Title: Book The Best Hotels in Defiance, MO for 2026 from CA $94 - Fully Refundable Options - Expedia.ca

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![A covered bridge at the Historic Daniel Boone Home Park in Defiance, Missouri](https://images.trvl-media.com/place/6353634/33b2b915-0d1b-4946-ae10-3b89e88434a7/historic-wooden-covered-bridge-countryside-scenic-autumn-day.jpg?impolicy=fcrop&w=1200&h=500&q=medium)

# Find hotels in Defiance, MO from CA $94

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## Go beyond your typical stay in Defiance

Cabin

[](https://www.expedia.ca/Hotel-Search?destination=Defiance%2C+Missouri%2C+United+States+of+America&regionId=6353634&latLong=38.632504%2C-90.778183&adults=2&startDate=2025-12-24&d1=2025-12-24&endDate=2025-12-26&d2=2025-12-26&lodging=CABIN)

Pool

[](https://www.expedia.ca/Hotel-Search?destination=Defiance%2C+Missouri%2C+United+States+of+America&regionId=6353634&latLong=38.632504%2C-90.778183&adults=2&startDate=2025-12-24&d1=2025-12-24&endDate=2025-12-26&d2=2025-12-26&amenities=POOL)

Family friendly

[](https://www.expedia.ca/Hotel-Search?destination=Defiance%2C+Missouri%2C+United+States+of+America&regionId=6353634&latLong=38.632504%2C-90.778183&adults=2&startDate=2025-12-24&d1=2025-12-24&endDate=2025-12-26&d2=2025-12-26&travelerType=family_friendly)

Hot tub

[](https://www.expedia.ca/Hotel-Search?destination=Defiance%2C+Missouri%2C+United+States+of+America&regionId=6353634&latLong=38.632504%2C-90.778183&adults=2&startDate=2025-12-24&d1=2025-12-24&endDate=2025-12-26&d2=2025-12-26&amenities=HOT_TUB)

Pet friendly

[](https://www.expedia.ca/Hotel-Search?destination=Defiance%2C+Missouri%2C+United+States+of+America&regionId=6353634&latLong=38.632504%2C-90.778183&adults=2&startDate=2025-12-24&d1=2025-12-24&endDate=2025-12-26&d2=2025-12-26&amenities=PETS)

Apart­ment

[](https://www.expedia.ca/Hotel-Search?destination=Defiance%2C+Missouri%2C+United+States+of+America&regionId=6353634&latLong=38.632504%2C-90.778183&adults=2&startDate=2025-12-24&d1=2025-12-24&endDate=2025-12-26&d2=2025-12-26&lodging=APARTMENT)

Cottage

[](https://www.expedia.ca/Hotel-Search?destination=Defiance%2C+Missouri%2C+United+States+of+America&regionId=6353634&latLong=38.632504%2C-90.778183&adults=2&startDate=2025-12-24&d1=2025-12-24&endDate=2025-12-26&d2=2025-12-26&lodging=COTTAGE)

Waterpark

[](https://www.expedia.ca/Hotel-Search?destination=Defiance%2C+Missouri%2C+United+States+of+America&regionId=6353634&latLong=38.632504%2C-90.778183&adults=2&startDate=2025-12-24&d1=2025-12-24&endDate=2025-12-26&d2=2025-12-26&amenities=WATER_PARK)

Condo

[](https://www.expedia.ca/Hotel-Search?destination=Defiance%2C+Missouri%2C+United+States+of+America&regionId=6353634&latLong=38.632504%2C-90.778183&adults=2&startDate=2025-12-24&d1=2025-12-24&endDate=2025-12-26&d2=2025-12-26&lodging=CONDO)

Chalet

[](https://www.expedia.ca/Hotel-Search?destination=Defiance%2C+Missouri%2C+United+States+of+America&regionId=6353634&latLong=38.632504%2C-90.778183&adults=2&startDate=2025-12-24&d1=2025-12-24&endDate=2025-12-26&d2=2025-12-26&lodging=CHALET)

## Check prices for these dates

Tonight

[Dec 10 - Dec 11](https://www.expedia.ca/Hotel-Search?regionId=6353634&startDate=2025-12-10&endDate=2025-12-11&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Tomorrow

[Dec 11 - Dec 12](https://www.expedia.ca/Hotel-Search?regionId=6353634&startDate=2025-12-11&endDate=2025-12-12&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

This weekend

[Dec 12 - Dec 14](https://www.expedia.ca/Hotel-Search?regionId=6353634&startDate=2025-12-12&endDate=2025-12-14&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Next weekend

[Dec 19 - Dec 21](https://www.expedia.ca/Hotel-Search?regionId=6353634&startDate=2025-12-19&endDate=2025-12-21&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

