Title: Book the Best BUSINESS Hotels in South Central Pennsylania in 2026 | Expedia.ca [South Central Pennsylania Travel Guide](https://expedia.ca/South-Central-Pennsylania.dx6234009)[Hotels in South Central Pennsylania](https://expedia.ca/South-Central-Pennsylania-Hotels.d6234009.Travel-Guide-Hotels)[Vacation Rentals in South Central Pennsylania](https://expedia.ca/South-Central-Pennsylania-Vacation-Rentals.d6234009.Travel-Guide-VacationRentals)[Flights to South Central Pennsylania](https://expedia.ca/Cheap-Flights-To-South-Central-Pennsylania.d6234009.Travel-Guide-Flights)[South Central Pennsylania Car Rentals](https://expedia.ca/Car-Rentals-In-South-Central-Pennsylania.d6234009.Car-Rental-Guide)[South Central Pennsylania Vacation Packages](https://expedia.ca/South-Central-Pennsylania.d6234009.Destination-Travel-Guides) ![A lovely quiet daytime spot. Lots of ghost hunters after dark.](https://images.trvl-media.com/place/553248621532662886/856a0ee5-b8de-44fe-8918-ce6aa4ff4a3d.jpg?impolicy=fcrop&w=1200&h=500&q=medium) Photo by Jeanne N ![](https://images.trvl-media.com/place/553248621532662886/856a0ee5-b8de-44fe-8918-ce6aa4ff4a3d.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on South Central Pennsylania Business Hotels Tonight [Jan 27 - Jan 28](https://www.expedia.ca/Hotel-Search?regionId=6234009&startDate=2026-01-27&endDate=2026-01-28&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) Tomorrow [Jan 28 - Jan 29](https://www.expedia.ca/Hotel-Search?regionId=6234009&startDate=2026-01-28&endDate=2026-01-29&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) This weekend [Jan 30 - Feb 1](https://www.expedia.ca/Hotel-Search?regionId=6234009&startDate=2026-01-30&endDate=2026-02-01&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) Next weekend [Feb 6 - Feb 8](https://www.expedia.ca/Hotel-Search?regionId=6234009&startDate=2026-02-06&endDate=2026-02-08&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) ## Our top choices for South Central Pennsylania business-friendly hotels ![Free daily full breakfast](https://images.trvl-media.com/lodging/58000000/57020000/57014800/57014703/45483034.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/58000000/57020000/57014800/57014703/99229a5a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, 2 Queen Beds](https://images.trvl-media.com/lodging/58000000/57020000/57014800/57014703/5a378402.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/58000000/57020000/57014800/57014703/27bb886e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Tru By Hilton Chambersburg, PA [](https://www.expedia.ca/Gettysburg-Hotels-Tru-By-Hilton-Chambersburg.h57014703.Hotel-Information) Chambersburg 9.4/10 Exceptional (721 reviews) "Hardwood floors in room, very clean, friendly/kind staff, and an aweso E hot cocoa bar for the kids." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) stephen CA $117 CA $130 total includes taxes & fees Feb 6 - Feb 7 [](https://www.expedia.ca/Gettysburg-Hotels-Tru-By-Hilton-Chambersburg.h57014703.Hotel-Information) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/1000000/20000/11800/11790/d439e5a3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Courtyard](https://images.trvl-media.com/lodging/1000000/20000/11800/11790/0e788116.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, 2 Queen Beds, Non Smoking](https://images.trvl-media.com/lodging/1000000/20000/11800/11790/f584a61a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/20000/11800/11790/944a3bdf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Baymont by Wyndham Harrisburg [](https://www.expedia.ca/Harrisburg-Hotels-Baymont-By-Wyndham-Harrisburg.h11790.Hotel-Information) Harrisburg 8.6/10 Excellent (1,699 reviews) "Just a nice warm and cozy place to stay at a really decent price" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) David CA $68 CA $76 total includes taxes & fees Feb 3 - Feb 4 [](https://www.expedia.ca/Harrisburg-Hotels-Baymont-By-Wyndham-Harrisburg.h11790.Hotel-Information) ![Front of property](https://images.trvl-media.com/lodging/32000000/31710000/31709500/31709458/71182762.