Title: Book the Best Wytheville LUXURY Hotels - Upscale Hotels in Wytheville, VA | Expedia.ca [Wytheville Travel Guide](https://expedia.ca/Wytheville.dx6056934)[Hotels in Wytheville](https://expedia.ca/Wytheville-Hotels.d6056934.Travel-Guide-Hotels)[Vacation Rentals in Wytheville](https://expedia.ca/Wytheville-Vacation-Rentals.d6056934.Travel-Guide-VacationRentals)[Wytheville Car Rentals](https://expedia.ca/Car-Rentals-In-Wytheville.d6056934.Car-Rental-Guide)[Wytheville Vacation Packages](https://expedia.ca/Wytheville.d6056934.Destination-Travel-Guides) ![From Bolling Wilson Hotel](https://images.trvl-media.com/place/6056934/1e2f8c54-9738-466f-9852-0f86eb56c271.jpg?impolicy=fcrop&w=1200&h=500&q=medium) Photo by Meng Fan # Find luxury hotels in Wytheville, VA - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Wytheville Luxury Hotels Tonight [Dec 27 - Dec 28](https://www.expedia.ca/Hotel-Search?regionId=6056934&startDate=2025-12-27&endDate=2025-12-28&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) Tomorrow [Dec 28 - Dec 29](https://www.expedia.ca/Hotel-Search?regionId=6056934&startDate=2025-12-28&endDate=2025-12-29&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) Next weekend [Jan 2 - Jan 4](https://www.expedia.ca/Hotel-Search?regionId=6056934&startDate=2026-01-02&endDate=2026-01-04&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) In two weeks [Jan 9 - Jan 11](https://www.expedia.ca/Hotel-Search?regionId=6056934&startDate=2026-01-09&endDate=2026-01-11&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) ## Find out more about Wytheville ### Wythevilleand its attractions for luxury travelers Nestled in the scenic Blue Ridge Mountains, Wytheville, Virginia, offers an array of experiences that appeal to luxury travellers seeking both tranquillity and adventure. Begin your exploration at the historic Wytheville Meeting Centre, where you can appreciate local art and culture through its rotating exhibitions. Just a stone's throw away, the beautiful Edith Bolling Wilson Birthplace Museum invites guests to delve into the life of this fascinating First Lady with its well-preserved artefacts and engaging storytelling. For those who enjoy the great outdoors, the nearby New River Valley boasts stunning hiking trails, perfect for a leisurely morning stroll or a more challenging hike, surrounded by breathtaking vistas. Meanwhile, the local wine scene has blossomed; indulge in tastings at one of the nearby vineyards, where you can savour exquisite wines paired with artisanal cheeses. After a day of exploration, unwind in one of Wytheville's elegant hotels, such as the the historic Bolling Wilson Hotel, which combines modern luxury with charming Southern hospitality, ensuring a pampered stay that caters to your every need. From attentive service to thoughtfully designed rooms with beautiful views, your experience in Wytheville will be both relaxing and memorable. ## Top Wytheville Hotel Reviews ![The Bolling Wilson Hotel](https://images.trvl-media.com/lodging/9000000/8670000/8668100/8668011/d3701a4e_y.jpg) ### The Bolling Wilson Hotel 10/10 Excellent "Friendly staff that checked us in quickly. The room was clean and comfotable. Hope to stay again and check out the restaurant and roof top views." [](https://expedia.ca/Wytheville-Hotels-The-Bolling-Wilson-Hotel.h8668011.Hotel-Information) ![Ramada by Wyndham Wytheville](https://images.trvl-media.com/lodging/1000000/20000/14200/14109/a531b7b8_y.jpg) ### Ramada by Wyndham Wytheville 10/10 Excellent "The check woman was extremely friendly. The restaurant was very good and the food