Title: Book the Best BOUTIQUE Hotels in Texas Medical Center in 2026 | Expedia.ca

[Texas Medical Center Travel Guide](https://expedia.ca/Houston-Texas-Medical-Center.dx6143504)[Vacation Rentals in Houston](https://expedia.ca/Houston-Vacation-Rentals.d178265.Travel-Guide-VacationRentals)[Flights to Houston](https://expedia.ca/Cheap-Flights-To-Houston.d178265.Travel-Guide-Flights)[Things to do in Houston](https://expedia.ca/Things-To-Do-In-Houston.d178265.Travel-Guide-Activities)[Texas Medical Center Car Rentals](https://expedia.ca/Car-Rentals-In-Texas-Medical-Center.d6143504.Car-Rental-Guide)[Texas Medical Center Vacations](https://expedia.ca/Texas-Medical-Center.d6143504.Destination-Travel-Guides)

![Houston_TexasChildrensHospital_553248635389801905_9](https://images.trvl-media.com/place/553248635389801905/db4dee74-4310-41e3-8220-625d7fc800e9.jpg?impolicy=fcrop&w=1200&h=500&q=medium)

# Find Boutique Hotels in Texas Medical Center, TX from CA $263

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## Check availability on Texas Medical Center Boutique Hotels

Tonight

[Dec 11 - Dec 12](https://www.expedia.ca/Hotel-Search?regionId=6143504&startDate=2025-12-11&endDate=2025-12-12&adults=2&propertyStyle=BOUTIQUE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Tomorrow

[Dec 12 - Dec 13](https://www.expedia.ca/Hotel-Search?regionId=6143504&startDate=2025-12-12&endDate=2025-12-13&adults=2&propertyStyle=BOUTIQUE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

This weekend

[Dec 12 - Dec 14](https://www.expedia.ca/Hotel-Search?regionId=6143504&startDate=2025-12-12&endDate=2025-12-14&adults=2&propertyStyle=BOUTIQUE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Next weekend

[Dec 19 - Dec 21](https://www.expedia.ca/Hotel-Search?regionId=6143504&startDate=2025-12-19&endDate=2025-12-21&adults=2&propertyStyle=BOUTIQUE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

## Our top choices for Texas Medical Center boutique hotels

![Breakfast, lunch, dinner served; American cuisine ](https://images.trvl-media.com/lodging/1000000/20000/13300/13295/f93e7d1b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/1000000/20000/13300/13295/4f5312ad.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Breakfast, lunch, dinner served; American cuisine ](https://images.trvl-media.com/lodging/1000000/20000/13300/13295/0ae73cac.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![55-inch flat-screen TV with cable channels, TV, MP3 dock](https://images.trvl-media.com/lodging/1000000/20000/13300/13295/da61737e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### The Lancaster Hotel

[](https://www.expedia.ca/Houston-Hotels-The-Lancaster-Hotel.h13295.Hotel-Information)

Downtown Houston

9.8/10

Exceptional

(1000)

"Great amenities and hospitality "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Varun

CA $288

CA $337 total

includes taxes & fees

Dec 21 - Dec 22

[](https://www.expedia.ca/Houston-Hotels-The-Lancaster-Hotel.h13295.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/3000000/2310000/2302900/2302841/5813a4b5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Hallway](https://images.trvl-media.com/lodging/3000000/2310000/2302900/2302841/3b152ea4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Deluxe Suite, 1 King Bed, Non Smoking (Junior)](https://images.trvl-media.com/lodging/3000000/2310000/2302900/2302841/w8204h5461x0y3-2502a655.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Terrace/patio](https://images.trvl-media.com/lodging/3000000/2310000/2302900/2302841/524bd131.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### The Moran CITYCENTRE

[](https://www.expedia.ca/Houston-Hotels-The-Moran-CITYCENTRE.h2302841.Hotel-Information)

Memorial

9.0/10

Wonderful

(1000)

"Great Stay "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Malcolm

CA $190

CA $263 total

includes taxes & fees

Dec 25 - Dec 26

[](https://www.expedia.ca/Houston-Hotels-The-Moran-CITYCENTRE.h2302841.Hotel-Information)

