Title: Book the Best West Main Historic District LUXURY Hotels - Upscale Hotels in West Main Historic District, Louisville | Expedia.ca [Vacation Rentals in Louisville](https://expedia.ca/Louisville-Vacation-Rentals.d603002.Travel-Guide-VacationRentals)[Flights to Louisville](https://expedia.ca/Cheap-Flights-To-Louisville.d603002.Travel-Guide-Flights)[Things to do in Louisville](https://expedia.ca/Things-To-Do-In-Louisville.d603002.Travel-Guide-Activities)[West Main Historic District Car Rentals](https://expedia.ca/Car-Rentals-In-West-Main-Historic-District.d6338837.Car-Rental-Guide)[West Main Historic District Vacations](https://expedia.ca/West-Main-Historic-District.d6338837.Destination-Travel-Guides) ![Kentucky Center for the Performing Arts showing modern architecture](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/297000/297198-Kentucky.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find Luxury Hotels in West Main Historic District, Louisville ![calendar shield illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation ![deals illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) ![bed illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on West Main Historic District Luxury Hotels Tonight [Oct 2 - Oct 3](https://www.expedia.ca/Hotel-Search?regionId=6338837&startDate=2025-10-02&endDate=2025-10-03&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Oct 3 - Oct 4](https://www.expedia.ca/Hotel-Search?regionId=6338837&startDate=2025-10-03&endDate=2025-10-04&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Oct 3 - Oct 5](https://www.expedia.ca/Hotel-Search?regionId=6338837&startDate=2025-10-03&endDate=2025-10-05&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Oct 10 - Oct 12](https://www.expedia.ca/Hotel-Search?regionId=6338837&startDate=2025-10-10&endDate=2025-10-12&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top West Main Historic District Luxury Hotels ![Front of property](https://images.trvl-media.com/lodging/2000000/1420000/1413400/1413350/a9b7038a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room (Asleep in the Cyclone)](https://images.trvl-media.com/lodging/2000000/1420000/1413400/1413350/fdd94051.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/2000000/1420000/1413400/1413350/22b7d23e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fountain](https://images.trvl-media.com/lodging/2000000/1420000/1413400/1413350/864ff441.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### 21c Museum Hotel Louisville Downtown Louisville 9.4/10 Exceptional (1001) "Great stay overall. " CA $237 CA $286 total includes taxes & fees Nov 2 - Nov 3 [](https://www.expedia.ca/Louisville-Hotels-21c-Museum-Hotel-Louisville.h1413350.Hotel-Information) ![4 restaurants, breakfast, lunch, dinner served; American cuisine](https://images.trvl-media.com/lodging/1000000/200000/191500/191434/b5c46c3f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![In-room safe, desk, laptop workspace, iron/ironing board](https://images.trvl-media.com/lodging/1000000/200000/191500/191434/594caae3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property - evening/night](https://images.trvl-media.com/lodging/1000000/200000/191500/191434/23521baa.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![In-room safe, desk, laptop workspace, iron/ironing board](https://images.trvl-media.com/lodging/1000000/200000/191500/191434/9c82234b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Galt House Hotel Trademark Collection by Wyndham Downtown Louisville 9.0/10 Wonderful (3629) "Hotel was nice and had beautiful historic features and such an awesome location. " CA $192 CA $226 total includes taxes & fees Nov 1 - Nov 2 [](https://www.expedia.ca/Louisville-Hotels-Galt-House-Hotel-Trademark-Collection-By-Wyndham.h191434.Hotel-Information) ![Dinner served](https://images.trvl-media.com/lodging/10000000/9030000/9027600/9027531/e02820b0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/10000000/9030000/9027600/9027531/f30004bd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/10000000/9030000/9027600/9027531/5bea9d61.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/10000000/9030000/9027600/9027531/c4d1fb67.