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Find hotels in Defiance, MO from CA $84

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Compare 823 hotels, room rates, hotel reviews and availability. Most hotels are fully refundable.

Our top choices for Defiance hotels

Drury Inn & Suites St. Louis St. Peters

3.0 star property
9.2 out of 10, Wonderful, (1000)
"Very friendly staff and very handy location!"
The price is CA $152
CA $175 total
includes taxes & fees
Sep 14 - Sep 15
Drury Inn & Suites St. Louis St. Peters

Drury Plaza Hotel St. Louis St. Charles

3.0 star property
9.6 out of 10, Exceptional, (1002)
"We liked the indoor/outdoor pool, the free drinks, and the breakfast was great"
The price is CA $152
CA $176 total
includes taxes & fees
Sep 21 - Sep 22
Drury Plaza Hotel St. Louis St. Charles

The Wildwood Hotel

3.5 star property
9.2 out of 10, Wonderful, (1563)
"Great place to stay."
The price is CA $122
CA $148 total
includes taxes & fees
Sep 10 - Sep 11
The Wildwood Hotel

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

3.0 star property
8.2 out of 10, Very good, (1001)
"Very good hotel for the price"
The price is CA $123
CA $143 total
includes taxes & fees
Sep 7 - Sep 8
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

Drury Plaza Hotel St. Louis Chesterfield

3.0 star property
9.6 out of 10, Exceptional, (1005)
"Great place to stay! "
The price is CA $180
CA $209 total
includes taxes & fees
Sep 14 - Sep 15
Drury Plaza Hotel St. Louis Chesterfield

Best Western Plus Fenton

2.5 star property
9.2 out of 10, Wonderful, (109)
"It was a perfect hotel"
The price is CA $137
CA $158 total
includes taxes & fees
Sep 10 - Sep 11
Best Western Plus Fenton

Super 8 by Wyndham Washington

2.0 star property
8.4 out of 10, Very good, (667)
"It was clean and quaint for the price and was also close to where I was going the next morning. "
The price is CA $121
CA $138 total
includes taxes & fees
Sep 14 - Sep 15
Super 8 by Wyndham Washington

Comfort Inn & Suites St. Louis - O'Fallon

2.5 star property
7.6 out of 10, Good, (1000)
"And nice hotel at a nice price "
The price is CA $103
CA $121 total
includes taxes & fees
Sep 29 - Sep 30
Comfort Inn & Suites St. Louis - O'Fallon

Comfort Suites St Charles - St Louis

2.5 star property
8.4 out of 10, Very good, (1002)
"Everything was great, clean, close to the places we were going too. "
The price is CA $143
CA $165 total
includes taxes & fees
Sep 7 - Sep 8
Comfort Suites St Charles - St Louis

Sleep Inn & Suites O'Fallon MO - Technology Drive

2.5 star property
8.8 out of 10, Excellent, (1005)
"Great location very clean and friendly staff!!!"
The price is CA $123
CA $145 total
includes taxes & fees
Sep 14 - Sep 15
Sleep Inn & Suites O'Fallon MO - Technology Drive

Hampton Inn St. Charles St. Peters

2.5 star property
8.0 out of 10, Very good, (1002)
"Easily accessible from I-70."
The price is CA $113
CA $130 total
includes taxes & fees
Sep 28 - Sep 29
Hampton Inn St. Charles St. Peters

Holiday Inn Express St. Louis West - O'Fallon by IHG

2.5 star property
8.6 out of 10, Excellent, (777)
"The staff were very nice & the breakfast was enjoyable. The hotel was clean."
The price is CA $140
CA $165 total
includes taxes & fees
Sep 9 - Sep 10
Holiday Inn Express St. Louis West - O'Fallon by IHG

Best Western Plus Washington Hotel

2.5 star property
9.0 out of 10, Wonderful, (590)
"Great breakfast, comfortable room, and wonderful staff, all for a reasonable price. We stay here every time we are in Washington."
The price is CA $178
CA $203 total
includes taxes & fees
Sep 7 - Sep 8
Best Western Plus Washington Hotel

Super 8 by Wyndham Union

2.0 star property
8.2 out of 10, Very good, (613)
"Good room for a reasonable price "
The price is CA $112
CA $124 total
includes taxes & fees
Sep 14 - Sep 15
Super 8 by Wyndham Union

