Title: Book the Best Upstate South Carolina Hotels with smoking rooms in 2025 | Expedia.ca [Upstate South Carolina Travel Guide](https://expedia.ca/Upstate-South-Carolina.dx6057939)[Hotels in Upstate South Carolina](https://expedia.ca/Upstate-South-Carolina-Hotels.d6057939.Travel-Guide-Hotels)[Vacation Rentals in Upstate South Carolina](https://expedia.ca/Upstate-South-Carolina-Vacation-Rentals.d6057939.Travel-Guide-VacationRentals)[Flights to Upstate South Carolina](https://expedia.ca/Cheap-Flights-To-Upstate-South-Carolina.d6057939.Travel-Guide-Flights)[Things to do in Upstate South Carolina](https://expedia.ca/Things-To-Do-In-Upstate-South-Carolina.d6057939.Travel-Guide-Activities)[Upstate South Carolina Car Rentals](https://expedia.ca/Car-Rentals-In-Upstate-South-Carolina.d6057939.Car-Rental-Guide)[Upstate South Carolina Vacation Packages](https://expedia.ca/Upstate-South-Carolina.d6057939.Destination-Travel-Guides) ![Greenville - Spartanburg featuring mountains, views and a sunset](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/63000/63748-Greenville-Spartanburg.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find Smoking Hotels in Upstate South Carolina, SC ![calendar shield illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation ![deals illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) ![bed illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Upstate South Carolina Hotels with smoking rooms Tonight [Sep 26 - Sep 27](https://www.expedia.ca/Hotel-Search?regionId=6057939&startDate=2025-09-26&endDate=2025-09-27&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Sep 27 - Sep 28](https://www.expedia.ca/Hotel-Search?regionId=6057939&startDate=2025-09-27&endDate=2025-09-28&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Sep 26 - Sep 28](https://www.expedia.ca/Hotel-Search?regionId=6057939&startDate=2025-09-26&endDate=2025-09-28&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Oct 3 - Oct 5](https://www.expedia.ca/Hotel-Search?regionId=6057939&startDate=2025-10-03&endDate=2025-10-05&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top Upstate South Carolina Hotels with smoking rooms ![Iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/104000000/103770000/103765700/103765675/5d10a77d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fitness facility](https://images.trvl-media.com/lodging/104000000/103770000/103765700/103765675/50982b01.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/104000000/103770000/103765700/103765675/c9ad0c3b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/104000000/103770000/103765700/103765675/8cd1e3fe.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Home2 Suites By Hilton Hendersonville Hendersonville 9.8/10 Exceptional (108) "Nice stay" CA $182 CA $203 total includes taxes & fees Sep 29 - Sep 30 [](https://www.expedia.ca/Hendersonville-Hotels-Home2-Suites-By-Hilton-Hendersonville.h103765675.Hotel-Information) ![Outdoor pool, sun loungers](https://images.trvl-media.com/lodging/55000000/54530000/54524400/54524318/0fc978a0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium Cabin, Non Smoking | Private kitchen](https://images.trvl-media.com/lodging/55000000/54530000/54524400/54524318/ed481a29.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Studio, 1 King Bed with Sofa bed, Slope side | Terrace/patio](https://images.trvl-media.com/lodging/55000000/54530000/54524400/54524318/24255478.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fireplace](https://images.trvl-media.com/lodging/55000000/54530000/54524400/54524318/ae95b708.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### SKYLARANNA Resort & Spa Hendersonville 8.2/10 Very good (323) "Quiet, close to I-26, and nice outdoor restaurant on premises with good food. " CA $125 CA $179 total includes taxes & fees Sep 29 - Sep 30 [](https://www.expedia.ca/Asheville-Hotels-Skylaranna-Hotel-And-Resort.h54524318.