Title: Book the Best Central San Diego LUXURY Hotels - Upscale Hotels in Central San Diego, CA | Expedia.ca [Central San Diego Travel Guide](https://expedia.ca/Central-San-Diego.dx6056570)[Hotels in Central San Diego](https://expedia.ca/Central-San-Diego-Hotels.d6056570.Travel-Guide-Hotels)[Vacation Rentals in Central San Diego](https://expedia.ca/Central-San-Diego-Vacation-Rentals.d6056570.Travel-Guide-VacationRentals)[Flights to Central San Diego](https://expedia.ca/Cheap-Flights-To-Central-San-Diego.d6056570.Travel-Guide-Flights)[Things to do in Central San Diego](https://expedia.ca/Things-To-Do-In-Central-San-Diego.d6056570.Travel-Guide-Activities)[Central San Diego Car Rentals](https://expedia.ca/Car-Rentals-In-Central-San-Diego.d6056570.Car-Rental-Guide)[Central San Diego Vacation Packages](https://expedia.ca/Central-San-Diego.d6056570.Destination-Travel-Guides) ![San Diego, California cityscape at the Gaslamp Quarter.; Shutterstock ID 446681584](https://images.trvl-media.com/place/6056570/11e424d0-560b-422b-97ab-cce270c46858.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://images.trvl-media.com/place/6056570/11e424d0-560b-422b-97ab-cce270c46858.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Central San Diego Luxury Hotels Tonight [Feb 4 - Feb 5](https://www.expedia.ca/Hotel-Search?regionId=6056570&startDate=2026-02-04&endDate=2026-02-05&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) Tomorrow [Feb 5 - Feb 6](https://www.expedia.ca/Hotel-Search?regionId=6056570&startDate=2026-02-05&endDate=2026-02-06&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) This weekend [Feb 6 - Feb 8](https://www.expedia.ca/Hotel-Search?regionId=6056570&startDate=2026-02-06&endDate=2026-02-08&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) Next weekend [Feb 13 - Feb 15](https://www.expedia.ca/Hotel-Search?regionId=6056570&startDate=2026-02-13&endDate=2026-02-15&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) ## Our top choices for Central San Diego luxury hotels ![3 bars/lounges, lobby lounge, cocktail bar, cocktail bar](https://images.trvl-media.com/lodging/39000000/38080000/38077800/38077738/ce2dc6d1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool, open 7:00 AM to 9:00 PM, cabanas (surcharge)](https://images.trvl-media.com/lodging/39000000/38080000/38077800/38077738/83e1bd28.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/39000000/38080000/38077800/38077738/abbee14b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 restaurants, breakfast served](https://images.trvl-media.com/lodging/39000000/38080000/38077800/38077738/fd80224d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Lafayette Hotel & Club [](https://www.expedia.ca/San-Diego-Hotels-Lafayette-Hotel.h38077738.Hotel-Information) University Heights 9.4/10 Exceptional (1,455 reviews) "Nice staff, very clean, good food" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) TIM CA $312 CA $358 total includes taxes & fees Feb 5 - Feb 6 [](https://www.expedia.ca/San-Diego-Hotels-Lafayette-Hotel.h38077738.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/42000000/41510000/41504800/41504735/43ef19cb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe Room, 1 King Bed (High Floor)](https://images.trvl-media.com/lodging/42000000/41510000/41504800/41504735/3d7acad3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Restaurant](https://images.trvl-media.com/lodging/42000000/41510000/41504800/41504735/21efa256.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool, free cabanas, pool umbrellas](https://images.trvl-media.com/lodging/42000000/41510000/41504800/41504735/981f9667.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Legacy Resort Hotel & Spa [](https://www.expedia.ca/San-Diego-Hotels-Legacy-Resort-Hotel-Spa.h41504735.Hotel-Information) Mission Valley 9.2/10 Wonderful (2,946 reviews) "Great relaxing hotel" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Christopher CA $235 CA $270 total includes taxes & fees Feb 8 - Feb 9 [](https://www.expedia.ca/San-Diego-Hotels-Legacy-Resort-Hotel-Spa.h41504735.Hotel-Information) ![Room, 2 Queen Beds (Trendy, Firepit) | Lobby](https://images.trvl-media.com/lodging/1000000/30000/21400/21394/bf902f64.