https://www.expedia.ca/Greenville-Hotels-New-Construction-Townhome-Less-Than-1-Mile-From-The-Heart-Of-Downtown-Greenville.h89205780.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/120000000/119350000/119343000/119342977/440ceb63.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/120000000/119350000/119343000/119342977/c613d9db.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/120000000/119350000/119343000/119342977/07f04546.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Microwave, oven, stovetop, dishwasher](https://images.trvl-media.com/lodging/120000000/119350000/119343000/119342977/8a8dbfbd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Delightful 2-bedroom house with AC in charming Easley Easley 10/10 Exceptional (3) "This home was newly renovated. The furnishings and decor were fantastic. Very close to a lot of food and event locations. " [](https://www.expedia.ca/Easley-Hotels-Delightful-2-Bedroom-House-With-AC-In-Charming-Easley.h119342977.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2025-10-10&endDate=2025-10-11®ionId=553248635975748552&adults=2&lodging=VACATION_HOME&sort=RECOMMENDED&openPlayBack=true) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in](https://expedia.ca/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FUpstate-South-Carolina-Private-Vacation-Homes.d553248635975748552-aaPrivateVacationHomes.Travel-Guide-Accommodation)[Sign up, it's free](https://expedia.ca/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FUpstate-South-Carolina-Private-Vacation-Homes.d553248635975748552-aaPrivateVacationHomes.Travel-Guide-Accommodation) ## Top Upstate South Carolina Hotel Reviews ![Woodspring Suites Greenville Airport](//images.trvl-media.com/lodging/115000000/114590000/114583600/114583570/69b6f44b_y.jpg) ### Woodspring Suites Greenville Airport 10/10 Excellent "Great location and very secure property" [](https://expedia.ca/Greenville-Hotels-Woodspring-Suites-Greenville-Airport.h114583570.Hotel-Information) ![Holiday Inn Greenville - Woodruff Road by IHG](//images.trvl-media.com/lodging/42000000/41970000/41964400/41964398/00aa6485_y.jpg) ### Holiday Inn Greenville - Woodruff Road by IHG 10/10 Excellent "Great 24/7 coffee bar in lobby with decaf coffee, assorted teas, creams, stevia and other sweeteners and great assortment of teas and honey and lemon. Rooms are comfortable and clean. Real pillows. Staff is friendly and courteous and great breakfast included. Nice, roomy and comfortable lobby with business center. Will definitely stay there again" [](https://expedia.ca/Greenville-Spartanburg-Hotels-Holiday-Inn-Woodruff-Road.h41964398.Hotel-Information) ![The Shepherd Hotel Downtown Clemson](//images.trvl-media.com/lodging/88000000/87690000/87688200/87688155/8f34da45_y.jpg) ### The Shepherd Hotel Downtown Clemson 10/10 Excellent "Everything! Beautiful, convenient and wonderful staff!" [](https://expedia.ca/Clemson-Hotels-The-Shepherd-Hotel-Downtown-Clemson.h87688155.Hotel-Information) ![Hyatt Regency Greenville](//images.trvl-media.com/lodging/1000000/30000/22300/22252/fa37e256_y.jpg) ### Hyatt Regency Greenville 10/10 Excellent "Nice easy walk to bon seCour center" [](https://expedia.ca/Greenville-Hotels-Hyatt-Regency-Greenville.h22252.Hotel-Information) ![La Quinta Inn & Suites by Wyndham Greenville Haywood](//images.trvl-media.com/lodging/1000000/170000/165800/165759/89ed0b3d_y.jpg) ### La Quinta Inn & Suites by Wyndham Greenville Haywood 10/10 Excellent "Great VALUE and great room. " [](https://expedia.ca/Greenville-Hotels-La-Quinta-Inn-Suites-By-Wyndham-Greenville-Haywood.h165759.Hotel-Information) ![Best Western Plus Greenville I-385 Inn & Suites](//images.trvl-media.com/lodging/1000000/30000/23100/23003/20a0c66a_y.jpg) ### Best Western Plus Greenville I-385 Inn & Suites 10/10 Excellent "Highly recommended Really good value for money " [](https://expedia.ca/Greenville-Hotels-Best-Western-Plus-Greenville-I-385-Inn-Suites.h23003.Hotel-Information) ![Embassy Suites Greenville Golf Resort & Conference