A calm body of water, a sandy beach, and a forested area in the distance.

Cape Girardeau Vacation Rentals

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Our top choices for Cape Girardeau vacation rentals

1. Little Blue Cottage on Spanish

Little Blue Cottage on Spanish
Cape Girardeau
8.4 out of 10, Very good, (57 reviews)
"Great cute place. "
United States
Jeremy W.
The price is CA $111
CA $149 total
includes taxes & fees
Aug 31 - Sep 1
Little Blue Cottage on Spanish

2. Fresh & Cozy Retreat w/ King Bed · By KeenStays

Fresh & Cozy Retreat w/ King Bed · By KeenStays
Cape Girardeau
The price is CA $138
CA $260 total
includes taxes & fees
Aug 26 - Aug 27
Fresh & Cozy Retreat w/ King Bed · By KeenStays

3. The Cottage, Rusted Route Farms

The Cottage, Rusted Route Farms
Jackson
10.0 out of 10, Exceptional, (3 reviews)
"This Cottage was very nice and clean and well maintained. The meat tray that we ordered and the breakfast tray was beyond Fabulous!!! My husband is still talking about it. . .Rick & Renee Christman"
United States
Renee C.
The price is CA $172
CA $271 total
includes taxes & fees
Aug 26 - Aug 27
The Cottage, Rusted Route Farms

4. European Inspired Lofted Cottage in Tiny Home Village

European Inspired Lofted Cottage in Tiny Home Village
Cape Girardeau
The price is CA $214
CA $310 total
includes taxes & fees
Aug 26 - Aug 27
European Inspired Lofted Cottage in Tiny Home Village

5. 3+ acre Home: Pool Table, Putt-Putt, 4 miles to Downtown and SEMO, Summer Pool

3+ acre Home: Pool Table, Putt-Putt, 4 miles to Downtown and SEMO, Summer Pool
Cape Girardeau
8.8 out of 10, Excellent, (43 reviews)
"Will definitely book again! Great location, comfortable stay."
United States
Pynktoria !.
The price is CA $246
CA $430 total
includes taxes & fees
Sep 3 - Sep 4
3+ acre Home: Pool Table, Putt-Putt, 4 miles to Downtown and SEMO, Summer Pool

6. Romantic Tea Cottage Retreat on Boulder Creek with Firepit and Deck

Romantic Tea Cottage Retreat on Boulder Creek with Firepit and Deck
Cape Girardeau
10.0 out of 10, Exceptional, (1 review)
"The property was amazing, and Holly's service was excellent. The community is a collection of tinyish homes that is really cool, with outside communal amenities to enjoy. Close to everything in Cape and Jackson, whether it's a couples getaway or a group experience and you book multiple units, this place would be great for you!"
United States
Dustin T.
The price is CA $214
CA $310 total
includes taxes & fees
Aug 28 - Aug 29
Romantic Tea Cottage Retreat on Boulder Creek with Firepit and Deck

7. Vibrant Lofted Tiny Home

Vibrant Lofted Tiny Home
Cape Girardeau
10.0 out of 10, Exceptional, (1 review)
"The tiny house was adorable, clean, and everything we expected. We can’t wait to stay in the others. We definitely recommend staying here. Lisa and Holly have done a wonderful job. Holly was great at getting back to me. Loved everything about our stay and the trip. Thank you so much"
United States
Kim K.
The price is CA $222
CA $321 total
includes taxes & fees
Sep 6 - Sep 7
Vibrant Lofted Tiny Home

8. The Twisted Sassafras Treehouse

The Twisted Sassafras Treehouse
Cape Girardeau
10.0 out of 10, Exceptional, (36 reviews)
"Amazing stay! Everything was perfect."
United States
Wayne F.
The price is CA $310
CA $494 total
includes taxes & fees
Aug 26 - Aug 27
The Twisted Sassafras Treehouse

9. Gorgeous 1856 Log Cabin, Completely Renovated

Gorgeous 1856 Log Cabin, Completely Renovated
Jackson
10.0 out of 10, Exceptional, (5 reviews)
"This was the coolest place! Our family absolutely loved it. Plenty of space, bathrooms, sitting areas outside were plenty as well as fireplaces and fire pit. The bedrooms are spacious- the area where the two twin beds are is downstairs and the beds are smaller but just know that going in. Beautiful area. We’d love to stay again."
United States
Victoria
The price is CA $275
CA $431 total
includes taxes & fees
Aug 31 - Sep 1
Gorgeous 1856 Log Cabin, Completely Renovated

