Title: 10 Best Hotels in Downtown South San Francisco, San Francisco for 2026 | Expedia.ca

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![Aerial view of downtown San Francisco and Financial District sky scrapers flying over South San Francisco The Industrial City inscription on San Bruno mountain circa 2015](https://images.trvl-media.com/place/553248635976481411/4dd74f8a-dfcd-4623-817e-767c96ff0c5c.jpg?impolicy=fcrop&w=1200&h=500&q=medium)

![](https://images.trvl-media.com/place/553248635976481411/4dd74f8a-dfcd-4623-817e-767c96ff0c5c.jpg?impolicy=fcrop&w=1200&h=500&q=medium)

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## Check prices for these dates

Tonight

[Jan 26 - Jan 27](https://www.expedia.ca/Hotel-Search?regionId=553248635976481411&startDate=2026-01-26&endDate=2026-01-27&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Tomorrow

[Jan 27 - Jan 28](https://www.expedia.ca/Hotel-Search?regionId=553248635976481411&startDate=2026-01-27&endDate=2026-01-28&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

This weekend

[Jan 30 - Feb 1](https://www.expedia.ca/Hotel-Search?regionId=553248635976481411&startDate=2026-01-30&endDate=2026-02-01&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Next weekend

[Feb 6 - Feb 8](https://www.expedia.ca/Hotel-Search?regionId=553248635976481411&startDate=2026-02-06&endDate=2026-02-08&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Recommended

Price (low to high)

Distance

Star rating

## Our top choices for Downtown South San Francisco hotels

![Exterior](https://images.trvl-media.com/lodging/1000000/10000/9400/9329/5d196618.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/1000000/10000/9400/9329/f426e9e8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Deluxe Suite, Multiple Beds, Accessible, Non Smoking (Mobility/Hearing Impaired Accessible)](https://images.trvl-media.com/lodging/1000000/10000/9400/9329/6c7a44bf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Free daily continental breakfast](https://images.trvl-media.com/lodging/1000000/10000/9400/9329/4becccdf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### La Quinta Inn & Suites by Wyndham San Francisco Airport N

[](https://www.expedia.ca/San-Francisco-Hotels-La-Quinta-Inn-Suites-By-Wyndham-San-Francisco-Airport-N.h9329.Hotel-Information)

Downtown South San Francisco

8.0/10

Very good

(2,029 reviews)

"Was a great stay. Front desk staff very personable, housekeeping friendly, and had a great breakfast. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Cora

CA $139

CA $163 total

includes taxes & fees

Jan 30 - Jan 31

[](https://www.expedia.ca/San-Francisco-Hotels-La-Quinta-Inn-Suites-By-Wyndham-San-Francisco-Airport-N.h9329.Hotel-Information)

![Interior detail](https://images.trvl-media.com/lodging/12000000/11980000/11974700/11974670/779a738f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Reception](https://images.trvl-media.com/lodging/12000000/11980000/11974700/11974670/380e42eb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior detail](https://images.trvl-media.com/lodging/12000000/11980000/11974700/11974670/466a0c10.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior detail](https://images.trvl-media.com/lodging/12000000/11980000/11974700/11974670/b1cfa504.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Airport Inn

[](https://www.expedia.ca/San-Francisco-Hotels-Airport-Inn.h11974670.Hotel-Information)

Downtown South San Francisco

8.8/10

Excellent

(980 reviews)

"Very clean room, friendly staff and secure parking."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Christopher

CA $134

CA $158 total

includes taxes & fees

Feb 10 - Feb 11

[](https://www.expedia.ca/San-Francisco-Hotels-Airport-Inn.h11974670.Hotel-Information)

![Premium bedding, pillowtop beds, in-room safe, desk](https://images.trvl-media.com/lodging/2000000/1140000/1139300/1139289/08473f85.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/2000000/1140000/1139300/1139289/b9912bba.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Check-in/check-out kiosk](https://images.trvl-media.com/lodging/2000000/1140000/1139300/1139289/9b3dc53f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/2000000/1140000/1139300/1139289/aeecf8ad.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Inn By The SFO

[](https://www.expedia.ca/San-Francisco-Hotels-Inn-By-The-SFO.h1139289.Hotel-Information)

Downtown South San Francisco

7.8/10

Good

(1,001 reviews)

"Everything great. Good location close to airport and walking distance to coffee, market, and restaurants. Try shabu shack!"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Gabriel

[](https://www.expedia.ca/San-Francisco-Hotels-Inn-By-The-SFO.h1139289.Hotel-Information)