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Embassy Suites Louisville Downtown Downtown Louisville 9.0/10 Wonderful (1048) "Nice room and great breakfast!! " CA $193 CA $227 total includes taxes & fees Oct 12 - Oct 13 [](https://www.expedia.ca/Louisville-Hotels-Embassy-Suites-Louisville-Downtown.h9027531.Hotel-Information) ![Standard Room, 2 Double Beds, Non Smoking](https://images.trvl-media.com/lodging/1000000/30000/27100/27037/1942d798.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/30000/27100/27037/33d8568b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast](https://images.trvl-media.com/lodging/1000000/30000/27100/27037/bea3ec0a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Room, 2 Double Beds, Non Smoking](https://images.trvl-media.com/lodging/1000000/30000/27100/27037/c90e9ace.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Econo Lodge Downtown Louisville Downtown Louisville 7.2/10 Good (1004) "Older hotel, but in general seemed to be clean" CA $88 CA $103 total includes taxes & fees Oct 19 - Oct 20 [](https://www.expedia.ca/Louisville-Hotels-Econo-Lodge-Downtown-Louisville.h27037.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/30000/26000/25958/3d017cc5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Meeting facility](https://images.trvl-media.com/lodging/1000000/30000/26000/25958/aa5a75a0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Full breakfast for a fee](https://images.trvl-media.com/lodging/1000000/30000/26000/25958/52012810.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/30000/26000/25958/12e6fe89.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Seelbach Hilton Louisville Downtown Downtown Louisville 8.6/10 Excellent (1001) "Fantastic stay. Loved the room and everything. " CA $218 CA $256 total includes taxes & fees Oct 4 - Oct 5 [](https://www.expedia.ca/Louisville-Hotels-The-Seelbach-Hilton-Louisville.h25958.Hotel-Information) ![Restaurant](https://images.trvl-media.com/lodging/2000000/1120000/1111400/1111358/6dbe73d1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Meeting facility](https://images.trvl-media.com/lodging/2000000/1120000/1111400/1111358/23bf82e1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/2000000/1120000/1111400/1111358/9fbac853.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/2000000/1120000/1111400/1111358/c5a6934a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Louisville Marriott Downtown Downtown Louisville 9.0/10 Wonderful (1000) "Great Hotel. Great restaurant. Great bar. " CA $239 CA $281 total includes taxes & fees Oct 31 - Nov 1 [](https://www.expedia.ca/Louisville-Hotels-Louisville-Marriott-Downtown.h1111358.Hotel-Information) ![Breakfast, lunch and dinner served](https://images.trvl-media.com/lodging/1000000/330000/327000/326983/f8482687.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/330000/327000/326983/e017e8a5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/330000/327000/326983/05585ee8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe Room, 1 King Bed](https://images.trvl-media.com/lodging/1000000/330000/327000/326983/db453fbf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hyatt Regency Louisville Downtown Louisville 8.8/10 Excellent (1002) "Clean room, plenty of restaurants nearby " CA $222 CA $261 total includes taxes & fees Oct 3 - Oct 4 [](https://www.expedia.ca/Louisville-Hotels-Hyatt-Regency-Louisville.h326983.Hotel-Information) ![Outdoor pool](https://images.trvl-media.com/lodging/1000000/10000/4900/4836/f94d4efb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Restaurant](https://images.trvl-media.com/lodging/1000000/10000/4900/4836/aa586c8d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, desk, laptop workspace, free WiFi](https://images.trvl-media.com/lodging/1000000/10000/4900/4836/ec8e5538.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/10000/4900/4836/28d098af.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hampton Inn Louisville Downtown Downtown Louisville 8.4/10 Very good (1001) "Nice stay" CA $119 CA $140 total includes taxes & fees Oct 12 - Oct 13 [](https://www.expedia.ca/Louisville-Hotels-Hampton-Inn-Louisville-Downtown.h4836.Hotel-Information) ![Reception](https://images.trvl-media.com/lodging/2000000/1260000/1253100/1253023/42f82b95.