Title: Book the Best Downtown Gainesville LUXURY Hotels - Upscale Hotels in Downtown Gainesville, Gainesville | Expedia.ca [Downtown Gainesville Travel Guide](https://expedia.ca/Gainesville-Downtown-Gainesville.dx939293992653533184)[Vacation Rentals in Gainesville](https://expedia.ca/Gainesville-Vacation-Rentals.d6048189.Travel-Guide-VacationRentals)[Flights to Gainesville](https://expedia.ca/Cheap-Flights-To-Gainesville.d6048189.Travel-Guide-Flights)[Things to do in Gainesville](https://expedia.ca/Things-To-Do-In-Gainesville.d6048189.Travel-Guide-Activities)[Downtown Gainesville Car Rentals](https://expedia.ca/Car-Rentals-In-Downtown-Gainesville.d939293992653533184.Car-Rental-Guide)[Downtown Gainesville Vacations](https://expedia.ca/Downtown-Gainesville.d939293992653533184.Destination-Travel-Guides) ![Gainesville featuring modern architecture](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/61000/61913-Gainesville.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find Luxury Hotels in Downtown Gainesville, Gainesville ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Downtown Gainesville Luxury Hotels Tonight [Oct 25 - Oct 26](https://www.expedia.ca/Hotel-Search?regionId=939293992653533184&startDate=2025-10-25&endDate=2025-10-26&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) Tomorrow [Oct 26 - Oct 27](https://www.expedia.ca/Hotel-Search?regionId=939293992653533184&startDate=2025-10-26&endDate=2025-10-27&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) Next weekend [Oct 31 - Nov 2](https://www.expedia.ca/Hotel-Search?regionId=939293992653533184&startDate=2025-10-31&endDate=2025-11-02&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) In two weeks [Nov 7 - Nov 9](https://www.expedia.ca/Hotel-Search?regionId=939293992653533184&startDate=2025-11-07&endDate=2025-11-09&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) ## Top Downtown Gainesville Luxury Hotels ## Top Downtown Gainesville Hotel Reviews ![Country Inn & Suites by Radisson, Gainesville, FL](//images.trvl-media.com/lodging/2000000/1290000/1289100/1289043/8584a629_y.jpg) ### Country Inn & Suites by Radisson, Gainesville, FL 10/10 Excellent "Nice stay for reasonable price" [](https://expedia.ca/Gainesville-Hotels-Country-Inn-Suites-By-Radisson.h1289043.Hotel-Information) ![Hilton Garden Inn Gainesville](//images.trvl-media.com/lodging/2000000/1640000/1631400/1631322/1560249f_y.jpg) ### Hilton Garden Inn Gainesville 10/10 Excellent "Room was so clean and comfortable. Easy check in, accommodating and kind staff. " [](https://expedia.ca/Gainesville-Hotels-Hilton-Garden-Inn-Gainesville.h1631322.Hotel-Information) ![Sleep Inn & Suites University/Shands](//images.trvl-media.com/lodging/2000000/1940000/1932400/1932346/3c8617a9_y.jpg) ### Sleep Inn & Suites University/Shands 10/10 Excellent "Friendly efficient staff, comfortable clean room, good location near college & have shuttle to game. Definitely would stay here again " [](https://expedia.ca/Gainesville-Hotels-Sleep-Inn-Suites-UniversityShands.h1932346.Hotel-Information) ![Super 8 by Wyndham Gainesville I-75 Hospital University Area](//images.trvl-media.com/lodging/1000000/440000/439800/439799/1210da70_y.jpg) ### Super 8 by Wyndham Gainesville I-75 Hospital University Area 10/10 Excellent "Clean room and affordable!" [](https://expedia.ca/Gainesville-Hotels-Super-8-By-Wyndham-Gainesville.h439799.Hotel-Information) ![Red Roof Inn PLUS+ Gainesville](//images.trvl-media.com/lodging/1000000/90000/82700/82677/5b4e3b0e_y.jpg) ### Red Roof Inn PLUS+ Gainesville 10/10 Excellent "Friendly staff" [](https://expedia.ca/Gainesville-Hotels-Red-Roof-Inn-PLUS-Gainesville.h82677.Hotel-Information) ![Best Western Gateway Grand](//images.trvl-media.com/lodging/1000000/160000/151100/151041/9a241e09_y.jpg) ### Best Western Gateway Grand 10/10 Excellent "Place was great, breakfast selection was not. Bring your own pillows if you can. " [](https://expedia.ca/Gainesville-Hotels-Best-Western-Gateway-Grand.h151041.Hotel-Information) ![Comfort Inn University](//images.trvl-media.com/lodging/1000000/800000/793600/793525/78ca2e85_y.jpg) ### Comfort Inn University 10/10 Excellent "The staff was unusually friendly & attentive. Fresh water, popcorn, cookies. Loved it!!!" [](https://expedia.ca/Gainesville-Hotels-Comfort-Inn-University.h793525.Hotel-Information) ![Travelodge by Wyndham Gainesville](//images.trvl-media.com/lodging/1000000/30000/22300/22209/13483769_y.jpg) ### Travelodge by Wyndham Gainesville 10/10 Excellent "Property was simple and kept up. Room as squared away and clean. Check in painless." [](https://expedia.ca/Gainesville-Hotels-Regency-Inn.h22209.Hotel-Information) ![Hampton Inn & Suites Gainesville-Downtown](//images.trvl-media.com/lodging/3000000/2880000/2874000/2873991/6ce917d9_y.jpg) ### Hampton Inn & Suites Gainesville-Downtown 10/10 Excellent "Great experience " [](https://expedia.ca/Gainesville-Hotels-Hampton-Inn-Suites-Gainesville-Downtown.h2873991.Hotel-Information) ## Frequently asked questions ### Are you searching for a great accommodation for your luxury getaway to Downtown Gainesville? > Use Expedia to arrange your flight to Gainesville Regional Airport (GNV) airport, and then choose from a variety of places to stay that will deliver the luxury you seek. Amenities are important when you plan a vacation, so we make it easy to find what you'd like to make your stay special. If you want an upscale hotel that has a spa, an indoor pool, or luxury bedding, Expedia can help you find the best luxury hotel experience that Downtown Gainesville offers. Downtown Gainesville has some interesting things to see and do including Hippodrome State Theatre, so you might want to take in the local sights during your visit. ### What's there to see and do in Downtown Gainesville? > Take in the sights and attractions that Downtown Gainesville offers with a visit to Hippodrome State Theatre, Thomas Center, and Ben Hill Griffin Stadium. If you have a little extra time during your trip, you might want to check out Stephen C. 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[Visit Gainesville](https://www.expedia.ca/Gainesville.dx6048189) - [Car rental Gainesville](https://www.expedia.ca/Car-Rentals-In-Gainesville.d6048189.Car-Rental-Guide) - [Convertible Car Rentals in Gainesville](https://www.expedia.ca/Convertible-Car-Rentals-In-Gainesville.d6048189-tConvertible.Car-Rental-Guide-Class) - [Enterprise Rental Cars in Gainesville](https://www.expedia.ca/Enterprise-Car-Rentals-In-Gainesville.d6048189-c15.Car-Rental-Guide-Suppliers) - [Gainesville Vacation Rentals](https://www.expedia.ca/Gainesville-Vacation-Rentals.d6048189.Travel-Guide-VacationRentals) - [Things to do in Gainesville](https://www.expedia.ca/Things-To-Do-In-Gainesville.d6048189.Travel-Guide-Activities)