## Our top choices for Defiance hotels

![Property entrance](https://images.trvl-media.com/lodging/2000000/1770000/1768200/1768149/035dee6c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Suite, 1 King Bed, Jetted Tub | Jetted tub](https://images.trvl-media.com/lodging/2000000/1770000/1768200/1768149/66ab3de8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Suite, 1 King Bed, Jetted Tub | Jetted tub](https://images.trvl-media.com/lodging/2000000/1770000/1768200/1768149/801c113b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Ballroom](https://images.trvl-media.com/lodging/2000000/1770000/1768200/1768149/800a6847.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### The Wildwood Hotel

[](https://www.expedia.ca/St-Louis-Hotels-The-Wildwood-Hotel.h1768149.Hotel-Information)

Wildwood

9.2/10

Wonderful

(1600)

"The King room with sofa and chair is spacious, well furnished"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Deborah

Traveling for leisure

CA $122

CA $148 total

includes taxes & fees

Dec 14 - Dec 15

[](https://www.expedia.ca/St-Louis-Hotels-The-Wildwood-Hotel.h1768149.Hotel-Information)

![Reception](https://images.trvl-media.com/lodging/1000000/50000/42200/42122/b53f4594.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/1000000/50000/42200/42122/70cee110.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Suite, 1 Bedroom, Non Smoking | Living area](https://images.trvl-media.com/lodging/1000000/50000/42200/42122/49aae62b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Reception](https://images.trvl-media.com/lodging/1000000/50000/42200/42122/c9087452.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

[](https://www.expedia.ca/St-Louis-Hotels-Drury-Inn-Suites-St-Louis-Fenton.h42122.Hotel-Information)

Fenton

8.0/10

Very good

(1037)

"The place was nice, spacious room, clean and quiet."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Boris

Traveling for leisure

CA $118

CA $136 total

includes taxes & fees

Dec 14 - Dec 15

[](https://www.expedia.ca/St-Louis-Hotels-Drury-Inn-Suites-St-Louis-Fenton.h42122.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/109000000/108930000/108922000/108921961/20625a7b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Desk, free WiFi, bed sheets](https://images.trvl-media.com/lodging/109000000/108930000/108922000/108921961/aa17bcae.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/109000000/108930000/108922000/108921961/8d754889.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/109000000/108930000/108922000/108921961/e299ff16.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### WoodSpring Suites St Peters-OFallon

[](https://www.expedia.ca/St-Louis-Hotels-Woodspring-Suites-St-Peters-Ofallon.h108921961.Hotel-Information)

St. Peters

9.8/10

Exceptional

(17)

"Tucked away, close to our leave point, very clean rooms!!!!"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Tiesha

Traveling with partner

CA $102

CA $118 total

includes taxes & fees

Dec 11 - Dec 12

[](https://www.expedia.ca/St-Louis-Hotels-Woodspring-Suites-St-Peters-Ofallon.h108921961.Hotel-Information)

![Lobby](https://images.trvl-media.com/lodging/1000000/50000/41500/41448/00255b25.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/1000000/50000/41500/41448/f09b4ea0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Suite, 1 Queen Bed, Non Smoking, Refrigerator & Microwave](https://images.trvl-media.com/lodging/1000000/50000/41500/41448/3a2303d7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Suite, 2 Queen Beds, Non Smoking, Refrigerator & Microwave](https://images.trvl-media.com/lodging/1000000/50000/41500/41448/16db26a0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Best Western Plus St. Louis West-Westport

[](https://www.expedia.ca/St-Louis-Hotels-Best-Western-Plus-St-Louis-West-Westport.h41448.Hotel-Information)

Maryland Heights

8.0/10

Very good

(1030)

"The room was very comfortable, clean and quiet."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

John

Traveling solo

CA $117

CA $135 total

includes taxes & fees

Dec 11 - Dec 12

[](https://www.expedia.ca/St-Louis-Hotels-Best-Western-Plus-St-Louis-West-Westport.h41448.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/74000000/73100000/73099900/73099889/b163097a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Garden](https://images.trvl-media.com/lodging/74000000/73100000/73099900/73099889/f6257321.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Property amenity](https://images.trvl-media.com/lodging/74000000/73100000/73099900/73099889/a6dd6a49.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/74000000/73100000/73099900/73099889/cca92dbf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### AC Hotel by Marriott St. Louis Chesterfield

[](https://www.expedia.ca/St-Louis-Hotels-AC-Hotel-By-Marriott-St-Louis-Chesterfield.h73099889.Hotel-Information)

Chesterfield

9.2/10

Wonderful

(237)

"The room was clean and in good condition"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

JANELL

Traveling for leisure

CA $165

CA $191 total

includes taxes & fees

Dec 21 - Dec 22

[](https://www.expedia.ca/St-Louis-Hotels-AC-Hotel-By-Marriott-St-Louis-Chesterfield.h73099889.Hotel-Information)