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior detail](https://images.trvl-media.com/lodging/1000000/30000/21400/21394/e51e5730.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/1000000/30000/21400/21394/38baf619.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property entrance](https://images.trvl-media.com/lodging/1000000/30000/21400/21394/62a9579b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Town and Country San Diego [](https://www.expedia.ca/San-Diego-Hotels-Town-And-Country-San-Diego.h21394.Hotel-Information) Mission Valley 8.6/10 Excellent (1,346 reviews) "Staff were pleasant and helpful. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jacquelin CA $231 CA $312 total includes taxes & fees Feb 7 - Feb 8 [](https://www.expedia.ca/San-Diego-Hotels-Town-And-Country-San-Diego.h21394.Hotel-Information) ![Restaurant](https://images.trvl-media.com/lodging/1000000/30000/21900/21891/717df324.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Restaurant](https://images.trvl-media.com/lodging/1000000/30000/21900/21891/f15931a3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Restaurant](https://images.trvl-media.com/lodging/1000000/30000/21900/21891/b197cd41.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/30000/21900/21891/8399b5a6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hyatt Regency La Jolla [](https://www.expedia.ca/San-Diego-Hotels-Hyatt-Regency-La-Jolla.h21891.Hotel-Information) University City 8.8/10 Excellent (1,002 reviews) "Really clean room, comfortable towels, would definitely come back!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Samuel CA $225 CA $309 total includes taxes & fees Feb 8 - Feb 9 [](https://www.expedia.ca/San-Diego-Hotels-Hyatt-Regency-La-Jolla.h21891.Hotel-Information) ![Outdoor pool, open 6:00 AM to 10:00 PM, cabanas (surcharge)](https://images.trvl-media.com/lodging/1000000/10000/8400/8332/acfdb883.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/10000/8400/8332/31ee5101.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Bar (on property)](https://images.trvl-media.com/lodging/1000000/10000/8400/8332/d6460a60.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/1000000/10000/8400/8332/272f3969.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### San Diego Marriott Mission Valley [](https://www.expedia.ca/San-Diego-Hotels-San-Diego-Marriott-Mission-Valley.h8332.Hotel-Information) Mission Valley 8.8/10 Excellent (1,002 reviews) "Staff was polite , room service amazing " ![Canada](https://a.travel-assets.com/egds/marks/flags/ca.svg) Francois CA $224 CA $257 total includes taxes & fees Mar 1 - Mar 2 [](https://www.expedia.ca/San-Diego-Hotels-San-Diego-Marriott-Mission-Valley.h8332.Hotel-Information) ![Restaurant](https://images.trvl-media.com/lodging/1000000/10000/8500/8434/a9b9662f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium Suite, 1 King + 1 Queen Murphy Bed](https://images.trvl-media.com/lodging/1000000/10000/8500/8434/956312dc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Point of interest](https://images.trvl-media.com/lodging/1000000/10000/8500/8434/50256145.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor spa tub](https://images.trvl-media.com/lodging/1000000/10000/8500/8434/6013e99c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Embassy Suites by Hilton San Diego La Jolla [](https://www.expedia.ca/San-Diego-Hotels-Embassy-Suites-By-Hilton-San-Diego-La-Jolla.h8434.Hotel-Information) University City 8.8/10 Excellent (1,850 reviews) "Great included breakfast!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Gina CA $242 CA $279 total includes taxes & fees Feb 8 - Feb 9 [](https://www.expedia.ca/San-Diego-Hotels-Embassy-Suites-By-Hilton-San-Diego-La-Jolla.h8434.Hotel-Information) ![Terrace/patio](https://images.trvl-media.com/lodging/1000000/10000/400/332/027b3bfa.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/10000/400/332/6ddceb14.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/10000/400/332/771038f3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Restaurant](https://images.trvl-media.com/lodging/1000000/10000/400/332/9fc85073.