Title: 4 Stars Hotels in Eastern Panama, Panama  - Find Cheap Eastern Panama Hotels With 4 Stars | Expedia.ca

[Eastern Panama Travel Guide](https://expedia.ca/Eastern-Panama.dx6246114)[Hotels in Eastern Panama](https://expedia.ca/Eastern-Panama-Hotels.d6246114.Travel-Guide-Hotels)[Vacation Rentals in Eastern Panama](https://expedia.ca/Eastern-Panama-Vacation-Rentals.d6246114.Travel-Guide-VacationRentals)[Flights to Eastern Panama](https://expedia.ca/Cheap-Flights-To-Eastern-Panama.d6246114.Travel-Guide-Flights)[Things to do in Eastern Panama](https://expedia.ca/Things-To-Do-In-Eastern-Panama.d6246114.Travel-Guide-Activities)[Eastern Panama Car Rentals](https://expedia.ca/Car-Rentals-In-Eastern-Panama.d6246114.Car-Rental-Guide)[Eastern Panama Vacation Packages](https://expedia.ca/Eastern-Panama.d6246114.Destination-Travel-Guides)

![50 Shades of blue. Sailing through the San Blas Islands in Panama lets you experience  a pure paradise and crystal clear water. You can buy fresh fish and other seefood drirectly from local fishermen. If you want you can also play Robinson Crusoe on islands with literally only one palm tree. 
#BVSBlue](https://images.trvl-media.com/place/6246376/42fe0cae-c805-47d5-a705-ee119c68d58c.jpg?impolicy=fcrop&w=1200&h=500&q=medium)

Photo by Nico Barner

# 4 Stars Hotels in Eastern Panama, Panama 

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## Check availability on Eastern Panama 4 Star Hotels

Tonight

[Dec 26 - Dec 27](https://www.expedia.ca/Hotel-Search?regionId=6246114&startDate=2025-12-26&endDate=2025-12-27&adults=2&star=40&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Tomorrow

[Dec 27 - Dec 28](https://www.expedia.ca/Hotel-Search?regionId=6246114&startDate=2025-12-27&endDate=2025-12-28&adults=2&star=40&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

This weekend

[Dec 26 - Dec 28](https://www.expedia.ca/Hotel-Search?regionId=6246114&startDate=2025-12-26&endDate=2025-12-28&adults=2&star=40&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Next weekend

[Jan 2 - Jan 4](https://www.expedia.ca/Hotel-Search?regionId=6246114&startDate=2026-01-02&endDate=2026-01-04&adults=2&star=40&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

## Our top choices for Eastern Panama 4-star hotels

![Outdoor pool](https://images.trvl-media.com/lodging/104000000/103770000/103761600/103761591/4a052041.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Luxury Suite](https://images.trvl-media.com/lodging/104000000/103770000/103761600/103761591/013d70fa.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Luxury Suite](https://images.trvl-media.com/lodging/104000000/103770000/103761600/103761591/5f317f8b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Junior Suite, Ocean View](https://images.trvl-media.com/lodging/104000000/103770000/103761600/103761591/38d2b5c3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Ordovician Beach Resort

[](https://www.expedia.ca/Ordovician-Beach-Resort.h103761591.Hotel-Information)

Isla Grande

10/10

Exceptional

(3)

"Amazing piece of Caribbean paradise! The staff went above and beyond to make us feel special."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Francisco

[](https://www.expedia.ca/Ordovician-Beach-Resort.h103761591.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/108000000/107720000/107714100/107714077/956c2c4f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Basic Suite, Mountain View | Private kitchen](https://images.trvl-media.com/lodging/108000000/107720000/107714100/107714077/beb3d81a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Basic Suite, Mountain View](https://images.trvl-media.com/lodging/108000000/107720000/107714100/107714077/14e84dc7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/108000000/107720000/107714100/107714077/65c1a6f4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Mandalas Ecolodge