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/32000000/31710000/31709500/31709458/dc6085f9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/32000000/31710000/31709500/31709458/800b8d30.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Studio Suite, 1 Queen Bed with Sofa Bed, Non Smoking](https://images.trvl-media.com/lodging/32000000/31710000/31709500/31709458/6184cc76.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Microtel Inn & Suites by Wyndham Carlisle [](https://www.expedia.ca/Carlisle-Hotels-Microtel-Inn-Suites-By-Wyndham-Carlisle.h31709458.Hotel-Information) Carlisle 9.6/10 Exceptional (1,215 reviews) "Enjoyed my stay. Will stay here again when in the area." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Steven CA $112 CA $124 total includes taxes & fees Feb 8 - Feb 9 [](https://www.expedia.ca/Carlisle-Hotels-Microtel-Inn-Suites-By-Wyndham-Carlisle.h31709458.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/4000000/3940000/3936400/3936379/d0cf6542.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free continental breakfast](https://images.trvl-media.com/lodging/4000000/3940000/3936400/3936379/2391d59d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe Room, 1 King Bed, Non Smoking (Deluxe Executive Room) | Room amenity](https://images.trvl-media.com/lodging/4000000/3940000/3936400/3936379/407de68d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/4000000/3940000/3936400/3936379/64e881d6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### La Quinta Inn & Suites by Wyndham Chambersburg [](https://www.expedia.ca/Gettysburg-Hotels-La-Quinta-Inn-Suites-By-Wyndham-Chambersburg.h3936379.Hotel-Information) Chambersburg 9.0/10 Wonderful (1,004 reviews) "Very friendly and efficient desk person. Always a pleasant stay!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Corinne CA $126 CA $140 total includes taxes & fees Feb 10 - Feb 11 [](https://www.expedia.ca/Gettysburg-Hotels-La-Quinta-Inn-Suites-By-Wyndham-Chambersburg.h3936379.Hotel-Information) ![Reception](https://images.trvl-media.com/lodging/4000000/3910000/3900600/3900515/765a3565.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/4000000/3910000/3900600/3900515/a1c3a7c9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![LCD TV](https://images.trvl-media.com/lodging/4000000/3910000/3900600/3900515/59207d72.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Two double beds non smoking](https://images.trvl-media.com/lodging/4000000/3910000/3900600/3900515/03d67d46.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### University Hotel & Suites Shippensburg, Trademark by Wyndham [](https://www.expedia.ca/Shippensburg-Hotels-University-Hotel-Suites-Shippensburg.h3900515.Hotel-Information) Shippensburg 8.8/10 Excellent (994 reviews) "Great stay" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Anthony CA $102 CA $113 total includes taxes & fees Feb 10 - Feb 11 [](https://www.expedia.ca/Shippensburg-Hotels-University-Hotel-Suites-Shippensburg.h3900515.Hotel-Information) ![Aerial view](https://images.trvl-media.com/lodging/2000000/1530000/1521500/1521457/b7064677.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Point of interest](https://images.trvl-media.com/lodging/2000000/1530000/1521500/1521457/64b1bf67.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/2000000/1530000/1521500/1521457/2a8ee0d2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior entrance](https://images.trvl-media.com/lodging/2000000/1530000/1521500/1521457/c58871f3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Wyndham Gettysburg Hotel & Conference Center [](https://www.expedia.ca/Gettysburg-Hotels-Wyndham-Gettysburg.h1521457.Hotel-Information) Gettysburg 8.8/10 Excellent (1,559 reviews) "The Wyndham was fantastic! Excellent location, super clean, very friendly staff and good food as well." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Edward CA $106 CA $118 total includes taxes & fees Feb 26 - Feb 27 [](https://www.expedia.ca/Gettysburg-Hotels-Wyndham-Gettysburg.h1521457.Hotel-Information) ![Suite, 1 King Bed, Non Smoking](https://images.trvl-media.com/lodging/14000000/13310000/13304700/13304657/10644e62.