![Premium bedding, desk, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/16000000/15590000/15583900/15583887/d9447723.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/16000000/15590000/15583900/15583887/28e7b062.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Indoor pool](https://images.trvl-media.com/lodging/16000000/15590000/15583900/15583887/9fba35aa.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/16000000/15590000/15583900/15583887/b1700171.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Sleep Inn & Suites O'Fallon MO - Technology Drive

[](https://www.expedia.ca/St-Louis-Hotels-Sleep-Inn-Suites-OFallon-MO-Technology-Drive.h15583887.Hotel-Information)

O'Fallon

8.8/10

Excellent

(1000)

"Clean room, friendly staff, quiet and comfortable"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Mary

Traveling solo

CA $116

CA $137 total

includes taxes & fees

Dec 14 - Dec 15

[](https://www.expedia.ca/St-Louis-Hotels-Sleep-Inn-Suites-OFallon-MO-Technology-Drive.h15583887.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/2000000/1210000/1206500/1206489/3e0ca2c9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/2000000/1210000/1206500/1206489/dbfe312f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Free daily buffet breakfast](https://images.trvl-media.com/lodging/2000000/1210000/1206500/1206489/b0c1520e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Hypo-allergenic bedding, down comforters, pillowtop beds, in-room safe](https://images.trvl-media.com/lodging/2000000/1210000/1206500/1206489/c06ddb8e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Holiday Inn Express St. Louis West - O'Fallon by IHG

[](https://www.expedia.ca/St-Louis-Hotels-Holiday-Inn-Express-St-Louis-West-OFallon.h1206489.Hotel-Information)

O'Fallon

8.6/10

Excellent

(832)

"The room was clean and comfortable...even efficiently stylish."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Joe

CA $115

CA $136 total

includes taxes & fees

Dec 14 - Dec 15

[](https://www.expedia.ca/St-Louis-Hotels-Holiday-Inn-Express-St-Louis-West-OFallon.h1206489.Hotel-Information)

![Indoor pool](https://images.trvl-media.com/lodging/1000000/30000/20200/20181/1d22ac52.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fitness facility](https://images.trvl-media.com/lodging/1000000/30000/20200/20181/68b7c425.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Free daily buffet breakfast](https://images.trvl-media.com/lodging/1000000/30000/20200/20181/15695a25.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Blackout drapes, iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/1000000/30000/20200/20181/3b030eed.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Hampton Inn St. Charles St. Peters

[](https://www.expedia.ca/St-Louis-Hotels-Hampton-Inn-St-LouisSt-Charles.h20181.Hotel-Information)

St. Charles

8.0/10

Very good

(1003)

"polite staff, great service, nice breakfast, clean room"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

John

Traveling solo

CA $121

CA $139 total

includes taxes & fees

Dec 21 - Dec 22

[](https://www.expedia.ca/St-Louis-Hotels-Hampton-Inn-St-LouisSt-Charles.h20181.Hotel-Information)

![Indoor pool](https://images.trvl-media.com/lodging/1000000/130000/124500/124484/188fac9c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Business centre](https://images.trvl-media.com/lodging/1000000/130000/124500/124484/ac863486.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/1000000/130000/124500/124484/97b3b5d8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Jetted tub](https://images.trvl-media.com/lodging/1000000/130000/124500/124484/052a5869.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Baymont by Wyndham Warrenton

[](https://www.expedia.ca/Warrenton-Hotels-Baymont-By-Wyndham-Warrenton.h124484.Hotel-Information)

Warrenton

7.4/10

Good

(1000)

"Room very clean, most of staff helpful"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Ranata

Traveling with small children

CA $108

CA $124 total

includes taxes & fees

Dec 24 - Dec 25

[](https://www.expedia.ca/Warrenton-Hotels-Baymont-By-Wyndham-Warrenton.h124484.Hotel-Information)

![Front of property](https://images.trvl-media.com/lodging/1000000/10000/500/422/6f160867.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Front of property](https://images.trvl-media.com/lodging/1000000/10000/500/422/eeede232.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Flat-screen TV](https://images.trvl-media.com/lodging/1000000/10000/500/422/b3fcce87.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Blackout drapes, soundproofing, iron/ironing board](https://images.trvl-media.com/lodging/1000000/10000/500/422/26193d73.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Sonesta ES Suites St. Louis - Chesterfield

[](https://www.expedia.ca/St-Louis-Hotels-Sonesta-ES-Suites-St-Louis-Chesterfield.h422.Hotel-Information)

Chesterfield

8.0/10

Very good

(1031)

"Clean room,Friendly staff, Good location and Good Breakfast options"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Micheal

Traveling for leisure

CA $128

CA $149 total

includes taxes & fees

Dec 11 - Dec 12

[](https://www.expedia.ca/St-Louis-Hotels-Sonesta-ES-Suites-St-Louis-Chesterfield.h422.Hotel-Information)

