Title: Book the Best BUSINESS Hotels in North Central Florida in 2026 | Expedia.ca [North Central Florida Travel Guide](https://expedia.ca/North-Central-Florida.dx6233773)[Hotels in North Central Florida](https://expedia.ca/North-Central-Florida-Hotels.d6233773.Travel-Guide-Hotels)[Vacation Rentals in North Central Florida](https://expedia.ca/North-Central-Florida-Vacation-Rentals.d6233773.Travel-Guide-VacationRentals)[Flights to North Central Florida](https://expedia.ca/Cheap-Flights-To-North-Central-Florida.d6233773.Travel-Guide-Flights)[Things to do in North Central Florida](https://expedia.ca/Things-To-Do-In-North-Central-Florida.d6233773.Travel-Guide-Activities)[North Central Florida Car Rentals](https://expedia.ca/Car-Rentals-In-North-Central-Florida.d6233773.Car-Rental-Guide)[North Central Florida Vacation Packages](https://expedia.ca/North-Central-Florida.d6233773.Destination-Travel-Guides) ![One of the famous glass bottom boats in Silver Springs State Park (Ocala, FL) floats by on the crystal clear water of the Silver River. If you visit Silver Springs, you must take one of these boat rides. In addition to seeing the underwater springs, we also saw manatees, alligators, turtles, monkeys, and birds on our 90 minute tour. #silversprings #florida](https://images.trvl-media.com/place/10102/70ef890d-5a7e-4d7c-ac71-04c7a28a93cd.jpg?impolicy=fcrop&w=1200&h=500&q=medium) Photo by Jen - Nealys On Wheels ![](https://images.trvl-media.com/place/10102/70ef890d-5a7e-4d7c-ac71-04c7a28a93cd.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on North Central Florida Business Hotels Tonight [Jan 28 - Jan 29](https://www.expedia.ca/Hotel-Search?regionId=6233773&startDate=2026-01-28&endDate=2026-01-29&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) Tomorrow [Jan 29 - Jan 30](https://www.expedia.ca/Hotel-Search?regionId=6233773&startDate=2026-01-29&endDate=2026-01-30&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) This weekend [Jan 30 - Feb 1](https://www.expedia.ca/Hotel-Search?regionId=6233773&startDate=2026-01-30&endDate=2026-02-01&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) Next weekend [Feb 6 - Feb 8](https://www.expedia.ca/Hotel-Search?regionId=6233773&startDate=2026-02-06&endDate=2026-02-08&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) ## Our top choices for North Central Florida business-friendly hotels ![Exterior](https://images.trvl-media.com/lodging/13000000/12710000/12704500/12704476/9ec8c850.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/13000000/12710000/12704500/12704476/3c4354df.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/13000000/12710000/12704500/12704476/87e50709.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, Multiple Beds, Non Smoking](https://images.trvl-media.com/lodging/13000000/12710000/12704500/12704476/a4f3a9f4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Comfort Suites Dunnellon near Rainbow Springs [](https://www.expedia.ca/Crystal-River-Hotels-Comfort-Suites-Near-Rainbow-Springs.h12704476.Hotel-Information) Dunnellon 9.0/10 Wonderful (1,001 reviews) "Great location and comfortable " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Sirbrina CA $139 CA $156 total includes taxes & fees Feb 8 - Feb 9 [](https://www.expedia.ca/Crystal-River-Hotels-Comfort-Suites-Near-Rainbow-Springs.h12704476.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/20000000/19490000/19484600/19484503/0dff4e4a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, laptop workspace, iron/ironing board, free cribs/infant beds](https://images.trvl-media.com/lodging/20000000/19490000/19484600/19484503/e93e0d3f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Restaurant](https://images.trvl-media.com/lodging/20000000/19490000/19484600/19484503/93f8f773.