10. Beautifully Renovated Farmhouse in Jackson, MO

Beautifully Renovated Farmhouse in Jackson, MO
Jackson
9.4 out of 10, Exceptional, (3 reviews)
" great stay,property landscape nicely manicured, quiet and relaxing inside and outside of the the dwelling."
United States
Sandy S.
The price is CA $275
CA $431 total
includes taxes & fees
Aug 26 - Aug 27
Beautifully Renovated Farmhouse in Jackson, MO

11. 4-Bedroom Home - 2 King Beds, Summer Pool, Pool Table, Air Hockey + More

4-Bedroom Home - 2 King Beds, Summer Pool, Pool Table, Air Hockey + More
Cape Girardeau
9.8 out of 10, Exceptional, (11 reviews)
"Nice place, great times"
United States
Jace W.
The price is CA $436
CA $728 total
includes taxes & fees
Sep 7 - Sep 8
4-Bedroom Home - 2 King Beds, Summer Pool, Pool Table, Air Hockey + More

12. A-Frame Cottage with Deck in Charming Inspiration Village

A-Frame Cottage with Deck in Charming Inspiration Village
Cape Girardeau
The price is CA $229
CA $331 total
includes taxes & fees
Aug 27 - Aug 28
A-Frame Cottage with Deck in Charming Inspiration Village

13. Cozy cabins on beautiful Horseshoe Lake

Cozy cabins on beautiful Horseshoe Lake
Olive Branch
9.8 out of 10, Exceptional, (42 reviews)
"This is the best place to stay in Southern Illinois and puts me right in the middle of everywhere I need to be. The rooms are always CLEAN, great view of the lake and Horseshoe Bar is down the road with my favorite pizza. I believe this is my fifth stay and will continue to stay here when I'm in the area."
United States
Diana R.
The price is CA $155
CA $193 total
includes taxes & fees
Aug 26 - Aug 27
Cozy cabins on beautiful Horseshoe Lake

14. The Rested Duck Mallard Room

The Rested Duck Mallard Room
Olive Branch
9.4 out of 10, Exceptional, (31 reviews)
"This is an excellent place to stay. With a nice lake right across the street. If i. In the are i will stay again for sure"
United States
mike b.
The price is CA $155
CA $193 total
includes taxes & fees
Aug 26 - Aug 27
The Rested Duck Mallard Room

15. Stunning 2 bedroom in town, close to Shawnee National Forest

Stunning 2 bedroom in town, close to Shawnee National Forest
Jonesboro
10.0 out of 10, Exceptional, (12 reviews)
"Cool renovated property that keeps that old fashioned charm. Spacious living with all the amenities you need for a vacation stay."
United States
Dylan
The price is CA $189
CA $393 total
includes taxes & fees
Aug 29 - Aug 30
Stunning 2 bedroom in town, close to Shawnee National Forest

16. Peaceful secluded cabin located near Horseshoe Lake

Peaceful secluded cabin located near Horseshoe Lake
Miller City
9.8 out of 10, Exceptional, (37 reviews)
"Great place in a beautiful location. "
United States
George B.
The price is CA $173
CA $273 total
includes taxes & fees
Aug 26 - Aug 27
Peaceful secluded cabin located near Horseshoe Lake

17. Charming cottage overlooking Lake Acre

Charming cottage overlooking Lake Acre
Dongola
10.0 out of 10, Exceptional, (105 reviews)
"beautiful property. house was clean and comfortable."
United States
john m.
The price is CA $186
CA $347 total
includes taxes & fees
Aug 26 - Aug 27
Charming cottage overlooking Lake Acre

18. Villa B offers peace and quiet with beautiful views of the countryside.

Villa B offers peace and quiet with beautiful views of the countryside.
Jackson
10.0 out of 10, Exceptional, (13 reviews)
"We were only there for 1 night for a business trip but it was perfect for our stay. Very clean and comfortable and the host was onsite to welcome us. She even gave us a tip on the best place nearby for dinner that we will be going to any time we can in the future. I would gladly stay here again for future trips."
United States
Terry H.
The price is CA $206
CA $246 total
includes taxes & fees
Aug 27 - Aug 28
Villa B offers peace and quiet with beautiful views of the countryside.