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool, open 6:00 AM to 10:00 PM, sun loungers](https://images.trvl-media.com/lodging/14000000/13310000/13304700/13304657/7b691ea4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/14000000/13310000/13304700/13304657/4f8b3d9f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/14000000/13310000/13304700/13304657/fd89eeb0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Comfort Inn PA Turnpike - 1-81 [](https://www.expedia.ca/Carlisle-Hotels-Comfort-Inn-PA-Turnpike-1-81.h13304657.Hotel-Information) Carlisle 9.2/10 Wonderful (1,001 reviews) "Good hotel decent pricing!" ![Canada](https://a.travel-assets.com/egds/marks/flags/ca.svg) Muhammad Omair CA $116 CA $129 total includes taxes & fees Jan 29 - Jan 30 [](https://www.expedia.ca/Carlisle-Hotels-Comfort-Inn-PA-Turnpike-1-81.h13304657.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/10000/5700/5647/9600d7e3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Cafe](https://images.trvl-media.com/lodging/1000000/10000/5700/5647/16c0bee6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Room, 2 Queen Beds](https://images.trvl-media.com/lodging/1000000/10000/5700/5647/w5470h3648x0y0-dfa33378.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/1000000/10000/5700/5647/ed4c9a21.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hotel Gettysburg [](https://www.expedia.ca/Gettysburg-Hotels-Gettysburg-Hotel.h5647.Hotel-Information) Gettysburg Historic District 9.4/10 Exceptional (1,208 reviews) "Great rooms, great location, friendly staff." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Amy CA $144 CA $160 total includes taxes & fees Feb 10 - Feb 11 [](https://www.expedia.ca/Gettysburg-Hotels-Gettysburg-Hotel.h5647.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/12000000/11920000/11919200/11919146/30952332.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/12000000/11920000/11919200/11919146/3e6d2fc1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/12000000/11920000/11919200/11919146/c7ef2c58.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/12000000/11920000/11919200/11919146/9729372a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Express & Suites Shippensburg by IHG [](https://www.expedia.ca/Gettysburg-Hotels-Holiday-Inn-Express-Suites-Shippensburg.h11919146.Hotel-Information) Shippensburg 9.2/10 Wonderful (755 reviews) "Wonderful check in! Loved our dogs! Great clean space…great amenities " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Sandy CA $129 CA $147 total includes taxes & fees Feb 13 - Feb 14 [](https://www.expedia.ca/Gettysburg-Hotels-Holiday-Inn-Express-Suites-Shippensburg.h11919146.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/20000/16000/15999/6353bbe3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/20000/16000/15999/3a620bf0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, pillowtop beds, in-room safe, desk](https://images.trvl-media.com/lodging/1000000/20000/16000/15999/78bf1b11.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool, sun loungers](https://images.trvl-media.com/lodging/1000000/20000/16000/15999/a66e2b17.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Days Inn by Wyndham Hershey [](https://www.expedia.ca/Hershey-Hotels-Days-Inn-By-Wyndham-Hershey.h15999.Hotel-Information) Downtown Hershey 8.6/10 Excellent (1,887 reviews) "Great breakfast and stay " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) subramanya CA $115 CA $130 total includes taxes & fees Jan 29 - Jan 30 [](https://www.expedia.ca/Hershey-Hotels-Days-Inn-By-Wyndham-Hershey.h15999.