Title: Book the Best West Main Historic District SPA Resorts from CA $122 - Spa Hotels in West Main Historic District, Louisville | Expedia.ca [Vacation Rentals in Louisville](https://expedia.ca/Louisville-Vacation-Rentals.d603002.Travel-Guide-VacationRentals)[Flights to Louisville](https://expedia.ca/Cheap-Flights-To-Louisville.d603002.Travel-Guide-Flights)[Things to do in Louisville](https://expedia.ca/Things-To-Do-In-Louisville.d603002.Travel-Guide-Activities)[West Main Historic District Car Rentals](https://expedia.ca/Car-Rentals-In-West-Main-Historic-District.d6338837.Car-Rental-Guide)[West Main Historic District Vacations](https://expedia.ca/West-Main-Historic-District.d6338837.Destination-Travel-Guides) ![Kentucky Center for the Performing Arts showing modern architecture](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/297000/297198-Kentucky.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find Spa Hotels in West Main Historic District, Louisville from CA $122 ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on West Main Historic District Spa Hotels Tonight [Oct 29 - Oct 30](https://www.expedia.ca/Hotel-Search?regionId=6338837&startDate=2025-10-29&endDate=2025-10-30&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Oct 30 - Oct 31](https://www.expedia.ca/Hotel-Search?regionId=6338837&startDate=2025-10-30&endDate=2025-10-31&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Oct 31 - Nov 2](https://www.expedia.ca/Hotel-Search?regionId=6338837&startDate=2025-10-31&endDate=2025-11-02&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Nov 7 - Nov 9](https://www.expedia.ca/Hotel-Search?regionId=6338837&startDate=2025-11-07&endDate=2025-11-09&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top West Main Historic District Spa Hotels ![4 restaurants, breakfast, lunch, dinner served; American cuisine](https://images.trvl-media.com/lodging/1000000/200000/191500/191434/b5c46c3f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property - evening/night](https://images.trvl-media.com/lodging/1000000/200000/191500/191434/23521baa.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![In-room safe, desk, laptop workspace, iron/ironing board](https://images.trvl-media.com/lodging/1000000/200000/191500/191434/594caae3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![4 restaurants, breakfast, lunch, dinner served; American cuisine](https://images.trvl-media.com/lodging/1000000/200000/191500/191434/ab0af7cb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Galt House Hotel Trademark Collection by Wyndham Downtown Louisville 9.0/10 Wonderful (3697) "Great place to stay " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Tia CA $177 CA $209 total includes taxes & fees Nov 24 - Nov 25 [](https://www.expedia.ca/Louisville-Hotels-Galt-House-Hotel-Trademark-Collection-By-Wyndham.h191434.Hotel-Information) ![Sauna, body treatments, aromatherapy, hot stone massages](https://images.trvl-media.com/lodging/22000000/21110000/21106200/21106192/4c7c479b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior detail](https://images.trvl-media.com/lodging/22000000/21110000/21106200/21106192/9798709f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![3 restaurants, breakfast served](https://images.trvl-media.com/lodging/22000000/21110000/21106200/21106192/w5757h3840x3y0-b0a2f211.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Pillowtop beds, minibar, in-room safe, desk](https://images.trvl-media.com/lodging/22000000/21110000/21106200/21106192/e108d0ee.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Omni Louisville Hotel Downtown Louisville 9.2/10 Wonderful (1659) "Beautiful hotel, friendly staff and close to a lot to do." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Colby CA $278 CA $327 total includes taxes & fees Nov 15 - Nov 16 [](https://www.expedia.ca/Louisville-Hotels-Omni-Louisville-Hotel.h21106192.Hotel-Information) ![Front of property](https://images.trvl-media.com/lodging/2000000/1420000/1413400/1413350/a9b7038a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Bar (on property)](https://images.trvl-media.com/lodging/2000000/1420000/1413400/1413350/cef338e9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room (Asleep in the Cyclone)](https://images.trvl-media.com/lodging/2000000/1420000/1413400/1413350/fdd94051.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/2000000/1420000/1413400/1413350/22b7d23e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### 21c Museum Hotel Louisville Downtown Louisville 9.2/10 Wonderful (1001) " Loved our stay, would definitely plan to come back if we are ever in the area again." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Erica CA $225 CA $271 total includes taxes & fees Nov 20 - Nov 21 [](https://www.expedia.ca/Louisville-Hotels-21c-Museum-Hotel-Louisville.h1413350.Hotel-Information) ![Premium bedding, iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/122000000/121880000/121877400/121877336/90ea7f39.