Title: 10 Best Hotels in Downtown South San Francisco, San Francisco for 2026 | Expedia.ca

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![Aerial view of downtown San Francisco and Financial District sky scrapers flying over South San Francisco The Industrial City inscription on San Bruno mountain circa 2015](https://images.trvl-media.com/place/553248635976481411/4dd74f8a-dfcd-4623-817e-767c96ff0c5c.jpg?impolicy=fcrop&w=1200&h=500&q=medium)

# Hotels in Downtown South San Francisco, San Francisco 

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## Check prices for these dates

Tonight

[Dec 23 - Dec 24](https://www.expedia.ca/Hotel-Search?regionId=553248635976481411&startDate=2025-12-23&endDate=2025-12-24&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Tomorrow

[Dec 24 - Dec 25](https://www.expedia.ca/Hotel-Search?regionId=553248635976481411&startDate=2025-12-24&endDate=2025-12-25&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

This weekend

[Dec 26 - Dec 28](https://www.expedia.ca/Hotel-Search?regionId=553248635976481411&startDate=2025-12-26&endDate=2025-12-28&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Next weekend

[Jan 2 - Jan 4](https://www.expedia.ca/Hotel-Search?regionId=553248635976481411&startDate=2026-01-02&endDate=2026-01-04&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

## Where to stay in Downtown South San Francisco

Find the best Downtown South San Francisco areas and neighborhoods for the activities you enjoy most. 

- Union Square
- Downtown San Francisco
- Fisherman's Wharf
- South of Market
- Nob Hill

![Union Square featuring a city and a skyscraper](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/22000/22611-Union-Square.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium)

![Union Square featuring a city, street scenes and signage](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/173000/173736-Union-Square.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium)

![Union Square featuring a city, a monument and a square or plaza](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/173000/173470-Northern-California.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium)

![Union Square showing street scenes and a city as well as a large group of people](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/67000/67250-Union-Square.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium)

![Union Square showing street scenes, a city and signage](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/173000/173732-Union-Square.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium)

[](https://www.expedia.ca/Hotel-Search?pwaOverlay=map&regionId=800129)

![Union Square map](https://maps.googleapis.com/maps/api/staticmap?&size=289x340&map_id=c017d89749dc74ad&markers=icon:%7C&path=enc:owseFngdjV_H%7BeAzRuBna%40%7Ej%40qPdCn%40pIwDv%40n%40tGaXjD&key=AIzaSyAoVHdVOa5-BDRxGhFoAHYIHPst1T09Jo0&signature=vbtXVjtvbbFJoglIicZiXTBOs3E=)

### Union Square

Major tourist destination in downtown San Francisco, Union Square boasts shopping, hotels, and theaters. Explore department stores, boutiques, and galleries, or catch a performance at various theaters. Enjoy the Dewey Monument and stunning views from nearby hotels. Easily accessible via cable car lines, buses, and subway systems.

[See properties](https://www.expedia.ca/Hotel-Search?regionId=800129)

![](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/476000/476363-Downtown-San-Francisco.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium)

![](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/476000/476367-Downtown-San-Francisco.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium)

![](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/476000/476362-Downtown-San-Francisco.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium)

![](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/476000/476359-Downtown-San-Francisco.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium)

![](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/476000/476366-Downtown-San-Francisco.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium)

[](https://www.expedia.ca/Hotel-Search?pwaOverlay=map&regionId=6151902)

![Downtown San Francisco map](https://maps.googleapis.com/maps/api/staticmap?&size=289x340&map_id=c017d89749dc74ad&markers=icon:%7C&path=enc:m%7EteFvzejViZadFhsAmj%40%60lBaHdLhWlEviCoQtFoGdcByHdFwR%7BUc%60ChY&key=AIzaSyAoVHdVOa5-BDRxGhFoAHYIHPst1T09Jo0&signature=gvmSEImu4_lfi0gTpvxWcEmihx8=)

### Downtown San Francisco

Serving as San Francisco's central business district, this area boasts Northern California's two tallest buildings, the Salesforce Tower and Transamerica Pyramid. Explore shopping malls like the Embarcadero Center and enjoy parks such as Sue Biermann Park, all easily accessible via Muni bus and rail lines.

[See properties](https://www.expedia.ca/Hotel-Search?regionId=6151902)

![Fisherman\'s Wharf featuring a bay or harbour](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/240000/240986-Fishermans-Wharf.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium)

![](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/548000/548532-fishermans-wharf.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium)

![Fisherman\'s Wharf which includes a bay or harbour](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/173000/173418-Fishermans-Wharf.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium)

![Fisherman\'s Wharf which includes a fountain](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/240000/240993-Fishermans-Wharf.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium)

![](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/173000/173428-Fishermans-Wharf.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium)

[](https://www.expedia.ca/Hotel-Search?pwaOverlay=map&regionId=800128)

![Fisherman's Wharf map](https://maps.googleapis.com/maps/api/staticmap?&size=289x340&map_id=c017d89749dc74ad&markers=icon:%7C&path=enc:mrweFnpfjVaIcEiDic%40wAal%40xF_c%40bZoH%60N%7CwBeMnBaIpEsF%7E%40&key=AIzaSyAoVHdVOa5-BDRxGhFoAHYIHPst1T09Jo0&signature=cSLnJ-bErQxSUv6GQKloGDHAW70=)

### Fisherman's Wharf

Discover Pier 39, Ghirardelli Square, and the San Francisco Maritime National Historical Park in this bustling tourist hotspot. Savor seafood at family-owned restaurants and explore the sea lion colony, while enjoying convenient cable car access.