![Lobby](https://images.trvl-media.com/lodging/19000000/18760000/18754300/18754262/79d56802.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fitness facility](https://images.trvl-media.com/lodging/19000000/18760000/18754300/18754262/25e461ee.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/19000000/18760000/18754300/18754262/7efb516b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Desk, blackout drapes, iron/ironing board, free cribs/infant beds](https://images.trvl-media.com/lodging/19000000/18760000/18754300/18754262/7f62e770.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Drury Plaza Hotel St. Louis St. Charles

[](https://www.expedia.ca/St-Louis-Hotels-Drury-Plaza-Hotel-St-Louis-St-Charles.h18754262.Hotel-Information)

St. Charles

9.6/10

Exceptional

(1000)

"Drury Inn provided an immaculate room with wonderful amenities."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Lela

Traveling with family

CA $159

CA $185 total

includes taxes & fees

Dec 21 - Dec 22

[](https://www.expedia.ca/St-Louis-Hotels-Drury-Plaza-Hotel-St-Louis-St-Charles.h18754262.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/36000000/35850000/35848800/35848753/d38dcff4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/36000000/35850000/35848800/35848753/da587b35.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![In-room safe, desk, laptop workspace, blackout drapes](https://images.trvl-media.com/lodging/36000000/35850000/35848800/35848753/50b5788d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Indoor pool, open 9:00 AM to 10:00 PM, sun loungers](https://images.trvl-media.com/lodging/36000000/35850000/35848800/35848753/ac681623.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Holiday Inn Express & Suites Wentzville St Louis West by IHG

[](https://www.expedia.ca/St-Louis-Hotels-Holiday-Inn-Express-Suites-Wentzville-St-Louis-West.h35848753.Hotel-Information)

Wentzville

9.4/10

Exceptional

(836)

"Room was spacious and very clean."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Kimberly

Traveling for leisure

CA $143

CA $172 total

includes taxes & fees

Jan 4 - Jan 5, 2026

[](https://www.expedia.ca/St-Louis-Hotels-Holiday-Inn-Express-Suites-Wentzville-St-Louis-West.h35848753.Hotel-Information)

![Lobby](https://images.trvl-media.com/lodging/2000000/1220000/1216300/1216259/9e4f56d6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fitness facility](https://images.trvl-media.com/lodging/2000000/1220000/1216300/1216259/2e3c4378.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/2000000/1220000/1216300/1216259/163dc30f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Combined shower/tub, free toiletries, hair dryer, towels](https://images.trvl-media.com/lodging/2000000/1220000/1216300/1216259/5d4de429.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Days Inn by Wyndham St Peters/St Charles

[](https://www.expedia.ca/St-Louis-Hotels-Days-Inn-By-Wyndham-St-PetersSt-Charles.h1216259.Hotel-Information)

St. Peters

6.4/10

(1000)

"Nice hotel in a safe area."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Brayden

Traveling for leisure

CA $88

CA $101 total

includes taxes & fees

Jan 4 - Jan 5, 2026

[](https://www.expedia.ca/St-Louis-Hotels-Days-Inn-By-Wyndham-St-PetersSt-Charles.h1216259.Hotel-Information)

![Front of property - evening/night](https://images.trvl-media.com/lodging/1000000/90000/82600/82568/7188325f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/1000000/90000/82600/82568/0c098574.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Casino](https://images.trvl-media.com/lodging/1000000/90000/82600/82568/cb1b5cb1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Hair dryer, towels](https://images.trvl-media.com/lodging/1000000/90000/82600/82568/65d5873d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Hollywood Casino & Hotel St. Louis

[](https://www.expedia.ca/St-Louis-Hotels-Hollywood-Casino-Hotel-St-Louis.h82568.Hotel-Information)

Maryland Heights

8.4/10

Very good

(2215)

"Room was nice and clean."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Jennifer

CA $145

CA $190 total

includes taxes & fees

Jan 8 - Jan 9, 2026

[](https://www.expedia.ca/St-Louis-Hotels-Hollywood-Casino-Hotel-St-Louis.h82568.Hotel-Information)

![Interior entrance](https://images.trvl-media.com/lodging/1000000/70000/68200/68132/c17520b0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Free daily continental breakfast](https://images.trvl-media.com/lodging/1000000/70000/68200/68132/41017772.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby sitting area](https://images.trvl-media.com/lodging/1000000/70000/68200/68132/a0c491b6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![In-room safe, desk, iron/ironing board, free cribs/infant beds](https://images.trvl-media.com/lodging/1000000/70000/68200/68132/8e7b8531.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Americas Best Value Inn & Suites St. Louis, St. Charles Inn

[](https://www.expedia.ca/St-Louis-Hotels-Americas-Best-Value-Inn-Suites-St-Louis.h68132.Hotel-Information)

St. Charles

5.8/10

(1003)

"the beds were pretty nice"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Lauretta

Traveling for leisure and business

CA $82

CA $96 total

includes taxes & fees

Dec 21 - Dec 22

[](https://www.expedia.ca/St-Louis-Hotels-Americas-Best-Value-Inn-Suites-St-Louis.h68132.Hotel-Information)

