Title: Book the Best BUSINESS Hotels in Upstate South Carolina in 2026 | Expedia.ca [Upstate South Carolina Travel Guide](https://expedia.ca/Upstate-South-Carolina.dx6057939)[Hotels in Upstate South Carolina](https://expedia.ca/Upstate-South-Carolina-Hotels.d6057939.Travel-Guide-Hotels)[Vacation Rentals in Upstate South Carolina](https://expedia.ca/Upstate-South-Carolina-Vacation-Rentals.d6057939.Travel-Guide-VacationRentals)[Flights to Upstate South Carolina](https://expedia.ca/Cheap-Flights-To-Upstate-South-Carolina.d6057939.Travel-Guide-Flights)[Things to do in Upstate South Carolina](https://expedia.ca/Things-To-Do-In-Upstate-South-Carolina.d6057939.Travel-Guide-Activities)[Upstate South Carolina Car Rentals](https://expedia.ca/Car-Rentals-In-Upstate-South-Carolina.d6057939.Car-Rental-Guide)[Upstate South Carolina Vacation Packages](https://expedia.ca/Upstate-South-Carolina.d6057939.Destination-Travel-Guides) ![The view from Caesars Head after a storm](https://images.trvl-media.com/place/553248621532656715/293b23c7-6024-49ab-80cb-4ee292c1b5a3.jpg?impolicy=fcrop&w=1200&h=500&q=medium) Photo by Michelle Hendrix # Find Business Hotels in Upstate South Carolina, SC from CA $104 - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Upstate South Carolina Business Hotels Tonight [Dec 26 - Dec 27](https://www.expedia.ca/Hotel-Search?regionId=6057939&startDate=2025-12-26&endDate=2025-12-27&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) Tomorrow [Dec 27 - Dec 28](https://www.expedia.ca/Hotel-Search?regionId=6057939&startDate=2025-12-27&endDate=2025-12-28&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) This weekend [Dec 26 - Dec 28](https://www.expedia.ca/Hotel-Search?regionId=6057939&startDate=2025-12-26&endDate=2025-12-28&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) Next weekend [Jan 2 - Jan 4](https://www.expedia.ca/Hotel-Search?regionId=6057939&startDate=2026-01-02&endDate=2026-01-04&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) ## Our top choices for Upstate South Carolina business-friendly hotels ![Free daily full breakfast](https://images.trvl-media.com/lodging/72000000/71520000/71515100/71515054/589dc000.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Seasonal outdoor pool](https://images.trvl-media.com/lodging/72000000/71520000/71515100/71515054/f5139881.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby lounge](https://images.trvl-media.com/lodging/72000000/71520000/71515100/71515054/d8b2892f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/72000000/71520000/71515100/71515054/3ccb6df6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Express Gaffney by IHG [](https://www.expedia.ca/Gaffney-Hotels-Holiday-Inn-Express-Gaffney.h71515054.Hotel-Information) Gaffney 8.6/10 Excellent (424) "Great place to stay" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Timothy CA $107 CA $116 total includes taxes & fees Jan 5 - Jan 6, 2026 [](https://www.expedia.ca/Gaffney-Hotels-Holiday-Inn-Express-Gaffney.h71515054.Hotel-Information) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/1000000/290000/281700/281618/eac10fcf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Seasonal outdoor pool, open 9:30 AM to 10:00 PM, pool umbrellas](https://images.trvl-media.com/lodging/1000000/290000/281700/281618/331b91d5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Pillowtop beds, desk, blackout drapes, iron/ironing board](https://images.trvl-media.com/lodging/1000000/290000/281700/281618/6f095093.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fitness facility](https://images.trvl-media.com/lodging/1000000/290000/281700/281618/8062e000.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hampton Inn Spartanburg-North I-85 [](https://www.expedia.ca/Spartanburg-Hotels-Hampton-Inn-Spartanburg-North-I-85.h281618.Hotel-Information) Spartanburg 8.8/10 Excellent (1001) "The staff was courteous in the room was spotless!