great. " [](https://expedia.ca/Wytheville-Hotels-Ramada-By-Wyndham-Wytheville.h14109.Hotel-Information) ![Days Inn by Wyndham Wytheville](https://images.trvl-media.com/lodging/1000000/10000/1200/1148/3c3a149c_y.jpg) ### Days Inn by Wyndham Wytheville 10/10 Excellent "Easy check in and check our" [](https://expedia.ca/Wytheville-Hotels-Days-Inn-By-Wyndham-Wytheville.h1148.Hotel-Information) ![Sleep Inn Wytheville I-77 and I-81](https://images.trvl-media.com/lodging/1000000/70000/64700/64617/13966a3a_y.jpg) ### Sleep Inn Wytheville I-77 and I-81 10/10 Excellent "Yes" [](https://expedia.ca/Wytheville-Hotels-Sleep-Inn-Wytheville-I-77-And-I-81.h64617.Hotel-Information) ![Quality Inn & Suites](https://images.trvl-media.com/lodging/2000000/1720000/1713900/1713858/2589322f_y.jpg) ### Quality Inn & Suites 10/10 Excellent "nice" [](https://expedia.ca/Wytheville-Hotels-Quality-Inn-Suites.h1713858.Hotel-Information) ![Red Roof Inn Wytheville](https://images.trvl-media.com/lodging/2000000/1040000/1037800/1037707/c4f63b85_y.jpg) ### Red Roof Inn Wytheville 10/10 Excellent "The staff was very friendly and the rooms were nice and clean" [](https://expedia.ca/Wytheville-Hotels-Red-Roof-Inn-Wytheville.h1037707.Hotel-Information) ![Comfort Suites Wytheville](https://images.trvl-media.com/lodging/2000000/1530000/1527500/1527459/b13fc58d_y.jpg) ### Comfort Suites Wytheville 10/10 Excellent "Beds were very comfortable. Loved the breakfast and cucumber water in the lobby. Front desk staff was nice and helped us out when we needed it. Will stay again!" [](https://expedia.ca/Wytheville-Hotels-Comfort-Suites-Wytheville.h1527459.Hotel-Information) ![Deluxe Inn Wytheville](https://images.trvl-media.com/lodging/1000000/20000/12600/12597/c30728c3_y.jpg) ### Deluxe Inn Wytheville 10/10 Excellent "This hotel was really nice a lot nicer than I even expected.The hot tub room is exceptional, clean and has a huge hot tub.It's not a best bathtub chat.It's an actual hot tub for 4 or 5 people.It's really nice.I recommend it to anybody" [](https://expedia.ca/Wytheville-Hotels-Deluxe-Inn.h12597.Hotel-Information) ## Frequently asked questions ### Which area of Wytheville is best to stay in for luxury hotels? > This area offers convenient access to the interstate, which is ideal for travellers stopping through or using Wytheville as a base for exploring the wider region. You'll find a selection of newer, upscale hotels here, often featuring modern amenities such as indoor pools and high-end fitness equipment. This part of town provides a comfortable and convenient experience without being far from local dining options. > > > Couples looking for a relaxing stopover will appreciate the ease of access and the quality of accommodation available. ### How much does a luxury hotel in Wytheville cost? ### How can I save on a luxury hotel in Wytheville with Expedia? ### Is it cheaper to book a luxury Wytheville hotel and flights as a package? ### Can I cancel my luxury hotel reservation on Expedia? ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - Vacation Rental - More ways to book - [Cheap Hotels in Atkins ](https://www.expedia.ca/Atkins-Hotels-Cheap-Hotels.0-0-d75357-tCheapHotels.Travel-Guide-Filter-Hotels) - [Wyndham Hotels in Atkins ](https://www.expedia.ca/Atkins-Hotels-Wyndham-Hotels.0-0-d75357--bWyndhamHotels.Travel-Guide-Filter-Hotels) - [Atkins Hotels ](https://www.expedia.ca/Atkins-Hotels.d75357.Travel-Guide-Hotels) - [Cottages in Austinville ](https://www.expedia.ca/Austinville-Cottages.d3000422577-aaCottages.Travel-Guide-Accommodation) - 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