![Deluxe Room](https://images.trvl-media.com/lodging/92000000/91120000/91116900/91116819/1e2e26cf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Living area](https://images.trvl-media.com/lodging/92000000/91120000/91116900/91116819/60ad2a4a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/92000000/91120000/91116900/91116819/d205a5de.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fridge, microwave, coffee/tea maker, dining tables](https://images.trvl-media.com/lodging/92000000/91120000/91116900/91116819/c5aa34b1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Miller Apartments

[](https://www.expedia.ca/San-Francisco-Hotels-Miller-Apartments.h91116819.Hotel-Information)

Downtown South San Francisco

7.4/10

Good

(15 reviews)

"Own bedroom was quiet and tidy, shared bathroom clean and tidy, good communication "

![Australia](https://a.travel-assets.com/egds/marks/flags/au.svg)

Kasey

CA $103

CA $224 total

includes taxes & fees

Jan 27 - Jan 28

[](https://www.expedia.ca/San-Francisco-Hotels-Miller-Apartments.h91116819.Hotel-Information)

![Lobby sitting area](https://images.trvl-media.com/lodging/1000000/30000/24700/24625/6fb55356.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/1000000/30000/24700/24625/fb03adf0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Hallway](https://images.trvl-media.com/lodging/1000000/30000/24700/24625/cd59b3af.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Food and drink](https://images.trvl-media.com/lodging/1000000/30000/24700/24625/4e4ef19d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Hotel Riu Plaza Fisherman's Wharf

[](https://www.expedia.ca/San-Francisco-Hotels-Hotel-Riu-Plaza-Fishermans-Wharf.h24625.Hotel-Information)

16.8 km from Downtown South San Francisco

9.0/10

Wonderful

(7,316 reviews)

"Great hotel "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Gino

CA $163

CA $248 total

includes taxes & fees

Feb 9 - Feb 10

[](https://www.expedia.ca/San-Francisco-Hotels-Hotel-Riu-Plaza-Fishermans-Wharf.h24625.Hotel-Information)

![Lobby](https://images.trvl-media.com/lodging/1000000/10000/4400/4302/96ca1121.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Front of property - evening/night](https://images.trvl-media.com/lodging/1000000/10000/4400/4302/77af977e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Point of interest](https://images.trvl-media.com/lodging/1000000/10000/4400/4302/0df576f8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Presidential Suite, 1 King Bed, Balcony, Bay View | Living area](https://images.trvl-media.com/lodging/1000000/10000/4400/4302/a2b2e8c8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Hilton San Francisco Financial District

[](https://www.expedia.ca/San-Francisco-Hotels-Hilton-San-Francisco-Financial-District.h4302.Hotel-Information)

15.4 km from Downtown South San Francisco

8.8/10

Excellent

(2,340 reviews)

"We loved our stay! "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Christine

CA $145

CA $171 total

includes taxes & fees

Feb 16 - Feb 17

[](https://www.expedia.ca/San-Francisco-Hotels-Hilton-San-Francisco-Financial-District.h4302.Hotel-Information)

![Egyptian cotton sheets, premium bedding, down comforters, pillowtop beds](https://images.trvl-media.com/lodging/39000000/38250000/38249400/38249309/575b2d5c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Point of interest](https://images.trvl-media.com/lodging/39000000/38250000/38249400/38249309/381993a8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lounge](https://images.trvl-media.com/lodging/39000000/38250000/38249400/38249309/ac2abcd1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Beach/ocean view](https://images.trvl-media.com/lodging/39000000/38250000/38249400/38249309/67096996.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Hotel Caza Fisherman's Wharf

[](https://www.expedia.ca/San-Francisco-Hotels-Hotel-Caza.h38249309.Hotel-Information)

16.6 km from Downtown South San Francisco

9.0/10

Wonderful

(3,835 reviews)

"Nice place to stay"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Harold Franklin

CA $171

CA $267 total

includes taxes & fees

Feb 12 - Feb 13

[](https://www.expedia.ca/San-Francisco-Hotels-Hotel-Caza.h38249309.Hotel-Information)

![Terrace/patio](https://images.trvl-media.com/lodging/1000000/10000/3600/3552/d9a28cf0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Breakfast, lunch and dinner served](https://images.trvl-media.com/lodging/1000000/10000/3600/3552/6a4c1f91.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Room amenity](https://images.trvl-media.com/lodging/1000000/10000/3600/3552/c37b3c13.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior entrance](https://images.trvl-media.com/lodging/1000000/10000/3600/3552/fcb07f26.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Hotel Zoe Fisherman's Wharf

