Title: Book the Best Uptown Greenville LUXURY Hotels - Upscale Hotels in Uptown Greenville, Greenville | Expedia.ca [Uptown Greenville Travel Guide](https://expedia.ca/Greenville-Uptown-Greenville.dx908648619872518144)[Vacation Rentals in Greenville](https://expedia.ca/Greenville-Vacation-Rentals.d2779.Travel-Guide-VacationRentals)[Flights to Greenville](https://expedia.ca/Cheap-Flights-To-Greenville.d2779.Travel-Guide-Flights)[Uptown Greenville Car Rentals](https://expedia.ca/Car-Rentals-In-Uptown-Greenville.d908648619872518144.Car-Rental-Guide)[Uptown Greenville Vacations](https://expedia.ca/Uptown-Greenville.d908648619872518144.Destination-Travel-Guides) ![](https://mediaim.expedia.com/destination/1/1889c62fff582460c1ba9499992a0d63.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find Luxury Hotels in Uptown Greenville, Greenville ![calendar shield illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation ![deals illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) ![bed illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Uptown Greenville Luxury Hotels Tonight [Oct 4 - Oct 5](https://www.expedia.ca/Hotel-Search?regionId=908648619872518144&startDate=2025-10-04&endDate=2025-10-05&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Oct 5 - Oct 6](https://www.expedia.ca/Hotel-Search?regionId=908648619872518144&startDate=2025-10-05&endDate=2025-10-06&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Oct 10 - Oct 12](https://www.expedia.ca/Hotel-Search?regionId=908648619872518144&startDate=2025-10-10&endDate=2025-10-12&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two weeks [Oct 17 - Oct 19](https://www.expedia.ca/Hotel-Search?regionId=908648619872518144&startDate=2025-10-17&endDate=2025-10-19&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top Uptown Greenville Luxury Hotels ## Top Uptown Greenville Hotel Reviews ![Quality Inn Greenville near University](//images.trvl-media.com/lodging/1000000/20000/13600/13542/dbd945d2_y.jpg) ### Quality Inn Greenville near University 10/10 Excellent "I expected this to be " [](https://expedia.ca/Greenville-Hotels-Quality-Inn-Greenville-Near-University.h13542.Hotel-Information) ![Microtel Inn & Suites by Wyndham Greenville/University Medic](//images.trvl-media.com/lodging/3000000/2010000/2009600/2009531/2e252281_y.jpg) ### Microtel Inn & Suites by Wyndham Greenville/University Medic 10/10 Excellent "We had accessible rm 1st floor. Had to complain several times abouut room above us Like a herd of elephants for several hrs. Even after 9pm" [](https://expedia.ca/Greenville-Hotels-Microtel-Inn-Suites-By-Wyndham-GreenvilleUniversity-Medic.h2009531.Hotel-Information) ![Affordable Suites Greenville](//images.trvl-media.com/lodging/3000000/2690000/2682700/2682635/41b082ee_y.jpg) ### Affordable Suites Greenville 10/10 Excellent "Clean, comfortable, spacious room. Well lit parking lot. Lady at front desk was very courteous and professional. Would stay again." [](https://expedia.ca/Greenville-Hotels-Affordable-Suites.h2682635.Hotel-Information) ![Holiday Inn Greenville by IHG](//images.trvl-media.com/lodging/1000000/20000/12900/12870/8d14df71_y.jpg) ### Holiday Inn Greenville by IHG 10/10 Excellent "Property was nice and well kept. Breakfast was good though not a lot of choice." [](https://expedia.ca/Greenville-Hotels-Holiday-Inn-Greenville.h12870.Hotel-Information) ![Baymont by Wyndham Greenville](//images.trvl-media.com/lodging/1000000/20000/10700/10685/b467b520_y.jpg) ### Baymont by Wyndham Greenville 10/10 Excellent "The property was alright and the amenities were fine. Close to where I needed to go." [](https://expedia.ca/Greenville-Hotels-Baymont-By-Wyndham-Greenville.h10685.Hotel-Information) ## Frequently asked questions ### Are you looking for a luxury hotel for your stay in Uptown Greenville? > Expedia can help you arrange a flight to Greenville, NC (PGV-Pitt-Greenville) airport, and then you can select from various places to stay that will deliver the luxury you'd like to find. Amenities are important when you plan a trip, so we make it easy to get what you want to make your stay relaxing and comfortable. If you want an upscale hotel with fine dining, a spa, or several swimming pools, Expedia can help you find the best luxury hotel experience that Uptown Greenville offers. Uptown Greenville has some interesting things to see and do including Town Common and Greenville Museum of Art, so you might want to take in the local sights during your visit. ### What's there to see and do in Uptown Greenville? > Experience Uptown Greenville and visit Town Common, Williams Arena at Minges Coliseum, and Dowdy–Ficklen Stadium. 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