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/21000000/20160000/20154600/20154563/9a08ae16.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Restaurant](https://images.trvl-media.com/lodging/21000000/20160000/20154600/20154563/70c039c1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/21000000/20160000/20154600/20154563/231b0fde.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/21000000/20160000/20154600/20154563/c94cbdde.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Fairfield Inn & Suites by Marriott Hendersonville Flat Rock Flat Rock 9.6/10 Exceptional (643) "Great location and very clean hotel." CA $152 CA $170 total includes taxes & fees Sep 28 - Sep 29 [](https://www.expedia.ca/Asheville-Hotels-Fairfield-Inn-Suites-By-Marriott-Hendersonville-Flat-Rock.h20154563.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/7000000/6700000/6696900/6696886/1436aba9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Hypo-allergenic bedding, down comforters, desk, laptop workspace](https://images.trvl-media.com/lodging/7000000/6700000/6696900/6696886/52f82f37.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/7000000/6700000/6696900/6696886/313b57b7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Seasonal outdoor pool](https://images.trvl-media.com/lodging/7000000/6700000/6696900/6696886/ce65516b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hampton Inn & Suites Seneca-Clemson Area Seneca 9.4/10 Exceptional (636) "The staff were very friendly and helpful. The room was clean and the breakfast was great!" CA $169 CA $186 total includes taxes & fees Oct 16 - Oct 17 [](https://www.expedia.ca/Anderson-Hotels-Hampton-Inn-Suites-Seneca-Clemson-Area.h6696886.Hotel-Information) ![Reception](https://images.trvl-media.com/lodging/43000000/42640000/42633300/42633276/e0ede3d6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/43000000/42640000/42633300/42633276/7f93b55c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/43000000/42640000/42633300/42633276/b257df86.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/43000000/42640000/42633300/42633276/0de5cb8a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Express & Suites Greenville - Taylors by IHG Greenville 9.2/10 Wonderful (633) "Very clean, great showers and b8g tv" CA $166 CA $182 total includes taxes & fees Sep 28 - Sep 29 [](https://www.expedia.ca/Greenville-Spartanburg-Hotels-Holiday-Inn-Express-And-Suites-Greenville-Taylors.h42633276.Hotel-Information) ![Free continental breakfast on weekdays](https://images.trvl-media.com/lodging/11000000/10580000/10570900/10570815/f3f791d4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Room, 1 King Bed, Non Smoking](https://images.trvl-media.com/lodging/11000000/10580000/10570900/10570815/d326e9f9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/11000000/10580000/10570900/10570815/e4895a88.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/11000000/10580000/10570900/10570815/1b233f02.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Rodeway Inn & Suites Walhalla Walhalla 7.6/10 Good (170) "Comfortable, clean, convenient and well located near nature interests in the area. Perfect for our stay to do white water raft on the Chatooga. Great shower and comfortable beds." CA $101 CA $112 total includes taxes & fees Oct 26 - Oct 27 [](https://www.expedia.ca/Walhalla-Hotels-Rodeway-Inn-Suites.h10570815.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/34000000/33410000/33403500/33403422/6940a631.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/34000000/33410000/33403500/33403422/00b3b1b1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, 2 Queen Beds](https://images.trvl-media.com/lodging/34000000/33410000/33403500/33403422/ac5828ff.