![Room, 2 Queen Beds, Non Smoking](https://images.trvl-media.com/lodging/1000000/50000/40200/40102/5429427c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Combined shower/tub, free toiletries, hair dryer, towels](https://images.trvl-media.com/lodging/1000000/50000/40200/40102/be84c5ed.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/1000000/50000/40200/40102/w1200h1088x0y0-5acdc4f3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Free daily continental breakfast](https://images.trvl-media.com/lodging/1000000/50000/40200/40102/81efc7c9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Wingate by Wyndham St. Louis/Fenton Route 66

[](https://www.expedia.ca/St-Louis-Hotels-Pear-Tree-Inn-St-Louis-Fenton.h40102.Hotel-Information)

Fenton

7.8/10

Good

(1107)

"Room was very nice, clean"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Lance

Traveling for leisure

CA $109

CA $126 total

includes taxes & fees

Dec 14 - Dec 15

[](https://www.expedia.ca/St-Louis-Hotels-Pear-Tree-Inn-St-Louis-Fenton.h40102.Hotel-Information)

![Lobby](https://images.trvl-media.com/lodging/2000000/1080000/1077200/1077183/3a1e3bea.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Indoor pool](https://images.trvl-media.com/lodging/2000000/1080000/1077200/1077183/d4f404b7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Suite, Multiple Beds, Non Smoking, Refrigerator & Microwave (with Sofabed)](https://images.trvl-media.com/lodging/2000000/1080000/1077200/1077183/fecb1b2d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/2000000/1080000/1077200/1077183/d2118181.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Best Western Plus Washington Hotel

[](https://www.expedia.ca/Washington-Hotels-Best-Western-Plus-Washington-Hotel.h1077183.Hotel-Information)

Washington

9.2/10

Wonderful

(635)

"My kids loved the pool!!"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Amanda

Traveling with family

CA $179

CA $203 total

includes taxes & fees

Dec 11 - Dec 12

[](https://www.expedia.ca/Washington-Hotels-Best-Western-Plus-Washington-Hotel.h1077183.Hotel-Information)

![Free daily continental breakfast](https://images.trvl-media.com/lodging/1000000/470000/460100/460034/b2add733.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Front of property](https://images.trvl-media.com/lodging/1000000/470000/460100/460034/be73da93.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/1000000/470000/460100/460034/8032c924.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fridge, microwave, coffee/tea maker](https://images.trvl-media.com/lodging/1000000/470000/460100/460034/55eb74aa.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Super 8 by Wyndham Warrenton

[](https://www.expedia.ca/Warrenton-Hotels-Super-8-By-Wyndham-Warrenton.h460034.Hotel-Information)

Warrenton

7.4/10

Good

(620)

"My room is always clean, good tv, comfortable bed."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Kimberly

Traveling solo

CA $85

CA $97 total

includes taxes & fees

Dec 17 - Dec 18

[](https://www.expedia.ca/Warrenton-Hotels-Super-8-By-Wyndham-Warrenton.h460034.Hotel-Information)

![Daily buffet breakfast (USD 12.95 per person)](https://images.trvl-media.com/lodging/1000000/300000/297100/297075/c23cebe0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Junior Suite, One King Bed, Non-Smoking](https://images.trvl-media.com/lodging/1000000/300000/297100/297075/2340dbe4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/1000000/300000/297100/297075/2a45ee7c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Indoor pool](https://images.trvl-media.com/lodging/1000000/300000/297100/297075/d3adc83f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Hilton Garden Inn Chesterfield

[](https://www.expedia.ca/St-Louis-Hotels-Hilton-Garden-Inn-Chesterfield.h297075.Hotel-Information)

Chesterfield

8.2/10

Very good

(783)

"Just a really nice hotel tucked away from everything, but still close to get whereevre you need to go!"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Roy

Traveling solo

CA $135

CA $157 total

includes taxes & fees

Dec 21 - Dec 22

[](https://www.expedia.ca/St-Louis-Hotels-Hilton-Garden-Inn-Chesterfield.h297075.Hotel-Information)

![Suite, 1 King Bed, Non Smoking (Upgraded)](https://images.trvl-media.com/lodging/1000000/860000/855500/855477/cc91e017.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/1000000/860000/855500/855477/a8d86cf5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/1000000/860000/855500/855477/b0977ad8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Property amenity](https://images.trvl-media.com/lodging/1000000/860000/855500/855477/390b6bf7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Super 8 by Wyndham St. Clair MO

[](https://www.expedia.ca/Washington-Hotels-Super-8-By-Wyndham-St-Clair-MO.h855477.Hotel-Information)

St. Clair

7.2/10

Good

(943)

"Room was very spacious and very clean."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Kristina

Traveling with partner

CA $92

CA $101 total

includes taxes & fees

Dec 17 - Dec 18

[](https://www.expedia.ca/Washington-Hotels-Super-8-By-Wyndham-St-Clair-MO.h855477.Hotel-Information)

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

[View all properties](https://expedia.ca/Hotel-Search?startDate=2025-12-24&endDate=2025-12-25&regionId=6353634&adults=2&sort=RECOMMENDED&openPlayBack=true)

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Save an average of 15% on thousands of hotels when you're signed in

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## Learn more about Defiance

Nestled along the Missouri River, this historic village offers scenic hiking trails and access to nearby wine country. Visit the Daniel Boone Home in neighbouring Defiance Township or enjoy tastings at the family-owned wineries dotting the surrounding countryside.