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![32-inch Smart TV with cable channels](https://images.trvl-media.com/lodging/122000000/121880000/121877400/121877336/00e4c915.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Full-size fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/122000000/121880000/121877400/121877336/eb0ea4ef.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exclusive Room](https://images.trvl-media.com/lodging/122000000/121880000/121877400/121877336/w1332h2000x0y0-dacf7d0f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Reserve on Main Downtown Louisville CA $194 CA $226 total includes taxes & fees Nov 2 - Nov 3 [](https://www.expedia.ca/Louisville-Hotels-The-Reserve-On-Main.h121877336.Hotel-Information) ![Indoor pool](https://images.trvl-media.com/lodging/1000000/800000/795900/795844/80fbdedc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![In-room safe, desk, blackout drapes, iron/ironing board](https://images.trvl-media.com/lodging/1000000/800000/795900/795844/2339d325.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Casino](https://images.trvl-media.com/lodging/1000000/800000/795900/795844/a36c57b3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![3 restaurants, breakfast, lunch, dinner served; American cuisine](https://images.trvl-media.com/lodging/1000000/800000/795900/795844/54f0e03a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Caesars Southern Indiana - A Caesars Rewards Destination Elizabeth 8.2/10 Very good (1029) "Easy parking, Very friendly/helpful staff, easy check in/out, Nice casino, Good food options" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Leslie CA $84 CA $122 total includes taxes & fees Nov 27 - Nov 28 [](https://www.expedia.ca/Elizabeth-Hotels-Caesars-Southern-Indiana.h795844.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2025-11-12&endDate=2025-11-13®ionId=6338837&adults=2&amenities=SPA_ON_SITE&sort=RECOMMENDED&openPlayBack=true) ## Top West Main Historic District Hotel Reviews ![Galt House Hotel Trademark Collection by Wyndham](//images.trvl-media.com/lodging/1000000/200000/191500/191434/b5c46c3f_y.jpg) ### Galt House Hotel Trademark Collection by Wyndham 10/10 Excellent "We enjoyed our stay" [](https://expedia.ca/Louisville-Hotels-Galt-House-Hotel-Trademark-Collection-By-Wyndham.h191434.Hotel-Information) ![21c Museum Hotel Louisville](//images.trvl-media.com/lodging/2000000/1420000/1413400/1413350/a9b7038a_y.jpg) ### 21c Museum Hotel Louisville 10/10 Excellent "21c Museum Hotel is a fun and unique experience. Beautiful rooms and centrally located to shops, restaurants and distilleries in Louisville." [](https://expedia.ca/Louisville-Hotels-21c-Museum-Hotel-Louisville.h1413350.Hotel-Information) ![Louisville Marriott Downtown](//images.trvl-media.com/lodging/2000000/1120000/1111400/1111358/6dbe73d1_y.jpg) ### Louisville Marriott Downtown 10/10 Excellent "Excellent " [](https://expedia.ca/Louisville-Hotels-Louisville-Marriott-Downtown.h1111358.Hotel-Information) ## Frequently asked questions ### Looking to vacation at a spa hotel in West Main Historic District? > Forget the stress of everyday life and book yourself a lush spa hotel. Travelers highly recommend the restaurants and bars in West Main Historic District. Enjoy the live music and riverfront during your vacation. Spa hotels are a great way to take a break from your daily routine and add a layer of luxury to your vacation. ### What is the best spa hotel in West Main Historic District? > [Galt House Hotel Trademark Collection by Wyndham](https://www.expedia.ca/Louisville-Hotels-Galt-House-Hotel-Trademark-Collection-By-Wyndham.h191434.Hotel-Information) is a top spa hotel featuring 4 restaurants, a fitness center, a hair salon, and a bar. Spend an afternoon at the spa where you'll find deep-tissue massages, hot stone massages, and mani/pedis. In-room massages are also available. Other popular spa hotels in West Main Historic District include [Omni Louisville Hotel](https://www.expedia.ca/Louisville-Hotels-Omni-Louisville-Hotel.h21106192.Hotel-Information) and [21c Museum Hotel Louisville](https://www.expedia.ca/Louisville-Hotels-21c-Museum-Hotel-Louisville.h1413350.Hotel-Information). ### How many spa hotels are there in West Main Historic District? > Among Expedia's 239 accommodation options in West Main Historic District, there are 3 spa hotels. ### What's there to see and do in West Main Historic District? > Experience all that West Main Historic District has to offer when you visit Ohio River Valley, Frazier International History Museum, and Louisville Slugger Museum. If you have a bit of extra time while you're in the area, you might want to check out Louisville Science Center and 21c Museum Hotel. ### What is a West Main Historic District spa hotel? > Spa hotels in West Main Historic District feature full on-site spas and offer services like couples massages and a range of beauty treatments. Some also provide a selection of in-room treatments for the ultimate luxury. 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