Title: Book the Best Vine SPA Resorts from CA $156 - Spa Hotels in Vine, Kalamazoo | Expedia.ca [Vacation Rentals in Kalamazoo](https://expedia.ca/Kalamazoo-Vacation-Rentals.d486.Travel-Guide-VacationRentals)[Flights to Kalamazoo](https://expedia.ca/Cheap-Flights-To-Kalamazoo.d486.Travel-Guide-Flights)[Things to do in Kalamazoo](https://expedia.ca/Things-To-Do-In-Kalamazoo.d486.Travel-Guide-Activities)[Vine Car Rentals](https://expedia.ca/Car-Rentals-In-Vine.d553248635976469494.Car-Rental-Guide)[Vine Vacations](https://expedia.ca/Vine.d553248635976469494.Destination-Travel-Guides) ![Aerial View of Kalamazoo Park Bridge and Ducks in Motion](https://images.trvl-media.com/place/553248635976469494/ab506df7-568f-47fd-88fd-62d812c079e1.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find Spa Hotels in Vine, Kalamazoo from CA $156 - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Vine Spa Hotels Tonight [Dec 15 - Dec 16](https://www.expedia.ca/Hotel-Search?regionId=553248635976469494&startDate=2025-12-15&endDate=2025-12-16&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Dec 16 - Dec 17](https://www.expedia.ca/Hotel-Search?regionId=553248635976469494&startDate=2025-12-16&endDate=2025-12-17&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Dec 19 - Dec 21](https://www.expedia.ca/Hotel-Search?regionId=553248635976469494&startDate=2025-12-19&endDate=2025-12-21&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Dec 26 - Dec 28](https://www.expedia.ca/Hotel-Search?regionId=553248635976469494&startDate=2025-12-26&endDate=2025-12-28&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Our top choices for Vine hotels with a spa ![Deluxe Room, Garden View](https://images.trvl-media.com/lodging/113000000/112310000/112309100/112309022/1e4a6b37.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/113000000/112310000/112309100/112309022/1f2594c5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe Room, Garden View | Living area](https://images.trvl-media.com/lodging/113000000/112310000/112309100/112309022/4d41881e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Hallway](https://images.trvl-media.com/lodging/113000000/112310000/112309100/112309022/15c7993b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Upjohn House Inn [](https://www.expedia.ca/Kalamazoo-Hotels-Upjohn-House-Inn.h112309022.Hotel-Information) Kalamazoo Central Business District 7.2/10 Good (22) "Gorgeous house, great staff, loved the unique rooms" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Andrea CA $140 CA $156 total includes taxes & fees Dec 26 - Dec 27 [](https://www.expedia.ca/Kalamazoo-Hotels-Upjohn-House-Inn.h112309022.Hotel-Information) ![Couples treatment rooms, steam room, body treatments, aromatherapy](https://images.trvl-media.com/lodging/1000000/10000/2300/2221/c9faa5a4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/1000000/10000/2300/2221/3f4d4568.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/10000/2300/2221/cf615ef4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![3 restaurants, breakfast, lunch, dinner served; American cuisine](https://images.trvl-media.com/lodging/1000000/10000/2300/2221/b1ba97e6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Radisson Plaza Hotel at Kalamazoo Center [](https://www.expedia.ca/Kalamazoo-Hotels-Radisson-Plaza-Hotel-At-Kalamazoo-Center.h2221.Hotel-Information) Kalamazoo Central Business District 9.0/10 Wonderful (1002) "Great location and restaurant options! " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Brooke CA $289 CA $333 total includes taxes & fees Dec 21 - Dec 22 [](https://www.expedia.ca/Kalamazoo-Hotels-Radisson-Plaza-Hotel-At-Kalamazoo-Center.h2221.