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### DoubleTree by Hilton Hotel San Diego - Mission Valley [](https://www.expedia.ca/San-Diego-Hotels-DoubleTree-By-Hilton-Hotel-San-Diego-Mission-Valley.h332.Hotel-Information) Mission Valley 8.4/10 Very good (1,520 reviews) "Clean and great staff " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Peter CA $206 CA $237 total includes taxes & fees Feb 26 - Feb 27 [](https://www.expedia.ca/San-Diego-Hotels-DoubleTree-By-Hilton-Hotel-San-Diego-Mission-Valley.h332.Hotel-Information) ![Outdoor pool](https://images.trvl-media.com/lodging/1000000/20000/11800/11725/f387ad25.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool](https://images.trvl-media.com/lodging/1000000/20000/11800/11725/88b059dc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lounge](https://images.trvl-media.com/lodging/1000000/20000/11800/11725/ad966b3d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Pure, Room, 1 King Bed](https://images.trvl-media.com/lodging/1000000/20000/11800/11725/3bae0140.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Sheraton Mission Valley San Diego Hotel [](https://www.expedia.ca/San-Diego-Hotels-Sheraton-Mission-Valley-San-Diego-Hotel.h11725.Hotel-Information) Mission Valley 8.6/10 Excellent (1,722 reviews) "Great stay!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Linda CA $217 CA $249 total includes taxes & fees Feb 5 - Feb 6 [](https://www.expedia.ca/San-Diego-Hotels-Sheraton-Mission-Valley-San-Diego-Hotel.h11725.Hotel-Information) ![Meeting facility](https://images.trvl-media.com/lodging/1000000/20000/16100/16019/2d829d4d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/1000000/20000/16100/16019/df29ea56.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Meeting facility](https://images.trvl-media.com/lodging/1000000/20000/16100/16019/9101297c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lounge](https://images.trvl-media.com/lodging/1000000/20000/16100/16019/6e469c5b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hilton San Diego Mission Valley [](https://www.expedia.ca/San-Diego-Hotels-Hilton-San-Diego-Mission-Valley.h16019.Hotel-Information) Mission Valley 8.0/10 Very good (2,322 reviews) "The cleanest room and nicest staff honestly would stay here again" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Kevin CA $174 CA $201 total includes taxes & fees Feb 7 - Feb 8 [](https://www.expedia.ca/San-Diego-Hotels-Hilton-San-Diego-Mission-Valley.h16019.Hotel-Information) ![Deluxe 2 King Bedrooms, Multiple Beds, Sleeps 11ppl | Terrace/patio](https://images.trvl-media.com/lodging/105000000/104150000/104140500/104140458/6ef835b1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/105000000/104150000/104140500/104140458/1b9a69bb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, in-room safe, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/105000000/104150000/104140500/104140458/aa1995cf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![BBQ/picnic area](https://images.trvl-media.com/lodging/105000000/104150000/104140500/104140458/333bf268.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### City24 Hotel Little Italy Mission Hills [](https://www.expedia.ca/San-Diego-Hotels-City24-Hotel-Little-Italy-Mission-Hill.h104140458.Hotel-Information) Middletown 9.6/10 Exceptional (115 reviews) "would definitely go back and stay there again " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Kounwick CA $174 CA $242 total includes taxes & fees Feb 6 - Feb 7 [](https://www.expedia.ca/San-Diego-Hotels-City24-Hotel-Little-Italy-Mission-Hill.h104140458.