Title: Book the Best BUSINESS Hotels in Tuscumbia in 2026 | Expedia.ca [Hotels in Tuscumbia](https://expedia.ca/Tuscumbia-Hotels.d6203.Travel-Guide-Hotels)[Vacation Rentals in Tuscumbia](https://expedia.ca/Tuscumbia-Vacation-Rentals.d6203.Travel-Guide-VacationRentals)[Tuscumbia Car Rentals](https://expedia.ca/Car-Rentals-In-Tuscumbia.d6203.Car-Rental-Guide)[Tuscumbia Vacation Packages](https://expedia.ca/Tuscumbia.d6203.Destination-Travel-Guides) ![An old waterwheel in a park in Tuscumbia, Alabama ](https://images.trvl-media.com/place/6203/bde4f759-ac00-4594-b96a-5e75bc066e0b.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find Business Hotels in Tuscumbia, AL from CA $99 - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Tuscumbia Business Hotels Tonight [Jan 2 - Jan 3](https://www.expedia.ca/Hotel-Search?regionId=6203&startDate=2026-01-02&endDate=2026-01-03&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) Tomorrow [Jan 3 - Jan 4](https://www.expedia.ca/Hotel-Search?regionId=6203&startDate=2026-01-03&endDate=2026-01-04&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) This weekend [Jan 2 - Jan 4](https://www.expedia.ca/Hotel-Search?regionId=6203&startDate=2026-01-02&endDate=2026-01-04&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) Next weekend [Jan 9 - Jan 11](https://www.expedia.ca/Hotel-Search?regionId=6203&startDate=2026-01-09&endDate=2026-01-11&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) ## Our top choices for Tuscumbia business-friendly hotels ![Lobby](https://images.trvl-media.com/lodging/2000000/1550000/1549300/1549240/46e8d6c3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Executive Studio Suite, 1 King Bed | Private kitchen](https://images.trvl-media.com/lodging/2000000/1550000/1549300/1549240/9b5fef1c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/2000000/1550000/1549300/1549240/d9cb9643.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Executive Studio Suite, 1 King Bed | Living area](https://images.trvl-media.com/lodging/2000000/1550000/1549300/1549240/758d5eba.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The ColdWater Inn [](https://www.expedia.ca/Florence-Hotels-The-ColdWater-Inn.h1549240.Hotel-Information) Tuscumbia 9.0/10 Wonderful (664) "Good hotel for the money. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Franklin CA $100 CA $112 total includes taxes & fees Jan 4 - Jan 5 [](https://www.expedia.ca/Florence-Hotels-The-ColdWater-Inn.h1549240.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/2000000/2000000/1990300/1990270/9a484ef4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free buffet breakfast](https://images.trvl-media.com/lodging/2000000/2000000/1990300/1990270/f364afb6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/2000000/2000000/1990300/1990270/57823e60.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![In-room safe, desk, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/2000000/2000000/1990300/1990270/c0b6ef4a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Comfort Inn & Suites Tuscumbia - Muscle Shoals [](https://www.expedia.ca/Florence-Hotels-Comfort-Inn-Suites-Tuscumbia-Muscle-Shoals.h1990270.Hotel-Information) Tuscumbia 8.2/10 Very good (251) "Clean room, courteous staff " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Paige CA $163 CA $181 total includes taxes & fees Jan 4 - Jan 5 [](https://www.expedia.ca/Florence-Hotels-Comfort-Inn-Suites-Tuscumbia-Muscle-Shoals.h1990270.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/18000000/17800000/17793400/17793356/b80a739c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily full breakfast](https://images.trvl-media.com/lodging/18000000/17800000/17793400/17793356/f8f5f0be.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/18000000/17800000/17793400/17793356/ab7fab37.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Room, 1 King Bed, Accessible, Non Smoking](https://images.trvl-media.com/lodging/18000000/17800000/17793400/17793356/30c0f646.