Title: Hotels by Independent in Uptown - Upper Duval | Expedia.ca [Uptown - Upper Duval Travel Guide](https://expedia.ca/Key-West-Uptown-Upper-Duval.dx553248635976473524)[Flights to Key West](https://expedia.ca/Cheap-Flights-To-Key-West.d1187.Travel-Guide-Flights)[Things to do in Key West](https://expedia.ca/Things-To-Do-In-Key-West.d1187.Travel-Guide-Activities)[Uptown - Upper Duval Car Rentals](https://expedia.ca/Car-Rentals-In-Uptown-Upper-Duval.d553248635976473524.Car-Rental-Guide)[Uptown - Upper Duval Vacations](https://expedia.ca/Uptown-Upper-Duval.d553248635976473524.Destination-Travel-Guides) ![Key West Butterfly and Nature Conservatory showing flowers, animals and zoo animals](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/63000/63942-Key-West-Butterfly-And-Nature-Conservatory.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find Hotels by Independent in Uptown - Upper Duval ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check prices for these dates Tonight [Oct 31 - Nov 1](https://www.expedia.ca/Hotel-Search?regionId=553248635976473524&startDate=2025-10-31&endDate=2025-11-01&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Nov 1 - Nov 2](https://www.expedia.ca/Hotel-Search?regionId=553248635976473524&startDate=2025-11-01&endDate=2025-11-02&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Oct 31 - Nov 2](https://www.expedia.ca/Hotel-Search?regionId=553248635976473524&startDate=2025-10-31&endDate=2025-11-02&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Nov 7 - Nov 9](https://www.expedia.ca/Hotel-Search?regionId=553248635976473524&startDate=2025-11-07&endDate=2025-11-09&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top Uptown - Upper Duval Independent Hotels ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in](https://expedia.ca/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FUptown-Upper-Duval-Key-West-Hotels-Independent.0-n553248635976473524-0--bIndependent.Travel-Guide-Filter-Hotels)[Sign up, it's free](https://expedia.ca/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FUptown-Upper-Duval-Key-West-Hotels-Independent.0-n553248635976473524-0--bIndependent.Travel-Guide-Filter-Hotels) ## Top Uptown - Upper Duval Hotel Reviews ![Margaritaville Beach House Key West](//images.trvl-media.com/lodging/49000000/48720000/48713900/48713884/32e70782_y.jpg) ### Margaritaville Beach House Key West 10/10 Excellent "Great place, loved it " [](https://expedia.ca/Key-West-Hotels-Margaritaville-Beach-House-Key-West.h48713884.Hotel-Information) ![Douglas House](//images.trvl-media.com/lodging/111000000/110490000/110488200/110488130/a2bf0992_y.jpg) ### Douglas House 10/10 Excellent "Property, room all were fabulous. Staff was great welcoming and took great care of us." [](https://expedia.ca/Key-West-Hotels-Douglas-House.h110488130.Hotel-Information) ![Orchid Key Inn - Adults Only](//images.trvl-media.com/lodging/1000000/810000/809100/809032/5e9e36b9_y.jpg) ### Orchid Key Inn - Adults Only 10/10 Excellent "The hotel was beautiful! The grounds were spectacular and blended well with the rooms in this setting. " [](https://expedia.ca/Key-West-Hotels-Orchid-Key-Inn.h809032.Hotel-Information) ![Southwinds Motel](//images.trvl-media.com/lodging/9000000/8990000/8984500/8984451/83ae09e3_y.jpg) ### Southwinds Motel 10/10 Excellent "A true hidden gem in Old Town - very clean, comfortable rooms, staff was wonderful!" [](https://expedia.ca/Key-West-Hotels-Southwinds-Motel.h8984451.Hotel-Information) ![Kona