Title: Book the Best BOUTIQUE Hotels in West Main Historic District in 2026 | Expedia.ca [Vacation Rentals in Louisville](https://expedia.ca/Louisville-Vacation-Rentals.d603002.Travel-Guide-VacationRentals)[Flights to Louisville](https://expedia.ca/Cheap-Flights-To-Louisville.d603002.Travel-Guide-Flights)[Things to do in Louisville](https://expedia.ca/Things-To-Do-In-Louisville.d603002.Travel-Guide-Activities)[West Main Historic District Car Rentals](https://expedia.ca/Car-Rentals-In-West-Main-Historic-District.d6338837.Car-Rental-Guide)[West Main Historic District Vacations](https://expedia.ca/West-Main-Historic-District.d6338837.Destination-Travel-Guides) ![Louisville Science Center showing signage](https://images.trvl-media.com/place/6062647/da3ea6c6-ce78-45c0-8a8d-660434d5aefb.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://images.trvl-media.com/place/6062647/da3ea6c6-ce78-45c0-8a8d-660434d5aefb.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on West Main Historic District Boutique Hotels Tonight [Feb 5 - Feb 6](https://www.expedia.ca/Hotel-Search?regionId=6338837&startDate=2026-02-05&endDate=2026-02-06&adults=2&propertyStyle=BOUTIQUE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Feb 6 - Feb 7](https://www.expedia.ca/Hotel-Search?regionId=6338837&startDate=2026-02-06&endDate=2026-02-07&adults=2&propertyStyle=BOUTIQUE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Feb 6 - Feb 8](https://www.expedia.ca/Hotel-Search?regionId=6338837&startDate=2026-02-06&endDate=2026-02-08&adults=2&propertyStyle=BOUTIQUE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Feb 13 - Feb 15](https://www.expedia.ca/Hotel-Search?regionId=6338837&startDate=2026-02-13&endDate=2026-02-15&adults=2&propertyStyle=BOUTIQUE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Our top choices for West Main Historic District boutique hotels ![Room (Asleep in the Cyclone)](https://images.trvl-media.com/lodging/2000000/1420000/1413400/1413350/fdd94051.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room (Asleep in the Cyclone)](https://images.trvl-media.com/lodging/2000000/1420000/1413400/1413350/aaadeb96.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fountain](https://images.trvl-media.com/lodging/2000000/1420000/1413400/1413350/864ff441.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Breakfast, lunch and dinner served](https://images.trvl-media.com/lodging/2000000/1420000/1413400/1413350/06213b95.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### 21c Museum Hotel Louisville [](https://www.expedia.ca/Louisville-Hotels-21c-Museum-Hotel-Louisville.h1413350.Hotel-Information) Downtown Louisville 9.4/10 Exceptional (1,001 reviews) "Location and the staff was fabulous." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Madeline CA $245 CA $295 total includes taxes & fees Feb 8 - Feb 9 [](https://www.expedia.ca/Louisville-Hotels-21c-Museum-Hotel-Louisville.h1413350.Hotel-Information) ![Interior](https://images.trvl-media.com/lodging/1000000/10000/9900/9861/764d3439.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/1000000/10000/9900/9861/f0221042.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Bar (on property)](https://images.trvl-media.com/lodging/1000000/10000/9900/9861/4fd8456f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/10000/9900/9861/3c2671ae.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Brown Hotel [](https://www.expedia.ca/Louisville-Hotels-The-Brown-Hotel.h9861.Hotel-Information) Downtown Louisville 9.4/10 Exceptional (1,180 reviews) "Very beautiful facility and great location " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Anthony CA $220 CA $259 total includes taxes & fees Feb 8 - Feb 9 [](https://www.expedia.ca/Louisville-Hotels-The-Brown-Hotel.h9861.Hotel-Information) ![Interior entrance](https://images.trvl-media.com/lodging/10000000/9680000/9678400/9678336/a276c9db.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily full breakfast](https://images.trvl-media.com/lodging/10000000/9680000/9678400/9678336/46279487.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/10000000/9680000/9678400/9678336/9d6b5686.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/10000000/9680000/9678400/9678336/d64d36b5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Market Street Inn [](https://www.expedia.ca/Louisville-Hotels-Market-Street-Inn.h9678336.Hotel-Information) Jeffersonville 9.8/10 Exceptional (120 reviews) "Warm greeting by Carol who shared all the information and details about the property. SUPER charming and convenient location. Highly recommend." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Kelly CA $253 CA $286 total includes taxes & fees Feb 8 - Feb 9 [](https://www.expedia.ca/Louisville-Hotels-Market-Street-Inn.h9678336.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2026-02-20&endDate=2026-02-21®ionId=6338837&adults=2&specialized_stays_group_explore=boutique_property&sort=RECOMMENDED&openPlayBack=true) ## Top West Main Historic District Hotel Reviews ![Embassy Suites Louisville Downtown](https://images.trvl-media.com/lodging/10000000/9030000/9027600/9027531/e02820b0_y.jpg) ### Embassy Suites Louisville Downtown 10/10 Excellent "staff was amazing!" [](https://expedia.ca/Louisville-Hotels-Embassy-Suites-Louisville-Downtown.h9027531.Hotel-Information) ![21c Museum Hotel Louisville](https://images.trvl-media.com/lodging/2000000/1420000/1413400/1413350/a9b7038a_y.jpg) ### 21c Museum Hotel Louisville 10/10 Excellent "Really interesting setting for a hotel with all of the artwork. The room was clean and comfortable. We would have appreciated softer towels." [](https://expedia.ca/Louisville-Hotels-21c-Museum-Hotel-Louisville.h1413350.Hotel-Information) ![Galt House Hotel Trademark Collection by Wyndham](https://images.trvl-media.com/lodging/1000000/200000/191500/191434/b5c46c3f_y.jpg) ### Galt House Hotel Trademark Collection by Wyndham 10/10 Excellent "plenty of room in suite, bath room, good lighting and seating. Nice to have multiple restaurants on site. Would stay again " [](https://expedia.ca/Louisville-Hotels-Galt-House-Hotel-Trademark-Collection-By-Wyndham.h191434.Hotel-Information) ## Frequently asked questions ### What's the best boutique-style hotel in West Main Historic District? ### What's there to see and do in West Main Historic District? ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - Vacation Rental - Other - More ways to book - [Hotels near 21c Museum Hotel ](https://www.expedia.ca/21c-Museum-Hotel-Hotels.0-l553248621559724956-0.Travel-Guide-Filter-Hotels) - [4 Star Hotels in Louisville ](https://www.expedia.ca/4Star-Louisville-Hotels.s40-0-d603002.Travel-Guide-Filter-Hotels) - [5 Star Hotels in Louisville ](https://www.expedia.ca/5Star-Louisville-Hotels.s50-0-d603002.Travel-Guide-Filter-Hotels) - [Hotels near Belle of Louisville ](https://www.expedia.ca/Belle-Of-Louisville-Hotels.0-l6062661-0.Travel-Guide-Filter-Hotels) - [Hotels near Big Four Bridge ](https://www.expedia.ca/Big-Four-Bridge-Hotels.0-l553248621559724954-0.Travel-Guide-Filter-Hotels) - 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