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2026-02-11&endDate=2026-02-12®ionId=6234009&adults=2&travelerType=business_friendly&sort=RECOMMENDED&openPlayBack=true) ## Top South Central Pennsylania Hotel Reviews ![Wyndham Gettysburg Hotel & Conference Center](https://images.trvl-media.com/lodging/2000000/1530000/1521500/1521457/b7064677_y.jpg) ### Wyndham Gettysburg Hotel & Conference Center 10/10 Excellent "Very clean" [](https://expedia.ca/Gettysburg-Hotels-Wyndham-Gettysburg.h1521457.Hotel-Information) ![Parkview Inn & Suites Lancaster ](https://images.trvl-media.com/lodging/1000000/810000/809200/809150/7d398240_y.jpg) ### Parkview Inn & Suites Lancaster 10/10 Excellent "Loved this hotel! Very clean, and staff were very friendly! " [](https://expedia.ca/Lancaster-Hotels-Country-Inn-Suites-By-Radisson.h809150.Hotel-Information) ![Eden Resort and Suites, BW Premier Collection](https://images.trvl-media.com/lodging/1000000/30000/27300/27257/429da8fa_y.jpg) ### Eden Resort and Suites, BW Premier Collection 10/10 Excellent "The rooms are clean and spacious! The hotel staff are knowledgeable and friendly. They have everything at the Eden Resorts " [](https://expedia.ca/Lancaster-Hotels-Eden-Resort-And-Suites.h27257.Hotel-Information) ![Ramada by Wyndham Harrisburg/Hershey Area](https://images.trvl-media.com/lodging/1000000/10000/9800/9731/fcb938a6_y.jpg) ### Ramada by Wyndham Harrisburg/Hershey Area 10/10 Excellent "Good " [](https://expedia.ca/Harrisburg-Hotels-Ramada-By-Wyndham-HarrisburgHershey-Area.h9731.Hotel-Information) ![Lancaster Marriott at Penn Square](https://images.trvl-media.com/lodging/3000000/2480000/2473700/2473637/619a3e51_y.jpg) ### Lancaster Marriott at Penn Square 10/10 Excellent "Wonderful, clean hotel. Customer service was great! " [](https://expedia.ca/Lancaster-Hotels-Lancaster-Marriott-At-Penn-Square.h2473637.Hotel-Information) ![Holiday Inn Express - Harrisburg East by IHG](https://images.trvl-media.com/lodging/1000000/10000/400/376/89809a62_y.jpg) ### Holiday Inn Express - Harrisburg East by IHG 10/10 Excellent "This was a great stay. Very friendly staff and easy check in and parking. Room was spacious and quiet. Bed was very comfortable. Would definitely stay again " [](https://expedia.ca/Harrisburg-Hotels-Holiday-Inn-Express-Harrisburg-East.h376.Hotel-Information) ![La Quinta Inn & Suites by Wyndham Harrisburg Airport Hershey](https://images.trvl-media.com/lodging/1000000/50000/49900/49896/b2b32d38_y.jpg) ### La Quinta Inn & Suites by Wyndham Harrisburg Airport Hershey 10/10 Excellent "Nick the manager was extremely helpful and accommodating. I arrived earlier than expected and he allowed me the check in and I was so grateful. The room was clean and the housekeeper was very kind. The breakfast was. a plus and was plentiful. I will be returning soon!!!" [](https://expedia.ca/Harrisburg-Hotels-La-Quinta-Inn-Suites-By-Wyndham-Harrisburg-Airport-Hershey.h49896.Hotel-Information) ![Lancaster Arts Hotel](https://images.trvl-media.com/lodging/2000000/1510000/1503900/1503824/7ea6ae52_y.jpg) ### Lancaster Arts Hotel 10/10 Excellent "Spotless and beautiful hotel. And the staff are amazing!" [](https://expedia.ca/Lancaster-Hotels-Lancaster-Arts-Hotel.h1503824.Hotel-Information) ![Lancaster Suites ](https://images.trvl-media.com/lodging/1000000/560000/551000/550914/3556501c_y.jpg) ### Lancaster Suites 10/10 Excellent "Friendly staff, clean rooms and nice breakfast." [](https://expedia.ca/Lancaster-Hotels-Lancaster-Suites.h550914.Hotel-Information) ## Frequently asked questions ### How much do business-friendly hotels in South Central Pennsylania cost? ### What are the best business-friendly hotels in South Central Pennsylania? ### How many business-friendly hotels are there in South Central Pennsylania? ### What are the best cheap business-friendly hotels in South Central Pennsylania? ### What are the top business-friendly motels in South Central Pennsylania? ### Are there any family-friendly hotels in South Central Pennsylania that are also business friendly? ### Why book your business-friendly hotel in South Central Pennsylania with Expedia? ### How can I find cheap business-friendly hotels in South Central Pennsylania? ### What is there to do in South Central Pennsylania near my business-friendly hotel? ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - Other - More ways to book - [Hotels near Antique Automobile Club of America Museum ](https://www.expedia.ca/Antique-Automobile-Club-Of-America-Museum-Hotels.0-l6143616-0.Travel-Guide-Filter-Hotels) - 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