Book The Best Hotels in Cross Keys, MO for 2026 from CA $140 - Fully Refundable Options

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Our top choices for Cross Keys hotels

A spacious lobby with modern seating, a reception desk, and large windows offering views of the parking area.

A seating area with three grey armchairs and a central glass-top table, a wooden floor, and a view of parked cars through large windows.

A hotel room with a bed, a desk, a television, and a lamp.

A spacious indoor area with a high ceiling and large windows, featuring multiple seating areas with sofas and chairs, and a visible outdoor view through the windows.

1. Pear Tree Inn St. Louis Airport

St. Ann

Murphy

CA $125

CA $149 total

includes taxes & fees

Oct 18 - Oct 19

A multi-level hotel lobby with seating areas, a reception desk, and large windows offering views.

A modern kitchen with a stainless steel range hood, a bar area with stools, and a large window providing a view of the outdoors.

A pool area with two hot tubs, seating, and a view of the outdoors.

A hotel reception area with a counter, seating, and a staircase.

2. Drury Inn & Suites St. Louis Airport

Edmundson

Ethan

CA $160

CA $190 total

includes taxes & fees

Oct 18 - Oct 19

A snack kiosk with a variety of packaged foods and beverages, a cash register, and a sign reading 'The Shop.'

A spacious indoor area with multiple dining tables and chairs, a fireplace, and a large artwork on the wall.

A lobby with a fireplace, seating area, and a large framed artwork.

An indoor swimming pool with clear signage, a tiled floor, and a seating area with chairs and tables.

3. Hilton Garden Inn St. Louis Airport

Berkeley

Darryl

CA $190

CA $222 total

includes taxes & fees

Oct 18 - Oct 19

A modern living room with a built-in fireplace, a large flat-screen TV, a unique hexagonal pendant light, and a patterned rug.

A modern lobby with blue seating, a reception desk, and large windows.

A multi-story hotel with a stone facade, a covered entrance, and a parking lot.

A modern dining area with a long table, multiple chairs, and a unique chandelier.

4. Hyatt Select St. Louis Airport

Woodson Terrace

Daisy

CA $156

CA $194 total

includes taxes & fees

Oct 26 - Oct 27

A modern hotel room with a dining area, wooden cabinets, a checkered floor, and a flat-screen TV.

A hotel room with a desk, chair, TV, and a framed picture on the wall.

A Wingate hotel with a covered entrance, outdoor seating, and a parking lot.

A hotel room with two beds, a desk, a chair, and a large window with curtains.

5. Wingate by Wyndham St. Louis Airport

St. Ann

Mary

CA $138

CA $163 total

includes taxes & fees

Oct 26 - Oct 27

An indoor swimming pool with clear glass walls, blue lounge chairs, and a lifeguard stand.

A hotel lobby with a reception desk, seating area, and a view of the parking lot.

A snack vending machine with various snack options.

A hotel room with two beds, a desk, a chair, a TV, and a window with curtains.

6. Hampton Inn By Hilton St Louis Airport

Woodson Terrace

Leia

CA $184

CA $221 total

includes taxes & fees

Oct 29 - Oct 30

A buffet with fruits, pastries, and beverages.

A modern living room with a flat-screen TV, comfortable seating, and decorative items on shelves.

The Renaissance Hotel with a modern architectural design, featuring a prominent central entrance and a symmetrical facade.

A spacious hotel lobby with multiple seating areas, a reception desk, and large windows offering a view of the cityscape.

7. Renaissance St. Louis Airport Hotel

Berkeley

Anthony

CA $169

CA $197 total

includes taxes & fees

Oct 29 - Oct 30

A hotel entrance with a covered driveway and a parking area.

A hotel room with two desks, each with a computer, a lamp, and a chair.

A dining area with multiple tables and chairs, a kitchen in the background, and artwork on the walls.

A hotel lobby with striped armchairs, a round coffee table, a sofa, and a clock on the wall.

8. Best Western Plus Parkway Hotel

Alton

Steve

CA $120

CA $137 total

includes taxes & fees

Oct 29 - Oct 30

The Clayton Plaza Hotel sign with a stone wall and plants in front.

A living room with a brown leather sofa, a small table, and a chair. There is a window with curtains, a lamp, and a framed picture on the wall.

A hotel room with two beds, a desk, a chair, and a television.

A lobby with a chandelier, a round table with a floral arrangement, and a painting on the wall.