[See all hotels in Defiance](https://www.expedia.ca/Hotel-Search?startDate=2025-12-24&endDate=2025-12-25&adults=2&regionId=6353634)

![A covered bridge at the Historic Daniel Boone Home Park in Defiance, Missouri](https://images.trvl-media.com/place/6353634/33b2b915-0d1b-4946-ae10-3b89e88434a7.jpg?impolicy=fcrop&w=900&h=600&p=1&q=high)

### Stay near popular Defiance attractions

[](https://expedia.ca/St-Louis-Union-Station-Hotels.0-l502868-0.Travel-Guide-Filter-Hotels)

![St. Louis Union Station](https://mediaim.expedia.com/destination/9/55f06578213cb4d3e5a61c6fa51be851.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

#### St. Louis Union Station

4.5/5(7 reviews)

You can learn about the local history of St. Louis when you make a stop at a well-known site like St. Louis Union Station. Experience the area's great live music or attend a baseball game. 

[See properties](https://expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests&regionId=502868)

[](https://expedia.ca/Gateway-Arch-Hotels.0-l502855-0.Travel-Guide-Filter-Hotels)

![Gateway Arch featuring modern architecture, a city and a skyscraper](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/28000/28954-Gateway-Arch.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

#### Gateway Arch

4.5/5(37 reviews)

Enjoy 360-degree views and learn about the history of St. Louis at this world-famous landmark.

[See properties](https://expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests&regionId=502855)

[](https://expedia.ca/St-Louis-Zoo-Hotels.0-l502878-0.Travel-Guide-Filter-Hotels)

![St. Louis Zoo](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/200000/200067-St-Louis-Zoo.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

#### St. Louis Zoo

4.5/5(7 reviews)

In the middle of St. Louis, meet the exotic and endangered animals that live in meticulously recreated ecosystems from all over the world.

[See properties](https://expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests&regionId=502878)

[](https://expedia.ca/Busch-Stadium-Hotels.0-l502872-0.Travel-Guide-Filter-Hotels)

![Busch Stadium](https://mediaim.expedia.com/destination/1/fc7b602fbc184e7e7e6b56e34fb1afe4.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

#### Busch Stadium

5/5(19 reviews)

Catch an event at Busch Stadium during your trip to St. Louis. Experience the area's great live music or attend a baseball game. 

[See properties](https://expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests&regionId=502872)

[](https://expedia.ca/City-Museum-Hotels.0-l6069375-0.Travel-Guide-Filter-Hotels)

![City Museum showing a city as well as children](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/199000/199840-City-Museum.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

#### City Museum

4.5/5(6 reviews)

This quirky children’s museum invites visitors to crawl through whales, climb into tree houses and whiz down three-story slides.

[See properties](https://expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests&regionId=6069375)

[](https://expedia.ca/Forest-Park-Hotels.0-l6005687-0.Travel-Guide-Filter-Hotels)

![Forest Park featuring a pond, flowers and a garden](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/199000/199633-Saint-Louis.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

#### Forest Park

4.5/5(9 reviews)

Nature, history and cultural institutions come together in one of the United States’ largest urban parks, which buzzes with St. Louis’ dynamic community spirit.

[See properties](https://expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests&regionId=6005687)

## More cheap stays in Defiance

![Americas Best Value Inn & Suites St. Louis, St. Charles Inn](https://images.trvl-media.com/lodging/1000000/70000/68200/68132/c17520b0_y.jpg?impolicy=resizecrop&rw=402&ra=fit)

### Americas Best Value Inn & Suites St. Louis, St. Charles Inn

1310 Bass Pro Drive St. Charles MO

CA $82

CA $96 total

Dec 21 - Dec 22

includes taxes & fees

5.6/10 (1,003 reviews)

[](https://expedia.ca/St-Louis-Hotels-Americas-Best-Value-Inn-Suites-St-Louis.h68132.Hotel-Information)

![Relax Inn Saint Charles ](https://images.trvl-media.com/lodging/2000000/1010000/1000800/1000712/3d3bc786_y.jpg?impolicy=resizecrop&rw=402&ra=fit)

### Relax Inn Saint Charles 

3800 Harry S Truman Blvd St. Charles MO

CA $85

CA $98 total

Dec 22 - Dec 23

includes taxes & fees

6.4/10 (999 reviews)