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/34000000/33410000/33403500/33403422/fbaccdbf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Tru by Hilton Greenville Woodruff Road Greenville 9.2/10 Wonderful (256) "Nice hotel with friendly, helpful staff and a great breakfast! Exactly what we were hoping and looking for. Would definitely stay again! " CA $163 CA $193 total includes taxes & fees Oct 27 - Oct 28 [](https://www.expedia.ca/Greenville-Spartanburg-Hotels-Tru-By-Hilton-Greenville-Woodruff-Road.h33403422.Hotel-Information) ![Property amenity](https://images.trvl-media.com/lodging/31000000/30630000/30628400/30628347/1b39bded.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/31000000/30630000/30628400/30628347/c91b43ef.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Signature Double Room, 1 Queen Bed, Non Smoking](https://images.trvl-media.com/lodging/31000000/30630000/30628400/30628347/993acccc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/31000000/30630000/30628400/30628347/e3a263eb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Whole Hearts Bed and Breakfast Wellford 9.8/10 Exceptional (56) "Property was beautiful and you can tell it is very well maintained! The staff was excellent and breakfast was delicious. Will definitely return on my next trip to SC! " CA $149 CA $165 total includes taxes & fees Oct 14 - Oct 15 [](https://www.expedia.ca/Wellford-Hotels-Whole-Hearts-Bed-And-Breakfast.h30628347.Hotel-Information) ![Lobby lounge](https://images.trvl-media.com/lodging/1000000/90000/84700/84636/d257793d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Double Room, 2 Queen Beds](https://images.trvl-media.com/lodging/1000000/90000/84700/84636/3e16f761.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/1000000/90000/84700/84636/78008f7f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Meeting facility](https://images.trvl-media.com/lodging/1000000/90000/84700/84636/10c576cf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Inn @ Clemson Clemson 8.0/10 Very good (1022) "Good location" CA $114 CA $127 total includes taxes & fees Sep 28 - Sep 29 [](https://www.expedia.ca/Anderson-Hotels-Inn-Clemson.h84636.Hotel-Information) ![Indoor pool, outdoor pool](https://images.trvl-media.com/lodging/2000000/1540000/1533500/1533439/6d7853ae.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, desk, blackout drapes, iron/ironing board](https://images.trvl-media.com/lodging/2000000/1540000/1533500/1533439/164da543.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, desk, blackout drapes, iron/ironing board](https://images.trvl-media.com/lodging/2000000/1540000/1533500/1533439/a7bfe0b0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/2000000/1540000/1533500/1533439/6e7a607b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Drury Inn & Suites Greenville Greenville 9.6/10 Exceptional (1023) "Kind staff and easy check in." CA $160 CA $176 total includes taxes & fees Oct 5 - Oct 6 [](https://www.expedia.ca/Greenville-Hotels-Drury-Inn-Suites-Greenville.h1533439.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2025-10-11&endDate=2025-10-12®ionId=6057939&adults=2&property_amenities_group_explore=designated_smoking_areas&sort=RECOMMENDED&openPlayBack=true) ## Top Upstate South Carolina Hotel Reviews ![La Quinta Inn & Suites by Wyndham Greenville Haywood](//images.trvl-media.com/lodging/1000000/170000/165800/165759/89ed0b3d_y.jpg) ### La Quinta Inn & Suites by Wyndham Greenville Haywood 10/10 Excellent "Great VALUE and great room. " [](https://expedia.ca/Greenville-Hotels-La-Quinta-Inn-Suites-By-Wyndham-Greenville-Haywood.h165759.Hotel-Information) ![Drury Inn & Suites Greenville](//images.trvl-media.com/lodging/2000000/1540000/1533500/1533439/6d7853ae_y.jpg) ### Drury Inn & Suites Greenville 10/10 Excellent "First time in a Drury Inn. Very pleased. Clean, great breakfast, friendly staff." 