[](https://www.expedia.ca/San-Francisco-Hotels-Hotel-Zoe-Fishermans-Wharf.h3552.Hotel-Information)

16.6 km from Downtown South San Francisco

9.2/10

Wonderful

(1,696 reviews)

"Very nice hotel and perfect location. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Syed

CA $140

CA $223 total

includes taxes & fees

Feb 12 - Feb 13

[](https://www.expedia.ca/San-Francisco-Hotels-Hotel-Zoe-Fishermans-Wharf.h3552.Hotel-Information)

![Courtyard](https://images.trvl-media.com/lodging/10000000/9870000/9868900/9868852/173b8dfb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby sitting area](https://images.trvl-media.com/lodging/10000000/9870000/9868900/9868852/4817709a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby sitting area](https://images.trvl-media.com/lodging/10000000/9870000/9868900/9868852/7bc06dc3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Premium bedding, pillowtop beds, in-room safe, desk](https://images.trvl-media.com/lodging/10000000/9870000/9868900/9868852/19abbe84.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Hotel Zephyr San Francisco

[](https://www.expedia.ca/San-Francisco-Hotels-Hotel-Zephyr-San-Francisco.h9868852.Hotel-Information)

16.8 km from Downtown South San Francisco

8.6/10

Excellent

(2,398 reviews)

"The balcony view was amazing and parking was perfect. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Ena M

CA $171

CA $258 total

includes taxes & fees

Feb 9 - Feb 10

[](https://www.expedia.ca/San-Francisco-Hotels-Hotel-Zephyr-San-Francisco.h9868852.Hotel-Information)

![Courtyard](https://images.trvl-media.com/lodging/1000000/20000/12400/12345/85c9e6e7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Reception](https://images.trvl-media.com/lodging/1000000/20000/12400/12345/2bfcf187.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Breakfast served, American cuisine](https://images.trvl-media.com/lodging/1000000/20000/12400/12345/9e8dcf27.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Reception](https://images.trvl-media.com/lodging/1000000/20000/12400/12345/8d3345b1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Hilton San Francisco Airport Bayfront

[](https://www.expedia.ca/San-Francisco-Hotels-Hilton-San-Francisco-Airport-Bayfront.h12345.Hotel-Information)

9.9 km from Downtown South San Francisco

8.6/10

Excellent

(2,903 reviews)

"The room and breakfast was perfect "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Daniel

CA $138

CA $157 total

includes taxes & fees

Feb 15 - Feb 16

[](https://www.expedia.ca/San-Francisco-Hotels-Hilton-San-Francisco-Airport-Bayfront.h12345.Hotel-Information)

![Breakfast, lunch, dinner served; local cuisine ](https://images.trvl-media.com/lodging/1000000/10000/900/828/550e44fa.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fireplace](https://images.trvl-media.com/lodging/1000000/10000/900/828/5dd21b54.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby sitting area](https://images.trvl-media.com/lodging/1000000/10000/900/828/10ee0463.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby sitting area](https://images.trvl-media.com/lodging/1000000/10000/900/828/6c45dc3a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### DoubleTree by Hilton San Francisco Airport

[](https://www.expedia.ca/San-Francisco-Hotels-DoubleTree-By-Hilton-San-Francisco-Airport.h828.Hotel-Information)

9.3 km from Downtown South San Francisco

8.6/10

Excellent

(1,445 reviews)

"Great hotel "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Jill

CA $150

CA $171 total

includes taxes & fees

Feb 21 - Feb 22

[](https://www.expedia.ca/San-Francisco-Hotels-DoubleTree-By-Hilton-San-Francisco-Airport.h828.Hotel-Information)

![Terrace/patio](https://images.trvl-media.com/lodging/1000000/920000/913000/912982/5ee1ba27.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Suite, 1 Queen Bed, Kitchenette (with Terrace)](https://images.trvl-media.com/lodging/1000000/920000/913000/912982/a4142b29.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Suite, 1 Queen Bed, Kitchenette (with Terrace)](https://images.trvl-media.com/lodging/1000000/920000/913000/912982/8e808fd6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Point of interest](https://images.trvl-media.com/lodging/1000000/920000/913000/912982/4c4de4ea.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Club Quarters Hotel in San Francisco

[](https://www.expedia.ca/San-Francisco-Hotels-Club-Quarters-Hotel-In-San-Francisco.h912982.Hotel-Information)

15.4 km from Downtown South San Francisco

9.0/10

Wonderful

(2,931 reviews)

"Clean room and helpful staff! "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Angelina