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Best Western Plus Tuscumbia Muscle Shoals Hotel and Suites [](https://www.expedia.ca/Florence-Hotels-Best-Western-Plus-Tuscumbia-Muscle-Shoals-Hotel-And-Suites.h17793356.Hotel-Information) Tuscumbia 9.2/10 Wonderful (628) "Great stay" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) EDDIE CA $166 CA $182 total includes taxes & fees Jan 9 - Jan 10 [](https://www.expedia.ca/Florence-Hotels-Best-Western-Plus-Tuscumbia-Muscle-Shoals-Hotel-And-Suites.h17793356.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/4000000/3180000/3173300/3173212/d1efc2ef.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Studio Suite, 1 Queen Bed, Non Smoking](https://images.trvl-media.com/lodging/4000000/3180000/3173300/3173212/79031bf4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, 2 Queen Beds, Non Smoking](https://images.trvl-media.com/lodging/4000000/3180000/3173300/3173212/295ef938.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/4000000/3180000/3173300/3173212/1c5240b5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Microtel Inn & Suites by Wyndham Tuscumbia/Muscle Shoals [](https://www.expedia.ca/Florence-Hotels-Microtel-Inn-Suites-By-Wyndham-TuscumbiaMuscle-Shoals.h3173212.Hotel-Information) Tuscumbia 8.2/10 Very good (1001) "Clean room, great staff, good breakfast and excellent location. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Sol CA $96 CA $106 total includes taxes & fees Jan 4 - Jan 5 [](https://www.expedia.ca/Florence-Hotels-Microtel-Inn-Suites-By-Wyndham-TuscumbiaMuscle-Shoals.h3173212.Hotel-Information) ![Interior](https://images.trvl-media.com/lodging/1000000/60000/57100/57085/c70479c3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![BBQ/picnic area](https://images.trvl-media.com/lodging/1000000/60000/57100/57085/e458e7ea.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property entrance](https://images.trvl-media.com/lodging/1000000/60000/57100/57085/4536ab1b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, iron/ironing board, rollaway beds, free WiFi](https://images.trvl-media.com/lodging/1000000/60000/57100/57085/71889933.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Key West Inn [](https://www.expedia.ca/Florence-Hotels-Key-West-Inn.h57085.Hotel-Information) Tuscumbia 7.0/10 Good (183) "Good place to stay" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Elias CA $89 CA $99 total includes taxes & fees Jan 4 - Jan 5 [](https://www.expedia.ca/Florence-Hotels-Key-West-Inn.h57085.Hotel-Information) ![Free buffet breakfast](https://images.trvl-media.com/lodging/3000000/2980000/2976500/2976409/1fbbd61b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 1 King Bed](https://images.trvl-media.com/lodging/3000000/2980000/2976500/2976409/b5eb58b6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/3000000/2980000/2976500/2976409/9c01203e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/3000000/2980000/2976500/2976409/6e11b726.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Express Hotel & Suites FLORENCE NORTHEAST by IHG [](https://www.expedia.ca/Florence-Hotels-Holiday-Inn-Express-Hotel-Suites-FLORENCE-NORTHEAST.h2976409.Hotel-Information) Florence 9.0/10 Wonderful (591) "Friendly staff, everything wasCLEAN!! " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Kelsey CA $152 CA $175 total includes taxes & fees Jan 9 - Jan 10 [](https://www.expedia.ca/Florence-Hotels-Holiday-Inn-Express-Hotel-Suites-FLORENCE-NORTHEAST.h2976409.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/4000000/3170000/3160100/3160009/e9e5832f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Gift shop](https://images.trvl-media.com/lodging/4000000/3170000/3160100/3160009/f8c56b28.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/4000000/3170000/3160100/3160009/f71d0716.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Pillowtop beds, desk, iron/ironing board, free cribs/infant beds](https://images.trvl-media.com/lodging/4000000/3170000/3160100/3160009/6fa7225a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Comfort Suites Florence Shoals Area [](https://www.expedia.ca/Florence-Hotels-Comfort-Suites-Florence-Shoals-Area.h3160009.Hotel-Information) Florence 8.8/10 Excellent (760) "Room was clean, staff was friendly and helpful. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Steven CA $144 CA $165 total includes taxes & fees Jan 11 - Jan 12 [](https://www.expedia.ca/Florence-Hotels-Comfort-Suites-Florence-Shoals-Area.h3160009.Hotel-Information) ![View from property](https://images.trvl-media.com/lodging/4000000/3560000/3557700/3557696/5c975983.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/4000000/3560000/3557700/3557696/8518663c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/4000000/3560000/3557700/3557696/8facec08.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Pillowtop beds, desk, laptop workspace, iron/ironing board](https://images.trvl-media.com/lodging/4000000/3560000/3557700/3557696/d3477481.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Residence Inn Florence Marriott [](https://www.expedia.ca/Florence-Hotels-Residence-Inn-Florence-Marriott.h3557696.Hotel-Information) East Florence 9.0/10 Wonderful (331) "The room was great!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Trevis CA $171 CA $197 total includes taxes & fees Jan 10 - Jan 11 [](https://www.expedia.ca/Florence-Hotels-Residence-Inn-Florence-Marriott.h3557696.Hotel-Information) ![Interior](https://images.trvl-media.com/lodging/1000000/70000/67100/67060/c13613f0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/1000000/70000/67100/67060/e3eee8cf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/70000/67100/67060/d69651c5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Egyptian cotton sheets, premium bedding, down comforters, pillowtop beds](https://images.trvl-media.com/lodging/1000000/70000/67100/67060/13b3aaeb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Baymont by Wyndham Florence/Muscle Shoals [](https://www.expedia.ca/Florence-Hotels-Baymont-By-Wyndham-FlorenceMuscle-Shoals.h67060.Hotel-Information) Florence 7.2/10 Good (897) "The staff was absolutely amazing they're so nice they welcome you they have a good breakfast I've been staying there now 4 weeks and it's been nothing but pleasant . they are absolutely amazing. Their pet friendly and they have a large area to walk your dog. They also have a washer and dryer for the guest that is very inexpensive. This is definitely by the best hotel I've ever stayed at." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Elvis CA $102 CA $117 total includes taxes & fees Jan 4 - Jan 5 [](https://www.expedia.ca/Florence-Hotels-Baymont-By-Wyndham-FlorenceMuscle-Shoals.h67060.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/10000/8600/8599/c9b1fdcd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/1000000/10000/8600/8599/2fdb7dd0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Hallway](https://images.trvl-media.com/lodging/1000000/10000/8600/8599/d4d9e518.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/10000/8600/8599/48e30122.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Clarion Inn Sheffield Muscle Shoals [](https://www.expedia.ca/Florence-Hotels-Clarion-Inn-Sheffield-Muscle-Shoals.h8599.Hotel-Information) Sheffield 7.2/10 Good (964) "Parking was great" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Kathy CA $93 CA $104 total includes taxes & fees Jan 4 - Jan 5 [](https://www.expedia.ca/Florence-Hotels-Clarion-Inn-Sheffield-Muscle-Shoals.h8599.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2026-01-17&endDate=2026-01-18®ionId=6203&adults=2&travelerType=business_friendly&sort=RECOMMENDED&openPlayBack=true) ## Top Tuscumbia Hotel Reviews ![Hampton Inn & Suites Florence-Downtown](https://images.trvl-media.com/lodging/2000000/1820000/1818400/1818371/3ec8817c_y.jpg) ### Hampton Inn & Suites Florence-Downtown 10/10 Excellent "Staff is great, clean rooms, great breakfast. Be back next December!" [](https://expedia.ca/Florence-Hotels-Hampton-Inn-Suites-Florence-Downtown.h1818371.Hotel-Information) ![Baymont by Wyndham Florence/Muscle Shoals](https://images.trvl-media.com/lodging/1000000/70000/67100/67060/c13613f0_y.jpg) ### Baymont