Title: Visit Commerce: Best of Commerce Tourism | Expedia Travel Guide - Expedia.ca [Hotels in Commerce](https://expedia.ca/Commerce-Hotels.d553248634983177483.Travel-Guide-Hotels)[Vacation Rentals in Commerce](https://expedia.ca/Commerce-Vacation-Rentals.d553248634983177483.Travel-Guide-VacationRentals)[Commerce Car Rentals](https://expedia.ca/Car-Rentals-In-Commerce.d553248634983177483.Car-Rental-Guide)[Commerce Vacation Packages](https://expedia.ca/Commerce.d553248634983177483.Destination-Travel-Guides) # Commerce ## Travel Guide ## Visit Commerce ![](https://forever.travel-assets.com/flex/flexmanager/images/2026/02/06/expedia-sale-2026-desktop-us-ca.jpg?impolicy=fcrop&w=1400&h=600&q=mediumHigh) ## The Annual Vacation Sale Members save up to 40% on hotels and homes. Plan this year’s big trip and save. [Book now](https://expedia.ca/deals?rfrr=DX_SPRING_PROMO_553248634983177483) - Commerce Hotel Deals - Vacation Rentals in Commerce ![Drury Plaza Hotel Cape Girardeau Conference Center](https://images.trvl-media.com/lodging/18000000/17270000/17270000/17269948/742aaf1e_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Drury Plaza Hotel Cape Girardeau Conference Center 3351 Percy Drive Cape Girardeau MO Fully refundableReserve now, pay when you stay CA $136 CA $154 total Mar 4 - Mar 5 includes taxes & fees Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ... 9.6/10 Exceptional! (1,004 reviews) Lovely room..bed so bet comfy..but we had very loud toilet ! Reviewed on Feb 28, 2026 [](https://expedia.ca/Hotel-Search?startDate=04%2F03%2F2026&endDate=05%2F03%2F2026&selected=17269948&PinnedHotelID=17269948&HadPinnedHotel=true®ionId=553248634983177483) ![The Riverview](https://images.trvl-media.com/lodging/106000000/105090000/105081400/105081384/d68c9046_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### The Riverview 777 Main St Cape Girardeau MO CA $122 CA $138 total Mar 10 - Mar 11 includes taxes & fees Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free WiFi, free parking, and 2 restaurants. Popular attractions Isle Casino Cape Girardeau ... 9.4/10 Exceptional! (513 reviews) Beautiful facility Reviewed on Feb 25, 2026 [](https://expedia.ca/Hotel-Search?startDate=10%2F03%2F2026&endDate=11%2F03%2F2026&selected=105081384&PinnedHotelID=105081384&HadPinnedHotel=true®ionId=553248634983177483) ![Drury Inn & Suites Cape Girardeau](https://images.trvl-media.com/lodging/1000000/50000/40900/40831/4b521966_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Drury Inn & Suites Cape Girardeau 3303 Campster Drive Cape Girardeau MO Fully refundableReserve now, pay when you stay CA $123 CA $138 total Mar 4 - Mar 5 includes taxes & fees Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the ... 9.4/10 Exceptional! (1,004 reviews) Everything above was excellent Reviewed on Feb 27, 2026 [](https://expedia.ca/Hotel-Search?startDate=04%2F03%2F2026&endDate=05%2F03%2F2026&selected=40831&PinnedHotelID=40831&HadPinnedHotel=true®ionId=553248634983177483) [See all 75 properties in Commerce](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.DestinationExperience&startDate=02%2F03%2F2026&endDate=03%2F03%2F2026®ionId=553248634983177483) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ![“Brickyard”-Recently Remodeled Dutch Colonial Revival in Downtown Cape Girardeau](https://images.trvl-media.com/lodging/77000000/76550000/76544100/76544096/b002a425_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### “Brickyard”-Recently Remodeled Dutch Colonial Revival in Downtown Cape Girardeau Cape Girardeau MO Book a stay at this family-friendly vacation home in Cape Girardeau. Enjoy free WiFi, a water park, and a garden. Popular attractions Isle Casino Cape Girardeau ... 10/10 Exceptional! (33 reviews) Every detail was thought of including fresh flowers when we arrived. Very thoughtful host Reviewed on Feb 21, 2026 [](https://expedia.ca/Cape-Girardeau-Hotels-Remodeled-1920s-Dutch-Colonial-Revival-In-Downtown-Cape-Girardeau.h76544096.Hotel-Information) ![3 Bed 3 Bath Beautiful Historic District Within Walking Downtown Cape Girardeau](https://images.trvl-media.com/lodging/121000000/120670000/120661800/120661701/7d35641a_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### 3 Bed 3 Bath Beautiful Historic District Within Walking Downtown Cape Girardeau Cape Girardeau MO Stay at this vacation home in Cape Girardeau. Enjoy laundry facilities and air conditioning. Popular attractions Show Me Center and Isle Casino Cape Girardeau ... 9.8/10 Exceptional! (10 reviews) Conveniently located to college and good restaurants. Is a large home with lots of space for a family. Reviewed on Feb 11, 2026 [](https://expedia.ca/Cape-Girardeau-Hotels-3-Bedroom-3-Full-Bath-In-Beautiful-Historic-District-Downtown-Cape-Girardeau.h120661701.Hotel-Information) ![Cozy cabins on beautiful Horseshoe Lake](https://images.trvl-media.com/lodging/91000000/90340000/90331200/90331191/53db6388_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Cozy cabins on beautiful Horseshoe Lake Olive Branch IL Stay at this cabin in Alexander County. Enjoy patios, an in-room coffeemaker, and air conditioning. 9.8/10 Exceptional! (37 reviews) The cabin was extremely clean and nice. Amenities were perfect. Right by the lake. Would highly recommend. Reviewed on Feb 28, 2026 [](https://expedia.ca/Cozy-Cabins-On-Beautiful-Horseshoe-Lake.h90331191.Hotel-Information) [See all properties in Commerce](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.DestinationExperience®ionId=553248634983177483&sort=VACATION_RENTAL) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ## Check Commerce hotel availability [Tonight ](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=553248634983177483&startDate=2026-03-01&endDate=2026-03-02)[Mar 1 - Mar 2](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=553248634983177483&startDate=2026-03-01&endDate=2026-03-02) [Tomorrow night ](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=553248634983177483&startDate=2026-03-02&endDate=2026-03-03)[Mar 2 - Mar 3](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=553248634983177483&startDate=2026-03-02&endDate=2026-03-03) [Next weekend ](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=553248634983177483&startDate=06%2F03%2F2026&endDate=08%2F03%2F2026)[Mar 6 - Mar 8](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=553248634983177483&startDate=06%2F03%2F2026&endDate=08%2F03%2F2026) - Cities near Commerce - Places of interest - [Mississippi River ](https://expedia.ca/Mississippi-River-United-States-of-America.d6209928.Vacation-Attraction) - [Ohio River Valley ](https://expedia.ca/Ohio-River-Valley-United-States-of-America.d6233674.Vacation-Attraction) - [Southeast Missouri State University ](https://expedia.ca/Southeast-Missouri-State-University-Cape-Girardeau.d553248621554122994.Vacation-Attraction) - [eDen Spa & Salon ](https://expedia.ca/EDen-Spa-Salon-Cape-Girardeau.d553248621532655776.Vacation-Attraction) ![](https://a.travel-assets.com/mad-service/footer/bnaBanners/BEX_Footer.jpg) ## Go further with the Expedia app Save on select hotels and earn double points when you book on the app. Our app deals help you to save on trips so you can travel more and manage it all on the go. 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