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, laptop workspace, iron/ironing board, free cribs/infant beds](https://images.trvl-media.com/lodging/20000000/19490000/19484600/19484503/57b6c63d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Drury Inn & Suites Gainesville [](https://www.expedia.ca/Gainesville-Hotels-Drury-Inn-Suites-Gainesville.h19484503.Hotel-Information) Gainesville 9.6/10 Exceptional (1,352 reviews) "Clean room, convenient and good breakfast " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) David CA $143 CA $161 total includes taxes & fees Feb 5 - Feb 6 [](https://www.expedia.ca/Gainesville-Hotels-Drury-Inn-Suites-Gainesville.h19484503.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/2000000/1380000/1378800/1378708/0ead3b62.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, laptop workspace, blackout drapes, iron/ironing board](https://images.trvl-media.com/lodging/2000000/1380000/1378800/1378708/82bfa53d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/2000000/1380000/1378800/1378708/2cdf35a0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/2000000/1380000/1378800/1378708/e1dc2812.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Quality Inn White Springs Suwanee [](https://www.expedia.ca/Lake-City-Hotels-Quality-Inn.h1378708.Hotel-Information) Live Oak 7.2/10 Good (630 reviews) "Clean rooms, very friendly staff" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Kristin L CA $90 CA $99 total includes taxes & fees Jan 29 - Jan 30 [](https://www.expedia.ca/Lake-City-Hotels-Quality-Inn.h1378708.Hotel-Information) ![Outdoor pool, open 9:00 AM to 10:00 PM, sun loungers](https://images.trvl-media.com/lodging/2000000/1510000/1505900/1505814/w5753h3835x0y5-8b760fc0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/2000000/1510000/1505900/1505814/0124d3bb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/2000000/1510000/1505900/1505814/45cc4db7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/2000000/1510000/1505900/1505814/5bb0fbdd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hampton Inn & Suites Lake City [](https://www.expedia.ca/Lake-City-Hotels-Hampton-Inn-Suites-Lake-City.h1505814.Hotel-Information) Lake City 9.4/10 Exceptional (1,000 reviews) "Room was spotless and great atmosphere " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Melissa CA $162 CA $182 total includes taxes & fees Feb 1 - Feb 2 [](https://www.expedia.ca/Lake-City-Hotels-Hampton-Inn-Suites-Lake-City.h1505814.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/23000000/22860000/22858300/22858269/e851cfaf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/23000000/22860000/22858300/22858269/a1c39a5a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/23000000/22860000/22858300/22858269/8f3d1583.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![BBQ/picnic area](https://images.trvl-media.com/lodging/23000000/22860000/22858300/22858269/758be2b7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Express & Suites Alachua - Gainesville Area by IHG [](https://www.expedia.ca/Gainesville-Hotels-Holiday-Inn-Express-Suites-Alachua-Gainesville-Area.h22858269.Hotel-Information) Alachua 9.4/10 Exceptional (1,000 reviews) "Great service and clean rooms " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Michael CA $155 CA $174 total includes taxes & fees Feb 1 - Feb 2 [](https://www.expedia.ca/Gainesville-Hotels-Holiday-Inn-Express-Suites-Alachua-Gainesville-Area.h22858269.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/49000000/48290000/48281500/48281488/2886b571.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free on-the-go breakfast on weekdays](https://images.trvl-media.com/lodging/49000000/48290000/48281500/48281488/9112bbc9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/49000000/48290000/48281500/48281488/c38f0eff.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/49000000/48290000/48281500/48281488/0011ea88.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### La Quinta Inn & Suite by Wyndham Lake City [](https://www.expedia.ca/Lake-City-Hotels-La-Quinta-Inn-Suite-By-Wyndham-Lake-City.h48281488.Hotel-Information) Lake City 8.8/10 Excellent (1,060 reviews) "Very nice property. Very clean, rooms nicely appointed, good breakfast. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Barry CA $133 CA $150 total includes taxes & fees Feb 3 - Feb 4 [](https://www.expedia.ca/Lake-City-Hotels-La-Quinta-Inn-Suite-By-Wyndham-Lake-City.h48281488.Hotel-Information) ![Lobby sitting area](https://images.trvl-media.com/lodging/1000000/210000/200800/200755/8a6fa57c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/210000/200800/200755/4e0d3764.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/210000/200800/200755/4d594d6a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Room, 2 Queen Beds, Non Smoking (Larger Room)](https://images.trvl-media.com/lodging/1000000/210000/200800/200755/f246ff96.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### HOM Hotel Gainesville, SureStay Collection by Best Western [](https://www.expedia.ca/Gainesville-Hotels-HOM-Hotel-Gainesville.h200755.Hotel-Information) Gainesville 8.4/10 Very good (1,813 reviews) "Awesome place to stay." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Aristeo CA $106 CA $119 total includes taxes & fees Feb 3 - Feb 4 [](https://www.expedia.ca/Gainesville-Hotels-HOM-Hotel-Gainesville.h200755.Hotel-Information) ![Property amenity](https://images.trvl-media.com/lodging/1000000/430000/429400/429339/fbb41ad1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/430000/429400/429339/c8aec93f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, laptop workspace, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/1000000/430000/429400/429339/c030ccfc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/430000/429400/429339/e5855067.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Best Western Ocala Park Centre [](https://www.expedia.ca/Ocala-Hotels-Best-Western-Ocala-Park-Centre.h429339.Hotel-Information) Ocala 8.4/10 Very good (1,253 reviews) "Spotless, friendly staffed, ample parking and great coffee!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jennifer CA $114 CA $128 total includes taxes & fees Feb 8 - Feb 9 [](https://www.expedia.ca/Ocala-Hotels-Best-Western-Ocala-Park-Centre.h429339.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/2000000/1290000/1289100/1289043/e387508a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/2000000/1290000/1289100/1289043/cf87e7bf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/2000000/1290000/1289100/1289043/f5784012.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Pillowtop beds, desk, laptop workspace, blackout drapes](https://images.trvl-media.com/lodging/2000000/1290000/1289100/1289043/w2878h1920x0y0-ae7e9910.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Country Inn & Suites by Radisson, Gainesville, FL [](https://www.expedia.ca/Gainesville-Hotels-Country-Inn-Suites-By-Radisson.h1289043.Hotel-Information) Gainesville 9.2/10 Wonderful (1,655 reviews) "Staff was great, breakfast was fantastic and check in was easy. I would definitely stay again. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Stephanie CA $121 CA $136 total includes taxes & fees Feb 9 - Feb 10 [](https://www.expedia.ca/Gainesville-Hotels-Country-Inn-Suites-By-Radisson.h1289043.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/910000/901400/901396/a415bbca.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/910000/901400/901396/1240f4d7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, pillowtop beds, desk, laptop workspace](https://images.trvl-media.com/lodging/1000000/910000/901400/901396/f5ec1000.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, pillowtop beds, desk, laptop workspace](https://images.trvl-media.com/lodging/1000000/910000/901400/901396/dc8aa87c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Best Western Plus Lake City [](https://www.expedia.ca/Lake-City-Hotels-Best-Western-Plus-Lake-City.h901396.Hotel-Information) Lake City 9.0/10 Wonderful (1,042 reviews) "Great place to stay" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jack CA $134 CA $151 total includes taxes & fees Jan 29 - Jan 30 [](https://www.expedia.ca/Lake-City-Hotels-Best-Western-Plus-Lake-City.h901396.