by Wyndham Florence/Muscle Shoals 10/10 Excellent "The staff was absolutely amazing they're so nice they welcome you they have a good breakfast I've been staying there now 4 weeks and it's been nothing but pleasant . they are absolutely amazing. Their pet friendly and they have a large area to walk your dog. They also have a washer and dryer for the guest that is very inexpensive. This is definitely by the best hotel I've ever stayed at." [](https://expedia.ca/Florence-Hotels-Baymont-By-Wyndham-FlorenceMuscle-Shoals.h67060.Hotel-Information) ![Best Western Plus Tuscumbia Muscle Shoals Hotel and Suites](https://images.trvl-media.com/lodging/18000000/17800000/17793400/17793356/b80a739c_y.jpg) ### Best Western Plus Tuscumbia Muscle Shoals Hotel and Suites 10/10 Excellent "Breakfast was great. Good food, staff so friendly and accommodating. Rooms very roomy and clean." [](https://expedia.ca/Florence-Hotels-Best-Western-Plus-Tuscumbia-Muscle-Shoals-Hotel-And-Suites.h17793356.Hotel-Information) ![Holiday Inn Express Hotel & Suites FLORENCE NORTHEAST by IHG](https://images.trvl-media.com/lodging/3000000/2980000/2976500/2976409/1fbbd61b_y.jpg) ### Holiday Inn Express Hotel & Suites FLORENCE NORTHEAST by IHG 10/10 Excellent "Friendly staff, everything wasCLEAN!! " [](https://expedia.ca/Florence-Hotels-Holiday-Inn-Express-Hotel-Suites-FLORENCE-NORTHEAST.h2976409.Hotel-Information) ![Comfort Suites Florence Shoals Area](https://images.trvl-media.com/lodging/4000000/3170000/3160100/3160009/e9e5832f_y.jpg) ### Comfort Suites Florence Shoals Area 10/10 Excellent "Room was clean, staff was friendly and helpful. " [](https://expedia.ca/Florence-Hotels-Comfort-Suites-Florence-Shoals-Area.h3160009.Hotel-Information) ![The ColdWater Inn](https://images.trvl-media.com/lodging/2000000/1550000/1549300/1549240/46e8d6c3_y.jpg) ### The ColdWater Inn 10/10 Excellent "Great staff and room." [](https://expedia.ca/Florence-Hotels-The-ColdWater-Inn.h1549240.Hotel-Information) ![Comfort Inn & Suites Tuscumbia - Muscle Shoals](https://images.trvl-media.com/lodging/2000000/2000000/1990300/1990270/9a484ef4_y.jpg) ### Comfort Inn & Suites Tuscumbia - Muscle Shoals 10/10 Excellent "Yes" [](https://expedia.ca/Florence-Hotels-Comfort-Inn-Suites-Tuscumbia-Muscle-Shoals.h1990270.Hotel-Information) ![Microtel Inn & Suites by Wyndham Tuscumbia/Muscle Shoals](https://images.trvl-media.com/lodging/4000000/3180000/3173300/3173212/d1efc2ef_y.jpg) ### Microtel Inn & Suites by Wyndham Tuscumbia/Muscle Shoals 10/10 Excellent "Nice room, friendly staff and yummy breakfast" [](https://expedia.ca/Florence-Hotels-Microtel-Inn-Suites-By-Wyndham-TuscumbiaMuscle-Shoals.h3173212.Hotel-Information) ![Residence Inn Florence Marriott](https://images.trvl-media.com/lodging/4000000/3560000/3557700/3557696/5c975983_y.jpg) ### Residence Inn Florence Marriott 10/10 Excellent "The room was great!" [](https://expedia.ca/Florence-Hotels-Residence-Inn-Florence-Marriott.h3557696.Hotel-Information) ## Frequently asked questions ### How much do business-friendly hotels in Tuscumbia cost? ### What are the best business-friendly hotels in Tuscumbia? ### How many business-friendly hotels are there in Tuscumbia? ### What are the best cheap business-friendly hotels in Tuscumbia? ### Why book your business-friendly hotel in Tuscumbia with Expedia? ### How can I find cheap business-friendly hotels in Tuscumbia? ### What is there to do in Tuscumbia near my business-friendly hotel? ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - Vacation Rental - Other - More ways to book - [Alabama Shores Hotels ](https://www.expedia.ca/Alabama-Shores-Hotels.d553248635975875941.Travel-Guide-Hotels) - [Resorts in Alabama Shores ](https://www.expedia.ca/Alabama-Shores-Resort-Hotels.d553248635975875941-aaResortHotels.Travel-Guide-Accommodation) - [Hotels near Blackberry Trail Golf Course ](https://www.expedia.ca/Blackberry-Trail-Golf-Course-Hotels.0-l553248621532655173-0.Travel-Guide-Filter-Hotels) - 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