CA $146

CA $172 total

includes taxes & fees

Feb 16 - Feb 17

[](https://www.expedia.ca/San-Francisco-Hotels-Club-Quarters-Hotel-In-San-Francisco.h912982.Hotel-Information)

![Hypo-allergenic bedding, in-room safe, desk, laptop workspace](https://images.trvl-media.com/lodging/1000000/20000/10600/10538/5971a3e7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Outdoor pool, open 9:00 AM to 7:00 PM, sun loungers](https://images.trvl-media.com/lodging/1000000/20000/10600/10538/9ba9bb1f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Restaurant](https://images.trvl-media.com/lodging/1000000/20000/10600/10538/a67c7266.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Terrace/patio](https://images.trvl-media.com/lodging/1000000/20000/10600/10538/8e61a8e6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Holiday Inn Golden Gateway by IHG

[](https://www.expedia.ca/San-Francisco-Hotels-Holiday-Inn-Golden-Gateway.h10538.Hotel-Information)

14.8 km from Downtown South San Francisco

9.0/10

Wonderful

(5,188 reviews)

"hotel was very clean, staff was friendly and knowledgeable. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Rafeal

CA $163

CA $192 total

includes taxes & fees

Feb 16 - Feb 17

[](https://www.expedia.ca/San-Francisco-Hotels-Holiday-Inn-Golden-Gateway.h10538.Hotel-Information)

![Lounge](https://images.trvl-media.com/lodging/1000000/20000/14500/14451/825e2808.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Billiards](https://images.trvl-media.com/lodging/1000000/20000/14500/14451/73b4f860.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Reception](https://images.trvl-media.com/lodging/1000000/20000/14500/14451/7e37f2cd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/1000000/20000/14500/14451/42c7dbc6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### King George Hotel

[](https://www.expedia.ca/San-Francisco-Hotels-King-George-Hotel.h14451.Hotel-Information)

14.5 km from Downtown South San Francisco

8.6/10

Excellent

(2,099 reviews)

"The staff were all friendly and courteous, the room and bathroom were very clean, the beds were comfortable and a very good location."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Jamie

CA $121

CA $163 total

includes taxes & fees

Jan 29 - Jan 30

[](https://www.expedia.ca/San-Francisco-Hotels-King-George-Hotel.h14451.Hotel-Information)

![Property amenity](https://images.trvl-media.com/lodging/1000000/580000/578900/578899/7d66de20.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![In-room safe, desk, blackout drapes, soundproofing](https://images.trvl-media.com/lodging/1000000/580000/578900/578899/cf567017.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/1000000/580000/578900/578899/3c779c9d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/1000000/580000/578900/578899/w5614h3742x0y0-0021dd27.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Holiday Inn Express and Suites Fisherman's Wharf by IHG

[](https://www.expedia.ca/San-Francisco-Hotels-Holiday-Inn-Express-And-Suites-Fishermans-Wharf.h578899.Hotel-Information)

16.7 km from Downtown South San Francisco

9.0/10

Wonderful

(2,293 reviews)

"Clean room, courteous staff, break fast and great location."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Claudia

CA $177

CA $253 total

includes taxes & fees

Feb 9 - Feb 10

[](https://www.expedia.ca/San-Francisco-Hotels-Holiday-Inn-Express-And-Suites-Fishermans-Wharf.h578899.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/1000000/10000/6700/6666/b8dfc462.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/1000000/10000/6700/6666/63a5d8bf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby sitting area](https://images.trvl-media.com/lodging/1000000/10000/6700/6666/18d49d8b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Outdoor pool, a heated pool, open 8 AM to 8 PM, sun loungers](https://images.trvl-media.com/lodging/1000000/10000/6700/6666/4fd95a3a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Handlery Union Square Hotel

[](https://www.expedia.ca/San-Francisco-Hotels-Handlery-Union-Square-Hotel.h6666.Hotel-Information)

14.5 km from Downtown South San Francisco

8.8/10

Excellent

(2,851 reviews)

"Great location, room was clean and staff was helpful."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Laura

CA $181

CA $213 total

includes taxes & fees

Jan 29 - Jan 30

[](https://www.expedia.ca/San-Francisco-Hotels-Handlery-Union-Square-Hotel.h6666.Hotel-Information)

![Lobby sitting area](https://images.trvl-media.com/lodging/1000000/30000/20600/20547/944f985c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Suite, 1 Bedroom (Corporate) | Living area](https://images.trvl-media.com/lodging/1000000/30000/20600/20547/57a12208.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Property entrance](https://images.trvl-media.com/lodging/1000000/30000/20600/20547/17458474.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![In-room safe, desk, blackout drapes, iron/ironing board](https://images.trvl-media.com/lodging/1000000/30000/20600/20547/aff7fa14.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Chancellor Hotel on Union Square

