Title: Book the Best BUSINESS Hotels in West Main Historic District in 2025 | Expedia.ca [Vacation Rentals in Louisville](https://expedia.ca/Louisville-Vacation-Rentals.d603002.Travel-Guide-VacationRentals)[Flights to Louisville](https://expedia.ca/Cheap-Flights-To-Louisville.d603002.Travel-Guide-Flights)[Things to do in Louisville](https://expedia.ca/Things-To-Do-In-Louisville.d603002.Travel-Guide-Activities)[West Main Historic District Car Rentals](https://expedia.ca/Car-Rentals-In-West-Main-Historic-District.d6338837.Car-Rental-Guide)[West Main Historic District Vacations](https://expedia.ca/West-Main-Historic-District.d6338837.Destination-Travel-Guides) ![Kentucky Center for the Performing Arts showing modern architecture](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/297000/297198-Kentucky.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find Business Hotels in West Main Historic District, KY from CA $139 ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on West Main Historic District Business Hotels Tonight [Oct 18 - Oct 19](https://www.expedia.ca/Hotel-Search?regionId=6338837&startDate=2025-10-18&endDate=2025-10-19&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) Tomorrow [Oct 19 - Oct 20](https://www.expedia.ca/Hotel-Search?regionId=6338837&startDate=2025-10-19&endDate=2025-10-20&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) Next weekend [Oct 24 - Oct 26](https://www.expedia.ca/Hotel-Search?regionId=6338837&startDate=2025-10-24&endDate=2025-10-26&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) In two weeks [Oct 31 - Nov 2](https://www.expedia.ca/Hotel-Search?regionId=6338837&startDate=2025-10-31&endDate=2025-11-02&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) ## Top West Main Historic District Business Hotels ![4 restaurants, breakfast, lunch, dinner served; American cuisine](https://images.trvl-media.com/lodging/1000000/200000/191500/191434/b5c46c3f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![4 restaurants, breakfast, lunch, dinner served; American cuisine](https://images.trvl-media.com/lodging/1000000/200000/191500/191434/ab0af7cb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![In-room safe, desk, laptop workspace, iron/ironing board](https://images.trvl-media.com/lodging/1000000/200000/191500/191434/9c82234b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![In-room safe, desk, laptop workspace, iron/ironing board](https://images.trvl-media.com/lodging/1000000/200000/191500/191434/594caae3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Galt House Hotel Trademark Collection by Wyndham Downtown Louisville 9.0/10 Wonderful (3705) "Great place to stay " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Tia CA $192 CA $226 total includes taxes & fees Nov 1 - Nov 2 [](https://www.expedia.ca/Louisville-Hotels-Galt-House-Hotel-Trademark-Collection-By-Wyndham.h191434.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/13000000/12560000/12552800/12552757/380612f2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/13000000/12560000/12552800/12552757/84bc2f36.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/13000000/12560000/12552800/12552757/7a04a28c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/13000000/12560000/12552800/12552757/bf3651e9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Express & Suites Louisville Downtown by IHG Downtown Louisville 8.8/10 Excellent (1595) "Super nice hotel, great breakfast, good location to downtown " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Laura CA $130 CA $153 total includes taxes & fees Oct 19 - Oct 20 [](https://www.expedia.ca/Louisville-Hotels-Holiday-Inn-Express-Suites-Louisville-Downtown.h12552757.Hotel-Information) ![Dining](https://images.trvl-media.com/lodging/58000000/57960000/57959300/57959281/5084ffc5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, desk, laptop workspace, iron/ironing board](https://images.trvl-media.com/lodging/58000000/57960000/57959300/57959281/24c25575.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/58000000/57960000/57959300/57959281/735a9908.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Dining](https://images.trvl-media.com/lodging/58000000/57960000/57959300/57959281/1296a89e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Cambria Hotel Louisville Downtown-Whiskey Row Downtown Louisville 9.4/10 Exceptional (1023) "Great stay " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Chic CA $130 CA $153 total includes taxes & fees Oct 31 - Nov 1 [](https://www.expedia.ca/Louisville-Hotels-CAMBRiA-Hotel-Louisville-Downtown-Whiskey-Row.h57959281.Hotel-Information) ![Bar (on property)](https://images.trvl-media.com/lodging/37000000/36890000/36884900/36884898/050ebd40.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby lounge](https://images.trvl-media.com/lodging/37000000/36890000/36884900/36884898/4979ca88.