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2025-12-29&endDate=2025-12-30®ionId=553248635976469494&adults=2&amenities=SPA_ON_SITE&sort=RECOMMENDED&openPlayBack=true) ## Find out more about Vine ### Top Vine attractions for a relaxing vacation In the Vine neighbourhood, travellers seeking a rejuvenating spa experience will find a range of luxury hotels that blend comfort with unique local charm. Begin your stay with a visit to the stunning Vine Street Park, where serene walking paths and lush greenery provide the perfect backdrop for relaxation or a leisurely picnic. Just a stone's throw away, indulge in a therapeutic session at the renowned Vine Spa, offering an array of treatments that utilise local ingredients to refresh both body and mind. For a taste of local culture, the nearby Wine & Art Festival showcases the best of regional wines and artistic talent, allowing you to sip and savour while exploring the vibrant community. After a day of exploration, unwind at the hotel’s exclusive rooftop pool, where panoramic views of the city and sunset cocktails create an unforgettable evening. Each hotel in Vine prides itself on exceptional service, ensuring that after your daily adventures, you return to luxurious rooms equipped with modern amenities and tranquil spa facilities, making every moment of your stay feel indulgent. ## Top Vine Hotel Reviews ![Radisson Plaza Hotel at Kalamazoo Center](https://images.trvl-media.com/lodging/1000000/10000/2300/2221/b1ba97e6_y.jpg) ### Radisson Plaza Hotel at Kalamazoo Center 10/10 Excellent "A few more pillows in the room and an extra blanket or 2 " [](https://expedia.ca/Kalamazoo-Hotels-Radisson-Plaza-Hotel-At-Kalamazoo-Center.h2221.Hotel-Information) ![Courtyard Kalamazoo Portage](https://images.trvl-media.com/lodging/7000000/6450000/6447900/6447847/3274f64e_y.jpg) ### Courtyard Kalamazoo Portage 10/10 Excellent "Greeted with a smile and easy to find. Great location for restaurants, shopping, and entertainment. " [](https://expedia.ca/Kalamazoo-Hotels-Courtyard-Kalamazoo-Portage.h6447847.Hotel-Information) ![Comfort Inn Wings Stadium](https://images.trvl-media.com/lodging/1000000/20000/10500/10470/175936aa_y.jpg) ### Comfort Inn Wings Stadium 10/10 Excellent "The room was spotless and the front desk personnel were so kind and helpful. Breakfast was what you would normally get at a hotel, it was hot and fresh so all was good!" [](https://expedia.ca/Kalamazoo-Hotels-Comfort-Inn-Wings-Stadium.h10470.Hotel-Information) ![Best Western Plus Kalamazoo Suites](https://images.trvl-media.com/lodging/1000000/550000/543800/543732/dcb5315d_y.jpg) ### Best Western Plus Kalamazoo Suites 10/10 Excellent "everything ok" [](https://expedia.ca/Kalamazoo-Hotels-Best-Western-Plus-Kalamazoo-Suites.h543732.Hotel-Information) ## Frequently asked questions ### Looking to vacation at a spa hotel in Vine? ### What's there to see and do in Vine? ### What is a Vine spa hotel? ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - Other - More ways to book - [Hotels with a Lazy River in Ann Arbor ](https://www.expedia.ca/Ann-Arbor-Hotels-Hotels-With-A-Lazy-River.0-0-d6059241-tHotelswithaLazyRiver.Travel-Guide-Filter-Hotels) - [Hotels with Childcare in Ann Arbor ](https://www.expedia.ca/Ann-Arbor-Hotels-Hotels-With-Childcare.0-0-d6059241-tHotelswithChildcare.Travel-Guide-Filter-Hotels) - [Hotels with Free Parking in Ann Arbor ](https://www.expedia.ca/Ann-Arbor-Hotels-Hotels-With-Free-Parking.0-0-d6059241-tHotelswithFreeParking.Travel-Guide-Filter-Hotels) - [Hotels with smoking rooms in Ann Arbor ](https://www.expedia.ca/Ann-Arbor-Hotels-Hotels-With-Smoking-Rooms.0-0-d6059241-tHotelswithsmokingrooms.Travel-Guide-Filter-Hotels) - [Ski Hotels in Ann Arbor ](https://www.expedia.ca/Ann-Arbor-Hotels-Ski-Hotel.0-0-d6059241-tSkiHotel.Travel-Guide-Filter-Hotels) - [Kalamazoo County Hotels ](https://www.expedia.ca/Destinations-In-Kalamazoo-County.d553248635976430400.Hotel-Destinations) - [Apartments in Eastwood ](https://www.expedia.ca/Eastwood-Apartments.d553248634983561236-aaApartments.Travel-Guide-Accommodation) - [Motels in Eastwood ](https://www.expedia.ca/Eastwood-Motels.d553248634983561236-aaMotels.Travel-Guide-Accommodation) - [Honeymoon Resorts and in Grand Rapids ](https://www.expedia.ca/Grand-Rapids-Hotels-Honeymoon-Hotels.0-0-d603005-tHoneymoonHotels.Travel-Guide-Filter-Hotels) - [Hotels with Bar in Grand Rapids ](https://www.expedia.ca/Grand-Rapids-Hotels-Hotels-With-Bar.0-0-d603005-tHotelswithBar.Travel-Guide-Filter-Hotels) - [Mountain Hotels in Grand Rapids ](https://www.expedia.ca/Grand-Rapids-Hotels-Mountain-Hotels.0-0-d603005-tMountainHotels.Travel-Guide-Filter-Hotels) - [Hotel Wedding Venues Hotels in Grand Rapids ](https://www.expedia.ca/Grand-Rapids-Hotels-Wedding-Hotels.0-0-d603005-tWeddingHotels.Travel-Guide-Filter-Hotels) - [Hotels near James W. 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