Holiday Inn St. Louis West Six Flags by IHG

3.0 star property
8.8 out of 10, Excellent, (1001)
"Beautiful property with a lot of history. Very fun place with a lot of things to do."
The price is CA $134
CA $156 total
includes taxes & fees
Sep 9 - Sep 10
Holiday Inn St. Louis West Six Flags by IHG

Best Western Plus The Charles Hotel

3.0 star property
8.0 out of 10, Very good, (1005)
"I enjoyed my stay the food was good!"
The price is CA $128
CA $149 total
includes taxes & fees
Sep 14 - Sep 15
Best Western Plus The Charles Hotel

Country Inn & Suites by Radisson, St. Charles Historic District

2.5 star property
9.4 out of 10, Exceptional, (1007)
"The hotel is so warm and comforting and fits right into the quaint downtown area. "
The price is CA $158
CA $181 total
includes taxes & fees
Sep 11 - Sep 12
Country Inn & Suites by Radisson, St. Charles Historic District

Hampton Inn St. Louis Southwest

2.5 star property
9.0 out of 10, Wonderful, (945)
"Room was very nice and comfortable bed….still ongoing hotel makeover happening but comfortable room…."
The price is CA $153
CA $179 total
includes taxes & fees
Oct 5 - Oct 6
Hampton Inn St. Louis Southwest

Extended Stay America Suites St Louis St Peters

2.5 star property
7.0 out of 10, Good, (564)
"Now hotel , bathroom new and very big "
The price is CA $110
CA $126 total
includes taxes & fees
Sep 7 - Sep 8
Extended Stay America Suites St Louis St Peters

Holiday Inn Express & Suites St Peters by IHG

2.5 star property
9.2 out of 10, Wonderful, (345)
"Very nice place. Clean... quiet and very friendly staff!! We will definitely stay here again!!"
The price is CA $134
CA $162 total
includes taxes & fees
Sep 21 - Sep 22
Holiday Inn Express & Suites St Peters by IHG
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Learn more about Defiance

Nestled along the Missouri River, this historic village offers scenic hiking trails and access to nearby wine country. Visit the Daniel Boone Home in neighbouring Defiance Township or enjoy tastings at the family-owned wineries dotting the surrounding countryside.

Stay near popular Defiance attractions

More cheap stays in Defiance

More cheap stays in Defiance

Hotels in Defiance with star-rating

Hotels in Defiance with star-rating

Explore a world of travel with Expedia

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Frequently asked questions

When is the best time to go to Defiance?
The most popular time to visit Defiance is during the summer months, particularly in July, when the weather is warm and inviting. With average temperatures ranging from 22 to 28°C, it's the superb backdrop for outdoor adventures, whether you're exploring the scenic Maumee River or enjoying local events in the parks.

During the peak season from July to September, Defiance buzzes with activity. Festivals and community gatherings take place, providing visitors with a delightful opportunity to immerse themselves in the local culture. The vibrant atmosphere makes it ideal for families and couples alike, as there are plenty of outdoor activities, such as hiking, biking, and picnicking, in the surrounding nature.

If you're looking for a more budget-friendly time to visit, consider late September or early October. While the weather may start to cool slightly, with temperatures around 15 to 20°C, the autumn foliage offers a beautiful setting for sightseeing. This time of year also means fewer crowds, allowing you to enjoy the attractions at a more leisurely pace.
Can I cancel my hotel reservation on Expedia?
Many Expedia hotel reservations are refundable, provided that you cancel before the hotel's cancellation deadline – this is often within 24-48 hours of your scheduled arrival. If you have a non-refundable booking, it might still be possible to receive a refund if you cancel it within 24 hours of booking. Be sure to check your booking confirmation for the exact cancellation policy. For maximum flexibility, use our "Fully refundable property" filter during your search to find the right Defiance hotel for you.
How can I save on a Defiance hotel booking with Expedia?
Members always get our best prices. Find our best Defiance hotel deals by joining Expedia's free travel rewards program today. As a member, you can unlock instant savings and member perks when you're logged in to your account. Another tip is to book your hotel and flights together on Expedia, where bundling can result in significant savings.
How much is the nightly rate at a Defiance hotel?
Prices for hotels in Defiance often vary, but you can find a great deal from CA $84 on Expedia. All sorts of factors affect price, such as the time of year or the days of the week you choose for your stay. Find the best deals by being flexible with your dates, and sort search results by "Price: low to high" for the cheapest rate.