9. Clayton Plaza Hotel & Extended Stay

Clayton

Daniele

CA $127

CA $148 total

includes taxes & fees

Oct 25 - Oct 26

A modern bathroom with a red bathtub, a white sink, and a shower. There is a bed with a white mattress and a grey curtain in the adjacent room.

A modern room with a stone wall, a flat-screen TV, two red chairs, a small table, and a view of the outside.

A modern kitchen area with a dining table and chairs, a refrigerator, a coffee machine, and a vending machine.

A modern kitchen with stainless steel appliances, a white countertop, and a framed picture on the wall.

10. Red Lion Inn & Suites Pontoon Beach

Granite City

Breannah

CA $102

CA $116 total

includes taxes & fees

Oct 18 - Oct 19

A bar area with a long counter, multiple seating options, and a television screen displaying a program.

An indoor swimming pool with clear blue water, surrounded by lounge chairs and large windows offering views of the outdoors.

A multi-story hotel with a prominent 'Hilton' sign, a parking area, and a covered walkway.

A hotel lobby with a central seating area featuring sofas and tables, a large TV screen displaying a sports game, and a bar area with chairs and a counter.

11. Hilton St. Louis Airport

Woodson Terrace

raymond

CA $195

CA $235 total

includes taxes & fees

Nov 13 - Nov 14

A hotel lobby with blue seating, a flat-screen TV, and a fireplace.

An indoor swimming pool with clear water, surrounded by lounge chairs and a tiled deck.

A spacious dining area with high tables and booths, large windows, and a view of greenery outside.

A reception area with two dark wooden reception desks, a stone-textured wall, and a sign reading "Comfort INN".

12. Comfort Inn Edwardsville - St. Louis

Edwardsville

Christina

CA $127

CA $147 total

includes taxes & fees

Oct 20 - Oct 21

A spacious lobby with a high ceiling, large windows, and a variety of seating options including sofas and chairs.

A spacious indoor area with a large table and chairs, a sofa, and a staircase leading to an upper level.

An indoor swimming pool with clear glass walls, a tiled edge, and a ceiling with metal beams. There are lounge chairs and tables around the pool area.

A restaurant with a brick wall, large windows, and a seating area with tables and chairs.

13. Drury Inn & Suites St. Louis Collinsville

Eastport

CA $139

CA $160 total

includes taxes & fees

Nov 1 - Nov 2

A modern living room with a sofa set, two armchairs, a coffee table, and a wall art piece.

A modern kitchen with wooden cabinets, a central island, and various appliances.

A snack display in a store with various packaged snacks and beverages.

14. Comfort Inn St. Louis Airport

Bridgeton

Crystal

CA $133

CA $160 total

includes taxes & fees

Nov 9 - Nov 10

A large hotel with a prominent tower and multiple parking areas.

A lobby with a large screen displaying "Hollywood Casino" and "Wood Casino" signs, multiple chandeliers, and a polished floor.

A crowded indoor space with a chandelier, brick walls, and tables where people are seated and standing.

A spacious lobby with a patterned carpet, a reception desk, and a seating area with a sofa and chairs.

15. Hollywood Casino & Hotel St. Louis

Riverport

Nicole

CA $134

CA $179 total

includes taxes & fees

Nov 1 - Nov 2

A modern lobby with a fireplace, comfortable seating, and a large TV screen.

A modern kitchen with dark cabinets, a central island, and various appliances including a coffee machine and a microwave.

A compact living space with a kitchenette, a flat-screen TV, a desk with a chair, a bench, and a sofa.

A hotel room with a large bed, two bedside tables with lamps, a wooden headboard, and a framed picture on the wall.

16. Best Western Plus St. Louis West-Westport

Westport

Ethan

CA $120

CA $140 total

includes taxes & fees

Nov 1 - Nov 2

An indoor swimming pool with a hot tub, lounge chairs, and a brick wall with artwork.

A hotel room with two beds, a desk, a TV, and a painting on the wall.

A multi-story hotel with a prominent sign for 'Pearl Tree Inn by O'Dell'.

17. Pear Tree Inn St. Louis Near Union Station

Downtown West

Samantha

CA $146

CA $171 total

includes taxes & fees

Oct 18 - Oct 19

A spacious lobby with a modern design, featuring a large seating area with sofas and chairs, a patterned carpet, and a view of the outside through large windows.

A modern kitchen with white cabinets, a long countertop, and overhead lighting.

