Title: Hotels by Independent in Uptown - Upper Duval | Expedia.ca [Uptown - Upper Duval Travel Guide](https://expedia.ca/Key-West-Uptown-Upper-Duval.dx553248635976473524)[Flights to Key West](https://expedia.ca/Cheap-Flights-To-Key-West.d1187.Travel-Guide-Flights)[Things to do in Key West](https://expedia.ca/Things-To-Do-In-Key-West.d1187.Travel-Guide-Activities)[Uptown - Upper Duval Car Rentals](https://expedia.ca/Car-Rentals-In-Uptown-Upper-Duval.d553248635976473524.Car-Rental-Guide)[Uptown - Upper Duval Vacations](https://expedia.ca/Uptown-Upper-Duval.d553248635976473524.Destination-Travel-Guides) ![Get here early. Crazy aggressive people in line to take their picture #lifeatexpedia ](https://images.trvl-media.com/place/1187/5d488261-cf7f-43ce-a448-690eeb186cd2.jpg?impolicy=fcrop&w=1200&h=500&q=medium) Photo by Monica Ferro ![](https://images.trvl-media.com/place/1187/5d488261-cf7f-43ce-a448-690eeb186cd2.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check prices for these dates Tonight [Jan 21 - Jan 22](https://www.expedia.ca/Hotel-Search?regionId=553248635976473524&startDate=2026-01-21&endDate=2026-01-22&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Jan 22 - Jan 23](https://www.expedia.ca/Hotel-Search?regionId=553248635976473524&startDate=2026-01-22&endDate=2026-01-23&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Jan 23 - Jan 25](https://www.expedia.ca/Hotel-Search?regionId=553248635976473524&startDate=2026-01-23&endDate=2026-01-25&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Jan 30 - Feb 1](https://www.expedia.ca/Hotel-Search?regionId=553248635976473524&startDate=2026-01-30&endDate=2026-02-01&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in ](https://expedia.ca/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FUptown-Upper-Duval-Key-West-Hotels-Independent.0-n553248635976473524-0--bIndependent.Travel-Guide-Filter-Hotels)[ Sign up, it's free ](https://expedia.ca/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FUptown-Upper-Duval-Key-West-Hotels-Independent.0-n553248635976473524-0--bIndependent.Travel-Guide-Filter-Hotels) ## Top Uptown - Upper Duval Hotel Reviews ![Southernmost Beach Resort and Guesthouses](https://images.trvl-media.com/lodging/1000000/870000/863400/863329/026f10af_y.jpg) ### Southernmost Beach Resort and Guesthouses 10/10 Excellent "The right location at the right price. They sent texts to update you on activities on-site." [](https://expedia.ca/Key-West-Hotels-Southernmost-Beach-Resort.h863329.Hotel-Information) ![The Reach Key West, Curio Collection by Hilton](https://images.trvl-media.com/lodging/1000000/460000/457900/457821/888fac6b_y.jpg) ### The Reach Key West, Curio Collection by Hilton 10/10 Excellent "The room was very clean, well appointed and very comfortable" [](https://expedia.ca/Key-West-Hotels-The-Reach-Key-West.h457821.Hotel-Information) ![Southernmost House](https://images.trvl-media.com/lodging/4000000/3840000/3830600/3830519/9dea706f_y.jpg) ### Southernmost House 10/10 Excellent "Fun place, great location, great staff. " [](https://expedia.ca/Key-West-Hotels-The-Southernmost-House-Hotel.h3830519.Hotel-Information) ![Margaritaville Beach House Key West](https://images.trvl-media.com/lodging/49000000/48720000/48713900/48713884/32e70782_y.jpg) ### Margaritaville Beach House Key West 10/10 Excellent "Room was clean, staff was very friendly, bartenders were outstanding and Johnny, our shuttle driver was