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2026-02-11&endDate=2026-02-12®ionId=6233773&adults=2&travelerType=business_friendly&sort=RECOMMENDED&openPlayBack=true) ## Top North Central Florida Hotel Reviews ![Equus Inn Ocala](https://images.trvl-media.com/lodging/1000000/30000/27200/27152/8ea1560b_y.jpg) ### Equus Inn Ocala 10/10 Excellent "The hotel was quiet. Clean. Staff was great. The breakfast was a very nice hot options buffet. The coffee was really good too! Will definitely stay there again " [](https://expedia.ca/Ocala-Hotels-Equus-Inn-Ocala.h27152.Hotel-Information) ![Best Western Gateway Grand](https://images.trvl-media.com/lodging/1000000/160000/151100/151041/9a241e09_y.jpg) ### Best Western Gateway Grand 10/10 Excellent "Friendly staff, clean hotel." [](https://expedia.ca/Gainesville-Hotels-Best-Western-Gateway-Grand.h151041.Hotel-Information) ![Days Inn by Wyndham Ocala North](https://images.trvl-media.com/lodging/1000000/10000/900/818/ffb5d22e_y.jpg) ### Days Inn by Wyndham Ocala North 10/10 Excellent "." [](https://expedia.ca/Ocala-Hotels-Days-Inn-By-Wyndham-Ocala-North.h818.Hotel-Information) ![DoubleTree by Hilton Gainesville](https://images.trvl-media.com/lodging/1000000/50000/49700/49617/ff7eaa86_y.jpg) ### DoubleTree by Hilton Gainesville 10/10 Excellent "👍" [](https://expedia.ca/Gainesville-Hotels-DoubleTree-By-Hilton-Gainesville.h49617.Hotel-Information) ![Comfort Inn University](https://images.trvl-media.com/lodging/1000000/800000/793600/793525/78ca2e85_y.jpg) ### Comfort Inn University 10/10 Excellent "Yes very nice excellent " [](https://expedia.ca/Gainesville-Hotels-Comfort-Inn-University.h793525.Hotel-Information) ![Sleep Inn & Suites University/Shands](https://images.trvl-media.com/lodging/2000000/1940000/1932400/1932346/3c8617a9_y.jpg) ### Sleep Inn & Suites University/Shands 10/10 Excellent "Muy limpio, café todo el tiempo, muy tranquilo en realidad me gusta mucho la atención de lo recomiendo " [](https://expedia.ca/Gainesville-Hotels-Sleep-Inn-Suites-UniversityShands.h1932346.Hotel-Information) ![HOM Hotel Gainesville, SureStay Collection by Best Western](https://images.trvl-media.com/lodging/1000000/210000/200800/200755/07c3ba53_y.jpg) ### HOM Hotel Gainesville, SureStay Collection by Best Western 10/10 Excellent "Room was clean , very convenient close to restaurants . Quiet . Breakfast was great . For the price u can't beat it . " [](https://expedia.ca/Gainesville-Hotels-HOM-Hotel-Gainesville.h200755.Hotel-Information) ![Country Inn & Suites by Radisson, Gainesville, FL](https://images.trvl-media.com/lodging/2000000/1290000/1289100/1289043/8584a629_y.jpg) ### Country Inn & Suites by Radisson, Gainesville, FL 10/10 Excellent "Friendly staff and very clean!" [](https://expedia.ca/Gainesville-Hotels-Country-Inn-Suites-By-Radisson.h1289043.Hotel-Information) ![Quality Inn & Suites Ocala I-75](https://images.trvl-media.com/lodging/1000000/20000/13100/13021/a4abf0dd_y.jpg) ### Quality Inn & Suites Ocala I-75 10/10 Excellent "The room was great, the staff was really nice. I would suggest to improve breakfast a little bit. One day we had eggs but the other day not. " [](https://expedia.ca/Ocala-Hotels-Quality-Inn-Suites-I-75.h13021.Hotel-Information) ## Frequently asked questions ### How much do business-friendly hotels in North Central Florida cost? ### What are the best business-friendly hotels in North Central Florida? ### How many business-friendly hotels are there in North Central Florida? ### What are the best cheap business-friendly hotels in North Central Florida? ### Are there any family-friendly hotels in North Central Florida that are also business friendly? ### Why book your business-friendly hotel in North Central Florida with Expedia? ### How can I find cheap business-friendly hotels in North Central Florida? ### What is there to do in North Central Florida near my business-friendly hotel? ## Explore a world of travel with Expedia - Lodging - More ways to book - [Green Hotels in Daytona Beach ](https://www.expedia.ca/Daytona-Beach-Hotels-Green-Sustainable.0-0-d6023995-tGreenSustainable.Travel-Guide-Filter-Hotels) - [Honeymoon Resorts and in Daytona Beach ](https://www.expedia.ca/Daytona-Beach-Hotels-Honeymoon-Hotels.0-0-d6023995-tHoneymoonHotels.Travel-Guide-Filter-Hotels) - 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