Title: Book the Best HISTORIC Hotels in Texas Medical Center in 2025 | Expedia.ca [Texas Medical Center Travel Guide](https://expedia.ca/Houston-Texas-Medical-Center.dx6143504)[Vacation Rentals in Houston](https://expedia.ca/Houston-Vacation-Rentals.d178265.Travel-Guide-VacationRentals)[Flights to Houston](https://expedia.ca/Cheap-Flights-To-Houston.d178265.Travel-Guide-Flights)[Things to do in Houston](https://expedia.ca/Things-To-Do-In-Houston.d178265.Travel-Guide-Activities)[Texas Medical Center Car Rentals](https://expedia.ca/Car-Rentals-In-Texas-Medical-Center.d6143504.Car-Rental-Guide)[Texas Medical Center Vacations](https://expedia.ca/Texas-Medical-Center.d6143504.Destination-Travel-Guides) ![](https://mediaim.expedia.com/destination/1/f4655cac96c82fca6c00f4ab3162178c.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find Historic Hotels in Texas Medical Center, TX ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Texas Medical Center Historic Hotels Tonight [Oct 28 - Oct 29](https://www.expedia.ca/Hotel-Search?regionId=6143504&startDate=2025-10-28&endDate=2025-10-29&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Oct 29 - Oct 30](https://www.expedia.ca/Hotel-Search?regionId=6143504&startDate=2025-10-29&endDate=2025-10-30&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Oct 31 - Nov 2](https://www.expedia.ca/Hotel-Search?regionId=6143504&startDate=2025-10-31&endDate=2025-11-02&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Nov 7 - Nov 9](https://www.expedia.ca/Hotel-Search?regionId=6143504&startDate=2025-11-07&endDate=2025-11-09&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top Texas Medical Center Historic Hotels ![City view](https://images.trvl-media.com/lodging/1000000/30000/20100/20005/3940b07d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/30000/20100/20005/bc2b564f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool](https://images.trvl-media.com/lodging/1000000/30000/20100/20005/2ce18769.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, premium bedding, in-room safe, desk](https://images.trvl-media.com/lodging/1000000/30000/20100/20005/6b7ff15f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hyatt Regency Houston Downtown Downtown Houston 9.2/10 Wonderful (1099) "Perfect place to stay! " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Yohlman CA $236 CA $285 total includes taxes & fees Nov 26 - Nov 27 [](https://www.expedia.ca/Houston-Hotels-Hyatt-Regency-Houston.h20005.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/20000/13300/13295/c40a6103.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite (Composer) | Dining room](https://images.trvl-media.com/lodging/1000000/20000/13300/13295/f9f8ae11.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby lounge](https://images.trvl-media.com/lodging/1000000/20000/13300/13295/dd9a3669.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, pillowtop beds, free minibar, in-room safe](https://images.trvl-media.com/lodging/1000000/20000/13300/13295/a617bbb9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Lancaster Hotel Downtown Houston 9.8/10 Exceptional (1011) "Friendly staff, comfortable bed, great breakfast." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Polly Gay CA $287 CA $336 total includes taxes & fees Nov 21 - Nov 22 [](https://www.expedia.ca/Houston-Hotels-The-Lancaster-Hotel.h13295.Hotel-Information) ![Smart TV, books](https://images.trvl-media.com/lodging/58000000/57870000/57862500/57862411/8fb3a7ed.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Dining](https://images.trvl-media.com/lodging/58000000/57870000/57862500/57862411/b2f1a53c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, free WiFi, bed sheets](https://images.trvl-media.com/lodging/58000000/57870000/57862500/57862411/90-507207b9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV, books](https://images.trvl-media.com/lodging/58000000/57870000/57862500/57862411/dd41bb5d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Mid-century Modern Apartment Tucked In The Montrose Montrose 9.4/10 Exceptional (23) "This place has a great location and quite enjoyable." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Brittany W. CA $107 CA $285 total includes taxes & fees Oct 29 - Oct 30 [](https://www.expedia.ca/Houston-Hotels-Mid-Century-Modern-Apartment-Tucked-In-The-Montrose.h57862411.Hotel-Information) ![Dining](https://images.trvl-media.com/lodging/70000000/69750000/69748200/69748186/1a5bd75b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/70000000/69750000/69748200/69748186/4f990e62.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/70000000/69750000/69748200/69748186/4dacb92a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior detail](https://images.trvl-media.com/lodging/70000000/69750000/69748200/69748186/d91a38f6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Mid-Century Mod-Pad @ East Downtown South Central Houston 7.0/10 Good (4) "Good parking quite area host was great will definitely stay there again" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) T M. CA $152 CA $203 total includes taxes & fees Oct 30 - Oct 31 [](https://www.expedia.ca/Houston-Hotels-Mid-Century-Mod-Pad-East-Downtown.h69748186.Hotel-Information) ![Outdoor dining](https://images.trvl-media.com/lodging/49000000/48370000/48365300/48365278/c45795b2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/49000000/48370000/48365300/48365278/a5d81b61.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/49000000/48370000/48365300/48365278/4bfe571e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/49000000/48370000/48365300/48365278/e86eb746.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Fully stocked, Modern & Cosy Studio with Patio. Best Location! Walk Everywhere! Midtown 9.8/10 Exceptional (75) "Great place, great location. Easy communication! " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Carly R. CA $117 CA $219 total includes taxes & fees Nov 2 - Nov 3 [](https://www.expedia.ca/Houston-Hotels-Vrbo-Property.h48365278.Hotel-Information) ![Iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/112000000/111900000/111893000/111892910/26d71e6b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/112000000/111900000/111893000/111892910/e5b1d476.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/112000000/111900000/111893000/111892910/c318d478.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/112000000/111900000/111893000/111892910/02f888b8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Blue Diamond Inn Central Southwest 6.4/10 (6) CA $105 CA $123 total includes taxes & fees Oct 29 - Oct 30 [](https://www.expedia.ca/Houston-Hotels-Blue-Diamond-Inn.h111892910.Hotel-Information) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/117000000/116710000/116706400/116706339/0b6e859b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![6 bedrooms, iron/ironing board, travel crib, free WiFi](https://images.trvl-media.com/lodging/117000000/116710000/116706400/116706339/26be1b8d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/117000000/116710000/116706400/116706339/1d509797.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/117000000/116710000/116706400/116706339/3ed27390.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Krakow | Sleeps 16 Southeast Houston CA $186 CA $927 total includes taxes & fees Oct 29 - Oct 30 [](https://www.expedia.ca/Houston-Hotels-The-Krakow-Sleeps-16.h116706339.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/71000000/70390000/70386100/70386097/8b657ad8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV, books](https://images.trvl-media.com/lodging/71000000/70390000/70386100/70386097/a8953305.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior detail](https://images.trvl-media.com/lodging/71000000/70390000/70386100/70386097/e5f2fed8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/71000000/70390000/70386100/70386097/28404f43.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Montrose Hist Dist - Cozy and comfortable 2 BR Montrose CA $119 CA $295 total includes taxes & fees Nov 11 - Nov 12 [](https://www.expedia.ca/Houston-Hotels-Montrose-Hist-Dist-Cozy-And-Comfortable-2-BR.h70386097.Hotel-Information) ![Terrace/patio](https://images.trvl-media.com/lodging/39000000/38730000/38725100/38725032/c87adebe.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor dining](https://images.trvl-media.com/lodging/39000000/38730000/38725100/38725032/2e9fd432.