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/37000000/36890000/36884900/36884898/0f8921c0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Meeting facility](https://images.trvl-media.com/lodging/37000000/36890000/36884900/36884898/f3e2f52d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Moxy Louisville Downtown Downtown Louisville 9.2/10 Wonderful (679) "Great staff, location, and atmosphere. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Haley CA $168 CA $198 total includes taxes & fees Oct 31 - Nov 1 [](https://www.expedia.ca/Louisville-Hotels-Moxy-Louisville-Downtown.h36884898.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/60000/51100/51059/49a58bab.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![View from property](https://images.trvl-media.com/lodging/1000000/60000/51100/51059/b4148500.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/60000/51100/51059/64b9aba8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/1000000/60000/51100/51059/7aaa96f1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Fairfield Inn & Suites by Marriott Louisville Downtown Downtown Louisville 8.2/10 Very good (1013) "Great hotel " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Denzel CA $118 CA $139 total includes taxes & fees Nov 16 - Nov 17 [](https://www.expedia.ca/Louisville-Hotels-Fairfield-Inn-Suites-By-Marriott-Louisville-Downtown.h51059.Hotel-Information) ![Restaurant](https://images.trvl-media.com/lodging/2000000/1120000/1111400/1111358/6dbe73d1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Meeting facility](https://images.trvl-media.com/lodging/2000000/1120000/1111400/1111358/e1a9281b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/2000000/1120000/1111400/1111358/9fbac853.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/2000000/1120000/1111400/1111358/c5a6934a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Louisville Marriott Downtown Downtown Louisville 9.0/10 Wonderful (1001) "Great Hotel. Great restaurant. Great bar. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) DON CA $240 CA $282 total includes taxes & fees Oct 31 - Nov 1 [](https://www.expedia.ca/Louisville-Hotels-Louisville-Marriott-Downtown.h1111358.Hotel-Information) ![Breakfast, lunch and dinner served](https://images.trvl-media.com/lodging/1000000/330000/327000/326983/f8482687.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/330000/327000/326983/0e69db21.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/330000/327000/326983/e017e8a5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/330000/327000/326983/05585ee8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hyatt Regency Louisville Downtown Louisville 8.8/10 Excellent (1016) "We loved our stay here!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Torre CA $206 CA $243 total includes taxes & fees Nov 16 - Nov 17 [](https://www.expedia.ca/Louisville-Hotels-Hyatt-Regency-Louisville.h326983.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/65000000/64700000/64696100/64696084/8f8322e9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/65000000/64700000/64696100/64696084/w4000h2662x0y0-c69fbcac.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Full-size fridge, microwave, dishwasher, toaster](https://images.trvl-media.com/lodging/65000000/64700000/64696100/64696084/995f4afb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, down comforters, desk, blackout drapes](https://images.trvl-media.com/lodging/65000000/64700000/64696100/64696084/5d16fd3c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Towneplace Suites By Marriott Louisville Downtown Downtown Louisville 9.2/10 Wonderful (482) "Great location" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Lauren CA $136 CA $160 total includes taxes & fees Nov 2 - Nov 3 [](https://www.expedia.ca/Louisville-Hotels-Towneplace-Suites-By-Marriott-Louisville-Downtown.h64696084.Hotel-Information) ![View from room](https://images.trvl-media.com/lodging/12000000/11680000/11673200/11673133/21a274da.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/12000000/11680000/11673200/11673133/fe2338c2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/12000000/11680000/11673200/11673133/97cd53e8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Bar (on property)](https://images.trvl-media.com/lodging/12000000/11680000/11673200/11673133/d9d00b0f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Aloft Louisville Downtown Downtown Louisville 9.0/10 Wonderful (1002) "We had a great stay!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Kevin CA $162 CA $190 total includes taxes & fees Nov 2 - Nov 3 [](https://www.expedia.ca/Louisville-Hotels-Aloft-Louisville-Downtown.h11673133.Hotel-Information) ![Front of property](https://images.trvl-media.com/lodging/2000000/1420000/1413400/1413350/a9b7038a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Bar (on property)](https://images.trvl-media.com/lodging/2000000/1420000/1413400/1413350/cef338e9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/2000000/1420000/1413400/1413350/22b7d23e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room (Asleep in the Cyclone)](https://images.trvl-media.com/lodging/2000000/1420000/1413400/1413350/fdd94051.