19. Relax in the country at Countryside Villas! - Villa A

Relax in the country at Countryside Villas! - Villa A
Jackson
10.0 out of 10, Exceptional, (37 reviews)
"Great place to stay, felt like home away from home. "
United States
Brittany
The price is CA $206
CA $246 total
includes taxes & fees
Aug 27 - Aug 28
Relax in the country at Countryside Villas! - Villa A

20. Cozy and Updated Farmhouse with King Suite

Cozy and Updated Farmhouse with King Suite
Anna
10.0 out of 10, Exceptional, (22 reviews)
"Nice little house that was perfect for our family of five plus our dog. We would stay here again if we found ourselves out this way again."
United States
Kyle
The price is CA $123
CA $217 total
includes taxes & fees
Sep 1 - Sep 2
Cozy and Updated Farmhouse with King Suite
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Cape Girardeau Hotel Reviews

Find out more about Cape Girardeau

You always said you would go on a dream vacation someday. Now, someday is here. But you don’t just want to dip your toe into the trip of a lifetime, you want to cannon ball into the deep end. Go ahead, unplug and unwind in style. When you book one of our vacation rentals, the ordinary is in the rearview. Instead of sharing your vacation with hundreds of hotel guests, you get to take advantage of all the space at your private apartment or room. You also get to enjoy all the amenities of a private residence for a truly unique and memorable stay. Why don’t you take off your shoes and settle in for a while? Your vacation just got upgraded.

As much as you love your short-term rental, it’s always good to get out and explore to soak up . Live like a local: Eat regional food, cheer on the home team, and visit the best cultural attractions in town. No matter the season, there is always something going on in . Seeing all the best attractions is bound to make you fall in love with Cape Girardeau. Who knows, you may even be tempted to extend your vacation rental stay. There’s a reason home rentals are so popular here—after a long day of exploration, going back to your very own living room to stretch out is a dream come true.

It’s your escape so why share it? You deserve your own slice of paradise. Booking your vacation rental on Expedia is simple and safe. Just pick your dates to search for the perfect property and book securely. We let you contact the property owner directly to make any special arrangements. All that’s left to do is show up with bells on and have a memorable vacation. With all the amenities available in short-term rentals, that won’t be hard to do.

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Frequently asked questions

Can I find vacation rentals in Cape Girardeau?

Yes, we offer vacation rentals in Cape Girardeau near Cape Splash Family Aquatic Center, or you can select a more remote option if you're looking for extra privacy while you relax. Visitors like the top-notch restaurants and shops in Cape Girardeau. Make sure you allow time to enjoy the riverfront during your vacation.

What are some of the best vacation home rentals in Cape Girardeau?

“Brickyard”-Recently Remodeled Dutch Colonial Revival in Downtown Cape Girardeau: This Cape Girardeau vacation home rental is located on a river and has a patio, a garden, and a barbecue grill to put you at ease in your new surroundings. It has 3 bedrooms as well as a kitchen with a dishwasher, a fridge, and a stovetop, so you can cook with friends or family. You and your friends and family can relax into your vacation with amenities like a selection of games. Some other homes for rent in Cape Girardeau include Serenity South -- Gardens, River-Views, and Refreshing Space and 3 Bed 3 Bath Beautiful Historic District Within Walking Downtown Cape Girardeau.

How many vacation rentals will I find in Cape Girardeau?

Choose from 26 Expedia vacation rentals in Cape Girardeau for a memorable vacation.

What can I see and do in Cape Girardeau?

Family-friendly attractions include Cape Splash Family Aquatic Center and Cape Girardeau Conservation Nature Center, whereas Shawnee National Forest and Mississippi River are a couple of great spots to enjoy the outdoors. While here, Century Casino & Hotel Cape Girardeau and Hunter Valley Winery are other places worth a visit.

What are vacation rentals like in Cape Girardeau?

Vacation rentals are private properties you can book for a couple days or more in Cape Girardeau. Vacation rentals offer amenities such as hot tubs, fire pits, and patios so your stay will be comfortable. If you're concerned about cleanliness, vacation rentals can offer a sense of privacy away from public hotel elevators and lobbies bustling with people while still allowing you the excitement and enjoyment of travel. You'll also find more space in a vacation rental than in a standard hotel, which is another reason why a vacation rental is an attractive option for a small group gathering.