[](https://expedia.ca/St-Louis-Hotels-Relax-Inn-Saint-Charles.h1000712.Hotel-Information)

![Comfort Suites St Charles - St Louis](https://images.trvl-media.com/lodging/1000000/670000/664500/664414/55d0714b_y.jpg?impolicy=resizecrop&rw=402&ra=fit)

### Comfort Suites St Charles - St Louis

1400 S 5th St St. Charles MO

CA $115

CA $132 total

Dec 18 - Dec 19

includes taxes & fees

8.2/10 Very Good! (1,006 reviews)

[](https://expedia.ca/St-Louis-Hotels-Comfort-Suites-St-Charles-St-Louis.h664414.Hotel-Information)

![Hampton Inn St. Charles St. Peters](https://images.trvl-media.com/lodging/1000000/30000/20200/20181/8c366380_y.jpg?impolicy=resizecrop&rw=402&ra=fit)

### Hampton Inn St. Charles St. Peters

3720 W Clay St St. Charles MO

CA $121

CA $139 total

Dec 21 - Dec 22

includes taxes & fees

8/10 Very Good! (1,011 reviews)

[](https://expedia.ca/St-Louis-Hotels-Hampton-Inn-St-LouisSt-Charles.h20181.Hotel-Information)

![Country Inn & Suites by Radisson, St. Charles Historic District](https://images.trvl-media.com/lodging/2000000/1340000/1330400/1330309/529fe0ff_y.jpg?impolicy=resizecrop&rw=402&ra=fit)

### Country Inn & Suites by Radisson, St. Charles Historic District

1190 S Main St St. Charles MO

CA $163

CA $187 total

Jan 1 - Jan 2, 2026

includes taxes & fees

9.4/10 Exceptional! (1,000 reviews)

[](https://expedia.ca/St-Louis-Hotels-Country-Inn-Suites-By-Radisson.h1330309.Hotel-Information)

![Baymont by Wyndham St. Charles](https://images.trvl-media.com/lodging/1000000/50000/41500/41491/8dfa5f2b_y.jpg?impolicy=resizecrop&rw=402&ra=fit)

### Baymont by Wyndham St. Charles

801 Veterans Memorial Parkway St. Charles MO

[Get rates](https://expedia.ca/Hotel-Search?startDate=24%2F12%2F2025&endDate=25%2F12%2F2025&selected=41491&PinnedHotelID=41491&HadPinnedHotel=true&regionId=6353634)

7.8/10 Good! (1,000 reviews)

[](https://expedia.ca/St-Louis-Hotels-Baymont-By-Wyndham-St-Charles.h41491.Hotel-Information)

## Hotels in Defiance with star-rating

![4 Star Hotels](https://images.trvl-media.com/lodging/1000000/30000/23700/23677/6ae928dd_z.jpg)

4 Star Hotels

7 properties

[](https://expedia.ca/4Star-Defiance-Hotels.s40-0-d6353634.Travel-Guide-Filter-Hotels)

![3 Star Hotels](https://images.trvl-media.com/lodging/20000000/19690000/19681400/19681371/84fffc75_z.jpg)

3 Star Hotels

114 properties

[](https://expedia.ca/3Star-Defiance-Hotels.s30-0-d6353634.Travel-Guide-Filter-Hotels)

![2 Star Hotels](https://images.trvl-media.com/lodging/92000000/91830000/91828000/91827910/6717a2ac_z.jpg)

2 Star Hotels

156 properties

[](https://expedia.ca/2Star-Defiance-Hotels.s20-0-d6353634.Travel-Guide-Filter-Hotels)

## Recent reviews of Defiance hotels

![Hollywood Casino & Hotel St. Louis](https://images.trvl-media.com/lodging/1000000/90000/82600/82568/7188325f_y.jpg)

### Hollywood Casino & Hotel St. Louis

5/5 Excellent

"Everything was great. Keep up the good work!"

A verified traveller stayed at Hollywood Casino & Hotel St. Louis

Posted 21 hours ago

[](https://expedia.ca/St-Louis-Hotels-Hollywood-Casino-Hotel-St-Louis.h82568.Hotel-Information)

![Hampton Inn St. Charles St. Peters](https://images.trvl-media.com/lodging/1000000/30000/20200/20181/8c366380_y.jpg)

### Hampton Inn St. Charles St. Peters

5/5 Excellent

"I enjoyed the welcoming staff at the desk. The morning breakfast was hot and nice variety. I'll be back in the area soon and this is where I'll be staying!"