Kai Oasis](//images.trvl-media.com/lodging/2000000/1640000/1635900/1635855/0be5a7c1_y.jpg) ### Kona Kai Oasis 10/10 Excellent "Clean and nervy walking or biking distance to everything ( free bikes for guests) close to dog beach beautiful landscaping and relaxing pool and deck , private and accommodative. I would definitely go back there again " [](https://expedia.ca/Key-West-Hotels-An-Island-Oasis.h1635855.Hotel-Information) ![Oceans Edge Key West Resort, Hotel & Marina](//images.trvl-media.com/lodging/17000000/16210000/16203000/16202992/3a4457a0_y.jpg) ### Oceans Edge Key West Resort, Hotel & Marina 10/10 Excellent "This was my 4th year in a row staying at this property. Great views and a great location. " [](https://expedia.ca/Key-West-Hotels-Oceans-Edge-Key-West-Resort.h16202992.Hotel-Information) ![Southernmost Beach Resort and Guesthouses](//images.trvl-media.com/lodging/1000000/870000/863400/863329/026f10af_y.jpg) ### Southernmost Beach Resort and Guesthouses 10/10 Excellent "Great stay and place , only thing that would make it better is a larger and more equipped gym. " [](https://expedia.ca/Key-West-Hotels-Southernmost-Beach-Resort.h863329.Hotel-Information) ![The Reach Key West, Curio Collection by Hilton](//images.trvl-media.com/lodging/1000000/460000/457900/457821/888fac6b_y.jpg) ### The Reach Key West, Curio Collection by Hilton 10/10 Excellent "Great job " [](https://expedia.ca/Key-West-Hotels-The-Reach-Key-West.h457821.Hotel-Information) ![DoubleTree Resort by Hilton Grand Key - Key West](//images.trvl-media.com/lodging/1000000/480000/470900/470834/be4147fb_y.jpg) ### DoubleTree Resort by Hilton Grand Key - Key West 10/10 Excellent "Some staff are rude but other wise it was a good stay" [](https://expedia.ca/Key-West-Hotels-DoubleTree-Resort-By-Hilton-Grand-Key-Key-West.h470834.Hotel-Information) ## Find out more about Uptown - Upper Duval ## Uptown - Upper Duval Hotels Guide Expedia.ca offers a selection of 2810 hotels in Uptown - Upper Duval. You are sure to find cheap deals and discount rates among them with our Best Price Guarantee. No matter what type of hotel strikes your fancy, we will let you search for your preferred one to accommodate your travel needs. Expedia.ca will not only save you time, but also money when booking your stay at a hotel in Uptown - Upper Duval. Making reservations so you can stay within your budget is easy with us. Expedia.ca even provides you with a map so you may find hotels in the Uptown - Upper Duval neighborhood you prefer. Go ahead. Enter your travel dates to view the best offers on hotel rooms in Uptown - Upper Duval, Key West now! ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Other - More ways to book - [Hilton Hotels in Big Pine Key](https://www.expedia.ca/Big-Pine-Key-Hotels-Hilton-Hotels.0-0-d7195--bHiltonHotels.Travel-Guide-Filter-Hotels) - [Adults Only Resorts & in Downtown Key West](https://www.expedia.ca/Downtown-Key-West-Key-West-Hotels-Adults-Only-Resorts.0-n553248635976470405-0-tAdultsOnlyResorts.Travel-Guide-Filter-Hotels) - [Beach Hotel Hotels in Downtown Key West](https://www.expedia.ca/Downtown-Key-West-Key-West-Hotels-Beach-Hotel.0-n553248635976470405-0-tBeachHotel.Travel-Guide-Filter-Hotels) - [Boutique Hotels in Downtown Key West](https://www.expedia.ca/Downtown-Key-West-Key-West-Hotels-Boutique-Hotel.0-n553248635976470405-0-tBoutiqueHotel.Travel-Guide-Filter-Hotels) - [Casino