[](https://www.expedia.ca/San-Francisco-Hotels-Chancellor-Hotel-On-Union-Square.h20547.Hotel-Information)

14.7 km from Downtown South San Francisco

9.4/10

Exceptional

(3,169 reviews)

"Fantastic....kindest hotel and such a comfortable stay!"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Amy

CA $159

CA $188 total

includes taxes & fees

Feb 22 - Feb 23

[](https://www.expedia.ca/San-Francisco-Hotels-Chancellor-Hotel-On-Union-Square.h20547.Hotel-Information)

![Terrace/patio](https://images.trvl-media.com/lodging/32000000/31420000/31419900/31419890/91986f78.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/32000000/31420000/31419900/31419890/6a4e602e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Hypo-allergenic bedding, desk, laptop workspace, blackout drapes](https://images.trvl-media.com/lodging/32000000/31420000/31419900/31419890/b089b5be.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Daily buffet breakfast (USD 16 per person)](https://images.trvl-media.com/lodging/32000000/31420000/31419900/31419890/f9d4387a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Hyatt Place San Francisco Downtown

[](https://www.expedia.ca/San-Francisco-Hotels-Hyatt-Place-San-Francisco-Downtown.h31419890.Hotel-Information)

13.7 km from Downtown South San Francisco

9.4/10

Exceptional

(1,963 reviews)

"Great overall stay, friendly staff"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Brian

CA $221

CA $260 total

includes taxes & fees

Feb 20 - Feb 21

[](https://www.expedia.ca/San-Francisco-Hotels-Hyatt-Place-San-Francisco-Downtown.h31419890.Hotel-Information)

![Building design](https://images.trvl-media.com/lodging/1000000/910000/902100/902027/5ec6ba9e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/1000000/910000/902100/902027/71a1e5ce.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/1000000/910000/902100/902027/5d60bf4b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Reception](https://images.trvl-media.com/lodging/1000000/910000/902100/902027/ff2e5eab.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Hotel Aluxor SFO

[](https://www.expedia.ca/San-Francisco-Hotels-Hotel-Aluxor-SFO.h902027.Hotel-Information)

3.7 km from Downtown South San Francisco

8.6/10

Excellent

(2,702 reviews)

"Nice place, would stay again "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Alondra

CA $117

CA $142 total

includes taxes & fees

Feb 24 - Feb 25

[](https://www.expedia.ca/San-Francisco-Hotels-Hotel-Aluxor-SFO.h902027.Hotel-Information)

![Lobby sitting area](https://images.trvl-media.com/lodging/1000000/30000/24300/24251/47630b7b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Front of property](https://images.trvl-media.com/lodging/1000000/30000/24300/24251/f6c9f16f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby lounge](https://images.trvl-media.com/lodging/1000000/30000/24300/24251/339fb7af.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Courtyard](https://images.trvl-media.com/lodging/1000000/30000/24300/24251/26b347aa.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### The Dylan at SFO

[](https://www.expedia.ca/San-Francisco-Hotels-The-Dylan-At-SFO.h24251.Hotel-Information)

7.1 km from Downtown South San Francisco

9.2/10

Wonderful

(1,843 reviews)

"great hotel, well designed, comfortable beds, easy access to the bart and aiport"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Alan

CA $148

CA $177 total

includes taxes & fees

Feb 14 - Feb 15

[](https://www.expedia.ca/San-Francisco-Hotels-The-Dylan-At-SFO.h24251.Hotel-Information)

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

[View all properties](https://expedia.ca/Hotel-Search?startDate=2026-02-09&endDate=2026-02-10&regionId=553248635976481411&adults=2&sort=RECOMMENDED&openPlayBack=true)

## Where to stay in Downtown South San Francisco

Find the best Downtown South San Francisco areas and neighborhoods for the activities you enjoy most. 

