Title: Top Hotels in Santo Tomé Department | Expedia.ca [Vacation Rentals in Santo Tomé Department](https://expedia.ca/Destinations-In-Santo-Tome-Department.d553248635975751431.Vacation-Rental-Destinations)[Santo Tomé Department Car Rentals](https://expedia.ca/Destinations-In-Santo-Tome-Department.d553248635975751431.Car-Rental-Destinations)[Santo Tomé Department Vacations](https://expedia.ca/Santo-Tome-Department.d553248635975751431.Destination-Travel-Guides) ![Default HTG hotel image](https://a.travel-assets.com/travel-assets-manager/fallback-images-brand/bex_lodging_v2.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Search Santo Tomé Department Hotels ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check prices for these dates Tonight [Oct 25 - Oct 26](https://www.expedia.ca/Hotel-Search?regionId=553248635975751431&startDate=2025-10-25&endDate=2025-10-26&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Oct 26 - Oct 27](https://www.expedia.ca/Hotel-Search?regionId=553248635975751431&startDate=2025-10-26&endDate=2025-10-27&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Oct 31 - Nov 2](https://www.expedia.ca/Hotel-Search?regionId=553248635975751431&startDate=2025-10-31&endDate=2025-11-02&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two weeks [Nov 7 - Nov 9](https://www.expedia.ca/Hotel-Search?regionId=553248635975751431&startDate=2025-11-07&endDate=2025-11-09&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top Hotels in Santo Tomé Department ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in](https://expedia.ca/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FDestinations-In-Santo-Tome-Department.d553248635975751431.Hotel-Destinations)[Sign up, it's free](https://expedia.ca/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FDestinations-In-Santo-Tome-Department.d553248635975751431.Hotel-Destinations) ## Top Santo Tomé Department Hotel Reviews ## Explore a world of travel with Expedia - Explore a world of travel with Expedia ### Top cities in Santo Tomé Department - [Gobernador Virasoro Hotels](https://expedia.ca/Gobernador-Virasoro-Hotels.d3000428985.Travel-Guide-Hotels) ### Explore more hotels - [Wild Wetlands Lodge](https://expedia.ca/Ituzaingo-Hotels-Wild-Wetlands-Lodge.h103441567.Hotel-Information) - [Puerto Valle Hotel de Esteros](https://expedia.ca/Ituzaingo-Hotels-Puerto-Valle-Hotel-De-Esteros.h2346397.Hotel-Information) [See a list of all hotels in Santo Tomé Department](https://expedia.ca/All-Santo-Tome-Department-Hotels.d553248635975751431.Travel-Guide-City-All-Hotels) ### More ways to book - [Book Hotels in Santo Tomé Department on Expedia.com.ar](https://www.expedia.com.ar/Destinos-En-Departamento-Santo-Tome.d553248635975751431.Destinos-con-Hoteles) ### Expedia's Latest Trends Hotels - [Tokyu Stay Shibuya](https://expedia.ca/Tokyo-Hotels-Tokyu-Stay-Shibuya.h2692097.Hotel-Information) - [Bahia Principe Grand Samana - Adults Only](https://expedia.ca/Samana-Hotels-Bahia-Principe-Luxury-Samana-Adults-Only.h11843755.Hotel-Information) - 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Scan the QR code with your device camera and download our app ![QR code to download the app](data:image/png;base64,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)