awesome. " [](https://expedia.ca/Key-West-Hotels-Margaritaville-Beach-House-Key-West.h48713884.Hotel-Information) ![Oceans Edge Key West Resort, Hotel & Marina](https://images.trvl-media.com/lodging/17000000/16210000/16203000/16202992/f7424907_y.jpg) ### Oceans Edge Key West Resort, Hotel & Marina 10/10 Excellent "The entire resort was absolutely beautiful. It was also very welcoming. Not just in appearance but the staff were all so friendly and wonderful to work with!" [](https://expedia.ca/Key-West-Hotels-Oceans-Edge-Key-West-Resort.h16202992.Hotel-Information) ![Parrot Key Hotel & Villas](https://images.trvl-media.com/lodging/1000000/30000/24700/24615/67735d0c_y.jpg) ### Parrot Key Hotel & Villas 10/10 Excellent "Very nice atmosphere beautiful plants and setup." [](https://expedia.ca/Key-West-Hotels-Parrot-Key-Hotel-Villas.h24615.Hotel-Information) ![Beachside Resort & Residences](https://images.trvl-media.com/lodging/1000000/30000/25900/25865/290b242a_y.jpg) ### Beachside Resort & Residences 10/10 Excellent "Was fantastic " [](https://expedia.ca/Key-West-Hotels-Key-West-Marriott-Beachside-Hotel.h25865.Hotel-Information) ![Hyatt Vacation Club at Beach House, Key West](https://images.trvl-media.com/lodging/1000000/860000/858000/857962/fc0a2a7e_y.jpg) ### Hyatt Vacation Club at Beach House, Key West 10/10 Excellent "Loved the Hyatt Beach House in Key West. The associate who checked us in was very helpful. We got a room with an amazing view of the sea. The unit very clean and comfortable. Loved the well-maintained premises and it was a pleasure walking around in the early morning and evenings enjoying nature and the peaceful ambience. Would love to go back and stay there again. " [](https://expedia.ca/Key-West-Hotels-Hyatt-Vacation-Club-At-Beach-House.h857962.Hotel-Information) ![The Southernmost Inn - Adults Only](https://images.trvl-media.com/lodging/5000000/4290000/4280800/4280752/2b7e8bad_y.jpg) ### The Southernmost Inn - Adults Only 10/10 Excellent "all good here" [](https://expedia.ca/Key-West-Hotels-The-Southernmost-Inn-Adults-Only.h4280752.Hotel-Information) ## Find out more about Uptown - Upper Duval ## Uptown - Upper Duval Hotels Guide Expedia.ca offers a selection of 2828 hotels in Uptown - Upper Duval. You are sure to find cheap deals and discount rates among them with our Best Price Guarantee. No matter what type of hotel strikes your fancy, we will let you search for your preferred one to accommodate your travel needs. Expedia.ca will not only save you time, but also money when booking your stay at a hotel in Uptown - Upper Duval. Making reservations so you can stay within your budget is easy with us. Expedia.ca even provides you with a map so you may find hotels in the Uptown - Upper Duval neighborhood you prefer. Go ahead. Enter your travel dates to view the best offers on hotel rooms in Uptown - Upper Duval, Key West now! ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Other - More ways to book - [Hilton Hotels in Big Pine Key ](https://www.expedia.ca/Big-Pine-Key-Hotels-Hilton-Hotels.0-0-d7195--bHiltonHotels.Travel-Guide-Filter-Hotels) - [Adults Only Resorts & in Downtown Key West ](https://www.expedia.ca/Downtown-Key-West-Key-West-Hotels-Adults-Only-Resorts.0-n553248635976470405-0-tAdultsOnlyResorts.Travel-Guide-Filter-Hotels) - [Beach Hotel Hotels in Downtown Key West ](https://www.expedia.ca/Downtown-Key-West-Key-West-Hotels-Beach-Hotel.0-n553248635976470405-0-tBeachHotel.Travel-Guide-Filter-Hotels) - [Boutique Hotels in