- Union Square
- Downtown San Francisco
- Fisherman's Wharf
- South of Market
- Nob Hill

![Union Square featuring a city and a skyscraper](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/22000/22611-Union-Square.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium)

![Union Square featuring a city, street scenes and signage](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/173000/173736-Union-Square.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium)

![Union Square featuring a city, a monument and a square or plaza](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/173000/173470-Northern-California.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium)

![Union Square showing street scenes and a city as well as a large group of people](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/67000/67250-Union-Square.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium)

![Union Square showing street scenes, a city and signage](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/173000/173732-Union-Square.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium)

[](https://www.expedia.ca/Hotel-Search?pwaOverlay=map&regionId=800129)

![Union Square map](https://maps.googleapis.com/maps/api/staticmap?&size=289x340&map_id=c017d89749dc74ad&markers=icon:%7C&path=enc:owseFngdjV_H%7BeAzRuBna%40%7Ej%40qPdCn%40pIwDv%40n%40tGaXjD&key=AIzaSyAoVHdVOa5-BDRxGhFoAHYIHPst1T09Jo0&signature=vbtXVjtvbbFJoglIicZiXTBOs3E=)

### Union Square

Major tourist destination in downtown San Francisco, Union Square boasts shopping, hotels, and theaters. Explore department stores, boutiques, and galleries, or catch a performance at various theaters. Enjoy the Dewey Monument and stunning views from nearby hotels. Easily accessible via cable car lines, buses, and subway systems.

[See properties](https://www.expedia.ca/Hotel-Search?regionId=800129)

![](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/476000/476363-Downtown-San-Francisco.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium)

![](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/476000/476367-Downtown-San-Francisco.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium)

![](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/476000/476362-Downtown-San-Francisco.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium)

![](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/476000/476359-Downtown-San-Francisco.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium)

![](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/476000/476366-Downtown-San-Francisco.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium)

[](https://www.expedia.ca/Hotel-Search?pwaOverlay=map&regionId=6151902)

![Downtown San Francisco map](https://maps.googleapis.com/maps/api/staticmap?&size=289x340&map_id=c017d89749dc74ad&markers=icon:%7C&path=enc:m%7EteFvzejViZadFhsAmj%40%60lBaHdLhWlEviCoQtFoGdcByHdFwR%7BUc%60ChY&key=AIzaSyAoVHdVOa5-BDRxGhFoAHYIHPst1T09Jo0&signature=gvmSEImu4_lfi0gTpvxWcEmihx8=)

### Downtown San Francisco

Serving as San Francisco's central business district, this area boasts Northern California's two tallest buildings, the Salesforce Tower and Transamerica Pyramid. Explore shopping malls like the Embarcadero Center and enjoy parks such as Sue Biermann Park, all easily accessible via Muni bus and rail lines.

[See properties](https://www.expedia.ca/Hotel-Search?regionId=6151902)

![Fisherman\'s Wharf featuring a bay or harbour](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/240000/240986-Fishermans-Wharf.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium)

![](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/548000/548532-fishermans-wharf.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium)

![Fisherman\'s Wharf which includes a bay or harbour](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/173000/173418-Fishermans-Wharf.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium)

![Fisherman\'s Wharf which includes a fountain](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/240000/240993-Fishermans-Wharf.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium)

![](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/173000/173428-Fishermans-Wharf.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium)

[](https://www.expedia.ca/Hotel-Search?pwaOverlay=map&regionId=800128)

![Fisherman's Wharf map](https://maps.googleapis.com/maps/api/staticmap?&size=289x340&map_id=c017d89749dc74ad&markers=icon:%7C&path=enc:mrweFnpfjVaIcEiDic%40wAal%40xF_c%40bZoH%60N%7CwBeMnBaIpEsF%7E%40&key=AIzaSyAoVHdVOa5-BDRxGhFoAHYIHPst1T09Jo0&signature=cSLnJ-bErQxSUv6GQKloGDHAW70=)

### Fisherman's Wharf

Discover Pier 39, Ghirardelli Square, and the San Francisco Maritime National Historical Park in this bustling tourist hotspot. Savor seafood at family-owned restaurants and explore the sea lion colony, while enjoying convenient cable car access.

[See properties](https://www.expedia.ca/Hotel-Search?regionId=800128)

![South of Market showing skyline, a city and city views](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/173000/173326-San-Francisco.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium)

![South of Market showing a fountain, city views and a city](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/173000/173924-South-Of-Market.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium)

![South of Market featuring a city, a skyscraper and central business district](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/173000/173938-South-Of-Market.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium)

![South of Market featuring skyline, city views and a city](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/173000/173935-South-Of-Market.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium)

![South of Market featuring city views and a city as well as a small group of people](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/173000/173937-South-Of-Market.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium)

[](https://www.expedia.ca/Hotel-Search?pwaOverlay=map&regionId=160166)

![South of Market map](https://maps.googleapis.com/maps/api/staticmap?&size=289x340&map_id=c017d89749dc74ad&markers=icon:%7C&path=enc:eipeF%7CxejVcaDsjEjv%40gt%40ffCuYvGdhDsKvBsD%7CF%7DBz%5BoCx%7C%40_E%7EGqC%7EA&key=AIzaSyAoVHdVOa5-BDRxGhFoAHYIHPst1T09Jo0&signature=ffiqKO1x2yhUpPKU2D52Jx63lg4=)

### South of Market

From baseball games to top-notch art exhibits, find endless entertainment in one of San Francisco’s fastest-growing neighborhoods.