![Outdoor pool, pool umbrellas, sun loungers](https://images.trvl-media.com/lodging/1000000/20000/15000/14958/dade7105.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Terrace/patio](https://images.trvl-media.com/lodging/1000000/20000/15000/14958/6721f1d9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lounge](https://images.trvl-media.com/lodging/1000000/20000/15000/14958/31bacfbb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lounge](https://images.trvl-media.com/lodging/1000000/20000/15000/14958/92274583.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### The St. Regis Houston

[](https://www.expedia.ca/Houston-Hotels-The-St-Regis-Houston.h14958.Hotel-Information)

The Galleria

9.2/10

Wonderful

(403)

"Clean room and good service "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

JAIME A CHAPA

CA $508

CA $605 total

includes taxes & fees

Dec 21 - Dec 22

[](https://www.expedia.ca/Houston-Hotels-The-St-Regis-Houston.h14958.Hotel-Information)

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

[View all properties](https://expedia.ca/Hotel-Search?startDate=2025-12-25&endDate=2025-12-26&regionId=6143504&adults=2&specialized_stays_group_explore=boutique_property&sort=RECOMMENDED&openPlayBack=true)

## Top Texas Medical Center Hotel Reviews

![Magnolia Hotel Houston, A Tribute Portfolio Hotel](https://images.trvl-media.com/lodging/1000000/910000/907500/907459/0b2adb37_y.jpg)

### Magnolia Hotel Houston, A Tribute Portfolio Hotel

10/10 Excellent

"Room was amazing. Quiet. Shower was excellent. Staff was friendly. "

[](https://expedia.ca/Houston-Hotels-Magnolia-Hotel-Houston.h907459.Hotel-Information)

![Club Quarters Hotel Downtown, Houston](https://images.trvl-media.com/lodging/2000000/1160000/1157000/1156923/44a9a3fd_y.jpg)

### Club Quarters Hotel Downtown, Houston

10/10 Excellent

"Excellent "

[](https://expedia.ca/Houston-Hotels-Club-Quarters-Hotel-In-Houston.h1156923.Hotel-Information)

![Hotel Zaza Houston Museum District](https://images.trvl-media.com/lodging/1000000/10000/3400/3306/47c5ade4_y.jpg)

### Hotel Zaza Houston Museum District

10/10 Excellent

"Great service "

[](https://expedia.ca/Houston-Hotels-Hotel-Zaza-Houston-Museum-District.h3306.Hotel-Information)

## Frequently asked questions

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- [Hermann Park ](https://www.expedia.ca/Hermann-Park-South-Central-Houston.d507227.Vacation-Attraction)
- [Visit Astrodome ](https://www.expedia.ca/Houston-Astrodome.dx553248635976007975)
- [Houston Museum of Fine Arts ](https://www.expedia.ca/Houston-Museum-Of-Fine-Arts-South-Central-Houston.d501255.Vacation-Attraction)
- [James Turrell's Twilight Epiphany Skyscape ](https://www.expedia.ca/James-Turrells-Twilight-Epiphany-Skyscape-South-Central-Houston.d553248621532644481.Vacation-Attraction)
- [Md Anderson Cancer Center ](https://www.expedia.ca/MD-Anderson-Cancer-Center-Texas-Medical-Center.d6248539.Vacation-Attraction)
- [Nrg Stadium ](https://www.expedia.ca/NRG-Stadium-Astrodome.d553248635929331916.Vacation-Attraction)

- [Car rentals near Houston Museum District ](https://www.expedia.ca/Car-Rentals-In-Houston-Museum-District.d6164045.Car-Rental-Guide)

- [Things to do in Houston ](https://www.expedia.ca/Things-To-Do-In-Houston.d178265.Travel-Guide-Activities)

- [Book Hotels in Texas Medical Center on Expedia.com ](https://www.expedia.com/Texas-Medical-Center-Houston-Hotels-Boutique-Hotel.0-n6143504-0-tBoutiqueHotel.Travel-Guide-Filter-Hotels)