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Kimberly CA $107 CA $118 total includes taxes & fees Jan 9 - Jan 10, 2026 [](https://www.expedia.ca/Spartanburg-Hotels-Hampton-Inn-Spartanburg-North-I-85.h281618.Hotel-Information) ![Free daily continental breakfast](https://images.trvl-media.com/lodging/1000000/30000/23100/23003/20a0c66a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/30000/23100/23003/ac0c08fd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/30000/23100/23003/ca99d7c9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Pillowtop beds, in-room safe, desk, laptop workspace](https://images.trvl-media.com/lodging/1000000/30000/23100/23003/b54ae3f0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Best Western Plus Greenville I-385 Inn & Suites [](https://www.expedia.ca/Greenville-Hotels-Best-Western-Plus-Greenville-I-385-Inn-Suites.h23003.Hotel-Information) Greenville 9.0/10 Wonderful (1422) "Clean room, great selection for breakfast, easy check in and check out" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Angelica CA $116 CA $128 total includes taxes & fees Dec 28 - Dec 29 [](https://www.expedia.ca/Greenville-Hotels-Best-Western-Plus-Greenville-I-385-Inn-Suites.h23003.Hotel-Information) ![Terrace/patio](https://images.trvl-media.com/lodging/1000000/10000/3300/3223/31b0d05e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fitness facility](https://images.trvl-media.com/lodging/1000000/10000/3300/3223/b840578e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/1000000/10000/3300/3223/b0e15e12.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/1000000/10000/3300/3223/8238721d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Embassy Suites Greenville Golf Resort & Conference Center [](https://www.expedia.ca/Greenville-Hotels-Embassy-Suites-Greenville-Golf-Resort-Conference-Center.h3223.Hotel-Information) Greenville 9.0/10 Wonderful (1004) "Great room, staff and location. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Neil CA $135 CA $148 total includes taxes & fees Jan 4 - Jan 5, 2026 [](https://www.expedia.ca/Greenville-Hotels-Embassy-Suites-Greenville-Golf-Resort-Conference-Center.h3223.Hotel-Information) ![Free daily on-the-go breakfast](https://images.trvl-media.com/lodging/1000000/70000/67500/67445/2183f59d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Room, 2 Queen Beds, Non Smoking](https://images.trvl-media.com/lodging/1000000/70000/67500/67445/1282aab2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/1000000/70000/67500/67445/ff4774c9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe Suite, 1 King Bed with Sofa bed, Non Smoking | Living area](https://images.trvl-media.com/lodging/1000000/70000/67500/67445/e799826e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Comfort Inn & Suites Greer - Greenville [](https://www.expedia.ca/Greer-Hotels-Comfort-Inn-Suites-Greer-Greenville.h67445.Hotel-Information) Greer 8.6/10 Excellent (733) "Staff very friendly, clean spacious room" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Arthur CA $128 CA $139 total includes taxes & fees Jan 11 - Jan 12, 2026 [](https://www.expedia.ca/Greer-Hotels-Comfort-Inn-Suites-Greer-Greenville.h67445.Hotel-Information) ![Seasonal outdoor pool](https://images.trvl-media.com/lodging/1000000/130000/123200/123112/56e58fe3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Studio Suite, 2 Queen Beds, Non Smoking](https://images.trvl-media.com/lodging/1000000/130000/123200/123112/d70730df.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily on-the-go breakfast](https://images.trvl-media.com/lodging/1000000/130000/123200/123112/fd0e7067.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/130000/123200/123112/bbe16f27.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Super 8 by Wyndham Greer/Spartanburg Area [](https://www.expedia.ca/Greer-Hotels-Super-8-By-Wyndham-GreerSpartanburg-Area.h123112.Hotel-Information) Greer 7.2/10 Good (525) "My stay at Super 8 was quite remarkable . I really enjoyed the place." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Rick CA $92 CA $104 total includes taxes & fees Jan 9 - Jan 10, 2026 [](https://www.expedia.ca/Greer-Hotels-Super-8-By-Wyndham-GreerSpartanburg-Area.h123112.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/12000000/11960000/11959000/11958914/d91c1d51.