Title: Book the Best De Soto LUXURY Hotels - Upscale Hotels in De Soto, MO | Expedia.ca [Hotels in De Soto](https://expedia.ca/De-Soto-Hotels.d6085105.Travel-Guide-Hotels)[Vacation Rentals in De Soto](https://expedia.ca/De-Soto-Vacation-Rentals.d6085105.Travel-Guide-VacationRentals)[De Soto Car Rentals](https://expedia.ca/Car-Rentals-In-De-Soto.d6085105.Car-Rental-Guide)[De Soto Vacation Packages](https://expedia.ca/De-Soto.d6085105.Destination-Travel-Guides) ![](https://mediaim.expedia.com/destination/2/1f71f3ee006639c0d49d18546ddf62b5.jpg?impolicy=fcrop&w=1200&h=500&q=medium) Photo by Jessica King # Find luxury hotels in De Soto, MO - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on De Soto Luxury Hotels Tonight [Nov 1 - Nov 2](https://www.expedia.ca/Hotel-Search?regionId=6085105&startDate=2025-11-01&endDate=2025-11-02&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) Tomorrow [Nov 2 - Nov 3](https://www.expedia.ca/Hotel-Search?regionId=6085105&startDate=2025-11-02&endDate=2025-11-03&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) Next weekend [Nov 7 - Nov 9](https://www.expedia.ca/Hotel-Search?regionId=6085105&startDate=2025-11-07&endDate=2025-11-09&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) In two weeks [Nov 14 - Nov 16](https://www.expedia.ca/Hotel-Search?regionId=6085105&startDate=2025-11-14&endDate=2025-11-16&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) ## Top De Soto Luxury Hotels ## Top De Soto Hotel Reviews ![Drury Inn & Suites St. Louis Arnold](//images.trvl-media.com/lodging/4000000/3870000/3861200/3861101/a7778b87_y.jpg) ### Drury Inn & Suites St. Louis Arnold 10/10 Excellent "ALWAYS ENJOY OUR STAY HERE TO SEE THE GRAND KIDS" [](https://expedia.ca/St-Louis-Hotels-Drury-Inn-Suites-St-Louis-Arnold.h3861101.Hotel-Information) ![Comfort Inn Festus - St Louis South](//images.trvl-media.com/lodging/1000000/50000/40200/40138/3ea7ebcc_y.jpg) ### Comfort Inn Festus - St Louis South 10/10 Excellent " Mika went above and beyond even getting us ice when we checked in. As I was checking out Gary fell out used.Mika got him up and inside. Got ice and bandages. We were soon on our way." [](https://expedia.ca/Farmington-Hotels-Comfort-Inn-Festus-St-Louis-South.h40138.Hotel-Information) ![Baymont by Wyndham Festus](//images.trvl-media.com/lodging/1000000/10000/5600/5523/5f8a3296_y.jpg) ### Baymont by Wyndham Festus 10/10 Excellent "Great place to stay " [](https://expedia.ca/Festus-Hotels-Baymont-By-Wyndham-Festus.h5523.Hotel-Information) ## Frequently asked questions ### Are you searching for a great accommodation for your luxury getaway to De Soto? > Use Expedia to arrange your flight to St. Louis, MO (SUS-Spirit of St. Louis) airport or St. Louis Lambert Intl. Airport (STL) airport, and then select from a variety of places to stay that will deliver the luxury you want. Amenities are important when you plan a trip, so we make it easy to get what you want to make your stay relaxing and comfortable. If you want an upscale hotel with fine dining, a spa, or several swimming pools, Expedia can assist you in finding the best luxury hotel experience that De Soto has to offer. De Soto has some interesting things to see and do including Sunrise Lake Beach and Washington State Park, so you might want to take in the local sights during your visit. ### When can I expect good weather in De Soto? > Planning for the weather is an important factor for making your trip to De Soto a success, especially when you're splurging. The hottest months are usually July and August with an average temp of 75°F, while the coldest months are January and February with an average of 38°F. Average annual precipitation for De Soto is 46 inches. ### What's there to see and do in De Soto? > Enjoy De Soto and visit Sunrise Lake Beach, Washington State Park, and Big River. 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