18. Elimwood Hotel, a Ramada by Wyndham

Riverport

Harry

CA $91

CA $106 total

includes taxes & fees

Nov 3 - Nov 4

A hotel lobby with seating areas, a fireplace, and a kitchen in the background.

A spacious kitchen with wooden cabinets, a central island with multiple bowls, and various kitchen appliances.

An outdoor patio area with tables and chairs, a barbecue grill, and a covered seating area.

A building with a red roof and a well-lit entrance.

19. Larkspur Landing Extended Stay Suites St. Louis Riverport - Airport West

Riverport

William

CA $94

CA $110 total

includes taxes & fees

Oct 29 - Oct 30

A hotel with a covered entrance, a tower with signage, and a landscaped area with planters.

A hotel room with purple walls, a flat-screen TV, a bed, a dining table with chairs, a sofa, and a window with curtains.

A covered outdoor seating area with a pergola, surrounded by landscaped bushes and a paved walkway.

A hotel lobby with multiple seating areas, including round tables and sofas, and a reception desk with a green plant.

20. La Quinta Inn & Suites by Wyndham St. Louis Westport

Westport

Gary

CA $110

CA $129 total

includes taxes & fees

Nov 1 - Nov 2

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Top Cross Keys Hotel Reviews

Pear Tree Inn St. Louis Airport

8/10 Good

"The property was great but the breakfast menu was the same every morning. I would’ve liked a little more variety. The happy hour cocktails were nice. The room and property were clean. I would’ve liked highly recommend thus property."

Hampton Inn St. Louis-Downtown (At the Gateway Arch)

10/10 Excellent

"This hotel is located in a great location, close to the Gateway Arch and the ballpark where the Cardinals play. There were numerous fun restaurants within walking distance, and we felt safe except down by the Old Spaghetti Factory. I would stay in this hotel again and recommend it to others."

Courtyard by Marriott St. Louis Downtown/Convention Center

10/10 Excellent

"Great place to stay! Highly recommend!"

Pear Tree Inn St. Louis Near Union Station

10/10 Excellent

"The property itself was maintained ok. It does need to be updated as the carpets and bathrooms are old. Our ceiling in the bathroom was peeling due to the humidity from the shower over the years. The carpet in the rooms and common areas is older. As for the staff everyone was nice and did what was expected of them. I would use this property again to stay as it’s walking distance from everything downtown."

Clayton Plaza Hotel & Extended Stay

8/10 Good

"Hotel staff were excellent, friendly, professional and by far the best reason to re-book. The hotel itself was very clean, located near professional buildings/courts and some eateries within walking distance. The room was clean as well and nicely proportioned with some of the best mattresses/bedding I've experienced. Only slight downside was the breakfast bar--the food and choices were ample and very good (especially the made to order omelets and waffles) but the setting was less than clean and rather worn--not in keeping with the rest of the hotel. All in all, a great place to stay and would definitely book again."

Drury Plaza Hotel St. Louis at the Arch

10/10 Excellent

"I loved the happy hour, you get a voucher for 3 free alcoholic beverages and the food was delicious."

Drury Plaza Hotel St. Louis Union Station

10/10 Excellent

"Location was great for us. Walked to an event. The drinks and food in the evening was nice and breakfast was good as well. Love the character of this one"

Moonrise Hotel

8/10 Good

"I slept well."

Live by Loews - St.Louis

10/10 Excellent

"The area was nice and in the center of what we wanted to do for the weekend!!"

More cheap stays in Cross Keys

Pear Tree Inn St. Louis Airport

10810 Pear Tree Ln St. Ann MO

CA $125

CA $149 total

Oct 18 - Oct 19

includes taxes & fees

9.2/10 Wonderful! (3,290 reviews)

Tru By Hilton St. Louis Downtown

1221 Locus Street St. Louis MO

CA $132

CA $154 total

Nov 1 - Nov 2

includes taxes & fees

7.8/10 Good! (1,013 reviews)

Comfort Suites St Charles - St Louis

1400 S 5th St St. Charles MO

CA $138

CA $158 total

Nov 1 - Nov 2

includes taxes & fees

The West End

4215 Lindell Blvd St. Louis MO

CA $142

CA $195 total

Nov 3 - Nov 4

includes taxes & fees

Hampton Inn St. Charles St. Peters

3720 W Clay St St. Charles MO

CA $170

CA $195 total

Oct 25 - Oct 26

includes taxes & fees

AC Hotel St. Louis Clayton

227 South Central Ave St. Louis MO

CA $183

CA $213 total

Oct 18 - Oct 19

includes taxes & fees

Hotels in Cross Keys with star rating

Frequently asked questions

Where is the best place to stay in Cross Keys?