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/39000000/38730000/38725100/38725032/6ba61f77.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![TV](https://images.trvl-media.com/lodging/39000000/38730000/38725100/38725032/25c4a86b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### ★ Glass Walls| Heart of Houston | Free Breakfast| Walk-able ★ Midtown CA $502 CA $713 total includes taxes & fees Oct 30 - Oct 31 [](https://www.expedia.ca/Houston-Hotels-Glass-Walls-Heart-Of-Houston-Free-Breakfast-Walk-Able.h38725032.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2025-11-11&endDate=2025-11-12®ionId=6143504&adults=2&specialized_stays_group_explore=historic_property&sort=RECOMMENDED&openPlayBack=true) ## Top Texas Medical Center Hotel Reviews ## Frequently asked questions ### What can a history buff expect from a stay in Texas Medical Center? > Significant historical sites in Texas Medical Center are likely at the top of your travel itinerary. Visit the shops and zoo while you're in town. You can also discover the museums during your vacation in this family-friendly area. ### How many historical hotels are there in Texas Medical Center? > Texas Medical Center is home to 186 hotels and other lodging options bookable on Expedia but not many designated as historic hotels. ### What are the top historical places and other sights in Texas Medical Center? > A favorite place to visit is Houston Zoo. In the area, you'll also find NRG Stadium and Toyota Center. ### What is a historic hotel like in Texas Medical Center? > When you choose a historic hotel, you'll stay in a place that has a national historic designation. A palace, castle, grand home or even an old police station, pub, lodge, or skyscraper can be identified as a historic hotel provided that it has special significance. Traditional architecture and period features can be admired in the public spaces and guestrooms of these historic hotels in Texas Medical Center, giving a real sense of character. ### What is the difference between a historic hotel and a heritage hotel? > You'll often hear the term "heritage hotel" in Asia and Europe, while "historic hotel" is a term often used in the U.S. but overall the terms are quite similar. The architecture and building of historic hotels are generally the most significant aspect. For a heritage hotel, mainly, it's cultural value and how it shaped the community. ### Do historic hotels in Texas Medical Center have modern facilities? > Hotels have the safety features and modern conveniences you expect to find, while every effort is made to preserve the historic aspects and traditions. Smart TVs, WiFi, updated bathroom facilities, and the usual amenities found in any hotel will also be available in a historic hotel. Rest assured that when you select a historic hotel in Texas Medical Center, you won't find yourself staying at a place that is rundown or uncomfortable. ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - Other - More ways to book - [3 Star Hotels in Houston Museum District](https://www.expedia.ca/3Star-Houston-Museum-District-Houston-Hotels.s30-n6164045-0.Travel-Guide-Filter-Hotels) - [5 Star Hotels in Houston Museum District](https://www.expedia.ca/5Star-Houston-Museum-District-Houston-Hotels.s50-n6164045-0.Travel-Guide-Filter-Hotels) - [Casino Hotels in Astrodome](https://www.expedia.ca/Astrodome-Houston-Hotels-Casino-Hotel.0-n553248635976007975-0-tCasinoHotel.Travel-Guide-Filter-Hotels) - [Cheap Hotels in Astrodome](https://www.expedia.ca/Astrodome-Houston-Hotels-Cheap-Hotels.0-n553248635976007975-0-tCheapHotels.Travel-Guide-Filter-Hotels) - [Luxury Hotels in Astrodome](https://www.expedia.ca/Astrodome-Houston-Hotels-Luxury-Hotel.0-n553248635976007975-0-tLuxuryHotel.Travel-Guide-Filter-Hotels) - 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[Macgregor Hotels](https://www.expedia.ca/MacGregor-Houston-Hotels.0-n553248635976383899-0.Travel-Guide-Filter-Hotels) - [Hotels near Main Street Theater - Rice Village](https://www.expedia.ca/Main-Street-Theater-Rice-Village-Hotels.0-l553248621561866623-0.Travel-Guide-Filter-Hotels) - [Hotels near Memorial Hermann Hospital/Houston Zoo Station](https://www.expedia.ca/Memorial-Hermann-HospitalHouston-Zoo-Station-Hotels.d6211668.Travel-Guide-Hotels) - [Resorts