Title: Top Hotels in Santo Tomé Department | Expedia.ca [Vacation Rentals in Santo Tomé Department](https://expedia.ca/Destinations-In-Santo-Tome-Department.d553248635975751431.Vacation-Rental-Destinations)[Santo Tomé Department Car Rentals](https://expedia.ca/Destinations-In-Santo-Tome-Department.d553248635975751431.Car-Rental-Destinations)[Santo Tomé Department Vacations](https://expedia.ca/Santo-Tome-Department.d553248635975751431.Destination-Travel-Guides) ![Default HTG hotel image](https://a.travel-assets.com/travel-assets-manager/fallback-images-brand/bex_lodging_v2.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://a.travel-assets.com/travel-assets-manager/fallback-images-brand/bex_lodging_v2.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check prices for these dates Tonight [Jan 20 - Jan 21](https://www.expedia.ca/Hotel-Search?regionId=553248635975751431&startDate=2026-01-20&endDate=2026-01-21&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Jan 21 - Jan 22](https://www.expedia.ca/Hotel-Search?regionId=553248635975751431&startDate=2026-01-21&endDate=2026-01-22&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Jan 23 - Jan 25](https://www.expedia.ca/Hotel-Search?regionId=553248635975751431&startDate=2026-01-23&endDate=2026-01-25&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Jan 30 - Feb 1](https://www.expedia.ca/Hotel-Search?regionId=553248635975751431&startDate=2026-01-30&endDate=2026-02-01&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in ](https://expedia.ca/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FDestinations-In-Santo-Tome-Department.d553248635975751431.Hotel-Destinations)[ Sign up, it's free ](https://expedia.ca/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FDestinations-In-Santo-Tome-Department.d553248635975751431.Hotel-Destinations) ## Top Santo Tomé Department Hotel Reviews ## Explore a world of travel with Expedia - Explore a world of travel with Expedia ### Top cities in Santo Tomé Department - [Gobernador Virasoro Hotels ](https://expedia.ca/Gobernador-Virasoro-Hotels.d3000428985.Travel-Guide-Hotels) ### Explore more hotels - [Puerto Valle Hotel de Esteros ](https://expedia.ca/Ituzaingo-Hotels-Puerto-Valle-Hotel-De-Esteros.h2346397.Hotel-Information) - [Wild Wetlands Lodge ](https://expedia.ca/Ituzaingo-Hotels-Wild-Wetlands-Lodge.h103441567.Hotel-Information) [See a list of all hotels in Santo Tomé Department](https://expedia.ca/All-Santo-Tome-Department-Hotels.d553248635975751431.Travel-Guide-City-All-Hotels) ### More ways to book - [Book Hotels in Santo Tomé Department on Expedia.com.ar ](https://www.expedia.com.ar/Destinos-En-Departamento-Santo-Tome.d553248635975751431.Destinos-con-Hoteles) ### Expedia's Latest Trends Hotels - [Tokyu Stay Shibuya](https://expedia.ca/Tokyo-Hotels-Tokyu-Stay-Shibuya.h2692097.Hotel-Information) - [Bahia Principe Grand Samana - Adults Only](https://expedia.ca/Samana-Hotels-Bahia-Principe-Luxury-Samana-Adults-Only.h11843755.Hotel-Information) - 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