Center](//images.trvl-media.com/lodging/1000000/10000/3300/3223/31b0d05e_y.jpg) ### Embassy Suites Greenville Golf Resort & Conference Center 10/10 Excellent "Golf Clean rooms Staff was awesome Beautiful property " [](https://expedia.ca/Greenville-Hotels-Embassy-Suites-Greenville-Golf-Resort-Conference-Center.h3223.Hotel-Information) ![Grand Bohemian Lodge Greenville, Autograph Collection](//images.trvl-media.com/lodging/72000000/71770000/71762700/71762652/6a375dd3_y.jpg) ### Grand Bohemian Lodge Greenville, Autograph Collection 10/10 Excellent "This an excellent property in a very good location, both for the natural surroundings, and the proximity to restaurants, shopping, and sightseeing." [](https://expedia.ca/Greenville-Hotels-Grand-Bohemian-Lodge-Greenville.h71762652.Hotel-Information) ![Hyatt Place Greenville Downtown](//images.trvl-media.com/lodging/28000000/27050000/27043000/27042919/dac522c0_y.jpg) ### Hyatt Place Greenville Downtown 10/10 Excellent "We parked in the garage across the street at $7 per 24 hours. Extremely reasonable. Super convenient location to Main Street, Falls Park, dining, etc. Left the car parked and walked everywhere." [](https://expedia.ca/Greenville-Hotels-Hyatt-Place-GreenvilleDowntown.h27042919.Hotel-Information) ## Find out more about Upstate South Carolina ## Upstate South Carolina Vacation Homes information | Number of reviews | 697 | | --- | --- | | Accommodation | 861 Vacation Homes | | Lowest Price | CA $301 | | Highest Price | CA $627 | ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - More ways to book - [Anglewood Hotels](https://www.expedia.ca/Anglewood-Hotels.d553248635975857985.Travel-Guide-Hotels) - [Cross Anchor Hotels](https://www.expedia.ca/Cross-Anchor-Hotels.d553248635519281641.Travel-Guide-Hotels) - [Cottages in Duncan](https://www.expedia.ca/Duncan-Cottages.d6761-aaCottages.Travel-Guide-Accommodation) - [Lodges in Duncan](https://www.expedia.ca/Duncan-Lodges.d6761-aaLodges.Travel-Guide-Accommodation) - [Aparthotels in Enoree](https://www.expedia.ca/Enoree-Apart-Hotels.d3000353124-aaApartHotels.Travel-Guide-Accommodation) - [B&B in Enoree](https://www.expedia.ca/Enoree-Bed-And-Breakfast.d3000353124-aaBedAndBreakfast.Travel-Guide-Accommodation) - 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[Flights from Trenton (TTN) to Spartanburg (SPA)](https://www.expedia.ca/lp/flights/ttn/spa/trenton-to-spartanburg) - [Flights from Tupelo (TUP) to Spartanburg (SPA)](https://www.expedia.ca/lp/flights/tup/spa/tupelo-to-spartanburg) - [Flights from Tokyo (TYO) to Spartanburg (SPA)](https://www.expedia.ca/lp/flights/tyo/spa/tokyo-to-spartanburg) - [Flights from Valdosta (VLD) to Spartanburg (SPA)](https://www.expedia.ca/lp/flights/vld/spa/valdosta-to-spartanburg) - [Flights from Halifax (YHZ) to Spartanburg (SPA)](https://www.expedia.ca/lp/flights/yhz/spa/halifax-to-spartanburg) - [Flights from Montreal (YUL) to Spartanburg (SPA)](https://www.expedia.ca/lp/flights/yul/spa/montreal-to-spartanburg) - [Flights from Vancouver (YVR) to Spartanburg (SPA)](https://www.expedia.ca/lp/flights/yvr/spa/vancouver-to-spartanburg) - [Flights from Toronto (YYZ) to Spartanburg (SPA)](https://www.expedia.ca/lp/flights/yyz/spa/toronto-to-spartanburg) - [295 Sports Complex](https://www.expedia.ca/295-Sports-Complex-Spartanburg.d6245676.Vacation-Attraction) - [Visit Anglewood](https://www.expedia.ca/Anglewood.dx553248635975857985) - [Central Vacations](https://www.expedia.ca/Central.d10503.Destination-Travel-Guides) - [Westgate Mall](https://www.expedia.ca/WestGate-Mall-Spartanburg.d6144854.Vacation-Attraction) - [Car rentals near 295 Sports Complex](https://www.expedia.ca/Car-Rentals-In-295-Sports-Complex.d6245676.Car-Rental-Guide) - [Rental cars Spartanburg Downtown Memorial airport](https://www.expedia.ca/Car-Rentals-In-Spartanburg-Downtown-Memorial.d6032031.Car-Rental-Guide) - [Book Vacation Homes in Upstate South Carolina on Expedia.com](https://www.expedia.com/Upstate-South-Carolina-Private-Vacation-Homes.d553248635975748552-aaPrivateVacationHomes.Travel-Guide-Accommodation)