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, stovetop, dishwasher](https://images.trvl-media.com/lodging/2000000/1260000/1253100/1253023/8a9eac81.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, desk, laptop workspace, blackout drapes](https://images.trvl-media.com/lodging/2000000/1260000/1253100/1253023/3a5020f2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/2000000/1260000/1253100/1253023/7b1e6bff.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Residence Inn by Marriott Louisville Downtown Downtown Louisville 8.8/10 Excellent (1000) "Enjoyed our stay " CA $134 CA $157 total includes taxes & fees Nov 2 - Nov 3 [](https://www.expedia.ca/Louisville-Hotels-Residence-Inn-By-Marriott-Louisville-Downtown.h1253023.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2025-10-16&endDate=2025-10-17®ionId=6338837&adults=2&star=50&sort=RECOMMENDED&openPlayBack=true) ## Top West Main Historic District Hotel Reviews ![Galt House Hotel Trademark Collection by Wyndham](//images.trvl-media.com/lodging/1000000/200000/191500/191434/b5c46c3f_y.jpg) ### Galt House Hotel Trademark Collection by Wyndham 10/10 Excellent "Everything about the Galt House is wonderful!!" [](https://expedia.ca/Louisville-Hotels-Galt-House-Hotel-Trademark-Collection-By-Wyndham.h191434.Hotel-Information) ![Embassy Suites Louisville Downtown](//images.trvl-media.com/lodging/10000000/9030000/9027600/9027531/e02820b0_y.jpg) ### Embassy Suites Louisville Downtown 10/10 Excellent "Very clean " [](https://expedia.ca/Louisville-Hotels-Embassy-Suites-Louisville-Downtown.h9027531.Hotel-Information) ![Hyatt Regency Louisville](//images.trvl-media.com/lodging/1000000/330000/327000/326983/f8482687_y.jpg) ### Hyatt Regency Louisville 10/10 Excellent "Within walking distance to many downtown sights. Comfortable rooms. The staff was great. They made us feel welcome." [](https://expedia.ca/Louisville-Hotels-Hyatt-Regency-Louisville.h326983.Hotel-Information) ![Econo Lodge Downtown Louisville](//images.trvl-media.com/lodging/1000000/30000/27100/27037/1942d798_y.jpg) ### Econo Lodge Downtown Louisville 8/10 Good "Older hotel, but in general seemed to be clean" [](https://expedia.ca/Louisville-Hotels-Econo-Lodge-Downtown-Louisville.h27037.Hotel-Information) ![21c Museum Hotel Louisville](//images.trvl-media.com/lodging/2000000/1420000/1413400/1413350/a9b7038a_y.jpg) ### 21c Museum Hotel Louisville 10/10 Excellent "Room was very clean and staff were very friendly. " [](https://expedia.ca/Louisville-Hotels-21c-Museum-Hotel-Louisville.h1413350.Hotel-Information) ![Louisville Marriott Downtown](//images.trvl-media.com/lodging/2000000/1120000/1111400/1111358/6dbe73d1_y.jpg) ### Louisville Marriott Downtown 10/10 Excellent "Great Hotel. Great restaurant. Great bar. " [](https://expedia.ca/Louisville-Hotels-Louisville-Marriott-Downtown.h1111358.Hotel-Information) ![Hampton Inn Louisville Downtown](//images.trvl-media.com/lodging/1000000/10000/4900/4836/f94d4efb_y.jpg) ### Hampton Inn Louisville Downtown 10/10 Excellent "Usual quality for a Hampton Inn. " [](https://expedia.ca/Louisville-Hotels-Hampton-Inn-Louisville-Downtown.h4836.Hotel-Information) ## Frequently asked questions ### Are you looking for a luxury hotel for your stay in West Main Historic District? > During your visit, you might want to enjoy the art and theater which West Main Historic District is known for. ### What's the best luxury accommodation in West Main Historic District? > [21c Museum Hotel Louisville](https://www.expedia.ca/Louisville-Hotels-21c-Museum-Hotel-Louisville.h1413350.Hotel-Information) is a luxury hotel with a full-service spa and in-room massages, and it's a popular choice for Expedia travelers looking for an elegant place to stay. ### What's there to see and do in West Main Historic District? > Take in the sights and attractions that West Main Historic District offers with a visit to Frazier International History Museum, Louisville Slugger Museum, and Louisville Science Center. 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