Located 10.1 mi (16.3 km) from the heart of Cross Keys, Clayton Plaza Hotel & Extended Stay is a top choice for your stay based on our traveler data. Other good choices for your trip to the area are Hyatt Regency St. Louis at The Arch and Pear Tree Inn St. Louis Airport. See all available top hotels, or vacation rentals in Cross Keys.

What are some of the best vacation home rentals in Cross Keys?

Cozy Studio Cottage on "The Hill," walkably close to everything! The Zoo, Park!!: This vacation home rental near Cross Keys is located in the city center and has a patio, a garden, and a barbecue grill to put you at ease in your new surroundings. Kitchen amenities include a dishwasher, a fridge, and a stovetop. You and your friends and family can relax into your vacation with amenities like a selection of games. See all vacation rentals in Cross Keys.

If I need to cancel my hotel reservation in Cross Keys, will I receive a refund?

Yes! Most hotel reservations are fully refundable if cancelled prior to the accommodation's cancellation deadline, which is often 24 or 48 hours before your scheduled arrival. If you have a reservation that's non-refundable, you may still be able to cancel and get a refund within 24 hours of your booking. Filter your search by fully refundable to find flexible hotel deals in Cross Keys.

What is staying in Cross Keys like?

Travelers to Cross Keys will find plenty to explore and enjoy. Top sights around the area include St. Louis Zoo and St. Louis Union Station. There are 1922 hotels and other accommodations in the surrounding area. Find out more about Cross Keys.

What is there to see in Cross Keys?

Notable places to visit in the surrounding area include St. Louis Zoo and St. Louis Union Station. You'll also find Argosy Casino and Alton Prison in the area. Check out what more to see and do in Expedia's Cross Keys guide.

What's the seasonal weather like in Cross Keys?

The hottest months are usually July and August with an average temp of 75°F, while the coldest months are January and February with an average of 37°F. Average annual precipitation for Cross Keys is 52 inches.

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Find hotels in Cross Keys, MO from CA $140

Change your mind

Treat yourself

Be picky

Go beyond your typical stay in Cross Keys

Check prices for these dates

Filter by

Star rating

Guest rating

Our top choices for Cross Keys hotels

1. Pear Tree Inn St. Louis Airport

2. Drury Inn & Suites St. Louis Airport

3. Hilton Garden Inn St. Louis Airport

4. Hyatt Select St. Louis Airport

5. Wingate by Wyndham St. Louis Airport

6. Hampton Inn By Hilton St Louis Airport

7. Renaissance St. Louis Airport Hotel

8. Best Western Plus Parkway Hotel

9. Clayton Plaza Hotel & Extended Stay

10. Red Lion Inn & Suites Pontoon Beach

11. Hilton St. Louis Airport

12. Comfort Inn Edwardsville - St. Louis

13. Drury Inn & Suites St. Louis Collinsville

14. Comfort Inn St. Louis Airport

15. Hollywood Casino & Hotel St. Louis

16. Best Western Plus St. Louis West-Westport

17. Pear Tree Inn St. Louis Near Union Station

18. Elimwood Hotel, a Ramada by Wyndham

19. Larkspur Landing Extended Stay Suites St. Louis Riverport - Airport West

20. La Quinta Inn & Suites by Wyndham St. Louis Westport

Top Cross Keys Hotel Reviews

Pear Tree Inn St. Louis Airport

Hampton Inn St. Louis-Downtown (At the Gateway Arch)

Courtyard by Marriott St. Louis Downtown/Convention Center

Pear Tree Inn St. Louis Near Union Station

Clayton Plaza Hotel & Extended Stay

Drury Plaza Hotel St. Louis at the Arch

Drury Plaza Hotel St. Louis Union Station

Moonrise Hotel

Live by Loews - St.Louis

More cheap stays in Cross Keys

Pear Tree Inn St. Louis Airport

Tru By Hilton St. Louis Downtown

Comfort Suites St Charles - St Louis

The West End

Hampton Inn St. Charles St. Peters

AC Hotel St. Louis Clayton

Hotels in Cross Keys with star rating

Frequently asked questions

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