in Memorial Hermann Hospital/Houston Zoo Station](https://www.expedia.ca/Memorial-Hermann-HospitalHouston-Zoo-Station-Resort-Hotels.d6211668-aaResortHotels.Travel-Guide-Accommodation) - [Hotels near Museum District Station](https://www.expedia.ca/Museum-District-Station-Hotels.d6211664.Travel-Guide-Hotels) - [Museum Park Hotels](https://www.expedia.ca/Museum-Park-Houston-Hotels.0-n553248635976385848-0.Travel-Guide-Filter-Hotels) - [Hotels near NRG Arena](https://www.expedia.ca/NRG-Arena-Hotels.0-l553248635975094722-0.Travel-Guide-Filter-Hotels) - 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[Riverside Terrace Hotels](https://www.expedia.ca/Riverside-Terrace-Houston-Hotels.0-n151857-0.Travel-Guide-Filter-Hotels) - [Adults Only Resorts & in South Central Houston](https://www.expedia.ca/South-Central-Houston-Houston-Hotels-Adults-Only-Resorts.0-n553248635976476176-0-tAdultsOnlyResorts.Travel-Guide-Filter-Hotels) - [Casino Hotels in South Central Houston](https://www.expedia.ca/South-Central-Houston-Houston-Hotels-Casino-Hotel.0-n553248635976476176-0-tCasinoHotel.Travel-Guide-Filter-Hotels) - [Luxury Hotels in South Central Houston](https://www.expedia.ca/South-Central-Houston-Houston-Hotels-Luxury-Hotel.0-n553248635976476176-0-tLuxuryHotel.Travel-Guide-Filter-Hotels) - [Pet-Friendly Hotels in South Central Houston](https://www.expedia.ca/South-Central-Houston-Houston-Hotels-Pet-Friendly-Hotel.0-n553248635976476176-0-tPetfriendlyHotel.Travel-Guide-Filter-Hotels) - [Shopping Hotels in South Central Houston](https://www.expedia.ca/South-Central-Houston-Houston-Hotels-Shopping-Hotel.0-n553248635976476176-0-tShoppingHotel.Travel-Guide-Filter-Hotels) - [Budget Host Hotels in Southgate](https://www.expedia.ca/Southgate-Houston-Hotels-Budget-Host.0-n553248635976470716-0--bBudgetHost.Travel-Guide-Filter-Hotels) - [Southgate Hotels](https://www.expedia.ca/Southgate-Houston-Hotels.0-n553248635976470716-0.Travel-Guide-Filter-Hotels) - [Aparthotels in Stadium Park/Astrodome Station](https://www.expedia.ca/Stadium-ParkAstrodome-Station-Apart-Hotels.d6211680-aaApartHotels.Travel-Guide-Accommodation) - [Hostels in Stadium Park/Astrodome Station](https://www.expedia.ca/Stadium-ParkAstrodome-Station-Hostels.d6211680-aaHostels.Travel-Guide-Accommodation) - [Hotels near Stadium Park/Astrodome Station](https://www.expedia.ca/Stadium-ParkAstrodome-Station-Hotels.d6211680.Travel-Guide-Hotels) - [Farmstay in TMC Transit Center](https://www.expedia.ca/TMC-Transit-Center-Agritourism.d6211673-aaAgritourism.Travel-Guide-Accommodation) - [Hotels near Texas Children's Hospital](https://www.expedia.ca/Texas-Childrens-Hospital-Hotels.0-l553248635389801905-0.Travel-Guide-Filter-Hotels) - [University Place Hotels](https://www.expedia.ca/University-Place-Houston-Hotels.0-n553248635976386985-0.Travel-Guide-Filter-Hotels) - [Flights to Houston](https://www.expedia.ca/Cheap-Flights-To-Houston.d178265.Travel-Guide-Flights) - [Cullen Sculpture Garden](https://www.expedia.ca/Cullen-Sculpture-Garden-South-Central-Houston.d6237440.Vacation-Attraction) - [Hermann Park](https://www.expedia.ca/Hermann-Park-South-Central-Houston.d507227.Vacation-Attraction) - [Visit Astrodome](https://www.expedia.ca/Houston-Astrodome.dx553248635976007975) - [Houston Museum of Fine Arts](https://www.expedia.ca/Houston-Museum-Of-Fine-Arts-South-Central-Houston.d501255.Vacation-Attraction) - [James Turrell's Twilight Epiphany Skyscape](https://www.expedia.ca/James-Turrells-Twilight-Epiphany-Skyscape-South-Central-Houston.d553248621532644481.Vacation-Attraction) - [Md Anderson Cancer Center](https://www.expedia.ca/MD-Anderson-Cancer-Center-Texas-Medical-Center.d6248539.Vacation-Attraction) - [Nrg Stadium](https://www.expedia.ca/NRG-Stadium-Astrodome.d553248635929331916.Vacation-Attraction) - [Car rentals near Houston Museum District](https://www.expedia.ca/Car-Rentals-In-Houston-Museum-District.d6164045.Car-Rental-Guide) - [Things to do in Houston](https://www.expedia.ca/Things-To-Do-In-Houston.d178265.Travel-Guide-Activities) - [Book Hotels in Texas Medical Center on Expedia.com](https://www.expedia.com/Texas-Medical-Center-Houston-Hotels-Historic-Hotel.0-n6143504-0-tHistoricHotel.Travel-Guide-Filter-Hotels)