Hotels in Downtown Key West](https://www.expedia.ca/Downtown-Key-West-Key-West-Hotels-Casino-Hotel.0-n553248635976470405-0-tCasinoHotel.Travel-Guide-Filter-Hotels) - 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[Luxury Hotels in Downtown Key West](https://www.expedia.ca/Downtown-Key-West-Key-West-Hotels-Luxury-Hotel.0-n553248635976470405-0-tLuxuryHotel.Travel-Guide-Filter-Hotels) - [Pet-Friendly Hotels in Downtown Key West](https://www.expedia.ca/Downtown-Key-West-Key-West-Hotels-Pet-Friendly-Hotel.0-n553248635976470405-0-tPetfriendlyHotel.Travel-Guide-Filter-Hotels) - [Scuba Diving Hotels in Downtown Key West](https://www.expedia.ca/Downtown-Key-West-Key-West-Hotels-Scuba-Diving-Vacations.0-n553248635976470405-0-tscubadivingvacations.Travel-Guide-Filter-Hotels) - [Spa Hotels in Downtown Key West](https://www.expedia.ca/Downtown-Key-West-Key-West-Hotels-Spa-Hotel.0-n553248635976470405-0-tSpaHotel.Travel-Guide-Filter-Hotels) - [Waterpark Hotels in Downtown Key West](https://www.expedia.ca/Downtown-Key-West-Key-West-Hotels-Waterpark-Hotels.0-n553248635976470405-0-tWaterparkHotels.Travel-Guide-Filter-Hotels) - [Downtown Key West Hotels](https://www.expedia.ca/Downtown-Key-West-Key-West-Hotels.0-n553248635976470405-0.Travel-Guide-Filter-Hotels) - 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[Beach Hotel Hotels in Key West](https://www.expedia.ca/Key-West-Hotels-Beach-Hotel.0-0-d1187-tBeachHotel.Travel-Guide-Filter-Hotels) - [Best Western Hotels in Key West](https://www.expedia.ca/Key-West-Hotels-Best-Western.0-0-d1187--bBestWestern.Travel-Guide-Filter-Hotels) - [Cheap Hotels in Key West](https://www.expedia.ca/Key-West-Hotels-Cheap-Hotels.0-0-d1187-tCheapHotels.Travel-Guide-Filter-Hotels) - [Four Seasons Hotels in Key West](https://www.expedia.ca/Key-West-Hotels-Four-Seasons.0-0-d1187--bFourSeasons.Travel-Guide-Filter-Hotels) - [Highgate Independent Hotels in Key West](https://www.expedia.ca/Key-West-Hotels-Highgate-Independent.0-0-d1187--bHighgateIndependent.Travel-Guide-Filter-Hotels) - [Hilton Hotels in Key West](https://www.expedia.ca/Key-West-Hotels-Hilton-Hotels.0-0-d1187--bHiltonHotels.Travel-Guide-Filter-Hotels) - [Hyatt Hotels in Key West](https://www.expedia.ca/Key-West-Hotels-Hyatt-Hotels.0-0-d1187--bHyattHotels.Travel-Guide-Filter-Hotels) - [Kimpton Hotels in Key West](https://www.expedia.ca/Key-West-Hotels-Kimpton-Hotels.0-0-d1187--bKimptonHotels.Travel-Guide-Filter-Hotels) - [Motel 6 Hotels in Key West](https://www.expedia.ca/Key-West-Hotels-Motel-6.0-0-d1187--bMotel6.Travel-Guide-Filter-Hotels) - [Red Roof Inn Hotels in Key West](https://www.expedia.ca/Key-West-Hotels-Red-Roof-Inn.0-0-d1187--bRedRoofInn.Travel-Guide-Filter-Hotels) - [Remington Hotels in Key West](https://www.expedia.ca/Key-West-Hotels-Remington.0-0-d1187--bRemington.Travel-Guide-Filter-Hotels) - [Wyndham Hotels in Key West](https://www.expedia.ca/Key-West-Hotels-Wyndham-Hotels.0-0-d1187--bWyndhamHotels.Travel-Guide-Filter-Hotels) - [Key West Hotels](https://www.expedia.ca/Key-West-Hotels.d1187.Travel-Guide-Hotels) - [Hotels near Key West Lighthouse and Keeper's Quarters Museum](https://www.expedia.ca/Key-West-Lighthouse-And-Keepers-Quarters-Museum-Hotels.0-l501383-0.Travel-Guide-Filter-Hotels) - [Aimbridge Hospitality Hotels in Lower Arsnicker Keys](https://www.expedia.ca/Lower-Arsnicker-Keys-Hotels-Aimbridge-Hospitality.0-0-d553248635975748872--bAimbridgeHospitality.Travel-Guide-Filter-Hotels) - [Benchmark