[See properties](https://www.expedia.ca/Hotel-Search?regionId=800128)

![South of Market showing skyline, a city and city views](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/173000/173326-San-Francisco.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium)

![South of Market showing a fountain, city views and a city](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/173000/173924-South-Of-Market.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium)

![South of Market featuring a city, a skyscraper and central business district](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/173000/173938-South-Of-Market.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium)

![South of Market featuring skyline, city views and a city](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/173000/173935-South-Of-Market.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium)

![South of Market featuring city views and a city as well as a small group of people](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/173000/173937-South-Of-Market.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium)

[](https://www.expedia.ca/Hotel-Search?pwaOverlay=map&regionId=160166)

![South of Market map](https://maps.googleapis.com/maps/api/staticmap?&size=289x340&map_id=c017d89749dc74ad&markers=icon:%7C&path=enc:eipeF%7CxejVcaDsjEjv%40gt%40ffCuYvGdhDsKvBsD%7CF%7DBz%5BoCx%7C%40_E%7EGqC%7EA&key=AIzaSyAoVHdVOa5-BDRxGhFoAHYIHPst1T09Jo0&signature=ffiqKO1x2yhUpPKU2D52Jx63lg4=)

### South of Market

From baseball games to top-notch art exhibits, find endless entertainment in one of San Francisco’s fastest-growing neighborhoods.

[See properties](https://www.expedia.ca/Hotel-Search?regionId=160166)

![Nob Hill featuring street scenes and a city](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/173000/173402-Nob-Hill.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium)

![Nob Hill which includes street scenes and a city](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/173000/173400-Nob-Hill.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium)

![Nob Hill which includes street scenes](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/173000/173393-Nob-Hill.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium)

![Nob Hill which includes street scenes](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/173000/173395-Nob-Hill.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium)

![Nob Hill featuring street scenes](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/173000/173391-Nob-Hill.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium)

[](https://www.expedia.ca/Hotel-Search?pwaOverlay=map&regionId=138629)

![Nob Hill map](https://maps.googleapis.com/maps/api/staticmap?&size=289x340&map_id=c017d89749dc74ad&markers=icon:%7C&path=enc:q%7EteFvxejVmIopAll%40cHnIppAol%40%60H&key=AIzaSyAoVHdVOa5-BDRxGhFoAHYIHPst1T09Jo0&signature=Skcsr6ZgxKZlWMjutOt189xwFug=)

### Nob Hill

Luxury hotels, historic mansions, and Michelin-starred restaurants abound in this upscale area. Explore Union Square shopping district, Grace Cathedral, and the SF Masonic Auditorium for a taste of culture and history.

[See properties](https://www.expedia.ca/Hotel-Search?regionId=138629)

## Top Downtown South San Francisco Hotel Reviews

![Hilton San Francisco Financial District](https://images.trvl-media.com/lodging/1000000/10000/4400/4302/77af977e_y.jpg)

### Hilton San Francisco Financial District

10/10 Excellent

"Good"

[](https://expedia.ca/San-Francisco-Hotels-Hilton-San-Francisco-Financial-District.h4302.Hotel-Information)

![Hyatt Place San Francisco Downtown](https://images.trvl-media.com/lodging/32000000/31420000/31419900/31419890/fc76649d_y.jpg)

### Hyatt Place San Francisco Downtown

10/10 Excellent

"Front desk staff was friendly and extremely professional. Great experience there."

[](https://expedia.ca/San-Francisco-Hotels-Hyatt-Place-San-Francisco-Downtown.h31419890.Hotel-Information)

![Handlery Union Square Hotel](https://images.trvl-media.com/lodging/1000000/10000/6700/6666/b8dfc462_y.jpg)

### Handlery Union Square Hotel

10/10 Excellent

"Very friendly staff. "

[](https://expedia.ca/San-Francisco-Hotels-Handlery-Union-Square-Hotel.h6666.Hotel-Information)

![Hotel Nikko San Francisco](https://images.trvl-media.com/lodging/1000000/30000/23500/23406/6c2cdc12_y.jpg)

### Hotel Nikko San Francisco

10/10 Excellent

"Front desk staff was incredible "

[](https://expedia.ca/San-Francisco-Hotels-Hotel-Nikko-San-Francisco.h23406.Hotel-Information)

![Fairmont San Francisco](https://images.trvl-media.com/lodging/1000000/20000/18200/18200/6f6889e4_y.jpg)

### Fairmont San Francisco

10/10 Excellent

"Staff is great and received an unexpected upgrade!"