[](https://www.expedia.ca/Caimitillo-Hotels-Mandalas-Ecolodge.h107714077.Hotel-Information)

Caimitillo

[](https://www.expedia.ca/Caimitillo-Hotels-Mandalas-Ecolodge.h107714077.Hotel-Information)

![Outdoor pool](https://images.trvl-media.com/lodging/5000000/4320000/4313000/4312945/a37c3663.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/5000000/4320000/4313000/4312945/849612f9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/5000000/4320000/4313000/4312945/a31596fc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Manicures and pedicures](https://images.trvl-media.com/lodging/5000000/4320000/4313000/4312945/58db5c1c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### El Otro Lado

[](https://www.expedia.ca/Portobelo-Hotels-El-Otro-Lado.h4312945.Hotel-Information)

Portobelo

9.8/10

Exceptional

(8)

"Amazing.. Amazing. You need extra words, We loved it. We loved it.Amazing.. Amazing. You need extra words, We loved it. We loved it. Amazing.. Amazing. You need extra words, We loved it. We loved it. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Jacob

[](https://www.expedia.ca/Portobelo-Hotels-El-Otro-Lado.h4312945.Hotel-Information)

![Premium bedding, down comforters, individually decorated](https://images.trvl-media.com/lodging/38000000/37040000/37032000/37031981/94721000.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Premier Apartment, Bay View | Bathroom](https://images.trvl-media.com/lodging/38000000/37040000/37032000/37031981/838e9b19.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![30-inch TV with premium channels, DVD player](https://images.trvl-media.com/lodging/38000000/37040000/37032000/37031981/5edecc13.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/38000000/37040000/37032000/37031981/576244d7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Portobello Historico

[](https://www.expedia.ca/Portobelo-Hotels-Portobello-Historico.h37031981.Hotel-Information)

Portobelo

[](https://www.expedia.ca/Portobelo-Hotels-Portobello-Historico.h37031981.Hotel-Information)

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## Learn more about Eastern Panama

Explore attractions like Cayos Holandeses and Isla Diablo as you discover things to see and do in Eastern Panama.

[See all hotels in Eastern Panama](https://www.expedia.ca/Hotel-Search?startDate=2026-01-09&endDate=2026-01-10&adults=2&regionId=6246114)

![50 Shades of blue. Sailing through the San Blas Islands in Panama lets you experience  a pure paradise and crystal clear water. You can buy fresh fish and other seefood drirectly from local fishermen. If you want you can also play Robinson Crusoe on islands with literally only one palm tree. 
#BVSBlue](https://images.trvl-media.com/place/6246376/42fe0cae-c805-47d5-a705-ee119c68d58c.jpg?impolicy=fcrop&w=899&h=602&p=1&q=high)

Photo by Nico Barner

## Top Eastern Panama Hotel Reviews

## Find out more about Eastern Panama

If you’re looking for a spot with great rates, just-for-you amenities, and a world of luxurious little perks, the best 4 Stars hotels in Eastern Panama are calling your name. Known for providing first-rate service in amazing locations, each of the Eastern Panama 4 Stars hotels lets discerning travelers bask in an unforgettable experience.

Kick back in your spacious room. Relax in the lobby’s sumptuous surroundings. Start the day with delicious room service, and then use the complimentary body care items to freshen up before you head out for the day.

It’s all waiting for you at the top four star hotels in Eastern Panama. Plus, when you book with Expedia.ca, you might find a cheap deal on a 4 Stars hotel in Eastern Panama, Panama, neighbourhoods near the most popular attractions, so you can see the sights and bask in the discounts all in one trip. Whether you’re planning a romantic retreat or simply want to experience everything the area has to offer, the top Eastern Panama hotels with 4 Stars provide everything you need to unwind in style.

## Frequently asked questions

### How much does it cost to stay in a 4-star hotel in Eastern Panama?

> - Search for the lowest price

### What's the difference between 5-star and 4-star hotels in Eastern Panama?

### Does Eastern Panama have any 4-star all-inclusive resorts?