Downtown Key West ](https://www.expedia.ca/Downtown-Key-West-Key-West-Hotels-Boutique-Hotel.0-n553248635976470405-0-tBoutiqueHotel.Travel-Guide-Filter-Hotels) - [Casino Hotels in Downtown Key West ](https://www.expedia.ca/Downtown-Key-West-Key-West-Hotels-Casino-Hotel.0-n553248635976470405-0-tCasinoHotel.Travel-Guide-Filter-Hotels) - 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[Luxury Hotels in Downtown Key West ](https://www.expedia.ca/Downtown-Key-West-Key-West-Hotels-Luxury-Hotel.0-n553248635976470405-0-tLuxuryHotel.Travel-Guide-Filter-Hotels) - [Pet-Friendly Hotels in Downtown Key West ](https://www.expedia.ca/Downtown-Key-West-Key-West-Hotels-Pet-Friendly-Hotel.0-n553248635976470405-0-tPetfriendlyHotel.Travel-Guide-Filter-Hotels) - [Scuba Diving Hotels in Downtown Key West ](https://www.expedia.ca/Downtown-Key-West-Key-West-Hotels-Scuba-Diving-Vacations.0-n553248635976470405-0-tscubadivingvacations.Travel-Guide-Filter-Hotels) - [Spa Hotels in Downtown Key West ](https://www.expedia.ca/Downtown-Key-West-Key-West-Hotels-Spa-Hotel.0-n553248635976470405-0-tSpaHotel.Travel-Guide-Filter-Hotels) - [Waterpark Hotels in Downtown Key West ](https://www.expedia.ca/Downtown-Key-West-Key-West-Hotels-Waterpark-Hotels.0-n553248635976470405-0-tWaterparkHotels.Travel-Guide-Filter-Hotels) - [Downtown Key West Hotels ](https://www.expedia.ca/Downtown-Key-West-Key-West-Hotels.0-n553248635976470405-0.Travel-Guide-Filter-Hotels) - [Benchmark Hotels in Duck Key ](https://www.expedia.ca/Duck-Key-Hotels-Benchmark.0-0-d184267--bBenchmark.Travel-Guide-Filter-Hotels) - [Hotels near Duval Street ](https://www.expedia.ca/Duval-Street-Hotels.0-l6068616-0.Travel-Guide-Filter-Hotels) - [Hotels near Ernest Hemingway Home and Museum ](https://www.expedia.ca/Ernest-Hemingway-Home-And-Museum-Hotels.0-l501376-0.Travel-Guide-Filter-Hotels) - [Hersha Hospitality Hotels in Fleming Key ](https://www.expedia.ca/Fleming-Key-Hotels-Hersha-Hospitality.0-0-d180162--bHershaHospitality.Travel-Guide-Filter-Hotels) - [Benchmark Hotels in Grassy Key ](https://www.expedia.ca/Grassy-Key-Hotels-Benchmark.0-0-d3000451823--bBenchmark.Travel-Guide-Filter-Hotels) - [Hersha Hospitality Hotels in Islamorada ](https://www.expedia.ca/Islamorada-Hotels-Hersha-Hospitality.0-0-d10768--bHershaHospitality.Travel-Guide-Filter-Hotels) - [Hilton Hotels in Islamorada ](https://www.expedia.ca/Islamorada-Hotels-Hilton-Hotels.0-0-d10768--bHiltonHotels.Travel-Guide-Filter-Hotels) - 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[Beach Hotel Hotels in Key West ](https://www.expedia.ca/Key-West-Hotels-Beach-Hotel.0-0-d1187-tBeachHotel.Travel-Guide-Filter-Hotels) - [Best Western Hotels in Key West ](https://www.expedia.ca/Key-West-Hotels-Best-Western.0-0-d1187--bBestWestern.Travel-Guide-Filter-Hotels) - [Cheap Hotels in Key West ](https://www.expedia.ca/Key-West-Hotels-Cheap-Hotels.0-0-d1187-tCheapHotels.Travel-Guide-Filter-Hotels) - [Four Seasons Hotels in Key West ](https://www.expedia.ca/Key-West-Hotels-Four-Seasons.0-0-d1187--bFourSeasons.Travel-Guide-Filter-Hotels) - [Highgate Independent Hotels in Key West ](https://www.expedia.ca/Key-West-Hotels-Highgate-Independent.0-0-d1187--bHighgateIndependent.Travel-Guide-Filter-Hotels) - [Hilton Hotels in Key West ](https://www.expedia.ca/Key-West-Hotels-Hilton-Hotels.0-0-d1187--bHiltonHotels.Travel-Guide-Filter-Hotels) - [Hyatt Hotels in Key West ](https://www.expedia.ca/Key-West-Hotels-Hyatt-Hotels.0-0-d1187--bHyattHotels.Travel-Guide-Filter-Hotels) - [Kimpton