[](https://expedia.ca/San-Francisco-Hotels-Fairmont-San-Francisco.h18200.Hotel-Information)

![Holiday Inn Golden Gateway by IHG](https://images.trvl-media.com/lodging/1000000/20000/10600/10538/9ba9bb1f_y.jpg)

### Holiday Inn Golden Gateway by IHG

10/10 Excellent

"Clean"

[](https://expedia.ca/San-Francisco-Hotels-Holiday-Inn-Golden-Gateway.h10538.Hotel-Information)

![DoubleTree by Hilton Hotel Berkeley Marina](https://images.trvl-media.com/lodging/1000000/30000/23800/23800/ba0da8d5_y.jpg)

### DoubleTree by Hilton Hotel Berkeley Marina

10/10 Excellent

"Absolutely lovely "

[](https://expedia.ca/Oakland-Hotels-DoubleTree-By-Hilton-Hotel-Berkeley-Marina.h23800.Hotel-Information)

![Club Quarters Hotel in San Francisco](https://images.trvl-media.com/lodging/1000000/920000/913000/912982/5ee1ba27_y.jpg)

### Club Quarters Hotel in San Francisco

10/10 Excellent

"Gym and vending a plus"

[](https://expedia.ca/San-Francisco-Hotels-Club-Quarters-Hotel-In-San-Francisco.h912982.Hotel-Information)

![LUMA Hotel San Francisco ](https://images.trvl-media.com/lodging/71000000/70100000/70097200/70097106/f72650f9_y.jpg)

### LUMA Hotel San Francisco 

10/10 Excellent

"Ron"

[](https://expedia.ca/San-Francisco-Hotels-LUMA-Hotel-San-Francisco.h70097106.Hotel-Information)

## Frequently asked questions

### What's it like in Downtown South San Francisco?

### What's a favorite place to stay in Downtown South San Francisco?

### How many hotels will I find in the Downtown South San Francisco area?

### If I need to cancel my hotel reservation in Downtown South San Francisco, will I receive a refund?

### What can I see and do in this South San Francisco neighborhood?

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- [Visitacion Valley Hotels ](https://www.expedia.ca/Visitacion-Valley-San-Francisco-Hotels.0-n553248635976480925-0.Travel-Guide-Filter-Hotels)

- [Flights to San Francisco ](https://www.expedia.ca/Cheap-Flights-To-San-Francisco.d178305.Travel-Guide-Flights)
- [Flights to South San Francisco ](https://www.expedia.ca/Cheap-Flights-To-South-San-Francisco.d6773.Travel-Guide-Flights)
- [Flights from Los Angeles (LAX) to San Francisco (SFO) ](https://www.expedia.ca/lp/flights/lax/sfo/los-angeles-to-san-francisco)
- [Flights from Edmonton (YEG) to San Francisco (SFO) ](https://www.expedia.ca/lp/flights/yeg/sfo/edmonton-to-san-francisco)
- [Flights from Montreal (YUL) to San Francisco (SFO) ](https://www.expedia.ca/lp/flights/yul/sfo/montreal-to-san-francisco)
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- [Flights from Calgary (YYC) to San Francisco (SFO) ](https://www.expedia.ca/lp/flights/yyc/sfo/calgary-to-san-francisco)
- [Flights from Toronto (YYZ) to San Francisco (SFO) ](https://www.expedia.ca/lp/flights/yyz/sfo/toronto-to-san-francisco)

- [Visit Paradise Valley ](https://www.expedia.ca/San-Francisco-Paradise-Valley.dx553248635976473811)
- [South San Francisco Vacations ](https://www.expedia.ca/South-San-Francisco.d6773.Destination-Travel-Guides)
- [Visit South San Francisco ](https://www.expedia.ca/South-San-Francisco.dx6773)

- [Rental cars San Francisco Intl. airport ](https://www.expedia.ca/Car-Rentals-In-San-Francisco-Intl.d5195347.Car-Rental-Guide)
- [Car rental South San Francisco ](https://www.expedia.ca/Car-Rentals-In-South-San-Francisco.d6773.Car-Rental-Guide)
- [Enterprise Rental Cars in South San Francisco ](https://www.expedia.ca/Enterprise-Car-Rentals-In-South-San-Francisco.d6773-c15.Car-Rental-Guide-Suppliers)
- [Hertz Rental Cars in South San Francisco ](https://www.expedia.ca/Hertz-Car-Rentals-In-South-San-Francisco.d6773-c40.Car-Rental-Guide-Suppliers)

- [South San Francisco Vacation Rentals ](https://www.expedia.ca/South-San-Francisco-Vacation-Rentals.d6773.Travel-Guide-VacationRentals)

- [Things to do in South San Francisco ](https://www.expedia.ca/Things-To-Do-In-South-San-Francisco.d6773.Travel-Guide-Activities)

- [Book Hotels in Downtown South San Francisco on Expedia.com ](https://www.expedia.com/Downtown-South-San-Francisco-San-Francisco-Hotels.0-n553248635976481411-0.Travel-Guide-Filter-Hotels)