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/12000000/11960000/11959000/11958914/7c5ccfc6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![In-room safe, desk, blackout drapes, iron/ironing board](https://images.trvl-media.com/lodging/12000000/11960000/11959000/11958914/5e9a8e7d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![In-room safe, desk, blackout drapes, iron/ironing board](https://images.trvl-media.com/lodging/12000000/11960000/11959000/11958914/a1d7ed0d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Aloft Greenville Downtown [](https://www.expedia.ca/Greenville-Hotels-Aloft-Greenville-Downtown.h11958914.Hotel-Information) Greenville Downtown 9.2/10 Wonderful (1001) "Always a great place to stay. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Daniel CA $171 CA $188 total includes taxes & fees Jan 18 - Jan 19, 2026 [](https://www.expedia.ca/Greenville-Hotels-Aloft-Greenville-Downtown.h11958914.Hotel-Information) ![Free daily on-the-go breakfast](https://images.trvl-media.com/lodging/1000000/80000/76800/76800/375f69b2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/80000/76800/76800/270-2efd6ebb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Seasonal outdoor pool](https://images.trvl-media.com/lodging/1000000/80000/76800/76800/3c50d204.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, 2 Double Beds, Accessible, Non Smoking](https://images.trvl-media.com/lodging/1000000/80000/76800/76800/347fe1fc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Quality Inn Seneca Clemson Area US-123 [](https://www.expedia.ca/Anderson-Hotels-Quality-Inn-Seneca-US-123.h76800.Hotel-Information) Downtown 8.0/10 Very good (665) "Friendly check in, clean room." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) connie CA $101 CA $119 total includes taxes & fees Jan 4 - Jan 5, 2026 [](https://www.expedia.ca/Anderson-Hotels-Quality-Inn-Seneca-US-123.h76800.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/51000000/50830000/50828700/50828647/f59bfe6c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/51000000/50830000/50828700/50828647/36a85341.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Restaurant](https://images.trvl-media.com/lodging/51000000/50830000/50828700/50828647/0007de95.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/51000000/50830000/50828700/50828647/586dbae9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### DoubleTree by Hilton Greenville Woodruff Road [](https://www.expedia.ca/Greenville-Hotels-DoubleTree-By-Hilton-Greenville-Woodruff-Road.h50828647.Hotel-Information) Greenville 9.4/10 Exceptional (1000) "Clean modern comfortable convenient location great cookie " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jimmy CA $150 CA $165 total includes taxes & fees Jan 1 - Jan 2, 2026 [](https://www.expedia.ca/Greenville-Hotels-DoubleTree-By-Hilton-Greenville-Woodruff-Road.h50828647.Hotel-Information) ![View from property](https://images.trvl-media.com/lodging/20000000/19220000/19218500/19218492/75c3dac7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby lounge, alfresco dining, open daily](https://images.trvl-media.com/lodging/20000000/19220000/19218500/19218492/bd09d7bb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 2 Queen Beds, Corner](https://images.trvl-media.com/lodging/20000000/19220000/19218500/19218492/fd28caf4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool, free cabanas, pool umbrellas](https://images.trvl-media.com/lodging/20000000/19220000/19218500/19218492/2016aea9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### AC Hotel by Marriott Spartanburg [](https://www.expedia.ca/Spartanburg-Hotels-AC-Hotel-By-Marriott-Spartanburg.h19218492.Hotel-Information) Spartanburg 9.2/10 Wonderful (586) "The gentleman at the front desk when I checked in made me feel very comfortable. He was so chill. It was a great stay" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) robert CA $176 CA $196 total includes taxes & fees Dec 30 - Dec 31 [](https://www.expedia.ca/Spartanburg-Hotels-AC-Hotel-By-Marriott-Spartanburg.h19218492.