Title: Book the Best BOUTIQUE Hotels in Texas Medical Center in 2025 | Expedia.ca [Texas Medical Center Travel Guide](https://expedia.ca/Houston-Texas-Medical-Center.dx6143504)[Vacation Rentals in Houston](https://expedia.ca/Houston-Vacation-Rentals.d178265.Travel-Guide-VacationRentals)[Flights to Houston](https://expedia.ca/Cheap-Flights-To-Houston.d178265.Travel-Guide-Flights)[Things to do in Houston](https://expedia.ca/Things-To-Do-In-Houston.d178265.Travel-Guide-Activities)[Texas Medical Center Car Rentals](https://expedia.ca/Car-Rentals-In-Texas-Medical-Center.d6143504.Car-Rental-Guide)[Texas Medical Center Vacations](https://expedia.ca/Texas-Medical-Center.d6143504.Destination-Travel-Guides) ![](https://mediaim.expedia.com/destination/1/f4655cac96c82fca6c00f4ab3162178c.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find Boutique Hotels in Texas Medical Center, TX from CA $278 ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Texas Medical Center Boutique Hotels Tonight [Oct 22 - Oct 23](https://www.expedia.ca/Hotel-Search?regionId=6143504&startDate=2025-10-22&endDate=2025-10-23&adults=2&propertyStyle=BOUTIQUE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Oct 23 - Oct 24](https://www.expedia.ca/Hotel-Search?regionId=6143504&startDate=2025-10-23&endDate=2025-10-24&adults=2&propertyStyle=BOUTIQUE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Oct 24 - Oct 26](https://www.expedia.ca/Hotel-Search?regionId=6143504&startDate=2025-10-24&endDate=2025-10-26&adults=2&propertyStyle=BOUTIQUE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Oct 31 - Nov 2](https://www.expedia.ca/Hotel-Search?regionId=6143504&startDate=2025-10-31&endDate=2025-11-02&adults=2&propertyStyle=BOUTIQUE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top Texas Medical Center Boutique Hotels ![Exterior](https://images.trvl-media.com/lodging/3000000/2310000/2302900/2302841/e3524014.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Egyptian cotton sheets, premium bedding, pillowtop beds, minibar](https://images.trvl-media.com/lodging/3000000/2310000/2302900/2302841/15b65951.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Rooftop bar, garden views, open daily](https://images.trvl-media.com/lodging/3000000/2310000/2302900/2302841/w6106h4075x5y0-36a0348c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/3000000/2310000/2302900/2302841/1f1ee4a4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Moran CITYCENTRE Memorial 9.0/10 Wonderful (1001) "Great place to stay." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Anthony CA $203 CA $278 total includes taxes & fees Nov 21 - Nov 22 [](https://www.expedia.ca/Houston-Hotels-The-Moran-CITYCENTRE.h2302841.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/20000/13300/13295/c40a6103.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite (Composer) | Dining room](https://images.trvl-media.com/lodging/1000000/20000/13300/13295/f9f8ae11.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, pillowtop beds, free minibar, in-room safe](https://images.trvl-media.com/lodging/1000000/20000/13300/13295/a617bbb9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/1000000/20000/13300/13295/077747b7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Lancaster Hotel Downtown Houston 9.8/10 Exceptional (1000) "Great place... lots of nice people and nice rooms." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Kenneth CA $278 CA $325 total includes taxes & fees Oct 26 - Oct 27 [](https://www.expedia.ca/Houston-Hotels-The-Lancaster-Hotel.h13295.Hotel-Information) ![Lounge](https://images.trvl-media.com/lodging/1000000/20000/15000/14958/31bacfbb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool, pool umbrellas, sun loungers](https://images.trvl-media.com/lodging/1000000/20000/15000/14958/d5969644.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Meeting facility](https://images.trvl-media.com/lodging/1000000/20000/15000/14958/1ff77d59.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool, pool umbrellas, sun loungers](https://images.trvl-media.com/lodging/1000000/20000/15000/14958/eab2d50e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The St. Regis Houston The Galleria 9.2/10 Wonderful (399) "Fantastic staff and service " ![United Kingdom](https://a.travel-assets.com/egds/marks/flags/uk.svg) Rishi CA $655 CA $781 total includes taxes & fees Nov 20 - Nov 21 [](https://www.expedia.ca/Houston-Hotels-The-St-Regis-Houston.h14958.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2025-11-05&endDate=2025-11-06®ionId=6143504&adults=2&specialized_stays_group_explore=boutique_property&sort=RECOMMENDED&openPlayBack=true) ## Top Texas Medical Center Hotel Reviews ![Club Quarters Hotel Downtown, Houston](//images.trvl-media.com/lodging/2000000/1160000/1157000/1156923/44a9a3fd_y.jpg) ### Club Quarters Hotel Downtown, Houston 10/10 Excellent "Excelente " [](https://expedia.ca/Houston-Hotels-Club-Quarters-Hotel-In-Houston.h1156923.Hotel-Information) ![Magnolia Hotel Houston, A Tribute Portfolio Hotel](//images.trvl-media.com/lodging/1000000/910000/907500/907459/0b2adb37_y.jpg) ### Magnolia Hotel Houston, A Tribute Portfolio Hotel 10/10 Excellent "We had a perfect time for our parents weekend visiting our son at college! " [](https://expedia.ca/Houston-Hotels-Magnolia-Hotel-Houston.h907459.Hotel-Information) ![Hotel Zaza Houston Museum District](//images.trvl-media.com/lodging/1000000/10000/3400/3306/47c5ade4_y.jpg) ### Hotel Zaza Houston Museum District 10/10 Excellent "Nice room- thought it would be fancier. The bathrooms were really nice! When we got back from out event there was a charcuterie board waiting for us. Loved that suprise!!" [](https://expedia.ca/Houston-Hotels-Hotel-Zaza-Houston-Museum-District.h3306.Hotel-Information) ## Frequently asked questions ### What's there to see and do in Texas Medical Center? > The shopping, museums, and zoo are just some of the things to enjoy while you're in the area. Favorite activities and sights around Texas Medical Center include NRG Stadium, Houston Zoo, and Toyota Center. You might also want to see places such as Daikin Park, Rice Stadium, and Houston Natural Science Museum during your trip. ### What's the best way to get to my boutique hotel in Texas Medical Center? > You have a few options for getting to Texas Medical Center. The closest major airport is Houston William Hobby Airport (HOU), which is located 8 mi (12.9 km) away, but Houston, TX (EFD-Ellington Field) may also be an option. 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