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Airport (EWR) to Greenville (GDC)](https://www.expedia.ca/lp/flights/ewr/gdc/newark-liberty-intl-airport-to-greenville) - [Flights from Rome (FCO) to Greenville (GDC)](https://www.expedia.ca/lp/flights/fco/gdc/rome-to-greenville) - [Flights from Gatlinburg (GKT) to Greenville (GDC)](https://www.expedia.ca/lp/flights/gkt/gdc/gatlinburg-to-greenville) - [Flights from Gatlinburg (GKT) to Greenville (GMU)](https://www.expedia.ca/lp/flights/gkt/gmu/gatlinburg-to-greenville) - [Flights from Greenwood (GRD) to Greenville (GDC)](https://www.expedia.ca/lp/flights/grd/gdc/greenwood-to-greenville) - [Flights from Greenwood (GRD) to Greenville (GMU)](https://www.expedia.ca/lp/flights/grd/gmu/greenwood-to-greenville) - [Flights from Huntsville (HSV) to Greenville (GMU)](https://www.expedia.ca/lp/flights/hsv/gmu/huntsville-to-greenville) - [Flights from Islip (ISP) to Greenville (GMU)](https://www.expedia.ca/lp/flights/isp/gmu/islip-to-greenville) - [Flights from Jacksonville (JAX) to Greenville (GMU)](https://www.expedia.ca/lp/flights/jax/gmu/jacksonville-to-greenville) - 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[Flights from New Orleans (MSY) to Greenville (GMU)](https://www.expedia.ca/lp/flights/msy/gmu/new-orleans-to-greenville) - [Flights from Chicago (ORD) to Greenville (GDC)](https://www.expedia.ca/lp/flights/ord/gdc/chicago-to-greenville) - [Flights from Norfolk (ORF) to Greenville (GMU)](https://www.expedia.ca/lp/flights/orf/gmu/norfolk-to-greenville) - [Flights from West Palm Beach (PBI) to Greenville (GMU)](https://www.expedia.ca/lp/flights/pbi/gmu/west-palm-beach-to-greenville) - [Flights from Philadelphia (PHL) to Greenville (GMU)](https://www.expedia.ca/lp/flights/phl/gmu/philadelphia-to-greenville) - [Flights from Raleigh (RDU) to Greenville (GMU)](https://www.expedia.ca/lp/flights/rdu/gmu/raleigh-to-greenville) - [Flights from Rocky Mount (RWI) to Greenville (GMU)](https://www.expedia.ca/lp/flights/rwi/gmu/rocky-mount-to-greenville) - [Flights from San Antonio (SAT) to Greenville (GDC)](https://www.expedia.ca/lp/flights/sat/gdc/san-antonio-to-greenville) - [Flights from Savannah (SAV) to Greenville (GMU)](https://www.expedia.ca/lp/flights/sav/gmu/savannah-to-greenville) - [Flights from Schenectady (SCH) to Greenville (GMU)](https://www.expedia.ca/lp/flights/sch/gmu/schenectady-to-greenville) - [Flights from Newburgh (SWF) to Greenville (GMU)](https://www.expedia.ca/lp/flights/swf/gmu/newburgh-to-greenville) - [Flights from Montreal (YUL) to Greenville (GMU)](https://www.expedia.ca/lp/flights/yul/gmu/montreal-to-greenville) - [Flights from Vancouver (YVR) to Greenville (GMU)](https://www.expedia.ca/lp/flights/yvr/gmu/vancouver-to-greenville) - [Flights from Toronto (YYZ) to Greenville (GDC)](https://www.expedia.ca/lp/flights/yyz/gdc/toronto-to-greenville) - [Flights from Toronto (YYZ) to Greenville (GMU)](https://www.expedia.ca/lp/flights/yyz/gmu/toronto-to-greenville) - [7th Inning Splash Waterpark](https://www.expedia.ca/7th-Inning-Splash-Waterpark-Piedmont.d553248621532656702.Vacation-Attraction) - [Central Vacations](https://www.expedia.ca/Central.d10503.Destination-Travel-Guides) - [Discovery Island Water Park](https://www.expedia.ca/Discovery-Island-Water-Park-Greenville.d553248621532656705.Vacation-Attraction) - [Frankie's Fun Park](https://www.expedia.ca/Frankies-Fun-Park-Greenville.d553248621532656780.Vacation-Attraction) - [Mauldin Vacations](https://www.expedia.ca/Mauldin.d183944.Destination-Travel-Guides) - [Prisma Health Greenville Memorial Hospital](https://www.expedia.ca/Prisma-Health-Greenville-Memorial-Hospital-Greenville.d553248635941390934.Vacation-Attraction) - [Terrace Shopping Center](https://www.expedia.ca/Terrace-Shopping-Center-Greenville.d553248621563220413.Vacation-Attraction) - [Car rentals near Prisma Health Greenville Memorial Hospital](https://www.expedia.ca/Car-Rentals-In-Prisma-Health-Greenville-Memorial-Hospital.d553248635941390934.Car-Rental-Guide) - [Book Hotels with smoking rooms in Upstate South Carolina on Expedia.com](https://www.expedia.com/Upstate-South-Carolina-Hotels-Hotels-With-Smoking-Rooms.0-0-d6057939-tHotelswithsmokingrooms.Travel-Guide-Filter-Hotels)