Hotels in Lower Arsnicker Keys](https://www.expedia.ca/Lower-Arsnicker-Keys-Hotels-Benchmark.0-0-d553248635975748872--bBenchmark.Travel-Guide-Filter-Hotels) - [Kimpton Hotels in Lower Florida Keys](https://www.expedia.ca/Lower-Florida-Keys-Hotels-Kimpton-Hotels.0-0-d553248635975748710--bKimptonHotels.Travel-Guide-Filter-Hotels) - [Hilton Hotels in Marathon](https://www.expedia.ca/Marathon-Hotels-Hilton-Hotels.0-0-d2437--bHiltonHotels.Travel-Guide-Filter-Hotels) - [Independent Hotels in Marathon](https://www.expedia.ca/Marathon-Hotels-Independent.0-0-d2437--bIndependent.Travel-Guide-Filter-Hotels) - [Marriott Hotels & Resorts in Marathon](https://www.expedia.ca/Marathon-Hotels-Marriott-Hotels-Resorts.0-0-d2437--bMarriottHotelsResorts.Travel-Guide-Filter-Hotels) - [Adults Only Resorts & in Old Town Key West](https://www.expedia.ca/Old-Town-Key-West-Key-West-Hotels-Adults-Only-Resorts.0-n553248635976481920-0-tAdultsOnlyResorts.Travel-Guide-Filter-Hotels) - [Beach Hotel Hotels in Old Town Key West](https://www.expedia.ca/Old-Town-Key-West-Key-West-Hotels-Beach-Hotel.0-n553248635976481920-0-tBeachHotel.Travel-Guide-Filter-Hotels) - [Boutique Hotels in Old Town Key West](https://www.expedia.ca/Old-Town-Key-West-Key-West-Hotels-Boutique-Hotel.0-n553248635976481920-0-tBoutiqueHotel.Travel-Guide-Filter-Hotels) - [Casino Hotels in Old Town Key West](https://www.expedia.ca/Old-Town-Key-West-Key-West-Hotels-Casino-Hotel.0-n553248635976481920-0-tCasinoHotel.Travel-Guide-Filter-Hotels) - [Cheap Hotels in Old Town Key West](https://www.expedia.ca/Old-Town-Key-West-Key-West-Hotels-Cheap-Hotels.0-n553248635976481920-0-tCheapHotels.Travel-Guide-Filter-Hotels) - [Family Hotels in Old Town Key West](https://www.expedia.ca/Old-Town-Key-West-Key-West-Hotels-Family-Hotel.0-n553248635976481920-0-tFamilyHotel.Travel-Guide-Filter-Hotels) - [Historic Hotels in Old Town Key West](https://www.expedia.ca/Old-Town-Key-West-Key-West-Hotels-Historic-Hotel.0-n553248635976481920-0-tHistoricHotel.Travel-Guide-Filter-Hotels) - [Honeymoon Resorts and in Old Town Key West](https://www.expedia.ca/Old-Town-Key-West-Key-West-Hotels-Honeymoon-Hotels.0-n553248635976481920-0-tHoneymoonHotels.Travel-Guide-Filter-Hotels) - 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[Luxury Hotels in Old Town Key West](https://www.expedia.ca/Old-Town-Key-West-Key-West-Hotels-Luxury-Hotel.0-n553248635976481920-0-tLuxuryHotel.Travel-Guide-Filter-Hotels) - [Mountain Hotels in Old Town Key West](https://www.expedia.ca/Old-Town-Key-West-Key-West-Hotels-Mountain-Hotels.0-n553248635976481920-0-tMountainHotels.Travel-Guide-Filter-Hotels) - [Oceanfront Hotels in Old Town Key West](https://www.expedia.ca/Old-Town-Key-West-Key-West-Hotels-Oceanfront-Hotels.0-n553248635976481920-0-tOceanfrontHotels.Travel-Guide-Filter-Hotels) - [Pet-Friendly Hotels in Old Town Key West](https://www.expedia.ca/Old-Town-Key-West-Key-West-Hotels-Pet-Friendly-Hotel.0-n553248635976481920-0-tPetfriendlyHotel.Travel-Guide-Filter-Hotels) - [Romantic Hotels in Old Town Key West](https://www.expedia.ca/Old-Town-Key-West-Key-West-Hotels-Romantic-Hotel.0-n553248635976481920-0-tRomanticHotel.Travel-Guide-Filter-Hotels) - [Scuba Diving Hotels in Old Town Key West](https://www.expedia.ca/Old-Town-Key-West-Key-West-Hotels-Scuba-Diving-Vacations.0-n553248635976481920-0-tscubadivingvacations.Travel-Guide-Filter-Hotels) - 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