[See properties](https://www.expedia.ca/Hotel-Search?regionId=160166)

![Nob Hill featuring street scenes and a city](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/173000/173402-Nob-Hill.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium)

![Nob Hill which includes street scenes and a city](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/173000/173400-Nob-Hill.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium)

![Nob Hill which includes street scenes](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/173000/173393-Nob-Hill.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium)

![Nob Hill which includes street scenes](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/173000/173395-Nob-Hill.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium)

![Nob Hill featuring street scenes](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/173000/173391-Nob-Hill.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium)

[](https://www.expedia.ca/Hotel-Search?pwaOverlay=map&regionId=138629)

![Nob Hill map](https://maps.googleapis.com/maps/api/staticmap?&size=289x340&map_id=c017d89749dc74ad&markers=icon:%7C&path=enc:q%7EteFvxejVmIopAll%40cHnIppAol%40%60H&key=AIzaSyAoVHdVOa5-BDRxGhFoAHYIHPst1T09Jo0&signature=Skcsr6ZgxKZlWMjutOt189xwFug=)

### Nob Hill

Luxury hotels, historic mansions, and Michelin-starred restaurants abound in this upscale area. Explore Union Square shopping district, Grace Cathedral, and the SF Masonic Auditorium for a taste of culture and history.

[See properties](https://www.expedia.ca/Hotel-Search?regionId=138629)

## Top Downtown South San Francisco Hotel Reviews

![Hotel Riu Plaza Fisherman's Wharf](https://images.trvl-media.com/lodging/1000000/30000/24700/24625/6fb55356_y.jpg)

### Hotel Riu Plaza Fisherman's Wharf

10/10 Excellent

"Everything was fantastic from check-in the beauty of the hotel the cleanliness the ease of parking friendlyness of the staff the room was made up perfectly truly enjoyed the great breakfast five stars. "

[](https://expedia.ca/San-Francisco-Hotels-Hotel-Riu-Plaza-Fishermans-Wharf.h24625.Hotel-Information)

![Hilton San Francisco Financial District](https://images.trvl-media.com/lodging/1000000/10000/4400/4302/77af977e_y.jpg)

### Hilton San Francisco Financial District

10/10 Excellent

"Beautiful hotel, great view, attentive staff. "

[](https://expedia.ca/San-Francisco-Hotels-Hilton-San-Francisco-Financial-District.h4302.Hotel-Information)

![Holiday Inn Golden Gateway by IHG](https://images.trvl-media.com/lodging/1000000/20000/10600/10538/9ba9bb1f_y.jpg)

### Holiday Inn Golden Gateway by IHG

10/10 Excellent

"Very good service and front staff was awesome. "

[](https://expedia.ca/San-Francisco-Hotels-Holiday-Inn-Golden-Gateway.h10538.Hotel-Information)

![Chancellor Hotel on Union Square](https://images.trvl-media.com/lodging/1000000/30000/20600/20547/944f985c_y.jpg)

### Chancellor Hotel on Union Square

10/10 Excellent

"The customer service and room were spectacular! This might be my go-to when traveling to SF. "

[](https://expedia.ca/San-Francisco-Hotels-Chancellor-Hotel-On-Union-Square.h20547.Hotel-Information)

![Taj Campton Place](https://images.trvl-media.com/lodging/1000000/30000/23400/23383/d044cc49_y.jpg)

### Taj Campton Place

10/10 Excellent

"Yes. Almost as soon as we called to replace a burnt out lightbulb, someone was there to change it. "

[](https://expedia.ca/San-Francisco-Hotels-Taj-Campton-Place.h23383.Hotel-Information)

![Comfort Inn by the Bay](https://images.trvl-media.com/lodging/1000000/10000/6000/5984/d439a184_y.jpg)

### Comfort Inn by the Bay

10/10 Excellent

"Had an amazing stay! My group of 4 got 1 room for 1 night, parking is simple and much cheaper than surrounding hotels. There’s a lot of coffee spots and restaurants within walking distance. The free breakfast is a huge plus, it was yummy and I loved the window seating with street view. Staff was super friendly and helpful, we didn’t ask for a bay view but still lucked out and got a great view of the city! Will definitely be staying again for my birthday ! ❤️"