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### 21c Museum Hotel Louisville Downtown Louisville 9.2/10 Wonderful (1005) "Great stay overall. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jeannette CA $226 CA $273 total includes taxes & fees Oct 26 - Oct 27 [](https://www.expedia.ca/Louisville-Hotels-21c-Museum-Hotel-Louisville.h1413350.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2025-11-01&endDate=2025-11-02®ionId=6338837&adults=2&travelerType=business_friendly&sort=RECOMMENDED&openPlayBack=true) ## Top West Main Historic District Hotel Reviews ![Louisville Marriott Downtown](//images.trvl-media.com/lodging/2000000/1120000/1111400/1111358/6dbe73d1_y.jpg) ### Louisville Marriott Downtown 10/10 Excellent "Very nice" [](https://expedia.ca/Louisville-Hotels-Louisville-Marriott-Downtown.h1111358.Hotel-Information) ![Galt House Hotel Trademark Collection by Wyndham](//images.trvl-media.com/lodging/1000000/200000/191500/191434/b5c46c3f_y.jpg) ### Galt House Hotel Trademark Collection by Wyndham 10/10 Excellent "Room and service was amazing. Easy to get to and plenty to do in the area. Will definitely be our go to hotel when we travel to Louisville for here on out. " [](https://expedia.ca/Louisville-Hotels-Galt-House-Hotel-Trademark-Collection-By-Wyndham.h191434.Hotel-Information) ![SpringHill Suites by Marriott Louisville Downtown](//images.trvl-media.com/lodging/2000000/1820000/1818500/1818408/2278ecb5_y.jpg) ### SpringHill Suites by Marriott Louisville Downtown 10/10 Excellent "Great!!" [](https://expedia.ca/Louisville-Hotels-SpringHill-Suites-By-Marriott-Louisville-Downtown.h1818408.Hotel-Information) ![Embassy Suites Louisville Downtown](//images.trvl-media.com/lodging/10000000/9030000/9027600/9027531/e02820b0_y.jpg) ### Embassy Suites Louisville Downtown 10/10 Excellent "Had a great check in and loved my amenity package after a long day of travel. Valet line was long but went quickly. Only downside is that it was after dark and we had someone lean into our car window while we were in line, asking for money. But we understand the hotel is downtown. Love the common sitting area outside our room (shared with three others " [](https://expedia.ca/Louisville-Hotels-Embassy-Suites-Louisville-Downtown.h9027531.Hotel-Information) ![Hilton Garden Inn Louisville Downtown](//images.trvl-media.com/lodging/10000000/9220000/9215400/9215348/d064e9c8_y.jpg) ### Hilton Garden Inn Louisville Downtown 10/10 Excellent "Very nice!" [](https://expedia.ca/Louisville-Hotels-Hilton-Garden-Inn-Louisville-Downtown.h9215348.Hotel-Information) ![Holiday Inn Express & Suites Louisville Downtown by IHG](//images.trvl-media.com/lodging/13000000/12560000/12552800/12552757/380612f2_y.jpg) ### Holiday Inn Express & Suites Louisville Downtown by IHG 10/10 Excellent "Great stay" [](https://expedia.ca/Louisville-Hotels-Holiday-Inn-Express-Suites-Louisville-Downtown.h12552757.Hotel-Information) ![Hampton Inn Louisville Downtown](//images.trvl-media.com/lodging/1000000/10000/4900/4836/f94d4efb_y.jpg) ### Hampton Inn Louisville Downtown 10/10 Excellent "Also Located 2 blocks from the UofL Downtown Hospital , Frazier Rehab Institute and childrens hospital are stay could not have been better. The staff could not have been more helpful and gracious. Thank you." [](https://expedia.ca/Louisville-Hotels-Hampton-Inn-Louisville-Downtown.h4836.Hotel-Information) ![Hyatt Regency Louisville](//images.trvl-media.com/lodging/1000000/330000/327000/326983/f8482687_y.jpg) ### Hyatt Regency Louisville 10/10 Excellent "Great location " [](https://expedia.ca/Louisville-Hotels-Hyatt-Regency-Louisville.h326983.Hotel-Information) ![21c Museum Hotel Louisville](//images.trvl-media.com/lodging/2000000/1420000/1413400/1413350/a9b7038a_y.jpg) ### 21c Museum Hotel Louisville 10/10 Excellent "We only stayed 1 night, but everything was excellent " [](https://expedia.ca/Louisville-Hotels-21c-Museum-Hotel-Louisville.h1413350.Hotel-Information) ## Frequently asked questions ### Why book your business-friendly hotel in West Main Historic District with Expedia? > With handy amenities like meeting rooms, housekeeping and on-site restaurants, our business-friendly hotels come with everything you'll need to settle your important deal — and then relax! Enter your preferred travel dates and destination and we'll help you plan everything else. ### How can I find cheap business-friendly hotels in West Main Historic District? > Click on the "business friendly" filter, located just under the "traveller experience" heading, to find cheap business-friendly hotels in West Main Historic District. Then narrow your search by your per-night budget. 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