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2026-01-10&endDate=2026-01-11®ionId=6057939&adults=2&travelerType=business_friendly&sort=RECOMMENDED&openPlayBack=true) ## Top Upstate South Carolina Hotel Reviews ![Best Western Plus Clemson Hotel & Conference Center](https://images.trvl-media.com/lodging/1000000/10000/1400/1370/w3840h2557x0y4-16ef7416_y.jpg) ### Best Western Plus Clemson Hotel & Conference Center 10/10 Excellent "This hotel was up-to-date, seemingly remodeled recently. I would definitely stay here again. " [](https://expedia.ca/Anderson-Hotels-Best-Western-Plus-University-Inn-Conference-Center.h1370.Hotel-Information) ![Hyatt Place Greenville/Haywood](https://images.trvl-media.com/lodging/1000000/70000/64600/64570/9a71f6a4_y.jpg) ### Hyatt Place Greenville/Haywood 10/10 Excellent "The table where you eat has long hair everyone on it !! Couldn’t eat at it ! " [](https://expedia.ca/Greenville-Hotels-Hyatt-Place-GreenvilleHaywood.h64570.Hotel-Information) ![Best Western Plus Greenville I-385 Inn & Suites](https://images.trvl-media.com/lodging/1000000/30000/23100/23003/20a0c66a_y.jpg) ### Best Western Plus Greenville I-385 Inn & Suites 10/10 Excellent "Delightful stay! " [](https://expedia.ca/Greenville-Hotels-Best-Western-Plus-Greenville-I-385-Inn-Suites.h23003.Hotel-Information) ![Aloft Greenville Downtown](https://images.trvl-media.com/lodging/12000000/11960000/11959000/11958914/d91c1d51_y.jpg) ### Aloft Greenville Downtown 10/10 Excellent "The hospitality and all amenities were top notch! We will definitely be staying there again with our dog." [](https://expedia.ca/Greenville-Hotels-Aloft-Greenville-Downtown.h11958914.Hotel-Information) ![Embassy Suites by Hilton Greenville Downtown Riverplace](https://images.trvl-media.com/lodging/16000000/15060000/15052000/15051911/b5c8aa89_y.jpg) ### Embassy Suites by Hilton Greenville Downtown Riverplace 10/10 Excellent "The room was spotless, the staff was extremely nice and caring. I was there to celebrate my girlfriend’s birthday and the lady at the front desk gave us great recommendations for local bars and restaurants. 10/10 would stay here again " [](https://expedia.ca/Greenville-Hotels-Embassy-Suites-By-Hilton-Greenville-Downtown-Riverplace.h15051911.Hotel-Information) ![Hyatt Regency Greenville](https://images.trvl-media.com/lodging/1000000/30000/22300/22252/fa37e256_y.jpg) ### Hyatt Regency Greenville 10/10 Excellent "This place was perfect all around-Great Location, and all staff was super helpful from the front desk to the restaurant and bar staff. So close to Ben Secour-just a short walk!!" [](https://expedia.ca/Greenville-Hotels-Hyatt-Regency-Greenville.h22252.Hotel-Information) ![The Westin Poinsett Greenville](https://images.trvl-media.com/lodging/1000000/580000/576000/575983/3e47bf88_y.jpg) ### The Westin Poinsett Greenville 10/10 Excellent "Free early morning coffee in the lounge area. Shazam!" [](https://expedia.ca/Greenville-Hotels-The-Westin-Poinsett-Greenville.h575983.Hotel-Information) ![Embassy Suites Greenville Golf Resort & Conference Center](https://images.trvl-media.com/lodging/1000000/10000/3300/3223/31b0d05e_y.jpg) ### Embassy Suites Greenville Golf Resort & Conference Center 10/10 Excellent "Very clean and very friendly staff highly recommend!" [](https://expedia.ca/Greenville-Hotels-Embassy-Suites-Greenville-Golf-Resort-Conference-Center.h3223.Hotel-Information) ![Hilton Greenville](https://images.trvl-media.com/lodging/1000000/30000/23200/23172/401b294d_y.jpg) ### Hilton Greenville 10/10 Excellent "Awesome and super clean " [](https://expedia.ca/Greenville-Hotels-Hilton-Greenville.h23172.Hotel-Information) ## Frequently asked questions ### How much do business-friendly hotels in Upstate South Carolina cost? ### What are the best business-friendly hotels in Upstate South Carolina? ### How many business-friendly hotels are there in Upstate South Carolina? ### What are the best cheap business-friendly hotels in Upstate South Carolina? ### What are the top business-friendly motels in Upstate South Carolina? ### Are there any family-friendly hotels in Upstate South Carolina that are also business friendly? ### Are there any 5-star business-friendly hotels in Upstate South Carolina? ### Why book your business-friendly hotel in Upstate South Carolina with Expedia? ### How can I find cheap business-friendly hotels in Upstate South Carolina? ### What is there to do in Upstate South Carolina near my business-friendly hotel? ## Explore a world of travel with Expedia - 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