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2026-02-18&endDate=2026-02-19®ionId=6056570&adults=2&sort=LUXURY&star=40,50&openPlayBack=true) ## Top Central San Diego Hotel Reviews ![California Suites Hotel](https://images.trvl-media.com/lodging/1000000/50000/40600/40531/4d1b251a_y.jpg) ### California Suites Hotel 10/10 Excellent "We stayed here for a 2day softball tournament. Needed a cheap room close to freeway & this fit the bill perfectly. It’s a vintage place but clean & neat. The rooms are large & spacious w/ laminate flooring & good large size mini-fridge (freezer bit actually freezes) which we really appreciated. Walking distance to a bunch of great food options - Asian, Mediterranean & Cuban - great perk. Ice machine was plentiful & hot tub was big. Pretty much all we needed in a place to sleep after long days at the ball park. Coffee was really good too! " [](https://expedia.ca/San-Diego-Hotels-California-Suites-Hotel.h40531.Hotel-Information) ![Hyatt Regency La Jolla](https://images.trvl-media.com/lodging/1000000/30000/21900/21891/0a66ad12_y.jpg) ### Hyatt Regency La Jolla 10/10 Excellent "Always great customer service. There was a problem with my toilet but they fixed it and moved me to another room and gave a credit to use while there. Always my favorite place to stay while in San Diego. Close to everything " [](https://expedia.ca/San-Diego-Hotels-Hyatt-Regency-La-Jolla.h21891.Hotel-Information) ![Best Western Seven Seas](https://images.trvl-media.com/lodging/1000000/10000/1800/1734/w3837h2556x3y3-8b148daf_y.jpg) ### Best Western Seven Seas 10/10 Excellent "The Best Western than seven seas is special to me because I stayed there as a child with my parents and grandparents. It is old motor in style San Diego or best Western in its old form.. The staff is great and it has a nice pool and Jacuzzi.. It is very affordable.. " [](https://expedia.ca/San-Diego-Hotels-Best-Western-Seven-Seas.h1734.Hotel-Information) ![Handlery Hotel](https://images.trvl-media.com/lodging/1000000/10000/8400/8374/ab6ccd55_y.jpg) ### Handlery Hotel 10/10 Excellent "I had a room overlooking the pool. It was quiet and very clean. The staff were very friendly. I would definitely recommend it" [](https://expedia.ca/San-Diego-Hotels-Handlery-Hotel.h8374.Hotel-Information) ![Courtyard by Marriott San Diego Mission Valley/Hotel Circle](https://images.trvl-media.com/lodging/2000000/1990000/1987700/1987617/43ae1d02_y.jpg) ### Courtyard by Marriott San Diego Mission Valley/Hotel Circle 10/10 Excellent "Very helpful staff. Quiet room. Excellent breakfast and dinner choices at the Bistro." [](https://expedia.ca/San-Diego-Hotels-Courtyard-By-Marriott-San-Diego-Mission-ValleyHotel-Circle.h1987617.Hotel-Information) ![DoubleTree by Hilton Hotel San Diego - Mission Valley](https://images.trvl-media.com/lodging/1000000/10000/400/332/8e34f752_y.jpg) ### DoubleTree by Hilton Hotel San Diego - Mission Valley 10/10 Excellent "Clean and great staff " [](https://expedia.ca/San-Diego-Hotels-DoubleTree-By-Hilton-Hotel-San-Diego-Mission-Valley.h332.Hotel-Information) ![Hilton San Diego Mission Valley](https://images.trvl-media.com/lodging/1000000/20000/16100/16019/w5586h3835x5y5-2b129a15_y.jpg) ### Hilton San Diego Mission Valley 10/10 Excellent "Staff was helpful" [](https://expedia.ca/San-Diego-Hotels-Hilton-San-Diego-Mission-Valley.h16019.Hotel-Information) ![Embassy Suites by Hilton San Diego La Jolla](https://images.trvl-media.com/lodging/1000000/10000/8500/8434/49079311_y.jpg) ### Embassy Suites by Hilton San Diego La Jolla 10/10 Excellent "Great included breakfast!" [](https://expedia.ca/San-Diego-Hotels-Embassy-Suites-By-Hilton-San-Diego-La-Jolla.h8434.Hotel-Information) ![Days Inn by Wyndham San Diego Hotel Circle](https://images.trvl-media.com/lodging/1000000/20000/19300/19220/3334d773_y.jpg) ### Days Inn by Wyndham San Diego Hotel Circle 10/10 Excellent "Great" [](https://expedia.ca/San-Diego-Hotels-Days-Inn-By-Wyndham-San-Diego-Hotel-Circle.h19220.Hotel-Information) ## Explore a world of travel with Expedia - Lodging - More ways to book - [Cheap Hotels in Birdland ](https://www.expedia.ca/Birdland-San-Diego-Hotels-Cheap-Hotels.0-n553248635976479135-0-tCheapHotels.Travel-Guide-Filter-Hotels) - [Beach Hotel Hotels in Camp Pendleton Marine Corps Base ](https://www.expedia.ca/Camp-Pendleton-Marine-Corps-Base-Hotels-Beach-Hotel.0-0-d6068523-tBeachHotel.Travel-Guide-Filter-Hotels) - [Hotels with an Indoor Pool in Camp Pendleton Marine Corps Base ](https://www.expedia.ca/Camp-Pendleton-Marine-Corps-Base-Hotels-Hotels-With-Indoor-Pool.0-0-d6068523-tHotelswithIndoorPool.Travel-Guide-Filter-Hotels) - 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