[](https://expedia.ca/San-Francisco-Hotels-Comfort-Inn-By-The-Bay.h5984.Hotel-Information)

![Hyatt Centric Fisherman's Wharf San Francisco](https://images.trvl-media.com/lodging/1000000/30000/22500/22500/1d699bf3_y.jpg)

### Hyatt Centric Fisherman's Wharf San Francisco

10/10 Excellent

"Great stay"

[](https://expedia.ca/San-Francisco-Hotels-Hyatt-Centric-Fishermans-Wharf-San-Francisco.h22500.Hotel-Information)

![Handlery Union Square Hotel](https://images.trvl-media.com/lodging/1000000/10000/6700/6666/b8dfc462_y.jpg)

### Handlery Union Square Hotel

10/10 Excellent

"The staff was wonderful. The room was very clean and spacious. Loved the charm!"

[](https://expedia.ca/San-Francisco-Hotels-Handlery-Union-Square-Hotel.h6666.Hotel-Information)

![Bay Landing San Francisco Airport Hotel](https://images.trvl-media.com/lodging/2000000/1120000/1110800/1110785/0c231d9b_y.jpg)

### Bay Landing San Francisco Airport Hotel

10/10 Excellent

"Very convenient, comfortable, and a good price."

[](https://expedia.ca/San-Francisco-Hotels-Bay-Landing-San-Francisco-Airport-Hotel.h1110785.Hotel-Information)

## Frequently asked questions

### What's it like in Downtown South San Francisco?

### What's a favorite place to stay in Downtown South San Francisco?

### How many hotels will I find in the Downtown South San Francisco area?

### If I need to cancel my hotel reservation in Downtown South San Francisco, will I receive a refund?

### What can I see and do in this South San Francisco neighborhood?

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- [Flights to San Francisco ](https://www.expedia.ca/Cheap-Flights-To-San-Francisco.d178305.Travel-Guide-Flights)
- [Flights to South San Francisco ](https://www.expedia.ca/Cheap-Flights-To-South-San-Francisco.d6773.Travel-Guide-Flights)
- [Flights from Los Angeles (LAX) to San Francisco (SFO) ](https://www.expedia.ca/lp/flights/lax/sfo/los-angeles-to-san-francisco)
- [Flights from Edmonton (YEG) to San Francisco (SFO) ](https://www.expedia.ca/lp/flights/yeg/sfo/edmonton-to-san-francisco)
- [Flights from Montreal (YUL) to San Francisco (SFO) ](https://www.expedia.ca/lp/flights/yul/sfo/montreal-to-san-francisco)
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- [Flights from Calgary (YYC) to San Francisco (SFO) ](https://www.expedia.ca/lp/flights/yyc/sfo/calgary-to-san-francisco)
- [Flights from Toronto (YYZ) to San Francisco (SFO) ](https://www.expedia.ca/lp/flights/yyz/sfo/toronto-to-san-francisco)

- [Visit Paradise Valley ](https://www.expedia.ca/San-Francisco-Paradise-Valley.dx553248635976473811)
- [South San Francisco Vacations ](https://www.expedia.ca/South-San-Francisco.d6773.Destination-Travel-Guides)
- [Visit South San Francisco ](https://www.expedia.ca/South-San-Francisco.dx6773)

- [Rental cars San Francisco Intl. airport ](https://www.expedia.ca/Car-Rentals-In-San-Francisco-Intl.d5195347.Car-Rental-Guide)
- [Car rental South San Francisco ](https://www.expedia.ca/Car-Rentals-In-South-San-Francisco.d6773.Car-Rental-Guide)
- [Enterprise Rental Cars in South San Francisco ](https://www.expedia.ca/Enterprise-Car-Rentals-In-South-San-Francisco.d6773-c15.Car-Rental-Guide-Suppliers)
- [Hertz Rental Cars in South San Francisco ](https://www.expedia.ca/Hertz-Car-Rentals-In-South-San-Francisco.d6773-c40.Car-Rental-Guide-Suppliers)

- [South San Francisco Vacation Rentals ](https://www.expedia.ca/South-San-Francisco-Vacation-Rentals.d6773.Travel-Guide-VacationRentals)

- [Things to do in South San Francisco ](https://www.expedia.ca/Things-To-Do-In-South-San-Francisco.d6773.Travel-Guide-Activities)

- [Book Hotels in Downtown South San Francisco on Expedia.com ](https://www.expedia.com/Downtown-South-San-Francisco-San-Francisco-Hotels.0-n553248635976481411-0.Travel-Guide-Filter-Hotels)