A verified traveller stayed at Hampton Inn St. Charles St. Peters

Posted 2 days ago

[](https://expedia.ca/St-Louis-Hotels-Hampton-Inn-St-LouisSt-Charles.h20181.Hotel-Information)

![Wingate by Wyndham St. Louis/Fenton Route 66](https://images.trvl-media.com/lodging/1000000/50000/40200/40102/5c35b8a4_y.jpg)

### Wingate by Wyndham St. Louis/Fenton Route 66

5/5 Excellent

"Room was clean "

A verified traveller stayed at Wingate by Wyndham St. Louis/Fenton Route 66

Posted 2 days ago

[](https://expedia.ca/St-Louis-Hotels-Pear-Tree-Inn-St-Louis-Fenton.h40102.Hotel-Information)

![Larkspur Landing Extended Stay Suites St. Louis Riverport - Airport West](https://images.trvl-media.com/lodging/2000000/1660000/1659000/1658956/ad47a940_y.jpg)

### Larkspur Landing Extended Stay Suites St. Louis Riverport - Airport West

5/5 Excellent

"Clean lobby, super friendly staff, effortless check in. There’s even a small market with food and essentials right next to the check in desk. "

A verified traveller stayed at Larkspur Landing Extended Stay Suites St. Louis Riverport - Airport West

Posted 2 days ago

[](https://expedia.ca/St-Louis-Hotels-Larkspur-Landing-Extended-Stay-Suites-St-Louis-Riverport-Airport-West.h1658956.Hotel-Information)

![Relax Inn Saint Charles ](https://images.trvl-media.com/lodging/2000000/1010000/1000800/1000712/3d3bc786_y.jpg)

### Relax Inn Saint Charles 

5/5 Excellent

"Great"

A verified traveller stayed at Relax Inn Saint Charles 

Posted 2 days ago

[](https://expedia.ca/St-Louis-Hotels-Relax-Inn-Saint-Charles.h1000712.Hotel-Information)

![Country Inn & Suites by Radisson, St. Charles Historic District](https://images.trvl-media.com/lodging/2000000/1340000/1330400/1330309/529fe0ff_y.jpg)

### Country Inn & Suites by Radisson, St. Charles Historic District

5/5 Excellent

"Staff was very welcoming and warming. The person responsible for the morning breakfast went out of her way to accommodate our needs."

A verified traveller stayed at Country Inn & Suites by Radisson, St. Charles Historic District

Posted 2 days ago

[](https://expedia.ca/St-Louis-Hotels-Country-Inn-Suites-By-Radisson.h1330309.Hotel-Information)

![The Wildwood Hotel](https://images.trvl-media.com/lodging/2000000/1770000/1768200/1768149/800a6847_y.jpg)

### The Wildwood Hotel

5/5 Excellent

"Clean quiet room. Friendly staff"

A verified traveller stayed at The Wildwood Hotel

Posted 2 days ago

[](https://expedia.ca/St-Louis-Hotels-The-Wildwood-Hotel.h1768149.Hotel-Information)

![Drury Inn & Suites Southwest St. Louis](https://images.trvl-media.com/lodging/1000000/980000/976200/976140/416a6a90_y.jpg)

### Drury Inn & Suites Southwest St. Louis

5/5 Excellent

"Friendly and helpful check in. Great breakfast."

A verified traveller stayed at Drury Inn & Suites Southwest St. Louis

Posted 4 days ago

[](https://expedia.ca/St-Louis-Hotels-Drury-Inn-Suites-Southwest-St-Louis.h976140.Hotel-Information)

![Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham](https://images.trvl-media.com/lodging/1000000/50000/42200/42122/bfca870c_y.jpg)

### Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

5/5 Excellent

"Fast "

A verified traveller stayed at Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

Posted 4 days ago

[](https://expedia.ca/St-Louis-Hotels-Drury-Inn-Suites-St-Louis-Fenton.h42122.Hotel-Information)

## Frequently asked questions

### What is the best area to stay in Defiance?

> This area is the heart of Defiance, offering a collection of local businesses, dining options, and access to the Katy Trail. It's a small, walkable village with a relaxed pace, surrounded by scenic vineyards and rolling hills. The historic Defiance Roadhouse is a popular landmark here.
> 
>   
> For couples looking for a romantic getaway, the village centre is ideal. You'll find boutique accommodation options, often with a focus on local wines and cuisine. It's great for enjoying leisurely meals, exploring the nearby wineries, and taking peaceful walks along the Katy Trail.
> 
>   
> Solo travellers seeking a peaceful retreat and outdoor activities will also find the village centre appealing.

### When is the best time to go to Defiance?

> Spring offers mild temperatures, making it ideal for outdoor activities like cycling and hiking along the Katy Trail. The vineyards begin to bud, and the countryside is lush and green. This period is particularly good for couples who enjoy scenic walks and wine tasting without the summer crowds.
> 
>   
> Autumn brings cooler, crisp air and the stunning transformation of the leaves, creating a picturesque backdrop for exploring the region. Many local wineries also host harvest festivals during this time. For those who appreciate outdoor beauty and a relaxed pace, this season provides an excellent experience.

### Can I cancel my hotel reservation on Expedia?

### How can I save on a Defiance hotel booking with Expedia?

### How much is the nightly rate at a Defiance hotel?

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