Title: Hotels by Red Roof Inn in Uptown Greenville | Expedia.ca [Uptown Greenville Travel Guide](https://expedia.ca/Greenville-Uptown-Greenville.dx908648619872518144)[Vacation Rentals in Greenville](https://expedia.ca/Greenville-Vacation-Rentals.d2779.Travel-Guide-VacationRentals)[Flights to Greenville](https://expedia.ca/Cheap-Flights-To-Greenville.d2779.Travel-Guide-Flights)[Things to do in Greenville](https://expedia.ca/Things-To-Do-In-Greenville.d2779.Travel-Guide-Activities)[Uptown Greenville Car Rentals](https://expedia.ca/Car-Rentals-In-Uptown-Greenville.d908648619872518144.Car-Rental-Guide)[Uptown Greenville Vacations](https://expedia.ca/Uptown-Greenville.d908648619872518144.Destination-Travel-Guides) ![Default HTG hotel image](https://a.travel-assets.com/travel-assets-manager/fallback-images-brand/bex_lodging_v2.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find Hotels by Red Roof Inn in Uptown Greenville - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check prices for these dates Tonight [Dec 19 - Dec 20](https://www.expedia.ca/Hotel-Search?regionId=908648619872518144&startDate=2025-12-19&endDate=2025-12-20&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Dec 20 - Dec 21](https://www.expedia.ca/Hotel-Search?regionId=908648619872518144&startDate=2025-12-20&endDate=2025-12-21&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Dec 19 - Dec 21](https://www.expedia.ca/Hotel-Search?regionId=908648619872518144&startDate=2025-12-19&endDate=2025-12-21&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Dec 26 - Dec 28](https://www.expedia.ca/Hotel-Search?regionId=908648619872518144&startDate=2025-12-26&endDate=2025-12-28&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in ](https://expedia.ca/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FUptown-Greenville-Greenville-Hotels-Red-Roof-Inn.0-n908648619872518144-0--bRedRoofInn.Travel-Guide-Filter-Hotels)[ Sign up, it's free ](https://expedia.ca/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FUptown-Greenville-Greenville-Hotels-Red-Roof-Inn.0-n908648619872518144-0--bRedRoofInn.Travel-Guide-Filter-Hotels) ## Top Uptown Greenville Hotel Reviews ![Residence Inn by Marriott Greenville](https://images.trvl-media.com/lodging/7000000/6060000/6057700/6057673/f8514e6b_y.jpg) ### Residence Inn by Marriott Greenville 10/10 Excellent "Rooms are very nice, quiet " [](https://expedia.ca/Greenville-Hotels-Residence-Inn-Greenville.h6057673.Hotel-Information) ![Homewood Suites By Hilton Greenville, NC](https://images.trvl-media.com/lodging/91000000/90160000/90153300/90153266/36cd8e9e_y.jpg) ### Homewood Suites By Hilton Greenville, NC 10/10 Excellent "Room was great. Staff was indifferent." [](https://expedia.ca/Greenville-Hotels-Homewood-Suites-By-Hilton-Greenville.h90153266.Hotel-Information) ![Best Western Plus Suites-Greenville](https://images.trvl-media.com/lodging/1000000/300000/296600/296584/60480ad3_y.jpg) ### Best Western Plus Suites-Greenville 10/10 Excellent "I missed breakfast but i have stayed here before and it was good. " [](https://expedia.ca/Greenville-Hotels-Best-Western-Plus-Suites-Greenville.h296584.Hotel-Information) ![Holiday Inn Greenville by IHG](https://images.trvl-media.com/lodging/1000000/20000/12900/12870/8d14df71_y.jpg) ### Holiday Inn Greenville by IHG 10/10 Excellent "Everything was good, except I just noticed some things that could use repair. Being in the maintenance industry, my eye is drawn to things that most may not see. Lights out in both elevators and in the elevator furthest from the office light is hanging in the elevator. Other than those things, I didn’t travel around the property very much but everything else I saw looked great. Customer service was fantastic. " [](https://expedia.ca/Greenville-Hotels-Holiday-Inn-Greenville.h12870.Hotel-Information) ![Staybridge Suites Greenville Medical Center by IHG](https://images.trvl-media.com/lodging/105000000/104470000/104466400/104466390/356f6fc4_y.jpg) ### Staybridge Suites Greenville Medical Center by IHG 10/10 Excellent "Spotless room and courteous staff!" [](https://expedia.ca/Greenville-Hotels-Staybridge-Suites-Greenville-Medical-Center.h104466390.Hotel-Information) ![Hampton Inn Washington](https://images.trvl-media.com/lodging/1000000/900000/890500/890485/e3b75742_y.jpg) ### Hampton Inn Washington 10/10 Excellent "Very nice and clean. Staff was super friendly. " [](https://expedia.ca/Greenville-Hotels-Hampton-Inn-Washington.h890485.Hotel-Information) ![Quality Inn Greenville near University](https://images.trvl-media.com/lodging/1000000/20000/13600/13542/d6fc4788_y.jpg) ### Quality Inn Greenville near University 10/10 Excellent "room clean, staff check in was efficient and helpful." [](https://expedia.ca/Greenville-Hotels-Quality-Inn-Greenville-Near-University.h13542.Hotel-Information) ![Holiday Inn Express Greenville by IHG](https://images.trvl-media.com/lodging/1000000/110000/102500/102482/30d4a3d9_y.jpg) ### Holiday Inn Express Greenville by IHG 10/10 Excellent "Great staff. Clean rooms" [](https://expedia.ca/Greenville-Hotels-Holiday-Inn-Express-Greenville.h102482.Hotel-Information) ![Microtel Inn & Suites by Wyndham Greenville/University Medic](https://images.trvl-media.com/lodging/3000000/2010000/2009600/2009531/2e252281_y.jpg) ### Microtel Inn & Suites by Wyndham Greenville/University Medic 10/10 Excellent "Small bed but good service " [](https://expedia.ca/Greenville-Hotels-Microtel-Inn-Suites-By-Wyndham-GreenvilleUniversity-Medic.h2009531.Hotel-Information) ## Find out more about Uptown Greenville ## Uptown Greenville Hotels Guide Expedia.ca offers a selection of 196 hotels in Uptown Greenville. You are sure to find cheap deals and discount rates among them with our Best Price Guarantee. No matter what type of hotel strikes your fancy, we will let you search for your preferred one to accommodate your travel needs. Expedia.ca will not only save you time, but also money when booking your stay at a hotel in Uptown Greenville. Making reservations so you can stay within your budget is easy with us. Expedia.ca even provides you with a map so you may find hotels in the Uptown Greenville neighborhood you prefer. Go ahead. 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