Hotels in Key West ](https://www.expedia.ca/Key-West-Hotels-Kimpton-Hotels.0-0-d1187--bKimptonHotels.Travel-Guide-Filter-Hotels) - [Motel 6 Hotels in Key West ](https://www.expedia.ca/Key-West-Hotels-Motel-6.0-0-d1187--bMotel6.Travel-Guide-Filter-Hotels) - [Red Roof Inn Hotels in Key West ](https://www.expedia.ca/Key-West-Hotels-Red-Roof-Inn.0-0-d1187--bRedRoofInn.Travel-Guide-Filter-Hotels) - [Remington Hotels in Key West ](https://www.expedia.ca/Key-West-Hotels-Remington.0-0-d1187--bRemington.Travel-Guide-Filter-Hotels) - [Wyndham Hotels in Key West ](https://www.expedia.ca/Key-West-Hotels-Wyndham-Hotels.0-0-d1187--bWyndhamHotels.Travel-Guide-Filter-Hotels) - [Key West Hotels ](https://www.expedia.ca/Key-West-Hotels.d1187.Travel-Guide-Hotels) - [Hotels near Key West Lighthouse and Keeper's Quarters Museum ](https://www.expedia.ca/Key-West-Lighthouse-And-Keepers-Quarters-Museum-Hotels.0-l501383-0.Travel-Guide-Filter-Hotels) - [Aimbridge Hospitality Hotels in Lower Arsnicker Keys ](https://www.expedia.ca/Lower-Arsnicker-Keys-Hotels-Aimbridge-Hospitality.0-0-d553248635975748872--bAimbridgeHospitality.Travel-Guide-Filter-Hotels) - [Benchmark Hotels in Lower Arsnicker Keys ](https://www.expedia.ca/Lower-Arsnicker-Keys-Hotels-Benchmark.0-0-d553248635975748872--bBenchmark.Travel-Guide-Filter-Hotels) - [Kimpton Hotels in Lower Florida Keys ](https://www.expedia.ca/Lower-Florida-Keys-Hotels-Kimpton-Hotels.0-0-d553248635975748710--bKimptonHotels.Travel-Guide-Filter-Hotels) - [Hilton Hotels in Marathon ](https://www.expedia.ca/Marathon-Hotels-Hilton-Hotels.0-0-d2437--bHiltonHotels.Travel-Guide-Filter-Hotels) - [Independent Hotels in Marathon ](https://www.expedia.ca/Marathon-Hotels-Independent.0-0-d2437--bIndependent.Travel-Guide-Filter-Hotels) - [Marriott Hotels & Resorts in Marathon ](https://www.expedia.ca/Marathon-Hotels-Marriott-Hotels-Resorts.0-0-d2437--bMarriottHotelsResorts.Travel-Guide-Filter-Hotels) - [Adults Only Resorts & in Old Town Key West ](https://www.expedia.ca/Old-Town-Key-West-Key-West-Hotels-Adults-Only-Resorts.0-n553248635976481920-0-tAdultsOnlyResorts.Travel-Guide-Filter-Hotels) - [Beach Hotel Hotels in Old Town Key West ](https://www.expedia.ca/Old-Town-Key-West-Key-West-Hotels-Beach-Hotel.0-n553248635976481920-0-tBeachHotel.Travel-Guide-Filter-Hotels) - [Boutique Hotels in Old Town Key West ](https://www.expedia.ca/Old-Town-Key-West-Key-West-Hotels-Boutique-Hotel.0-n553248635976481920-0-tBoutiqueHotel.Travel-Guide-Filter-Hotels) - [Casino Hotels in Old Town Key West ](https://www.expedia.ca/Old-Town-Key-West-Key-West-Hotels-Casino-Hotel.0-n553248635976481920-0-tCasinoHotel.Travel-Guide-Filter-Hotels) - [Cheap Hotels in Old Town Key West ](https://www.expedia.ca/Old-Town-Key-West-Key-West-Hotels-Cheap-Hotels.0-n553248635976481920-0-tCheapHotels.Travel-Guide-Filter-Hotels) - [Family Hotels in Old Town Key West ](https://www.expedia.ca/Old-Town-Key-West-Key-West-Hotels-Family-Hotel.0-n553248635976481920-0-tFamilyHotel.Travel-Guide-Filter-Hotels) - [Historic Hotels in Old Town Key West ](https://www.expedia.ca/Old-Town-Key-West-Key-West-Hotels-Historic-Hotel.0-n553248635976481920-0-tHistoricHotel.Travel-Guide-Filter-Hotels) - [Honeymoon Resorts and in Old Town Key West ](https://www.expedia.ca/Old-Town-Key-West-Key-West-Hotels-Honeymoon-Hotels.0-n553248635976481920-0-tHoneymoonHotels.Travel-Guide-Filter-Hotels) - 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